Activation of M2 macrophage autophagy by rapamycin increases the radiosensitivity of colorectal cancer xenografts
CONCLUSIONS: Therefore, autophagy-activated M2 supernatant can downregulate the expression of the antiapoptotic genes Livin and Survivin in CRC xenografts, improving the radiosensitivity of CRC by inducing apoptosis in combination with radiotherapy and inhibiting the growth of transplanted tumors.PMID:38687942 | DOI:10.4103/jcrt.jcrt_215_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Lening Shao Yongyou Wu Jianping Cao Fengyun Zhong Xiaodong Yang Chungen Xing Source Type: research
Does Antibiotic Use Increase the Risk of Post-Transplantation Diabetes Mellitus? A Retrospective Study of Renal Transplant Patients
CONCLUSIONS In addition to age, BMI, and TAC concentration after RT, antibiotic use may be a novel factor affecting PTDM. The use of antibiotics may influence the development of PTDM.PMID:38685698 | DOI:10.12659/AOT.943282 (Source: Annals of Transplantation)
Source: Annals of Transplantation - April 30, 2024 Category: Transplant Surgery Authors: Zhenwei Jiang Caomei Xu Huan Hou Xuping Yang Minyan Qian Lian Zuo Peipei Wang Qing Qian Yan Jiang Nan Hu Source Type: research
Myeloablation Followed by Hematopoietic Stem Cell Transplantation and Long ‐Term Normalization of Systemic Sclerosis Molecular Signatures
ConclusionParalleling the observed clinical benefit, HSCT leads to durable long-term normalization of the molecular signature in SSc, with completion of immune resetting to 54 months after HSCT. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 30, 2024 Category: Rheumatology Authors: Nancy Wareing,
Xuan Wang,
Lynette Keyes ‐Elstein,
Ellen A. Goldmuntz,
Marka A. Lyons,
Peter McSweeney,
Daniel E. Furst,
Richard A. Nash,
Leslie J. Crofford,
Beverly Welch,
Ashley Pinckney,
Maureen D. Mayes,
Keith M. Sullivan,
Shervin Assass Tags: Brief Report Source Type: research
GSE130288 The effect of acidosis on adipose-derived stem cell
In this study, different pH levels of medium were performed to treat adipose-derived stem cells (ADSCs) with 24/48h time- exposure, to explore the effect of extracellular acidosis on ADSCs. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE255545 Calcineurin inhibition rescues alloantigen-specific central memory T cell subsets and promotes chronic GVHD
Contributors : Ping Zhang ; Olivia G Waltner ; Shruti S Bhise ; Scott N Furlan ; Simone A Minnie ; Geoffrey R HillSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCalcineurin inhibitors (CNIs) constitute the backbone of modern acute graft-versus-host disease (aGVHD) prophylaxis regimens but have limited efficacy in the prevention and treatment of chronic GVHD (cGVHD). We investigated the effect of CNIs on immune tolerance after stem cell transplantation with discovery-based single cell gene expression and T-cell receptor (TCR) assays of clonal immunity in tandem with traditional prote...
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Transplanting human infant gut microbiome species into Galleria mellonella
Study of the human infant gut microbiome requires the use of surrogate mammalian species such as mice. We sought to investigate the usefulness of the greater wax moth larva, Galleria mellonella, as an alternative... (Source: BMC Research Notes)
Source: BMC Research Notes - April 30, 2024 Category: Research Authors: Harriet C.C. Gooch, Marjorie Labedan, Lindsay J. Hall and Anthony Maxwell Tags: Research Note Source Type: research
Letermovir primary cytomegalovirus prophylaxis in allogeneic hematopoietic cell transplant recipients: could infection and disease no longer be a significant problem?
Conclusions: LET primary prophylaxis proved effective in preventing cs-CMVi and CMVd and reducing hospitalizations in allo-HCT adults. Blips can occur during prophylaxis and do not require LET discontinuation.Keywords: letermovir; cytomegalovirus; hematopoietic cell transplantation. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - April 30, 2024 Category: Hematology Authors: Fabian Herrera Source Type: research
Dengue-related acute liver failure —A scoping review
AbstractInfection by dengue virus is common in tropical countries. Hepatic involvement in dengue can range from asymptomatic elevation of transaminases to life-threatening acute liver failure (ALF). Dengue-related ALF (DALF) is responsible for significant morbidity and mortality, especially in Southeast Asia. However, there is a scarcity of literature on DALF, necessitating a thorough examination of its clinical determinants and management strategies. All relevant studies related to DALF were reviewed until December 2023. Case reports, case series and studies reporting ALF in dengue infection were included. Demographics, c...
Source: Indian Journal of Gastroenterology - April 30, 2024 Category: Gastroenterology Source Type: research
Survival After Hematopoietic Stem Cell Transplantation in Severe Combined Immunodeficiency (SCID): A Worldwide Review of the Prognostic Variables
This study aims to perform an extensive review of the literature that evaluates various factors that affect the survival rates of patients with severe combined immunodeficiency (SCID) after hematopoietic stem cell transplantation (HSCT) in developed and developing countries. An extensive search of the literature was made in four different databases (PubMed, Embase, Scopus, and Web of Science). The search was carried out in December 2022 and updated in July 2023, and the terms such as “hematopoietic stem cell transplantation,” “bone marrow transplant,” “mortality,” “opportunistic infections,” and “survival...
Source: Clinical Reviews in Allergy and Immunology - April 30, 2024 Category: Allergy & Immunology Source Type: research
Risk factors for migration of retrievable covered expandable metallic stent in patients with persistent benign ureter strictures
ConclusionsStent migration is more likely to occur in patients with the five prognostic factors mentioned above. Our study developed a nomogram to predict stent migration in patients with ureteral strictures treated using RCEMS. (Source: World Journal of Urology)
Source: World Journal of Urology - April 30, 2024 Category: Urology & Nephrology Source Type: research
Antibody-Mediated Rejection: Mechanisms, Pathology, and Therapeutics
AbstractPurpose of ReviewThe goal of this paper is to review the latest advances in antibody-mediated rejection with regards to lung transplantation. We review definitions, mechanisms, pathology, and the most recent therapeutics that have been trialed for treating AMR. We hope to answer questions regarding diagnostic ambiguity that previously surrounded AMR and hope to shed light to the latest treatments which have shown promise in recent clinical trials.Recent FindingsWe review the benefits of single bead Luminex assays, and how the implementation of these assays has improved detection for donor specific antibodies, a key...
Source: Current Respiratory Care Reports - April 30, 2024 Category: Respiratory Medicine Source Type: research
ECMO Bridge to Lung Transplant in Children with Idiopathic Pulmonary Arterial Hypertension
AbstractIdiopathic pulmonary arterial hypertension (IPAH) represents an important clinical indication for lung transplant (LTx) in children. Recent trends show fewer children with IPAH are undergoing LTx nowadays compared to previous time periods, including those with most severe form of the disease. Using the UNOS Registry, we investigated if ECMO at the time of transplant impacts post-transplant survival in children with IPAH. A total of 74 LTx recipients while on ECMO at the time of transplant were identified (IPAH: N = 12). Children with IPAH who underwent LTx while on ECMO had shown comparable survival rates to tho...
Source: Lung - April 30, 2024 Category: Respiratory Medicine Source Type: research
Pulmonary Complications of Portal Hypertension
Portopulmonary hypertension (POPH), hepatopulmonary syndrome, and hepatic hydrothorax constitute significant complications of portal hypertension, with important implications for management and liver transplantation (LT) candidacy. POPH is characterized by obstruction and remodeling of the pulmonary resistance arterial bed. Hepatopulmonary syndrome is the most common pulmonary vascular disorder, characterized by intrapulmonary vascular dilatations causing impaired gas exchange. LT may improve prognosis in select patients with POPH. LT is the only effective treatment of hepatopulmonary syndrome. Hepatic hydrothorax is defin...
Source: Clinics in Liver Disease - April 30, 2024 Category: Gastroenterology Authors: Shoma Bommena, Michael B. Fallon Source Type: research
Application of High-Frequency Ultrasound to Evaluate Forehead Filling Materials
ConclusionHigh-frequency ultrasound is a safe and reliable method to evaluate the type and position of forehead filling materials, which can be easily applied in clinical practice.Level of Evidence IVThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authorswww.springer.com/00266. (Source: Aesthetic Plastic Surgery)
Source: Aesthetic Plastic Surgery - April 30, 2024 Category: Cosmetic Surgery Source Type: research
The International Society of Heart and Lung Transplantation (ISHLT): 2024 infection definitions for durable and acute mechanical circulatory support devices
Infections remain a significant concern in patients receiving mechanical circulatory support (MCS), encompassing both durable and acute devices. This consensus manuscript provides updated definitions for infections associated with durable MCS devices and new definitions for infections in acute MCS, integrating a comprehensive review of existing literature and collaborative discussions among multidisciplinary specialists. By establishing consensus definitions, we seek to enhance clinical care, facilitate consistent reporting in research studies, and ultimately improve outcomes for patients receiving MCS. (Source: The Journa...
Source: The Journal of Heart and Lung Transplantation - April 30, 2024 Category: Transplant Surgery Authors: Saima Aslam, Jennifer Cowger, Palak Shah, Valentina Stosor, Hannah Copeland, Anna Reed, David Morales, Gerard Giblin, Jacob Mathew, Orla Morrissey, Paola Morejon, Alina Nicoara, Ezequiel Molina Tags: Consensus statement Source Type: research
