Leukotriene B4: A Potential Mediator and Biomarker for Cardiac Allograft Vasculopathy

Cardiac allograft vasculopathy (CAV) remains the leading cause of long-term graft failure and mortality after heart transplantation. Effective preventive and treatment options are not available to-date, largely because underlying mechanisms remain poorly understood. We studied the potential role of leukotriene B4 (LTB4), an inflammatory lipid mediator, in development of CAV.

Source: The Journal of Heart and Lung Transplantation - April 23, 2024 Category: Transplant Surgery Authors: Dong Wang, Grigol Tediashvili, Daniel Kim, Xiaomeng Hu, Helen Luikart, Thomas Renne, Amy Tian, Kari C. Nadeau, Joachim Velden, Sonja Schrepfer, Kiran K. Khush Source Type: research