The Journal of Heart and Lung Transplantation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Aberrant IL-33 Signaling Modulates Extracellular Matrix Remodeling and is Associated with Acute Cellular Rejection in Lung Transplant Recipients
In this study, we investigate the roles for IL-33 in ACR and feedforward extracellular matrix (ECM) breakdown and fibrogenesis. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , M. khan, N. Sharma Source Type: research

Longitudinal Lower Airway Microbial Signatures of Acute Cellular Rejection in Lung Transplantation
Purpose: Dynamic changes in the lower airway microbiome after lung transplantation (LT) have been shown to influence immunologic tone within the allograft, although its overall impact on risk for acute cellular rejection (ACR) remains poorly understood. Our study aimed to evaluate whether temporal changes in certain microbial signatures were associated with the development of ACR. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , K.K. Wong, N.C. Nelson, B.G. Wu, D. Rudym, M.B. Lesko, S. Qayum, T.C. Lewis, S.H. Chang, J.C. Chan, T.C. Geraci, F.A. Tiripicchio, Y. Li, C. Wang, H. Li, J. Schnier, P. Pamar, I.J. Mahoney, T. Malik, F. Darawshy, I. Sulaiman, R. Singh, D.E. Collazo, M. Source Type: research

Engraftment of Alveolar Macrophages from Human LT Recipients into Immunodeficient Mice as a Tool to Study Mechanisms of Lung Allograft Inflammation
Purpose: We previously identified a subset of alveolar macrophages (AMs) with expression of interferon stimulating genes (ISG) associated with acute and chronic lung allograft dysfunction. Here, we show successful engraftment of AMs from human lung transplant (LT) recipients in an immunodeficient NOD scid γc-/- (NSG) mouse model and demonstrate its utility as a tool to study how ISG AMs may contribute to allograft dysfunction. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , Y. Suzuki, A. Duong, J. Oliver, T. Martinu, S. Juvet Source Type: research

Waitlist Mortality for Patients with Cardiac Allograft Vasculopathy Under the 2018 UNOS Donor Heart Allocation System
Purpose: On October 18, 2018 the UNOS donor heart allocation system was redesigned to prioritize patients on the basis of predicted waitlist mortality. Patients listed for re-transplantation due to cardiac allograft vasculopathy (CAV) are assigned to Status 4 unless hemodynamic criteria are met to qualify for a more urgent status. We sought to examine the waitlist outcomes of this unique cohort of patients compared to all other adult heart transplant candidates. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S.S. Patel, S. Sidhu, A.B. Massie, S. Golob, R. Goldberg, N. Moazami, A. Reyentovich Source Type: research

Myocardial Blood Flow Assessment with PET Improves Risk Stratification Among HT Recipients with CAV1
Purpose: Cardiac allograft vasculopathy (CAV) results in impaired blood flow in epicardial vessels and/or coronary microvasculature. ISHLT CAV guidelines stratify disease into 4 groups based on severity of epicardial disease measured by coronary angiography (CA), with mild CAV (CAV 1) encompassing a broad phenotype, from luminal irregularities up to 69% stenosis of a primary vessel. Studies have shown that impaired myocardial blood flow (MBFR ≤ 2, CFR25) is associated with increased mortality risk. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , E.S. Harris, D. Skoll, J. Fried, V.S. Topkara, J. Raikhelkar, E.M. DeFilippis, F. Latif, M. Yuzefpolskaya, P.C. Colombo, G. Sayer, N. Uriel, A.J. Einstein, K.J. Clerkin Source Type: research

Re-Evaluating Natriuretic Peptides as Biomarkers of Cardiac Allograft Vasculopathy
Purpose: Despite initial evidence supporting the use of elevated B-type natriuretic peptide (BNP) to predict cardiac allograft vasculopathy (CAV), a recent meta-analysis questioned the diagnostic accuracy of BNP and N-terminal-pro brain natriuretic peptide (NT-proBNP) in the detection of CAV following heart transplantation (HTx). To our knowledge, no study has assessed both BNP and NT-proBNP in the prediction of CAV in HTx. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Yadalam, M.E. Gold, P. Patel, J. Waller, A.S. Gillet, A. Panagopoulos, A. Alkhoder, Z. Siddiqui, O. Khawaja, H. Allaqaband, S. Sakr, A. Rahbar, Y. Haroun, H. Hashmi, A. Shamim, K. Ejaz, D. Gupta, W. Book, A.A. Quyyumi Source Type: research

Epicardial and Microvascular CAV are Associated with Restrictive Physiology After Heart Transplantation
Purpose: Cardiac allograft vasculopathy (CAV) is a major cause of graft failure following heart transplantation (HT). One criterion for ISHLT CAV3 is restrictive physiology (RP), and recently, modified RP (RA>8 mmHg, PCWP>15 mmHg, CI (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , N. Prasad, J.A. Fried, V.K. Topkara, J. Raikhelkar, E.M. DeFilippis, F. Latif, M. Yuzefpolskaya, P.C. Colombo, G. Sayer, N. Uriel, K. Clerkin Source Type: research

Phenotyping of Left Ventricular Volume Unloading During Echocardiographic Speed Ramp Tests and Non-Invasive Heartmate 3 Snoopy Monitoring
This study aimed to delve into the heterogeneous left ventricular (LV) unloading observed during echocardiographic speed ramp tests. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A.K. Schaefer, T. Abart, G. Widhalm, C. Marko, R. Moayedifar, J. Riebandt, D. Wiedemann, D. Zimpfer, T. Schloeglhofer Source Type: research

Optimized or Not? International Practices for VAD Speed Optimization
Purpose: VAD pump speed optimization plays a critical role in achieving optimal hemodynamics and improving clinical outcomes. To date, there is no global consensus guideline on this topic, so the primary objective of this International Consortium of Circulatory Assist Clinicians (ICCAC) study was to describe international practices for pump speed optimization and to identify differences between U.S. and international (INT) centers. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , Y. Wu, K. Marz, T. Schloeglhofer Source Type: research

Right Ventriculo-Arterial Coupling Assessment by High-Fidelity Hemodynamic Measurements in Patients Undergoing Left Ventricular Assist Device Implantation
We present early results from our study investigating RV adaptive changes after LVAD implantation by intraoperative placement of RV conductance catheters. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , K. Hunter, C. Culp, M. Cooter Wright, A.D. Cherry, J. Schroder, R. Krasuski, C. Milano, J. Keenan, M. Podgoreanu Source Type: research

Normalized Hemodynamics at Submaximal Exercise in Patients with Left Ventricular Assist Devices (LVAD)
Purpose: Peak O2 uptake (pVO2) is minimally improved after LVAD. Less is known about the impact of LVAD therapy on physiologic responses to submaximal exercise. We hypothesize that hemodynamics at submaximal exercise normalize with LVAD, but are abnormal at peak exercise. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Minasian, K. Drezek, C. Yturralde, S. Charounipha, J. Rouvina, C. White, A. Kowal, J. Camuso, T. Logan, K. Milley, A. Dempsey, E. Coglianese, I. Mastoris, A. Osho, E. Michel, D. D'Alessandro, G.D. Lewis Source Type: research

Utility of CardioMEMS HF System Data in Management of Patients Supported with Durable Left Ventricular Assist Devices (INTELLECT 3-HF Study)
Purpose: Among patients with HFrEF supported with HM3 LVADs, exercise tolerance and hemodynamics have been demonstrated to be limited. We sought to investigate if echocardiographic and CardioMEMS HF - directed LVAD speed changes would improve exercise tolerance during cardiopulmonary exercise testing. Our study complements prior studies looking at means to optimize exercise tolerance (including the INTELLECT 2-HF). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , I. Dimarakis, S. Lin, R. Zhang, J. Pal Source Type: research

Lung Transplant Using Extra-Corporeal Membrane Oxygenation: Outcomes and Predictors of Conversion to Cardiopulmonary Bypass
Purpose: We analyzed the multicenter international extracorporeal life support (ECLS) in lung transplant (LTx) registry to determine risk factors for intraoperative conversion from extracorporeal membrane oxygenation (ECMO) to cardiopulmonary bypass (CPB) and compared outcomes in LTx recipients who require conversion to CPB versus those who do not. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , G. Loor, Q. Zhang, M. Salan-Gomez, N.D. de Manna, D. Van Raemdonck, M. Hartwig, A. Leon Pena, Q. Luo, R. Li, M. Villavicencio, N. Langer, A. Emtiazjoo, S. Chandrashekaran, T. Machuca, A. Neyrinck, A. Kashem, R. Kelly, N. Lemke, K. Subramaniam, G. Warnec Source Type: research

Outcomes of Candidates Bridged to Lung Transplant Using Non-Intubated Extracorporeal Membrane Oxygenation
Purpose: Non-intubated extracorporeal membrane oxygenation (ECMO) has become an increasingly common method of support for patients with severe respiratory failure. Since data on its use as a bridge to lung transplant remain limited to single-center studies, we evaluated its use in a national cohort. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A.F. Akbar, J.M. Ruck, M.R. Jennings, A. Kalra, E.L. Larson, A.J. Casillan, J.S. Ha, C.A. Merlo, E.L. Bush Source Type: research

Concomitant Heart and Lung Surgery During Lung Transplantation
This study compares the survival outcomes of concomitant cardiac and lung surgeries during LTx. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: M. Azuma, , R. Yanagida, N. Shigemura, Y. Toyoda Source Type: research