The Journal of Heart and Lung Transplantation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

An Exploration of Gene Expression Patterns Underlying Restrictive and Obstructive Chronic Lung Allograft Dysfunction (CLAD) Phenotypes Using Non-Negative Matrix Factorization
Purpose: Pathways active in CLAD subtypes, bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS), remain poorly understood. We aimed to uncover CLAD phenotype-specific mechanisms using the comprehensive and unsupervised non-negative matrix factorization (NMF)-based clustering algorithm applied to bulk RNA sequencing data from human CLAD lungs. We hypothesized this would uncover differential transcriptomic signatures related to epithelial, pro-fibrotic, and immune pathways in RAS and BOS. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J. Allen, G. Berra, R. Ghany, S. Keshavjee, G. Wilson, J. Yeung, S. Juvet, T. Martinu Source Type: research

Divergent Transcriptional Features of Obstructive and Restrictive Forms of Chronic Lung Allograft Rejection Modeled in a Single Mouse Strain Combination
Purpose: Chronic lung allograft dysfunction (CLAD) after lung transplantation (LTx) is augmented by innate immunity and has two main histologic patterns: pleuroparenchymal fibroelastosis (PPFE) and obliterative bronchiolitis (OB). The extent to which PPFE and OB arise from distinct pathways in unknown. In a mouse orthotopic LTx model using a single strain combination (C57BL/10 to C57BL/6), we recapitulated PPFE-predominant fibrosis with OB induced by ischemia-reperfusion injury (IRI) and OB-predominant fibrosis with minimal PPFE using repeated airway lipopolysaccharide (LPS) administration (Figure A). (Source: The Journal ...
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J. Allen, S. Keshavjee, Y. Okada, J. Yeung, T. Martinu, S. Juvet Source Type: research

Integrative Multi-Omics Profiling in Human Decedents Receiving Genetically Modified Pig Hearts Reveals Early Immune-Cell Responses Indicative of Perioperative Cardiac Xenograft Dysfunction
Purpose: Recent advances in living and decedent human xenotransplantation using pig organs show promise for first-in-human trials. In 2022, two heart xenografts from 10-gene edited pigs were transplanted into 2 human decedents, primarily to evaluate hyper-acute antibody mediated rejection and function of the xenograft over 3 days. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , E. schmauch, N. Moazami, M. Snyder, B. Piening, R. Montgomery Source Type: research

Extended Survival of 9- and 10-Gene-Edited Pig Heart Xenografts with Ischemia Minimization and Cd154 Costimulation Blockade-Based Immunosuppression
Purpose: Xenotransplantation has made significant advances recently using pigs genetically engineered to remove carbohydrate antigens, either alone or with addition of various human complement, coagulation, and anti-inflammatory ‘transgenes’. Here we evaluated results associated with gene-edited (GE) pig hearts transplanted in baboons using an established costimulation-based immunosuppressive regimen and a cold-perfused graft preservation technique. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , I. Ileka, K. Kinoshita, Z. Habibabady, S. Lederman, L. Burdorf, W. Eyestone, R. Prather, R. Pierson Source Type: research

Pilot Evaluation of a Clinical Xeno Heart Transplant Regimen in A Preclinical Model
Purpose: Significant advances have been made recently in xenotransplantation using gene-edited (GE) pigs with up to 3 carbohydrate transferase knockouts in various combinations, alone or with additional human complement (CD46, CD55, CD59), coagulation (TBM, EPCR, TFPI), and anti-inflammatory (CD47, CD39,HLAE/ β2M, A20, PD-1, HO-1) ‘transgenes’. In this pilot study we evaluated hearts from 3-GE and multi-GE pigs treated with an established costimulation-based immunosuppressive (IS) regimen and cold-perfused ‘ischemia minimization’ (IM). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , I. Ileka, K. Kinoshita, Z. Habibabady, S. Low, K. Whitworth, R. Pierson Source Type: research

Heart Allograft Survival in Juvenile Nonhuman Primates Undergoing Mixed Chimerism Conditioning is Prolonged by Donor Thymus Co-Transplantation
Purpose: Tolerance of heart allografts in nonhuman primates (NHPs) has been achieved by inducing transient mixed chimerism and co-transplanting a kidney, which promotes regulatory T cells. Here, we test whether co-transplanting the thymus could be a clinically relevant alternative to kidney co-transplantation in achieving heart tolerance in children. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. Landino, J. O, J. Muoio, N. Hays, D. Muldoon, A. Dehnadi, I. Hanekamp, J. Allan, J. Madsen Source Type: research

IL-6 Receptor Blockade Induces Tolerance of Heart Allografts in NHPs in a Simultaneous but Not Delayed Mixed-Chimerism Protocol
Purpose: Previously, we have achieved tolerance of isolated heart allografts in cynomolgus monkeys for the first time by using tocilizumab to block the IL-6 receptor in a mixed-chimerism protocol wherein donor bone marrow (DBM) is given simultaneously with the organ transplant. Here we investigated whether tocilizumab can induce tolerance of a cardiac allograft when the DBM transplant is delayed 2-4 months following heart transplantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J. Nawalaniec, S. Landino, N. Hays, A. Dehnadi, J.M. Muoio, C. Winter, I. Hanekamp, G. Benichou, J. Allan, J. Madsen Source Type: research

Optimizing Hearts for Transplantation Using Small Interfering RNA-Based Therapies During Ex Vivo Machine Perfusion
Purpose: Ex vivo heart perfusion (EVHP) is a promising platform for delivery of candidate therapeutics designed to improve the quality of hearts used for transplantation. We have previously reported that, after systemic administration, docosanoic acid (DCA) conjugates yield superior delivery to the heart relative to other molecules. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , H.H. Fakih, M. Bolger-Chen, M. Lopera Higuita, R. Pierson, A.A. Osho, S. Tessier, A. Khvorova, S. Rabi Source Type: research

Longer Duration of Ex-Vivo Perfusion is Associated with Worse Survival in Donation After Circulatory Death Heart Recipients: A National Database Analysis
Purpose: We explored the effect of duration of ex-vivo heart perfusion (EVHP) on patient outcomes following donation after circulatory death (DCD) heart transplantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: K. Punu, R. Singh, , S.A. Brownlee, A. Kreso, S. Rabi, E. Michel, G. Lewis, D. D'Alessandro, A. Osho Source Type: research

Organ Care System (OCS) Perfusion Time During Donation After Circulatory Death (DCD) Heart Transplantation: Not Too Little, Not Too Much: There Safety Lie
This study aims to determine the impact of OCS perfusion time on outcomes after transplantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , L. Martinez Marin, S. Pettit, P. Kaul, M. Rafiq, S. Tsui, D. Jenkins, S. Large, S. Bhagra, A. Kydd, L. Simmonds, R. Hogg, J. Parameshwar, C. Lewis, J. Nunes, S. Messer, A. Page, A. Al-Adhami, M. Berman Source Type: research

Impact of Ex Vivo Machine Perfusion on Post-Transplant Survival in Extended Criteria Hearts Donated After Brain Death
Purpose: Ex vivo machine perfusion has been employed to extend the heart preservation period. While prior research has primarily centered on its effects on donation after circulatory death, this study examines the influence of machine perfusion on outcomes following donation after brain death (DBD) heart transplantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , N. Hess, L. Ziegler, A. Dorken-Gallastegi, M. Abdullah, N. Agrawal, I. Sultan, G. Hickey, M. Keebler, D. Kaczorowski Source Type: research

Initial Single Centre Experience with The XVIVO Hypothermic Perfusion System: Outcomes from the First 32 Cases
Purpose: The initial Australian-New Zealand Non-ischaemic hypothermic perfusion (NIHP) trial demonstrated the feasibility of using the XVIVO non-ischaemic hypothermic perfusion (NIHP) system in prolonged organ preservation, improving the number of available donor hearts for all transplant centres within the region. The device has now been in use for 2 years at St Vincent ’s Hospital, Sydney, Australia and this paper will highlight the post-transplant outcomes from the first 32 patients who received donor hearts preserved by this device. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , P. MacDonald, C. Hayward, K. Muthiah, A. Watson, A. Iyer, M. Connellan, E. Granger, D. Kaye, D. McGiffin, P. Jansz Source Type: research

Health Literacy in Lung Transplant Patients: An Area for Improvement
This study aims to assess the prevalence of low HL in lung transplant candidates and to evaluate patient factors associated with HL. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J. Vinales, K. Walter, J. Shevket, B. Hunt, V. Sood, S. Zaientz, J. Clay, K. Lagisetty, R. Sagana Source Type: research

The Impact of Pre-Transplant Mental Toughness on Short-Term Outcomes in Lung Allograft Recipients
Purpose: Grit and resilience are associated with improvements in mood, therapeutic adherence, quality of life, and survival in several chronic illnesses; their association with lung transplant outcomes is unknown. We hypothesized that greater mental toughness is associated with shorter index hospital length of stay (LOS). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , K.C. Chapin, K. Xu, J. Liu, L. Lipworth, C.M. Shaver, A.J. Trindade Source Type: research

Comparison of Frailty Trajectories in Lung Transplantation
Purpose: Two conceptual models of frailty, physical/frailty phenotype and cumulative deficits/frailty index, have both been associated with lung transplant outcomes. We aimed to compare the trajectories of physical and cumulative deficits frailty before and after lung transplantation (LTx). While physical frailty has been shown to improve post-LTx, we hypothesized that cumulative deficits would not improve as new deficits accrue after LTx. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: A. Rajkumar, N. Chowdhury, D. Rozenberg, P. Riddell, K. Rockwood, S. Mathur, Source Type: research