Heart Allograft Survival in Juvenile Nonhuman Primates Undergoing Mixed Chimerism Conditioning is Prolonged by Donor Thymus Co-Transplantation

Purpose: Tolerance of heart allografts in nonhuman primates (NHPs) has been achieved by inducing transient mixed chimerism and co-transplanting a kidney, which promotes regulatory T cells. Here, we test whether co-transplanting the thymus could be a clinically relevant alternative to kidney co-transplantation in achieving heart tolerance in children.

Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. Landino, J. O, J. Muoio, N. Hays, D. Muldoon, A. Dehnadi, I. Hanekamp, J. Allan, J. Madsen Source Type: research