Timing of Stroke in Children Supported by Ventricular Assist Devices - An ACTION Registry Report
Purpose: Ventricular assist devices (VADs) are frequently utilized for long-term support for children awaiting heart transplantation (HT). Despite significant improvements in recent years, neurological events remain an important cause of morbidity and mortality during VAD support. We aimed to identify the timing of ischemic and hemorrhagic strokes (IS and HS) during VAD support in children as a foundation for building upon mitigation strategies already accomplished within the Advanced Cardiac Therapies Improving Network (ACTION). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J. Murray, M. Mehegan, A. Lorts, M. O'Connor, M. Rivkin, J. Edelson, D. Rosenthal, S. Law, C. VanderPluym Source Type: research

Early and Late Invasive Aspergillosis in the First Year Post Lung Transplant (LT) - A Multicentre Study
Purpose: Invasive Aspergillosis (IA) mostly occurs within the first year after LT. However, IA incidence, associated factors and outcomes potentially differ according to time after transplant. We therefore compared IA occurring within the first vs. the second 6 months post-transplant. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , C. Crone, R. Bitterman, R. Nadeem, M. Helleberg, M. Perch, A. Perez Cortes Villalobos, T. Martinu, S. Keshavjee, S. Husain Source Type: research

Invasive Candidiasis Following Lung Transplant: An Assessment of Impact Utilizing a National Insurance Claims Cohort
Purpose: Lung transplant recipients are at increased risk for invasive fungal infections (IFI). Recent single-center studies suggest that invasive candidiasis (IC) may be an important cause of IFI. Although universal antifungal prophylaxis may seem like a good preventative measure for IC, its benefit remains unclear, and use carries significant risks of adverse effects, drug interactions, and increased cost. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , H.C. Heien, S.G. Peters, R.R. Razonable, C.C. Kennedy, K.M. Pennington Source Type: research

The Ability of an Electronic Nose to Distinguish Between Infections in Lung Transplant Recipients
Purpose: Early post-transplant, airway infections are common, with reported incidences between 22-36% in the first year. Infections significantly contribute to the development of chronic lung allograft dysfunction, impacting long-term survival and quality of life. Common issues include over- and under-treatment, along with delays in diagnosis of infections. Early infection type (viral, bacterial, or fungal) diagnosis and correct treatment could further improve outcomes. As potential alternative and faster point-of-care test (POCT) to distinguish between different types of airway infections, we assessed the ability of exhal...
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , C.E. Luijendijk, R. van Pel, B.J. Mathot, L. Seghers, D. Bos, O.C. Manintveld, M.E. Hellemons Source Type: research

Use of Letermovir for Cytomegalovirus Prophylaxis in Lung Transplant
Purpose: To evaluate the efficacy and safety of letermovir (LTV) compared to valganciclovir (VGC) for primary (1PPX) and secondary (2PPX) prophylaxis of cytomegalovirus (CMV) in lung transplant (LTX). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J. Wang, N. Borkowski, B. Miner, M. Mahesri, M. Venkata Subramani, R. Tomic, A. Arunachalam, C. Myers Source Type: research

HOPE For a Bright Future
Purpose: As people living with Human Immunodeficiency Virus (PLWH) approach near normal life expectancy, chronic heart and lung diseases in this group are also increasing. HIV Organ Policy Equity (HOPE) Act transplants using HIV+ thoracic donors are underutilized given regulatory barriers. More data is needed to examine the path to transplant and outcomes for thoracic organ recipients of PLWH (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J. Messina, J. Steinbrink, J. Reynolds, A. Devore, A. Baker, M. Carugati, B. Ni, I. schwartz, C.R. Wolfe Source Type: research

Waitlist Time and Outcomes of Adult Congenital Heart Disease Patients Listed for Heart Transplantation
Purpose: Despite improvements in risk stratification for orthotopic heart transplant (OHT) in adults with congenital heart disease (ACHD) after the 2018 allocation change, waitlist times for lower risk patients may actually be longer; making timely status upgrade crucial. We investigated variables impacting waitlist time and negative waitlist outcomes in ACHD OHT candidates. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , B.L. Shou, A. Kilic, A.M. Cedars Source Type: research

Outcomes After Ecmo Bridge to Heart Transplantation- Pre and Post-Heart Allocation Change
Purpose: Utilization of ECMO as a bridge to heart transplantation (HT) has increased since the revised heart allocation policy took effect in October 2018. While short term (6 and 12 months) post-HT survival has improved among ECMO-bridged patients in the current era, little is known about long-term (3-year) outcomes. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , H. Patel, A. Hernandez, M. Bacchetta, A. Shah, J. Lindenfeld, K. Schlendorf Source Type: research

Nonlinear Effect of Body Mass Index on Postoperative Survival Following Isolated Heart Transplant
Purpose: Guidelines regarding a patient ’s fitness to receive isolated heart transplant in terms of a candidate’s Body Mass Index (BMI) are evolving. Guidelines for BMI cutoffs range from 30 to 40 depending on country and institution. Previous studies have reported a negative association between recipient BMI and probability of receiv ing a transplant, and other studies have characterized the effect of BMI as U-shaped. Given this association, it is imperative to provide updated nonlinear estimates of postoperative risk attributable to a recipient’s BMI to evaluate the optimality of existing cutoffs. (Source: The Jour...
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , N. Bahatyrevich, M. Leipzig, M. Currie Source Type: research

Evaluating Mid-Term Outcomes of COVID-19 Donor Heart Transplantation in the United States
Purpose: We sought to evaluate the mid-term outcomes of COVID-19+ heart transplantation in the United States. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , P. Cho, P.T. Gaynor, A. Ardehali Source Type: research

Young at Heart: Survival Among Septuagenarian Heart Transplant Recipient Has Decreased Over the Past Decade
Purpose: Due to advances in the field of heart transplant, many centers have increased acceptable candidate age limits over time. The implications of this trend for post-transplant outcomes, particularly among the oldest recipients, remain unclear and were assessed in this analysis. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , B. Wayda, J. Teuteberg, H. Luikart, J. Njoroge, B. Guenthart, K. Khush Source Type: research

Just a Number? Donor Age and (Lack of) Associated Reasons for Heart Offer Refusal in the Donor Heart Study
Purpose: Use of 50+ year old donors for heart transplant (HT) is relatively rare in the United States (US). We assessed reasons for this - and whether it reflects concern about age itself or associated risk factors - using a survey of US HT centers. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: C. Bhowmik, , H. Luikart, Y. Weng, S. Zhang, R.P. Wood, J. Nieto, T. Groat, N. Neidlinger, K.K. Khush Source Type: research

Incorporating Donor Variables Improves Accuracy of One-Year Post-Transplant Survival Prediction for Adult Heart Transplant Recipients
Purpose: Post-transplant survival is a component of the proposed continuous distribution framework for donor heart allocation in the United States. Predictive models for post-transplant survival using donor variables have not been developed since the 2018 donor heart allocation policy change. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , K. Zhang, N. Narang, W.F. Parker Source Type: research

The Effect of Donor Distance on Post-Transplant Mortality
This study compares post-transplantation mortality based on distance between donor and transplant centers. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , C. Song, A. Iyengar, N. Weingarten, M. Shin, S. Kim, J. Jiang, M. Asher, M. Helmers, M. Cevasco, P. Atluri Source Type: research

Reasons for Donor Heart Offer Refusal Often Contradict Objective Cardiac Diagnostic Findings: Results from the Donor Heart Study
Purpose: Most potential organ donors in the United States (US) are turned down for use in heart transplant (HT). We assessed the prevalence of left ventricular hypertrophy (LVH), low ejection fraction (EF), and coronary artery disease (CAD) as reasons for turndown and their consistency with objective diagnostic findings. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , H. Luikart, Y. Weng, S. Zhang, R.P. Wood, J. Nieto, T. Groat, N. Neidlinger, D. Malinoski, J. Zaroff, K.K. Khush Source Type: research