The Journal of Heart and Lung Transplantation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Evaluation of Seralutinib Treatment Effect Across Four Risk Tools in the TORREY Study in Pulmonary Arterial Hypertension (PAH)
Purpose: Several risk stratification tools may be used to estimate the risk of adverse outcomes, monitor disease progression, and inform treatment decision-making in PAH. In TORREY, a randomized placebo-controlled phase 2 study, the tyrosine kinase inhibitor seralutinib met its primary endpoint of reduction in pulmonary vascular resistance (PVR) at 24 weeks (NCT04456998). A post-hoc exploratory analysis evaluated changes in REVEAL 2.0, REVEAL Lite 2, COMPERA 2.0 and Non-Invasive French risk tools with treatment. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , R. Osterhout, S. Hoffman, R.T. Zamanian, A.R. Hemnes, R.N. Channick, K.M. Chin, R.P. Frantz, A. Ghofrani, L.S. Howard, V.V. McLaughlin, J. Vachiery, L.S. Zisman, M. Cravets, J. Bruey, R.F. Roscigno, D. Mottola, R. Aranda, O. Sitbon Source Type: research

Consistency of the Efficacy and Safety Profile of Sotatercept across Baseline Cardiac Index Subgroups: A Pooled Analysis of STELLAR and PULSAR Trials
Purpose: Compare efficacy/safety of the activin signaling inhibitor, sotatercept (SOTA), across subgroups defined by baseline cardiac index (CI) value (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , D.B. Badesch, J.R. Gibbs, E. Grunig, M.M. Hoeper, M. Humbert, G. Kopec, V.V. McLaughlin, G. Meyer, K.M. Olsson, I. Preston, S. Rosenkranz, R. Souza, A. Waxman, L. Perchenet, J. Strait, A. Xing, A.O. Johnson-Levonas, A.G. Cornell, J. de Oliveira Pena, H. Source Type: research

Pre-Transplant Psychosocial Evaluation Characteristics and Associations with Pediatric Heart Transplant Outcomes
Purpose: The impact of specific socioeconomic resources and family characteristics on pediatric heart transplant (HTx) outcomes is unknown. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , K. Puri, V. Jack, E. Ormiston, J. Spinner, K. Watanabe, S. Choudhry, H. Tunuguntla, J. Price, W. Dreyer, K. Hope Source Type: research

Pediatric and Emerging Adult Heart Transplant Recipients Lost to Follow-Up: Risk Factors and Outcomes
Purpose: Solid organ transplant recipients who are lost to follow-up (LTFU) have worse outcomes. There is a lack of data regarding the incidence, risk factors, and outcomes in pediatric and emerging adult heart transplant recipients who are lost to follow-up. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , K. Watanabe, K. Hope, K. Puri, J. Spinner, H. Tunuguntla, S. Denfield, J. Price, W. Dreyer, S. Choudhry Source Type: research

In-Hospital Outcomes After Cardiac Transplantation in Patients with Neurodevelopmental Disorders: Insights from The National Inpatient Sample 2011-2019
Purpose: There is a lack of data regarding in-hospital outcomes after heart transplant (HTx) in patients with neurodevelopmental disorders (NDDs). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , L. Grazette Source Type: research

The Effect of Everolimus vs Calcineurin Inhibitors on Quality of Life 11 Years After Heart Transplantation: The Results of a Randomized Controlled Trial (Schedule Trial)
Purpose: Long-term complications of calcineurin inhibitors (CNI) in heart transplantation (HTx) has increased the interest in everolimus (EVR)-based regimens allowing for CNI withdrawal. We compared quality of Life (QoL) in a CNI-based regimen versus a CNI-free, EVR-based regimen during long-term treatment in The Scandinavian heart transplant everolimus de novo study with early CNI avoidance (SCHEDULE trial). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Relbo Authen, N. Bergh, K. Rolid, F. Gustafsson, H. Eiskjaer, G. Radegran, E. Gude, S. Arora, A. Andreassen, T. Halden, K. Broch, L. Gullestad Source Type: research

Role of KCCQ Overall Summary Score in Predicting Mortality in Heart Failure Patients
Purpose: Heart failure (HF) is a complex clinical syndrome associated with morbidity and mortality. Identification of independent predictors of risk in HF patients is crucial for guiding proper management strategies. The Kansas City Cardiomyopathy Questionnaire (KCCQ) is a validated tool that assesses the quality of life and functional status in HF patients. Therefore, we aimed to assess the KCCQ ’s Overall Summary Score (KCCQ-OSS) and independent parameters such as demographics, ejection fraction (EF), and other KCCQ-related variables as predictors of outcome in the study population. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J. Patel, M. Kittleson, M. White, A. Velleca, I. Kim, E. Kransdorf, L. Czer, F. Esmailian, J. Kobashigawa Source Type: research

Comparing Delayed versus Simultaneous Bone Marrow Transplantation to Achieve Lung Allograft Tolerance in Non-Human Primates
Purpose: Long-term, immunosuppression-free survival of haplo-matched lung allografts has been achieved in non-human primates (NHPs) using a delayed mixed-chimerism protocol. Previous work in kidney and heart transplantation suggest that the timing of donor bone marrow transplant (BMT) is critical for tolerance induction. We investigated whether simultaneous versus delayed BMT generates a more effective protocol for inducing tolerance of mismatched lung allografts. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J. Nawalaniec, J. O, A. Dehnadi, N. Hays, J. Muoio, C. Winter, I. Hanekamp, J. Madsen, J.S. Allan Source Type: research

Targeting Immunometabolism in Chronic Lung Transplant Rejection
Purpose: Bronchiolitis obliterans syndrome (BOS) is the main survival limiting factor after lung transplant, in part due to poor mechanistic understanding. We previously noted that lung transplant patients with a specific mutation in an autophagy gene ATG16l1 are at increased risk of early BOS. We made a mouse lung transplant model with this mutation in monocyte-derived antigen presenting cells (Mo-APCs) that also showed accelerated obliterative (OB) lesions. ATG16l1-deficient Mo-APCs show evidence of mitochondrial dysfunction and a metabolic shift to increased glycolysis with enhanced T cell alloimmune response. (Source: ...
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , F. Liao, C. Chen, D. Zhou, Z. Liu, J. Zhu, K. Pugh, R. Ebenezer, D. Byers, S. Brody, R. Hachem, A. Gelman Source Type: research

Mesenchymal Stromal Cells as Rescue Therapy for Refractory Chronic Lung Allograft Dysfunction: Analysis of Immunoregulatory Effects In Vitro and Preliminary Data of Safety In Vivo
Purpose: Mesenchymal stromal cells (MSCs) have been reported as a promising therapy for CLAD due to their immunomodulatory and tolerogenic properties. To assess MSC immunoregulatory/anti-remodeling effects in vitro and the safety profile in vivo we: 1) assessed bone marrow-derived MSC (BMSC) activity on normal precision cut lung slices (PCLS) cultures and 2) we monthly administered 1 x 106 BMSC/Kg BW to end stage CLAD patients who had previously failed several treatment lines including azithromycin, ECP and montelukast. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. Bozzini, E. Bozza, C. Bagnera, D. Briganti, K. Mucaj, G. Melloni, P. Comoli, F. Meloni Source Type: research

Safety and Efficacy of Total Lymphoid Irradiation in the Treatment of Chronic Lung Allograft Dysfunction
Purpose: To describe the safety and efficacy of total lymphoid irradiation (TLI) for chronic lung allograft dysfunction (CLAD), focusing on forced expiratory volume in 1 second (FEV1) change post-TLI, survival rates, and associated complications. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , F. Filippidis, R. Njafuh, M. Carby, K. Dave, J. Dunning, A. Reed, P. Hoskin, V. Gerovasili Source Type: research

Anti-Reflux Surgery for Prevention of CLAD Onset After Lung Transplantation: The Earlier the Better? A Single-Center Series of 284 Patients
Purpose: GERD is highly prevalent after lung transplantation (LTx), and suspected to favor chronic lung allograft disease (CLAD) development, mainly in its bronchiolitis obliterans syndrome (BOS) phenotype. Preventive effect of antireflux surgery (ARS) on BOS/CLAD onset in patients with GERD still remains debated. We aimed to compare the outcome of GERD patients with or without performed ARS, and those without GERD. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: A. Hamid, A. Vall ée, S. Rong, S. De Miranda, O. Boche, J. Rouillet-Audy, M. Stern, D. Grenet, L. Beaumont, F. Parquin, S. Colin De Verdiere, C. Picard, B. Zuber, J. Devaquet, J. Fessler, M. Le Guen, J. De Wolf, C. Pricopi, M. Glorion, E. Sage, A. Roux, Source Type: research

Modulation of Programmed Cell Death Mechanisms in Human Hearts Donated After Circulatory Death
Purpose: This research aimed to explore the two programmed cell death pathways (apoptosis and necroptosis) in human hearts donated after circulatory death (DCD) with varying warm ischemic times (WIT) and cold storage. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. Li, K.V. Nordick, A.E. Elsenousi, R. Bhattacharya, A. Mattar, C. Hochman-Mendez, T.K. Rosengart, K.K. Liao Source Type: research

Blocking Signaling Pathways Like Notch and Hedgehog Reduces Chronic Rejection in a Murine Aortic Transplant Model
Purpose: Cardiac allograft vasculopathy (CAV) remains a primary contributor to chronic rejection following heart transplantation. A combination of effects including immunological and non-immunological factors contributes to the development of CAV. The main objective of this study is to investigate whether LDE225, as a Hedgehog pathway inhibitor, and/or DAPT, as a γ-secretase inhibitor known to disrupt the Notch signaling pathway, can attenuate chronic rejection in a mouse aortic transplant model and act as potential targets to prevent the development of CAV to improve long-term outcomes for heart transplant recipients. (S...
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , C. Gr äbner, A. Kuckhahn, J. Distler, B. Spriewald, M. Ramsperger-Gleixner, O. Dewald, C. Heim Source Type: research

Persistent Alterations in Gene Expression Despite Phenotypic Normalization in a Non-Ischemic Mouse Model of Heart Failure Recovery: Are ECM and Ferroptosis Genes the Key for Complete, Sustained Recovery?
Purpose: MCS assisted cardiac recovery has not seen high prevalence outside of trials. We aimed to identify genes that exhibit persistent dysregulation in the recovered state (RS) when compared to changes in heart failure (HF) state in a mouse model of recovery. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: K.A. Patel, M. Krishnamoorthi, L.W. Moore, Source Type: research