The Journal of Heart and Lung Transplantation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Availability, Volumes, and Referral Strategies of Advanced Heart Failure Therapies in the Eastern Mediterranean Region: Results from The AHF-EMR Survey
Purpose: The Eastern Mediterranean Region (EMR) consists of 21 countries and one territory with a population of almost 745 million. Despite the global downtrend in advanced heart failure (AHF) prevalence in the last three decades, the EMR is experiencing a growing burden. Data on AHF therapies (AHFT) in the EMR are scarce and primarily limited to single-center experiences. The AHF-EMR survey aims to quantify the availability and volumes of AHFT [including left ventricular assist devices (LVAD) and heart transplantation (HTx)], describe referral strategies for AHFT abroad, and underscore current challenges in AHF care in th...
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: Y. Manla, , F. Khaliel, M. Yacoub, K. Shaker, A. Amin, R. Tarazi, K. Alhumood, H. Skouri, A. Badr, A. Bennis, L. Abid, A. Turk, A. Abdin, N. Elsammani, N. Paktin, S. Bhatti, O. Bheleel, H. Farhan, K. Sulaiman, A. Al-Motarreb, M. AlQaseer, F. Bader Source Type: research

Social Deprivation Explains Racial Disparities in Heart Transplantation Outcomes
Purpose: Extensive disparities in access to HT and post-HT outcomes among Black recipients are widely recognized, yet underlying causes remain poorly understood. We investigated the impact of Social Deprivation Index (SDI, scored 1 to 100), with higher scores indicating greater social deprivation, on post-HT outcomes in both Non-Hispanic White (NH-W) and Non-Hispanic Black (NH-B) recipients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. Ramineni, O. Saeed, J. Ovalle Ramos, S. Forest, D. Goldstein, S. Patel, U. Jorde Source Type: research

Exploring New Molecular Biomarkers in Transbronchial Biopsies from Patients with Chronic Lung Allograft Dysfunction: A Bicentric Longitudinal Study
Purpose: Chronic lung allograft dysfunction (CLAD) is the first cause of graft failure in lung transplant recipients, affecting almost 50% of patients in the first five years after lung transplantation (LTx). Today, CLAD is diagnosed by clinical and histological findings, but often too late for an effective therapeutic approach. Thus, it is mandatory to identify potential biomarkers for an earlier diagnosis and a targeted management of the patients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , M. Orlandi, G. Benvenuto, F. Pezzuto, G. Comacchio, M. Loy, C. Giraudo, F. Braccioni, E. Cozzi, M. Boffini, L. Delsedime, F.P. Schena, F. Rea, F. Calabrese Source Type: research

Developing a Molecular Classifier to Predict Graft Loss in Lung Transplant Mucosal Biopsies
Purpose: The molecular mechanisms involved in lung transplant graft loss are poorly understood, and studying them using transbronchial biopsies carries risk that excludes patients with advanced lung dysfunction. Mucosal biopsies (3BMBs) are safer, and provide molecular information related to graft outcome (JHLT 2020;39:1327-1337). We carried out a targeted genome-wide assessment of the molecular changes associated with graft loss in 3BMBs taken from a large prospectively collected international cohort, and developed a molecular classifier to test their prognostic value for predicting graft loss in lung transplant recipient...
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , M. Mackova, R. Hachem, J. Havlin, A. Hirji, P. Jaksch, S. Juvet, S. Keshavjee, W. Klepetko, D. Kreisel, B. Kubisa, D.J. Levine, R. Lischke, M. Piotrowska, J. Simonek, G. Snell, I. Timofte, J. Weinkauf, G. Westall, A. Zajacova, K. Halloran, P. Halloran Source Type: research

Multicenter Assessment of the Bronchiolar Brushing Molecular Inflammation Score, AIS2, to Identify Incipient CLAD and Mortality Risk
Purpose: Gene expression analysis of small airway cytology brushings has been proposed as a novel strategy to diagnose and subtype chronic lung allograft dysfunction (CLAD). Although multiple gene sets have shown promise, it is not known whether this approach can predict CLAD before its onset. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: R. Mohanty, K. Moghbeli, J. Singer, D. Calabrese, S. Hays, L. Leard, R. Shah, A. Venado, M. Kleinhenz, J. Golden, J. Kukreja, S. Lieber, R. Ward, C. Love, T. Martinu, C. Iasella, C. Langelier, J. McDyer, Source Type: research

Airway Oscillometry Reactance Area Provides Independent Prognostication for Graft Loss in Recipients with Chronic Lung Allograft Dysfunction
Purpose: Airway oscillometry (Osc) reactance area (Ax) is a novel tool to assess peripheral airway& lung parenchymal function after lung transplant (LTx). The aim of this study was to assess the prognostic value of Ax on graft loss in recipients with chronic lung allograft dysfunction (CLAD) in relation to spirometric decline. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , K. Nilsen, J. Vazirani, B. Borg, B. Levvey, G. Snell, M. Plit, K. Tonga Source Type: research

Comparison of Plethysmographic Total Lung Capacity and Computed Tomography Volumetry in Lung Transplant Recipients (The ScanCLAD Study)
Purpose: Plethysmographic total lung capacity measurement (TLC) is part of the consensus definition of restrictive allograft syndrome (RAS) type chronic lung allograft dysfunction (CLAD). However, TLC is neither universally available nor suitable for all patients, whereas high-resolution computed tomography (HRCT) is universally performed after lung transplantation. Thus, we compared CT volumetry and TLC after lung transplantation in a prospective study setting. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , R. Kes ävuori, A. Nykänen, J. Magnusson, T. Lund, I. Leuckfeld, J. Svahn, T. Mäkelä, G. Dellgren, P. Raivio Source Type: research

Updates from the International Consortium on Primary Graft Dysfunction: An Interim Report and Important Themes
Purpose: In 2021, we presented the first report from the International Consortium on Primary Graft Dysfunction (PGD) inclusive of 2476 patients from 10 centers. Herein, we present an updated interim analysis and highlight key themes that have emerged from this multicenter collaboration. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , Y. Moayedi, F. Foroutan, J. Han, E. Henricksen, H. Luikart, E. R ódenas Alesina, J. Guzman Bofarull, D. Couto Mallon, R. Moayedifar, K. Takeda, G. Kim, M. Crespo-Leiro, J. Felius, S. Hall, A.D. DeVore, J.B. Lerman, M. Sabatino, L. Potena, M. Rivas-Lasa Source Type: research

Primary Graft Dysfunction After Heart Transplant in Adults: A Gene Expression Analysis
Purpose: Primary Graft Dysfunction (PGD) is the main cause of early mortality after heart transplant. Several centers are studying the pathophysiology of PGD by analyzing the epidemiological, clinical factors and evaluation of the genetic profile. The purpose of this study was to evaluate the tissue gene expression profile of patients with PGD and to compare it with patients who did not developed PGD. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , F. Gaiotto, R. Honorado Santos, D. Filho, S. Gaspar, F. Marcondes-Braga, A. Pereira, E. Cunha-Neto, F. Bacal, J. Krieger, R. Kalil, F. Jatene Source Type: research

Validation of a Machine Learning Primary Graft Dysfunction Risk Score in a Contemporary Heart Transplant Cohort: An Analysis of the International Consortium on PGD
Purpose: Primary Graft Dysfunction (PGD) is the leading cause of early mortality after heart transplantation (HT). To address this critical concern, the PGD Consortium was formed with the aim of developing a contemporary clinical risk prediction model. In 2022, an international collaborative effort involving 10 centers culminated in the development of an AI-powered PGD risk score. In the present study, this AI-PGD risk score will be validated utilizing data from an additional 6 centers. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , L. Truby, C. Fan, F. Foroutan, E. Henricksen, H. Luikart, E. R ódenas Alesina, J. Han, D. Couto Mallon, J. Guzman Bofarull, M. Crespo-Leiro, R. Moayedifar, G. Kim, J. Felius, M. Sabatino, L. Potena, M. Lerman, K. Takeda, M. Tremblay-Gravel, P. Noly, R. Source Type: research

Improved 2-Year Heart Transplant Survival with Moderate Hypothermic Donor Heart Preservation in the Guardian Heart Registry
Purpose: Use of advanced moderate hypothermic donor heart preservation is increasing due to reports of consistently strong post-transplant outcomes. Approximately half of all DBD donor hearts in the US in 2023 have been transported in a Paragonix SherpaPak Cardiac Transport System (SCTS). The GUARDIAN Heart Registry, the largest global registry studying effects of static cold preservation, provides data to evaluate real-world benefits of using SCTS compared to conventional ice storage. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , D. Meyer, S. Pham, J.P. Jacobs, Y. Shudo, J. Schroder, M. Leacche, C. Sciortino, H. Copeland, M.E. Rodrigo, K. Takeda, M. Kawabori, B. Mahesh, L. Klein, A. Vidic, S. Patel, D. D'Alessandro Source Type: research

Fifteen Years Experience of Veno-Arterial Extracorporeal Membrane Oxygenation for Primary Graft Dysfunction After Heart Transplantation
Purpose: To evaluate outcomes of patients needing a Veno-Arterial Extra-Corporeal Membrane Oxygenation (VA ECMO) temporary support for primary graft dysfunction after heart transplantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , G. Coutance, S. Varnous, A. Carillion, C. D'Alessandro, P. Demondion, G. Lebreton, P. Leprince Source Type: research

External Validation of a Risk Score Assessment for Pediatric Ventricular Assist Device Mortality
Purpose: No guideline to inform optimal candidacy of ventricular assist device implantation in pediatrics exists. Recent research focusing on risk factors for poor outcome on device resulted in the development of a risk score (ACTION score) assessment to predict mortality. To determine the appropriateness of implementing this score, we sought external validation. We also seek to compare performance of the ACTION score to the performance of the Intermacs profile. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , K. Boucek, A. Lorts, D. Rosenthal, K. Yan, J. Zhang, R. Niebler Source Type: research

Long Term Ventricular Assist Devices in Children
Purpose: 1 in 5 children with a ventricular assist device (VAD) remain on device for> 6 months. However, there are sparse data regarding outcomes in this group. We sought to characterize pre-implant characteristics, survival and frequency of adverse events (AE). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , D. Koehl, R. Cantor, J. Kirklin, D. Morales, T. Perry, K. Maeda, K. Lin, J. Edelson, M. O'Connor, C. Wittlieb-Weber, J. Edwards, J. Rossano Source Type: research

The Outcomes of Temporary Mechanical Circulatory Support Using Paracorporeal Continuous Flow Pump in Children; A Multicenter Study Using ACTION Learning Network
This study aims to reveal clinical outcomes of temporary mechanical circulatory support (tMCS) using paracorporeal continuous flow (pCF) pumps in children. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , V. Sood, A. Lorts, M. Shezad, M. O'Connor Source Type: research