Development of a universal cutting guide for raising deep circumflex iliac artery flaps
ConclusionReady-made cutting guides for the DCIA flap fit to the iliac crest and make quick and accurate flap raising possible while radiation dose and resources can be saved. The cutting guides fit sufficient to the iliac crest and should keep the advantages of a standard CAD planning. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - April 27, 2024 Category: Intensive Care Source Type: research
Radiological and Surgical Treatments of Portal Hypertension
Interventions for portal hypertension are continuously evolving and expanding beyond the realm of medical management. When complications such as varices and ascites persist despite conservative interventions, procedures including transjugular intrahepatic portosystemic shunt creation, transvenous obliteration, portal vein recanalization, splenic artery embolization, surgical shunt creation, and devascularization are all potential interventions detailed in this article. Selection of the optimal procedure to address the underlying cause, treat symptoms, and, in some cases, bridge to liver transplantation depends on the speci...
Source: Clinics in Liver Disease - April 27, 2024 Category: Gastroenterology Authors: Charlotte Hunt, Mausam Patel, Maria del Pilar Bayona Molano, Madhukar S. Patel, Lisa B. VanWagner Source Type: research
Changing etiological spectrum of acute liver failure
ConclusionsThe most common cause for ALF was hepatitis A virus, followed by hepatitis B virus, while in ALF mimics it was malaria followed by dengue fever, in our study. Patients of ALF mimics can have similar presentation, but a high index of suspicion and awareness is required to identify the common infectious ALF mimics for early diagnosis.Graphical Abstract (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - April 27, 2024 Category: Gastroenterology Source Type: research
Pre-eruptive intramural resorption in unerupted teeth: a cone-beam computed tomography evaluation of prevalence and related factors
ConclusionPEIR should be suspected in transverse, inverted-angulated, centrally positioned unerupted teeth, particularly in molars, with no pericoronal space. Further monitoring through CBCT is recommended in such cases.Clinical relevanceThe management of unerupted teeth does not always involve surgical removal. Instead, they could be utilized for artificial eruption or tooth transplantation. The present study emphasizes the significance of early detection of PEIR. Clinical recommendations for screening PEIR in unerupted teeth are also proposed, which can be applied to routine plain radiographs. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - April 27, 2024 Category: Dentistry Source Type: research
Microbial Symphony: Exploring the Role of the Gut in Osteoarthritis-Related Pain. A Narrative Review
AbstractOne of the most common musculoskeletal disorders, osteoarthritis (OA), causes worldwide disability, morbidity, and poor quality of life by degenerating articular cartilage, modifying subchondral bone, and inflaming synovial membranes. OA pathogenesis pathways must be understood to generate new preventative and disease-modifying therapies. In recent years, it has been acknowledged that gut microbiota (GM) can significantly contribute to the development of OA. Dysbiosis of GM can disrupt the “symphony” between the host and the GM, leading to a host immunological response that activates the “gut–joint” axis,...
Source: Pain and Therapy - April 27, 2024 Category: Anesthesiology Source Type: research
Treatment with Elapegademase Restores Immunity in Infants with Adenosine Deaminase Deficient Severe Combined Immunodeficiency
ConclusionRevcovi was safe and effective as initial therapy to restore immune function in these newly diagnosed infants with ADA-SCID, however, time course and degree of reconstitution varied. Revcovi dose may need to be optimized based on immune reconstitution, clinical status, and biochemical data. (Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - April 27, 2024 Category: Allergy & Immunology Source Type: research
Transient receptor potential vanilloid 4 channel inhibition attenuates lung ischemia-reperfusion injury in a porcine lung transplant model
Transient receptor potential vanilloid 4 (TRPV4) is a nonselective cation channel important in many physiological and pathophysiological processes, including pulmonary disease. Using a murine model, we previously demonstrated that TRPV4 mediates lung ischemia-reperfusion injury, the major cause of primary graft dysfunction after transplant. The current study tests the hypothesis that treatment with a TRPV4 inhibitor will attenuate lung ischemia-reperfusion injury in a clinically relevant porcine lung transplant model. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 27, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Raymond J. Strobel, Huy Q. Ta, Andrew M. Young, Alex M. Wisniewski, Anthony V. Norman, Evan P. Rotar, Mark H. Stoler, Irving L. Kron, Swapnil K. Sonkusare, Mark E. Roeser, Victor E. Laubach Tags: Thoracic Source Type: research
Case Study: The Weighty Issue of Treatment Options for Obese Dialysis Patients
We report on a successful bariatric surgery with a young adult after 5.5 years on dialysis with hope for a future transplant. Success was demonstrated with progressive weight loss without adverse changes in renal clinical markers accompanied by improvements in exercise tolerance and health status thereby improving her suitability for a kidney transplant. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - April 27, 2024 Category: Urology & Nephrology Authors: Desiree de Waal, Macaulay Onuigbo, Thomas Alan Golper Tags: Case Studies Source Type: research
Outcomes of a Formal Hematopoietic Cell Transplantation (HCT) Survivorship Program on Screening for Late Effects
Advances in the treatment of hematologic malignancies, allogeneic hematopoietic cell transplantation (HCT), and supportive care continue to improve post-HCT outcomes, and the number of long-term HCT survivors in the past decade has dramatically increased.1,2 With improved post-HCT survival, it is increasingly important to consider late-treatment effects from chemotherapy and/or radiation and chronic graft-vs-host disease (GVHD) which may lead to decrements in quality of life (QOL) and survival,3 –5 especially since life expectancy post-HCT remains lower than that of the general population. (Source: Biology of Blood and M...
Source: Biology of Blood and Marrow Transplantation - April 27, 2024 Category: Hematology Authors: Richard A. Newcomb, Lucy Gao, Julie Vanderklish, Alexandra Tse, Meredith Saylor, Colleen Danielson, Nisha Wali, Matthew Frigault, Steven McAfee, Thomas Spitzer, Zachariah DeFilipp, Yi-Bin Chen, Hermioni L. Amonoo, Areej El-Jawahri Source Type: research
High-dimensional Mass Cytometry identified circulating Natural Killer T-cell subsets associated with protection from Cytomegalovirus infection in kidney transplant recipients
Cytomegalovirus (CMV) infection is associated with poor kidney transplant outcomes. While innate and adaptive immune cells have been implicated in its prevention, an in-depth characterization of the in vivo kinetics of multiple cell subsets and their role in protecting against CMV infection has not been achieved. Here, we performed high-dimensional immune phenotyping by mass cytometry, and functional assays, on 112 serially collected samples from CMV seropositive kidney transplant recipients. Advanced unsupervised deep learning analysis was used to assess immune cell populations that significantly correlated with preventio...
Source: Kidney International - April 27, 2024 Category: Urology & Nephrology Authors: Laura Donadeu, Thomas Jouve, Sofia Bin, Susan Hartzell, Elena Crespo, Alba Torija, Marta Jarque, Delphine Kevella, Jos é Zúñiga, Weijia Zhang, Zeguo Sun, Alberto Verlato, Mónica Martínez-Gallo, Cristina Font-Miñarro, Maria Meneghini, Nestor Toapanta Tags: clinical investigation Source Type: research
True Donor Cell Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation: Diagnostic and Therapeutic Considerations-Brief Report
Curr Oncol. 2024 Apr 5;31(4):2067-2075. doi: 10.3390/curroncol31040153.ABSTRACTDonor cell leukemia (DCL) is a rare complication after allogeneic hematopoietic stem cell transplantation (HSCT) accounting for 0.1% of relapses and presenting as secondary leukemia of donor origin. Distinct in phenotype and cytogenetics from the original leukemia, DCL's clinical challenge lies in its late onset. Its origin is affected by donor cell anomalies, transplant environment, and additional mutations. A 43-year-old woman, treated for early stage triple-negative breast cancer, developed mixed-phenotype acute leukemia (MPAL), 12 years late...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Mich èle Hoffmann Yara Banz J örg Halter Jacqueline Schoumans Jo ëlle Tchinda Ulrike Bacher Thomas Pabst Source Type: research
Myelodysplastic Neoplasms (MDS): The Current and Future Treatment Landscape
Curr Oncol. 2024 Apr 3;31(4):1971-1993. doi: 10.3390/curroncol31040148.ABSTRACTMyelodysplastic neoplasms (MDS) are a heterogenous clonal disorder of hemopoietic stem cells characterized by cytomorphologic dysplasia, ineffective hematopoiesis, peripheral cytopenias and risk of progression to acute myeloid leukemia (AML). Our understanding of this disease has continued to evolve over the last century. More recently, prognostication and treatment have been determined by cytogenetic and molecular data. Specific genetic abnormalities, such as deletion of the long arm of chromosome 5 (del(5q)), TP53 inactivation and SF3B1 mutati...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Daniel Karel Claire Valburg Navitha Woddor Victor E Nava Anita Aggarwal Source Type: research
Effects of Trehalose Preconditioning on H9C2 Cell Viability and Autophagy Activation in a Model of Donation after Circulatory Death for Heart Transplantation
Curr Issues Mol Biol. 2024 Apr 12;46(4):3353-3363. doi: 10.3390/cimb46040210.ABSTRACTDonation after circulatory death (DCD) is a promising strategy for alleviating donor shortage in heart transplantation. Trehalose, an autophagy inducer, has been shown to be cardioprotective in an ischemia-reperfusion (IR) model; however, its role in IR injury in DCD remains unknown. In the present study, we evaluated the effects of trehalose on cardiomyocyte viability and autophagy activation in a DCD model. In the DCD model, cardiomyocytes (H9C2) were exposed to 1 h warm ischemia, 1 h cold ischemia, and 1 h reperfusion. Trehalose was adm...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Jingwen Gao Yasushige Shingu Satoru Wakasa Source Type: research
Nutritional status and its relationship with COVID-19 prognosis in hemodialysis patients
CONCLUSIONS: higher body mass index and higher body fat content, along with lower baseline levels of triglycerides and ferritin, are significantly associated with higher COVID-19 mortality in patients on chronic hemodialysis. These findings suggest that the initial nutritional status of these patients can significantly influence the prognosis of SARSCoV-2 infection.PMID:38666342 | DOI:10.20960/nh.04850 (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - April 26, 2024 Category: Nutrition Authors: Paz Andrea Bersano-Reyes Gema Nieto Alicia Cana-Poyatos Paula Guerrero Sanz Rafa Garc ía-Maset Alicia Garc ía-Testal Source Type: research
True Donor Cell Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation: Diagnostic and Therapeutic Considerations-Brief Report
Curr Oncol. 2024 Apr 5;31(4):2067-2075. doi: 10.3390/curroncol31040153.ABSTRACTDonor cell leukemia (DCL) is a rare complication after allogeneic hematopoietic stem cell transplantation (HSCT) accounting for 0.1% of relapses and presenting as secondary leukemia of donor origin. Distinct in phenotype and cytogenetics from the original leukemia, DCL's clinical challenge lies in its late onset. Its origin is affected by donor cell anomalies, transplant environment, and additional mutations. A 43-year-old woman, treated for early stage triple-negative breast cancer, developed mixed-phenotype acute leukemia (MPAL), 12 years late...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Mich èle Hoffmann Yara Banz J örg Halter Jacqueline Schoumans Jo ëlle Tchinda Ulrike Bacher Thomas Pabst Source Type: research
