High-Dimensional Lung Tissue Imaging Reveals Temporal Changes in Immune Cell Populations and Cell Interactions During Progression of Chronic Lung Allograft Dysfunction (CLAD)

Purpose: The immunological drivers of progressive CLAD at a tissue level are poorly understood. Tissue imaging using mass spectrometry (IMC) and laser ablation of regions of interest (ROI) offers single-cell resolution of distinct immune cell populations and their spatial relationships in disease and may improve our understanding of CLAD pathophysiology.

Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , B. Hunter, D. McDonald, G. Merces, G. Sheldon, P. Pradere, J. Majo, J. Pulle, A. Vanstapel, B. Vanaudenaerde, R. Vos, A.J. Filby, A.J. Fisher Source Type: research