The Journal of Heart and Lung Transplantation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

CD38-Antibody Daratumumab in Allosensitized Recipients for Heart Transplantation: Outcomes and 3-Years of Single-Centre Experience
Purpose: Consistent increase in number of sensitized patients at the waitlist requires strategies to prevent antibody-mediated rejection. In Vienna Daratumumab is used in this cohort, an antibody targeting CD38 at plasma cells, natural killer cells and T-regulatory cells. In the past short-term results confirmed its efficacy in heart transplantation (HT), however mid-term results are still missing. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , R. Moayedifar, D. Koren, G. Fischer, M. Nackenhorst, K. Uyanik-Uenal, J. Goekler, G. Boehmig, A. Aliabadi-Zuckermann, A. Zuckermann Source Type: research

Dot Your I's and Check Your T's? Impact of Various T Cell Monitoring Methods on Heart Transplant Outcomes
Purpose: The use of antithymocyte globulin for induction therapy is limited by toxicity, such as infections and malignancy. ISHLT guidelines recommend checking CD3 T- Cell counts (CD3) or absolute lymphocyte counts (ALC) to mitigate this risk. As data are limited comparing CD3 and ALC, we compared the two measurements for concordance and examined their corresponding post-transplant outcomes. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , K. Khush, R. Lee, T. Intieri, H. Luikart, D. Kim, A. Skoda, A. Subramanian, B. Wayda, M.B. ZHang, R. Imai, T. Le, U. Wang, Y. Moayedi, K. Sallam, S. Hsiao, F. Haddad, Y. Shudo, J. Teuteberg Source Type: research

Incidence and Risk Factors for Rejection After Conversion to Sirolimus-Based Immunosuppression in Orthotopic Heart Transplant Recipients
This study sought to evaluate the incidence and risk factors for biopsy-proven, clinically relevant rejection following conversion from calcineurin-based to sirolimus-based immunosuppression. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , M. Abbas, R. Asleh, S. Kushwaha, A. Clavell, M. Villavicencio, P. Spencer, R. Daly, A. Behfar, A. Rosenbaum Source Type: research

Diabetes Therapy with Novel Agents After Heart Transplant: A Multi-Institutional Analysis
Purpose: Diabetes mellitus (DM) after heart transplant (HTx) is associated with increased risk of kidney dysfunction and cardiovascular (CV) morbidity and mortality. Glucagon-like peptide-1 receptor agonists (GLP1-RA) and sodium-glucose cotransporter 2 inhibitors (SGLT2i) are novel therapies shown to improve CV and metabolic outcomes, but HTx recipients were excluded from pivotal clinical trials and few data exist on their use after HTx. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , K. Sideris, R. Singh, M. Nevers, G. Wei, S. Hartsell, A. Sarwal, C. Kyriakopoulos, E. Maneta, S. Drakos, T. Hanff, S. Carter, J. Fang, M. Cho, S. Beddhu, J. Stehlik Source Type: research

Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss in End-Stage Heart Failure Patients Considered for Heart Transplantation
Purpose: Morbid obesity is a major exclusion criterion for heart transplantation, with a body mass index (BMI) (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , R. Jeyakumar, D. Robson, L. Honeysett, L. Raven, R. Campos Deveza e Silva, A. Jabbour, E. Kotlyar, A. Keogh, J. Greenfield, P. MacDonald, C. Hayward, K. Muthiah Source Type: research

AlloSure Stratifies Prognosis of Asymptomatic AMR
Purpose: The progression of asymptomatic antibody-mediated rejection (asAMR) is poorly understood. We aimed to determine if elevated donor-derived cell-free DNA (dd-cfDNA; AlloSure) in the setting of asAMR risk stratifies heart transplant recipients (HTs) who have a worse prognosis and may warrant further intervention. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Alam, P. Shah, N. Uriel, Y. Fu, M. Zhou, L. Shen, K. Qu, K. Oreschak, K. Foster Source Type: research

Cell-Free DNA Identifies High-Risk Donor Specific Antibodies in Heart Transplant Recipients
This study evaluates if donor-derived cell free DNA (dd-cfDNA) can identify high-risk DSA that lead to AMR. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , Y. Xu, X. Tian, A. Bon, G. Eleanor, R. Brower, M. Jang, H. Kong, T. Andargie, W. Park, S. Najjar, I. Tchoukina, K. Shah, S. Hsu, M. Rodrigo, C. Marboe, G. Berry, H. Valantine, P. Shah, S. Agbor-Enoh Source Type: research

Correlation Between Donor-Specific Antibodies and Molecular Microscope Results in Heart Transplant Recipients
Purpose: Diagnosing antibody-mediated rejection (ABMR) in heart transplant (HT) recipients remains challenging, and is based on the combination of symptoms, the existence of donor specific antibodies (DSA) and histological assessment. The Molecular Microscope (MMDx), which employs tissue-based gene expression analysis, may add important adjunctive information. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: C.M. Moeller, , D. Oren, G. Rubinstein, J. Baranowska, S. Rahman, C. Lee, Y. Mehlman, D. Lotan, D. Bae, K. Oh, K. Theodoropoulos, E.M. DeFilippis, J. Fried, E. Lin, V. Topkara, M. Yuzefpolskaya, P. Colombo, D. Majure, K. Clerkin, J. Raikhelkar, F. Latif, Source Type: research

Impact of Innate Rejection on Graft Survival in Heart Transplantation: Preliminary Findings on Missing-Self Induced Microvascular Rejection
Purpose: Missing self (MS), the inability of donor endothelial cells to deliver HLA I-mediated signals to inhibitory killer cell Ig-like receptors (KIRs) on recipient natural killer (NK) cells, can lead to microvascular inflammation (MVI) in kidney transplantation, independently of donor-specific anti-HLA antibodies (DSA). The clinical significance of MS in heart transplantation is unknown. We aimed to evaluate the role of innate rejection mediated by NK cells in heart transplanted (HT) patients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Koenig, M. Masetti, V. Dubois, C. Saison, L. Borgese, L. Giovannini, L. Marcantoni, L. Botta, S. Manfroi, O. Thaunat, L. Potena Source Type: research

Long Term Outcome of First-Year C1q Positive Donor Specific Antibodies After Heart Transplantation
Purpose: Detection of donor specific antibodies (DSA) after heart transplantation (HTx) has been associated with poor outcome in the long term. DSA have been associated with decreased survival, increased incidence of cardiac allograft vasculopathy (CAV), increase in cardiac dysfunction, and increase in non-fatal major adverse cardiac events (NF-MACE). DSA are heterogeneous and amount of antibody-binding can be detected by the Luminex assay. Functional studies indicate whether the DSA can cause killing by the ability to bind complement. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J. Patel, M. Kittleson, M. Welton, N. Bhatnagar, A. Kanungo, M. Lee, Z. Wakefield, M. Hamilton, A. Hage, L. Czer, P. Catarino, J. Kobashigawa Source Type: research

Predictors of Intraoperative Donor Lung Turndown After Initial Acceptance
Purpose: Turndown of donor lungs at the time of potential recovery wastes transplant team, hospital, and system resources. We investigated predictors of intraoperative turndown (ITD) of donor lung allografts that were initially accepted. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A.L. Zhou, J.M. Ruck, A. Kalra, A.J. Casillan, J.S. Ha, C.A. Merlo, E.L. Bush Source Type: research

The Respiratory Physiotherapy, a New Tool to Increase the Lung Donors Pool
Purpose: Mechanical Insufflation-Exsufflation (MI-E) is a non-invasive respiratory physiotherapy device that simulates a cough, aiding in the clearance of secretions and improving oxygenation. Although routinely used for respiratory physiotherapy in critically ill patients, no evidence is available regarding its use in the maintenance/optimization of solid organ donors. We aimed to evaluate the impact on oxygenation, lung compliance and safety when used as a part of the donor management protocol. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , G. Ballesteros, B. Garc és, J. Mercabal, D. Paredes, M. Peñalver, E. Miñambres, Á. Suarez, A. Gómez, B. Pascual, G. Sánchez-Etayo, D. Martí, E. Navas, A. Gómez, M. Boada, L. Grando, B. Dominguez-Gil, A. Sandiumenge Source Type: research

Satisfactory Short and Long-Term Outcomes from Careful Selection of Older Donors for Lung Transplantation: An Australian Single-Centre Experience
Purpose: Availability of ideal lung donors is insufficient to meet the demands of waitlisted lung transplant (LTx) recipients. Donors aged> 55 have traditionally been considered marginal. We hypothesise that carefully selected older donors may provide satisfactory short and long-term outcomes after LTx. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Iyer, A. Watson, M. Connellan, E. Granger, M. Plit, P. Jansz, D. Darley Source Type: research

Controlled Donation After Circulatory Death Lung Transplantation in University Hospital Zurich: 10-years' Experience
Purpose: Controlled organ donation after circulatory death (cDCD) was launched in Switzerland in 2012. We aim to analyze the outcomes of lung transplantations (LTx) with cDCD after ten years in our center. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , T. Papasotiropoulos, G. Lang, I. Iskender, M. Schuurmans, R. Hage, I. Opitz Source Type: research

Outcomes in Donation After Circulatory Death Pediatric Lung Transplants: An Analysis of the ISHLT Registry
Purpose: Donation after circulatory death (DCD) lung transplantation has increased, but there is limited data in children. We sought to characterize the international experience of pediatric DCD lung transplant (LTx) in comparison to donation after brain death (DBD). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: H. Ahmed, S. Hogue, , M. Hossain, Y. Zhang, A. Ashfaq, D. Morales, D. Hayes Source Type: research