Blocking Signaling Pathways Like Notch and Hedgehog Reduces Chronic Rejection in a Murine Aortic Transplant Model

Purpose: Cardiac allograft vasculopathy (CAV) remains a primary contributor to chronic rejection following heart transplantation. A combination of effects including immunological and non-immunological factors contributes to the development of CAV. The main objective of this study is to investigate whether LDE225, as a Hedgehog pathway inhibitor, and/or DAPT, as a γ-secretase inhibitor known to disrupt the Notch signaling pathway, can attenuate chronic rejection in a mouse aortic transplant model and act as potential targets to prevent the development of CAV to improve long-term outcomes for heart transplant recipients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research