IL-6 Receptor Blockade Induces Tolerance of Heart Allografts in NHPs in a Simultaneous but Not Delayed Mixed-Chimerism Protocol

Purpose: Previously, we have achieved tolerance of isolated heart allografts in cynomolgus monkeys for the first time by using tocilizumab to block the IL-6 receptor in a mixed-chimerism protocol wherein donor bone marrow (DBM) is given simultaneously with the organ transplant. Here we investigated whether tocilizumab can induce tolerance of a cardiac allograft when the DBM transplant is delayed 2-4 months following heart transplantation.

Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J. Nawalaniec, S. Landino, N. Hays, A. Dehnadi, J.M. Muoio, C. Winter, I. Hanekamp, G. Benichou, J. Allan, J. Madsen Source Type: research