Alveolar Macrophage –CD8 T Cell Interactions after Acute Lung Allograft Dysfunction: Insights from Single-Cell RNA Sequencing
Editorial: (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 12, 2024 Category: Transplant Surgery Authors: Peter T. Bell, Andrew E. Gelman Tags: Editorial Source Type: research

Sex-Specific Patterns of Donor-Derived Cell-Free DNA in Heart Transplant Rejection: An Analysis from the Genomic Research Alliance for Transplantation (GRAfT)
Non-invasive methods for surveillance of acute rejection are increasingly used in heart transplantation (HT), including donor-derived cell-free DNA (dd-cfDNA). As other cardiac biomarkers differ by sex, we hypothesized that there may be sex-specific differences in performance of dd-cfDNA for detection of acute rejection. The purpose of the current study was to examine patterns of dd-cfDNA seen in quiescence and acute rejection in males and female transplant recipients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 7, 2024 Category: Transplant Surgery Authors: Ersilia M. DeFilippis, Benjamin Sweigart, Kiran K. Khush, Palak Shah, Sean Agbor-Enoh, Hannah A. Valantine, Amanda R. Vest Source Type: research

Impact of Prolonged Ischemic Time on Pediatric Heart Transplantation Outcomes: Improved Outcomes in the Most Recent Era
Impacts of ischemic time (IT) on pediatric heart transplant outcomes are multifactorial. We aimed to analyze the effect of prolonged IT on graft loss after pediatric heart transplantation. We hypothesized that graft survival with prolonged IT has improved across eras. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 7, 2024 Category: Transplant Surgery Authors: Scott R. Auerbach, Adam Arshad, Estela Azeka, Ryan S. Cantor, James K. Kirklin, Devin Koehl, JonDavid Menteer, David M. Peng, William Ravekes, Fawwaz R. Shaw, Renata Shih, Jacob Simmonds, Jean Ballweg Source Type: research

IL-33: Friend or Foe in Transplantation?
Several reports have highlighted the dichotomous nature of the IL-33 system in cardiac and lung disease, where this cytokine can exert both protective effects and drive pro-inflammatory responses in a context-specific manner. This State-of-the-Art review focuses on preclinical mechanistic studies of the IL-33 system in development of allograft rejection in heart and lung transplantation. We address the scope of potential cellular sources of IL-33 and pathways for cellular release that may impact the study of this cytokine system in transplant models. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 5, 2024 Category: Transplant Surgery Authors: Ghandi F. Hassan, Lucy S. Cohen, Jen Alexander-Brett Tags: State of the art Source Type: research

Oversizing lung allografts deteriorates outcomes in patients with pulmonary fibrosis
Lung transplantation is the only curative treatment for patients with end-stage pulmonary fibrosis. Due to the shortage of donor organs most lung allografts are either oversized or undersized. It is still under debate whether over- or undersizing is preferably performed regarding the postoperative outcome. We therefore analysed our data using predicted total lung capacity to compare size-mismatches. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 2, 2024 Category: Transplant Surgery Authors: Maximilian Franz, Saleh Tavil, Nunzio Davide de Manna, Khalil Aburahma, Dietmar Boethig, Dmitry Bobylev, Tobias Welte, Mark Greer, Nicolaus Schwerk, Arjang Ruhparwar, Christian Kuehn, Jawad Salman, Fabio Ius Tags: Original Clinical Science Source Type: research

Knowledge Gaps in Heart and Lung Donation after the Circulatory Determination of Death: Report of a Workshop of the National Heart, Lung, and Blood Institute
In a workshop sponsored by the U.S. National Heart, Lung, and Blood Institute, experts identified current knowledge gaps and research opportunities in the scientific, conceptual, and ethical understanding of organ donation after the circulatory determination of death and its technologies. To minimize organ injury from warm ischemia and produce better recipient outcomes, innovative techniques to perfuse and oxygenate organs postmortem in situ, such as thoracoabdominal normothermic regional perfusion, are being implemented in several medical centers in the US and elsewhere. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 1, 2024 Category: Transplant Surgery Authors: James L. Bernat, Kiran K. Khush, Sam D. Shemie, Matthew G. Hartwig, Peter P. Reese, Anne Dalle Ave, JD Brendan Parent, Alexandra K. Glazier, Alexander M. Capron, Matt Craig, Teneille Gofton, Elisa J. Gordon, Andrew Healey, Mary E. Homan, Keren Ladin, Simo Source Type: research

Anticoagulation in LVAD recipients and thrombembolic complications: Where do we stand? Where are we going to?
Editorial: (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 28, 2024 Category: Transplant Surgery Authors: Alexander M. Bernhardt, Hermann Reichenspurner Tags: Editorial Source Type: research

Post-transplant survival after normothermic regional perfusion versus direct procurement and perfusion in donation after circulatory determination of death in heart transplantation
Since 2019, the annual transplantation rate of hearts donated following circulatory death (DCD) has increased significantly in the United States. The 2 major heart procurement techniques following circulatory death are direct procurement and perfusion (DPP) and normothermic regional perfusion (NRP). Post-transplant survival for heart recipients has not been compared between these 2  techniques. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 27, 2024 Category: Transplant Surgery Authors: Gege Ran, Anji E. Wall, Nikhil Narang, Kiran K. Khush, Jordan R.H. Hoffman, Kevin C. Zhang, William F. Parker Tags: Original clinical science Source Type: research

Vasoplegic Syndrome during Heart Transplantation: A Systematic Review and Meta-analysis
Vasoplegic syndrome (VS) is a common occurrence during heart transplantation (HT). It currently lacks a uniform definition between transplant centers, and its pathophysiology and treatment remain enigmatic. This systematic review summarizes the available published clinical data regarding VS during HT. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 27, 2024 Category: Transplant Surgery Authors: Nicolas Kumar, Michael G. Fitzsimons, Manoj H. Iyer, Michael Essandoh, Julia E. Kumar, Adam A. Dalia, Asishana Osho, Tamara R. Sawyer, Amit Bardia Tags: Original Clinical Science Source Type: research

Randomized Trial Of Routine Versus On-demand Intraoperative Extracorporeal Membrane Oxygenation In Lung Transplantation: A Feasibility Study
In most centers, extracorporeal membrane oxygenation (ECMO) is the preferred means to provide cardiopulmonary support during lung transplantation. However, there is controversy about whether intraoperative venoarterial (VA) ECMO should be used routinely or selectively. A randomized controlled trial is the best way to address this controversy. In this publication, we describe a feasibility study to assess the practicality of a protocol comparing routine versus selective VA ECMO during lung transplantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 27, 2024 Category: Transplant Surgery Authors: Basil Nasir, Jason Weatherald, Tim Ramsay, Marcelo Cypel, Laura Donahoe, Chris Durkin, Travis Schisler, Jayan Nagendran, Moishe Liberman, Caroline Landry, Charles Overbeek, Alex Moore, Pasquale Ferraro Source Type: research

Post-transplant Survival after Normothermic Regional Perfusion vs Direct Procurement and Perfusion in Donation after Circulatory Determination of Death Heart Transplantation
Since 2019, the annual transplantation rate of hearts donated following circulatory death (DCD) has increased significantly in the United States. The two major heart procurement techniques following circulatory death are direct procurement and perfusion (DPP) and normothermic regional perfusion (NRP). Post-transplant survival for heart recipients has not been compared between these two techniques. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 27, 2024 Category: Transplant Surgery Authors: Gege Ran, Anji E. Wall, Nikhil Narang, Kiran K. Khush, Jordan R.H. Hoffman, Kevin C Zhang, William F. Parker Source Type: research

Impact of a Positive Crossmatch on Pediatric Heart Transplant Outcomes
Pediatric heart transplant (HT) candidates experience high waitlist mortality due to a limited donor pool that is constrained in part by anti-HLA sensitization. We evaluated the impact of CDC and Flow donor-specific crossmatch (XM) results on pediatric HT outcomes. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 27, 2024 Category: Transplant Surgery Authors: Caitlin Milligan, Ryan J. Williams, Tajinder P. Singh, Heather J. Bastardi, Paul Esteso, Christopher S.D. Almond, Kimberlee Gauvreau, Kevin P. Daly Tags: Original Clinical Science Source Type: research

Influence of socioeconomic status on rates of advanced heart failure therapies
Socioeconomic deprivation is associated with a lower likelihood of referral for advanced heart failure (HF) evaluation, but it is not known whether it influences rates of advanced HF therapies independently of key hemodynamic measures and comorbidity following advanced HF evaluation in a universal healthcare system. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 24, 2024 Category: Transplant Surgery Authors: Johan E. Larsson, S øren Lund Kristensen, Tania Deis, Peder E. Warming, Peter L. Graversen, Morten Schou, Lars Køber, Kasper Rossing, Finn Gustafsson Tags: Original Clinical Science Source Type: research

COVID-19 infection is mild and has minimal impact on lung function in well vaccinated and widely treated lung transplant recipients
COVID-19 has become a common infection affecting lung transplant recipients (LTR), who are at high risk for poor outcomes. Outcomes early in the pandemic were poor, but since the rollout of vaccination and novel COVID-19 treatments, outcomes of LTR have not been well described. Our aim was to evaluate the effect of COVID-19 on the clinical course and lung function trajectory in an Australian cohort of LTR. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 24, 2024 Category: Transplant Surgery Authors: Samantha L. Ennis, Bronwyn J. Levvey, Helen V. Shingles, Sue J. Lee, Gregory I. Snell, Bradley J. Gardiner Tags: Original Clinical Science Source Type: research

Editorial Board
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 21, 2024 Category: Transplant Surgery Source Type: research