Pilot Evaluation of a Clinical Xeno Heart Transplant Regimen in A Preclinical Model

Purpose: Significant advances have been made recently in xenotransplantation using gene-edited (GE) pigs with up to 3 carbohydrate transferase knockouts in various combinations, alone or with additional human complement (CD46, CD55, CD59), coagulation (TBM, EPCR, TFPI), and anti-inflammatory (CD47, CD39,HLAE/ β2M, A20, PD-1, HO-1) ‘transgenes’. In this pilot study we evaluated hearts from 3-GE and multi-GE pigs treated with an established costimulation-based immunosuppressive (IS) regimen and cold-perfused ‘ischemia minimization’ (IM).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research