Divergent Transcriptional Features of Obstructive and Restrictive Forms of Chronic Lung Allograft Rejection Modeled in a Single Mouse Strain Combination

Purpose: Chronic lung allograft dysfunction (CLAD) after lung transplantation (LTx) is augmented by innate immunity and has two main histologic patterns: pleuroparenchymal fibroelastosis (PPFE) and obliterative bronchiolitis (OB). The extent to which PPFE and OB arise from distinct pathways in unknown. In a mouse orthotopic LTx model using a single strain combination (C57BL/10 to C57BL/6), we recapitulated PPFE-predominant fibrosis with OB induced by ischemia-reperfusion injury (IRI) and OB-predominant fibrosis with minimal PPFE using repeated airway lipopolysaccharide (LPS) administration (Figure A).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research