A Prospective Real-World Study Exploring Associations Between Passively Collected Tracker Data and Headache Burden Among Individuals with Tension-Type Headache and Migraine
ConclusionThis study adds to existing evidence that activity trackers can be used to quantify headache burden in real-world settings and aid in understanding symptom management. (Source: Pain and Therapy)
Source: Pain and Therapy - December 7, 2021 Category: Anesthesiology Source Type: research

Abuse-Deterrent Opioids: A Survey of Physician Beliefs, Behaviors, and Psychology
ConclusionsThe primary motivator for prescribing ADFs was preventing diversion by family members, not patient-level abuse concerns. (Source: Pain and Therapy)
Source: Pain and Therapy - December 6, 2021 Category: Anesthesiology Source Type: research

Pain Relief and Safety Outcomes with Cervical 10  kHz Spinal Cord Stimulation: Systematic Literature Review and Meta-analysis
ConclusionFindings suggest 10  kHz SCS is a promising, safe, minimally invasive alternative for managing chronic upper limb and neck pain. (Source: Pain and Therapy)
Source: Pain and Therapy - November 12, 2021 Category: Anesthesiology Source Type: research

Correction to: Analgesic Effects of Navigated Repetitive Transcranial Magnetic Stimulation in Patients With Acute Central Poststroke Pain
A correction to this paper has been published: https://doi.org/10.1007/s40122-021-00270-z (Source: Pain and Therapy)
Source: Pain and Therapy - November 12, 2021 Category: Anesthesiology Source Type: research

Evaluation of Interfascial Plane and Pericapsular Nerve Blocks to the Shoulder Joint: A Preliminary Analysis of Shoulder Anterior Capsular Block
AbstractIntroductionThe aim of this study is to verify if the shoulder anterior capsular block (SHAC), combined with other nerve blocks, is effective in relieving shoulder pain, avoiding motor block and allowing an early rehabilitation program.MethodsSeventy-five consecutive patients with painful shoulder were treated with the SHAC, alone (30 patients) or in combination with a suprascapular nerve block (SSnb: 25 patients) or with pectoralis and serratus plane block (PECS-2: 20 patients). All blocks were performed with 0.2% ropivacaine plus 8  mg dexamethasone. All patients were treated with three-weekly physiotherapy ...
Source: Pain and Therapy - October 20, 2021 Category: Anesthesiology Source Type: research

Combining Virtual Reality and Behavioral Health to Promote Pain Resiliency: Analysis of a Novel BioPsychoSocial Modality for Solving Pain in the Workplace
ConclusionsThe Harvard MedTech Vx Therapy appears to be an effective tool in the treatment of pain and the psycho-social issues associated with pain. This translates into a greater degree of pain resiliency and an overall improvement in general wellness and improved workplace functionality. (Source: Pain and Therapy)
Source: Pain and Therapy - October 16, 2021 Category: Anesthesiology Source Type: research

Percutaneous Spinal Cord Stimulation Lead Placement Under Deep Sedation and General Anesthesia
ConclusionsThis survey provides initial data on SCS practices among a large cohort of clinicians who utilize SCS. SCS lead placement under deep sedation and general anesthesia appears to be common practice for many physicians who perform implants. This survey should stimulate further research on this topic, given that the current safety guidelines and the rate of physicians reporting the use of deep sedation and general anesthesia for spinal cord stimulator placement remain at odds. (Source: Pain and Therapy)
Source: Pain and Therapy - October 15, 2021 Category: Anesthesiology Source Type: research

Comparison of Ultrasound-Guided Erector Spinae Plane Block and Oblique Subcostal Transverse Abdominis Plane Block for Postoperative Analgesia in Elderly Patients After Laparoscopic Colorectal Surgery: A Prospective Randomized Study
ConclusionsCompared with oblique subcostal TAPB, ESPB more effectively reduced postoperative pain and opioid consumption. Thus, ESPB is suitable for postoperative analgesia in elderly patients who have undergone laparoscopic colorectal surgery.Trial RegistrationChinese Clinical Trial Registry: ChiCTR2000033236. (Source: Pain and Therapy)
Source: Pain and Therapy - October 15, 2021 Category: Anesthesiology Source Type: research

Burden of Migraine in Patients With Preventive Treatment Failure Attending European Headache Specialist Centers: Real-World Evidence From the BECOME Study
ConclusionsThis study provides real-world evidence of the high personal, social, and HRU burden of migraine in Europe and Israel. (Source: Pain and Therapy)
Source: Pain and Therapy - October 13, 2021 Category: Anesthesiology Source Type: research

Gabapentin has Longer-Term Efficacy for the Treatment of Chronic Pelvic Pain in Women: A Systematic Review and Pilot Meta-analysis
AbstractIntroductionGabapentin has potential analgesic benefits in patients with neuropathic pain, such as post-herpetic neuralgia and diabetic peripheral neuropathy neuropathic pain. However, its efficacy in women with chronic pelvic pain (CPP) remains contradictory. In the present study, we performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to ascertain the efficacy of this treatment.MethodsWe systematically reviewed RCTs published in PubMed, Embase, the Cochrane Library, Web of Science, and Google Scholar databases, up to July 2021. These articles compared gabapentin with placebo or a...
Source: Pain and Therapy - October 4, 2021 Category: Anesthesiology Source Type: research

The Impact of Clinical Setting on Evaluating Patients Using the PROMIS-29 Baseline Measures in the COVID Era: A Retrospective Multicenter Quantitative Analysis
ConclusionsThis data set is the first published data describing the influence of environment (remote versus in person) on PROMIS-29 outcome measurements in the chronic pain population. (Source: Pain and Therapy)
Source: Pain and Therapy - October 2, 2021 Category: Anesthesiology Source Type: research

Effect of Different Modes of Administration of Dexmedetomidine Combined with Nerve Block on Postoperative Analgesia in Total Knee Arthroplasty
AbstractIntroductionDexmedetomidine (DEX) as a nerve block adjuvant can significantly prolong analgesia. However, whether perineural or systemic administration of DEX is more beneficial in patients undergoing total knee arthroplasty (TKA) has not been thoroughly investigated. To this end, we evaluated the effects of perineural and systemic DEX administration on postoperative analgesia in patients undergoing TKA surgery.MethodsWe randomly assigned patients undergoing TKA under general anesthesia combined with femoral nerve block and sciatic nerve block to one of three groups: (1) ropivacaine plus perineural dexmedetomidine ...
Source: Pain and Therapy - September 30, 2021 Category: Anesthesiology Source Type: research

Tapentadol Safety and Patient Characteristics Associated with Treatment Discontinuation in Cancer Therapy: A Retrospective Multicentre Study in Japan
AbstractIntroductionTapentadol has analgesic effects comparable to those of conventional opioids and is associated with fewer side effects, including gastrointestinal symptoms, drowsiness, and dizziness, than other opioids. However, the safety of tapentadol in the Japanese population remains unclear; the present multicentre study aimed to examine the safety of tapentadol and the characteristics of patients likely to discontinue this treatment owing to adverse events.MethodsThe safety of tapentadol was assessed retrospectively in patients with any type of cancer treated between August  18, 2014 and October 31, 201...
Source: Pain and Therapy - September 28, 2021 Category: Anesthesiology Source Type: research

Association of Postpartum Pain Sensitivity and Postpartum Depression: A Prospective Observational Study
AbstractIntroductionPostpartum depression (PPD) is a severe psychiatric disorder that negatively affects postnatal mothers worldwide. The aim of the study is to investigate the association between postpartum pain sensitivity and PPD as well as to identify the other potential risk factors for PPD and their interconnections.MethodsThe current study was a prospective observational clinical study that enrolled 210 singleton pregnant women in a tertiary referral hospital from January to December 2020. Postpartum pain sensitivity was assessed by the Mandarin Chinese version of the Pain Sensitivity Questionnaire (PSQ), and PSQ-C-...
Source: Pain and Therapy - September 27, 2021 Category: Anesthesiology Source Type: research

Machine Learning in Pain Medicine: An Up-To-Date Systematic Review
ConclusionML is increasingly used in pain medicine and appears to be more effective compared to traditional statistical approaches in the diagnosis, classification, and management of pain. (Source: Pain and Therapy)
Source: Pain and Therapy - September 26, 2021 Category: Anesthesiology Source Type: research

Is There a Gender Difference in the Response to onabotulinumtoxinA in Chronic Migraine? Insights from a Real-Life European Multicenter Study on 2879 Patients
We reported the 50% responder rates during each BT-A cycle, defined as percentage of reduction in monthly headache days (MHDs) compared to baseline, along with 75% and 30% responder rates. We also reported the mean decrease in MHDs and in days of acute medication use (DAMs) during each BT- A cycle as compared to baseline. We also evaluated the reasons for stopping the treatment within the third cycle.ResultsWe included an overall cohort of 2879 patients, 522 of whom (18.1%) were men. In men, 50% responder rates were 27.7% during the first BT-A cycle, 29.2% during the second, and 35.6% during the third cycle; in women, the ...
Source: Pain and Therapy - September 26, 2021 Category: Anesthesiology Source Type: research

CT-Guided Coeliac Plexus Neurolysis in Patients with Intra-Abdominal Malignancy: A Retrospective Evaluation of 52 Palliative In-Patients
ConclusionsIn patients with intra-abdominal malignancy-related CAP, CPN is a safe and effective procedure which can provide long-lasting significant relief of background pain and BTcP. As part of a multimodal approach, CPN should be considered as an earlier option for pain management in these patients. (Source: Pain and Therapy)
Source: Pain and Therapy - September 21, 2021 Category: Anesthesiology Source Type: research

Intercostal Cryo Nerve Block in Minimally Invasive Cardiac Surgery: The Prospective Randomized FROST Trial
ConclusionsThe results of FROST demonstrated that intercostal CryoNB provided enhanced FEV1 score at 48 h postoperatively with optimized analgesic effectiveness versus SOC. Future larger prospective randomized trials are warranted to determine whether intercostal CryoNB has an  opioid-sparing effect in patients undergoing Mini-HVS.Trial RegistrationClinicaltrials.gov identifier: NCT02922153. (Source: Pain and Therapy)
Source: Pain and Therapy - September 20, 2021 Category: Anesthesiology Source Type: research

The Role of Serratus Anterior Plane Block During in Video-Assisted Thoracoscopic Surgery
This article introduces the anatomical mechanism of the SAPB, diverse operation approaches, how to choose drugs and adjuvants, and the resulting impacted area r ange. It summarizes the advantages and disadvantages of the SAPB compared with other analgesic methods and posits that the SAPB is beneficial to the recovery of postoperative lung function, which provides more options for postoperative analgesia after VATS. (Source: Pain and Therapy)
Source: Pain and Therapy - September 19, 2021 Category: Anesthesiology Source Type: research

Clinical Efficacy of Conservative Treatment with Micronized Purified Flavonoid Fraction in Female Patients with Pelvic Congestion Syndrome
This study evaluated the clinical efficacy of micronized purified flavonoid fraction (MPFF) in women with PCS.MethodsIn a single-blind, placebo-controlled study, women with duplex ultrasound diagnosis of pelvic varicose veins (PVV) and PCS were randomized to MPFF 1000  mg once daily or placebo for 2 months. Clinical manifestations of PCS were evaluated at baseline and end of treatment (M2) using three assessment tools: disease-specific quality of life (QoL) Pelvic Varicose Vein Questionnaire (PVVQ), Pelvic Venous Clinical Severity Score (PVCSS), and the Visual Analog Scale (VAS) for the main symptoms of the disea...
Source: Pain and Therapy - September 19, 2021 Category: Anesthesiology Source Type: research

Migraine Characteristics, Comorbidities, Healthcare Resource Utilization, and Associated Costs of Early Users of Erenumab in the USA: A Retrospective Cohort Study Using Administrative Claims Data
ConclusionsWe observed reductions in claims for important migraine characteristics, comorbidities, and a shift to decreased use of acute and preventive migraine medications —observations indicative of the real-world effectiveness of erenumab. Further examination is required as persistence to erenumab, which may be influenced by dose titration, appears to be an important factor in changes to healthcare resource utilization and costs. (Source: Pain and Therapy)
Source: Pain and Therapy - September 17, 2021 Category: Anesthesiology Source Type: research

Historical Review of Studies on Sacroiliac Fatty Nodules (Recently Termed “Back Mice”) as a Potential Cause of Low Back Pain
AbstractLow back pain is a widespread and poorly understood condition that is frequently diagnosed as non-specific low back pain. We were intrigued by the presence of painful sacroiliac nodules in patients with this condition. We conducted a historical review to elucidate this relationship. This chronicled review summarizes the overlooked literature from different countries, especially from around the 1950s, regarding the diagnosis and management of these painful nodules. Biopsies have confirmed the adipose nature of these nodules and revealed distinct pathological signs, including oedema and fascial fatty herniation. Stud...
Source: Pain and Therapy - September 16, 2021 Category: Anesthesiology Source Type: research

Status of N-of-1 Trials in Chronic Pain Management: A Narrative Review
AbstractN-of-1 trials are randomized controlled clinical trials conducted exclusively on a single patient. The ultimate aim of N-of-1 trials is to optimize a strategy in a particular individual. Chronic pain is a common but refractory clinical problem. Its diverse etiologies and broad variations among patients often lead to the requirement of individualizing medicine. Thus, chronic pain represents a classical condition for N-of-1 clinical trials. Studies have indicated that N-of-1 benefits patients with chronic pain, multiple comorbidities, and uncertain variations during therapies; however, this approach it is not yet ado...
Source: Pain and Therapy - September 16, 2021 Category: Anesthesiology Source Type: research

Caudad Insertion of Pedicle Screws Facilitates Interbody Distraction During Spondylolisthetic Vertebrae Restoration: A Retrospective Study
AbstractIntroductionBased on the results of long-term clinical and radiological follow-up studies of decompression and fusion with internal fixation for degenerative lumbar spondylolisthesis (DLS), we recognized that the direction of the pedicle screw affects the stability of the fixation. However, few studies have analyzed the role of pedicle screw insertion trajectory in disc height recovery after fusion. We therefore analyzed patients ’ general information, clinical efficacy and sagittal, coronal and implant parameters to determine whether there is a correlation between the insertion trajectory of screws and the r...
Source: Pain and Therapy - September 15, 2021 Category: Anesthesiology Source Type: research

A Qualitative Study to Explore Patient Perspectives of Prophylactic Treatment with OnabotulinumtoxinA for Chronic Migraine
ConclusionUnderstanding patients ’ perspective is an important part of clinical practice and may impact on decision-making. Qualitative data can provide a more holistic view of patient care and treatment insights that may not be evaluated during a clinical trial. This study revealed potential barriers to treatment that can inform future policy and practice. (Source: Pain and Therapy)
Source: Pain and Therapy - September 14, 2021 Category: Anesthesiology Source Type: research

Clinical Characteristics, Treatment Effectiveness, and Predictors of Response to Pharmacotherapeutic Interventions Among Patients with Herpetic-Related Neuralgia: A Retrospective Analysis
AbstractBackgroundThe treatment for herpetic-related neuralgia focuses on symptom control by use of antiviral drugs, anticonvulsants, and tricyclic antidepressants. We aimed to explore the clinical characteristics associated with medication responsiveness, and to build a classifier for identification of patients who have risk of inadequate pain management.MethodsWe recruited herpetic-related neuralgia patients during a 3-year period. Patients were stratified into a medication-resistant pain (MRP) group when the pain decrease in the visual analogue scale (VAS) is  
Source: Pain and Therapy - September 12, 2021 Category: Anesthesiology Source Type: research

Pregabalin and Gabapentin in Patients with Spinal Cord Injury-Related Neuropathic Pain: A Network Meta-Analysis
ConclusionsThis study revealed that for patients with SCI-related neuropathic pain, pregabalin was the most effective for relieving pain, whereas gabapentin performed better in aspects associated with drug therapy-related safety. (Source: Pain and Therapy)
Source: Pain and Therapy - September 7, 2021 Category: Anesthesiology Source Type: research

Endoscopic Transforaminal Lumbar Foraminotomy: A Systematic Review and Meta-Analysis
ConclusionTELF is a useful and safe method to achieve decompression in foraminal stenosis. This technique is indicated in the elderly or patients with comorbidities. Preoperative planning is paramount in determining the foraminal size and endoscope trajectory. A diamond burr is recommended because it has an advantage over the regular endoscopic shaver in bleeding control and complication avoidance. (Source: Pain and Therapy)
Source: Pain and Therapy - September 6, 2021 Category: Anesthesiology Source Type: research

Assessment of Neuropathic Pain in Ankylosing Spondylitis: Prevalence and Characteristics
AbstractIntroductionPain in ankylosing spondylitis is currently considered an inflammatory pain (IP). However, it was found that some patients still had the sensation of pain even without inflammation. Our study was to investigate the prevalence and characteristics of neuropathic pain (NeP) in Chinese Han ankylosing spondylitis (AS) patients.MethodsThe study consisted of three parts. Firstly, we assessed the prevalence and clinical data of NeP in 182 AS patients. Secondly, we evaluated pain improvement after etanercept therapy in 63 patients. Finally, serum neurotransmitters were measured for 20 AS patients and ten healthy...
Source: Pain and Therapy - September 4, 2021 Category: Anesthesiology Source Type: research

Pharmacological Advances in Opioid Therapy: A Review of the Role of Oliceridine in Pain Management
AbstractProblems with the treatment of acute pain may arise when a patient is opioid-tolerant, such as those on chronic therapy with opioids or opiate replacement therapy, those who misuse opioids, and those who are in recovery. While some of the adverse effects of opioid medications are well known, it is also important to recognize the roles of tolerance and hyperalgesia. Oliceridine can target and modulate a novel μ-receptor pathway. The G protein-biased agonism of oliceridine allows for effective re-sensitization and desensitization of the mu-opioid receptor, which decreases the formation of opioid tolerance in patie...
Source: Pain and Therapy - September 4, 2021 Category: Anesthesiology Source Type: research

Peripheral Nerve Stimulation for Chronic Pain: A Systematic Review of Effectiveness and Safety
AbstractPeripheral nerve stimulation (PNS) was the first application of neuromodulation. Widespread application of PNS was limited by technical concerns. Recent advances now allow the percutaneous placement of leads with ultrasound or fluoroscopic guidance, while the transcutaneous powering of these leads removes the need for leads to cross major joints. This systematic review was written to assess the current status of high-quality evidence supporting the use of PNS for pain conditions treated by interventional pain physicians. The available literature on PNS, limited to conditions treated by interventional pain physician...
Source: Pain and Therapy - September 3, 2021 Category: Anesthesiology Source Type: research

Restorative Neurostimulation for Chronic Mechanical Low Back Pain: Results from a Prospective Multi-centre Longitudinal Cohort
AbstractIntroductionLow back pain impacts most people throughout the course of their lives and contributes significantly to the global burden of disease. In some patients, symptoms resolve with little intervention, while others are amenable to surgical intervention, some cases are intractable to current care paradigms. Restorative neurostimulation is an emerging therapy for chronic mechanical low back pain.MethodsWe conducted a prospective post-market follow-up of 42 patients treated for longstanding chronic mechanical low back pain with restorative neurostimulation. Patients were followed up at 45, 90, and 180  days ...
Source: Pain and Therapy - September 3, 2021 Category: Anesthesiology Source Type: research

A Prospective Study to Examine the Association of the Foramen Ovale Size with Intraluminal Pressure of Pear-Shaped Balloon in Percutaneous Balloon Compression for Trigeminal Neuralgia
ConclusionsPreoperative assessment of FO may be a potential predictor of intraluminal pressure to reach a pear-shaped balloon during PBC treatment. Narrow FO is associated lower intraluminal balloon pressure. (Source: Pain and Therapy)
Source: Pain and Therapy - August 30, 2021 Category: Anesthesiology Source Type: research

Prevalence and Characteristics of Chronic Pain Among Patients in Portuguese Primary Care Units
ConclusionGiven the high prevalence of CP, strategies to improve the quality of life of these patients and decrease the negative impacts, as well as awareness campaigns to increase the populations ’ knowledge of this condition, are essential for the suitable and timely treatment of CP. (Source: Pain and Therapy)
Source: Pain and Therapy - August 28, 2021 Category: Anesthesiology Source Type: research

A Response to: Letter to the Editor regarding “Influences of Gender on Intravenous Nalbuphine Actions After Major Abdominal Surgery: A Multicenter Study”
(Source: Pain and Therapy)
Source: Pain and Therapy - August 24, 2021 Category: Anesthesiology Source Type: research

Letter to the Editor regarding “Influences of Gender on Intravenous Nalbuphine Actions After Major Abdominal Surgery: A Multicenter Study”
(Source: Pain and Therapy)
Source: Pain and Therapy - August 24, 2021 Category: Anesthesiology Source Type: research

Demographics, Pain Characteristics and Diagnostic Classification Profile of Chronic Non-Cancer Pain Patients Attending a Canadian University-Affiliated Community Pain Clinic
ConclusionOur study highlights regional differences between CNCP population phenotypes. Recognition of biomedical, psychological and socio-environmental factors affecting pain should be considered for patient stratification and rational approaches to treatment, as “one size treatment does not fit all”. (Source: Pain and Therapy)
Source: Pain and Therapy - August 19, 2021 Category: Anesthesiology Source Type: research

Musculoskeletal Pain Due to Wheelchair Use: A Systematic Review and Meta-Analysis
AbstractIntroductionWheelchair users are at a high risk of experiencing non-neuropathic pain of musculoskeletal origin as a result of being wheelchair-bound. The aim of this systematic review was to establish the prevalence of musculoskeletal pain in wheelchair users that is attributable to wheelchair use, and to describe the different pain syndromes and discuss risk factors and management options.MethodsAfter a systematic MEDLINE search, we identified 40 papers eligible for inclusion.ResultsThe pooled prevalence of musculoskeletal pain at any location was 50% (95% CI 33 –67%). The most common pain syndrome was shoul...
Source: Pain and Therapy - August 13, 2021 Category: Anesthesiology Source Type: research

Sex-Specific Pharmacotherapy for Back Pain: A Proof-of-Concept Randomized Trial
ConclusionsThese results provide the first evidence for preventing transition to chronic back pain using sex-specific pharmacotherapy. These provocative observations require confirmation in a larger study. ClinicalTrials.gov identifier: NCT01951105. (Source: Pain and Therapy)
Source: Pain and Therapy - August 10, 2021 Category: Anesthesiology Source Type: research

Comparison of Vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) and Laparoendoscopic Single-Site (LESS) Hysterectomy on Postoperative  Pain Reduction: A Randomized Pilot Study
ConclusionsvNOTES hysterectomy can be safely performed for benign uterine disease requiring hysterectomy. However, vNOTES hysterectomy might be associated with higher postoperative vaginal pain intensity compared to LESS hysterectomy.Trial RegistrationCRIS identifier KCT0004605. (Source: Pain and Therapy)
Source: Pain and Therapy - August 10, 2021 Category: Anesthesiology Source Type: research

Painful Diabetic Peripheral Neuropathy Study of Chinese Outpatients (PDNSCOPE): A Multicentre Cross-Sectional Registry Study of Clinical Characteristics and Treatment in Mainland China
ConclusionModerate to severe neuropathic pain in PDN was identified in 73.11% of participants. Age, diabetic duration, depression history, PHQ-9 score, GAD-7 score and FBG were risk factors for VAS pain scores. PAD was protective factor. The majority of pain relief therapies prescribed were in accordance with guidelines.Trial registrationClinicalTrials.gov identifier, NCT03520608, retrospectively registered, 2018-05-11. (Source: Pain and Therapy)
Source: Pain and Therapy - August 7, 2021 Category: Anesthesiology Source Type: research

Oliceridine Exhibits Improved Tolerability Compared to Morphine at Equianalgesic Conditions: Exploratory Analysis from Two Phase 3 Randomized Placebo and Active Controlled Trials
ConclusionFindings from this exploratory analysis suggest that at comparable levels of analgesia, patients receiving oliceridine were less likely to experience the composite safety endpoint consisting of ORAEs compared to patients treated with morphine. (Source: Pain and Therapy)
Source: Pain and Therapy - August 5, 2021 Category: Anesthesiology Source Type: research

Comparison of Two Ultrasound-guided Plane Blocks for Pain and Postoperative Opioid Requirement in Lumbar Spine Fusion Surgery: A Prospective, Randomized, and Controlled Clinical Trial
AbstractIntroductionThe erector spinae plane (ESP) block and thoracolumbar interfascial plane (TLIP) block were two novel plane blocks. The purpose of this study was to investigate TLIP block and ESP block on the effect of analgesic and opioid consumption in lumbar spine fusion surgery in the perioperative period.MethodsThree hundred and four patients who suffered lumbar spine fusion were included and randomly divided into three groups: a control group (n = 102), an ESP block group (n = 100), and a TLIP block group (n = 102). We recorded the numerical rating scale (NRS) pain at mov...
Source: Pain and Therapy - August 4, 2021 Category: Anesthesiology Source Type: research

Peripheral Nerve Stimulation: A Review of Techniques and Clinical Efficacy
AbstractChronic pain is a common source of morbidity in many patient populations worldwide. There are growing concerns about the potential side effects of currently prescribed medications and a continued need for effective treatment. Related to these concerns, peripheral nerve stimulation has been regaining popularity as a potential treatment modality. Peripheral nerve stimulation components include helically coiled electrical leads, which direct an applied current to afferent neurons providing sensory innervation to the painful area. In theory, the applied current to the peripheral nerve will alter the large-diameter myel...
Source: Pain and Therapy - July 31, 2021 Category: Anesthesiology Source Type: research

Decompression Using Minimally Invasive Surgery for Lumbar Spinal Stenosis Associated with Degenerative Spondylolisthesis: A Review
AbstractLumbar spinal stenosis (LSS), which often occurs concurrently with degenerative spondylolisthesis (DS), is a common disease in the elderly population, affecting the quality of life of aged people significantly. Notwithstanding the frequently good effect of conservative therapy on LSS, a minority of the patients ultimately require surgery. Surgery for LSS aims to decompress the narrowed spinal canals with preservation of spinal stability. Traditional open surgery, either pure decompression or decompression with fusion, was considered effective for the treatment of LSS with or without DS. However, the long-term clini...
Source: Pain and Therapy - July 28, 2021 Category: Anesthesiology Source Type: research

Headache Attributed to Vaccination Against COVID-19 (Coronavirus SARS-CoV-2) with the ChAdOx1 nCoV-19 (AZD1222) Vaccine: A Multicenter Observational Cohort Study
ConclusionHeadaches attributed to COVID-19 vaccination with the ChAdOx1 nCoV-19 (AZD1222) vaccine demonstrate an extensive and characteristic complex of symptoms. The findings have several important clinical implications for the differentiation of post-vaccinal headache and other primary as well as secondary headaches. (Source: Pain and Therapy)
Source: Pain and Therapy - July 27, 2021 Category: Anesthesiology Source Type: research

Opioid-Free Recovery After Hernia Repair with HTX-011 as the Foundation of a Non-Opioid, Multimodal Analgesia Regimen in a Real-World Setting: A Randomized, Open-Label Study
ConclusionsHTX-011, used with over-the-counter products ibuprofen/acetaminophen and personalized opioid prescription algorithm in a real-world environment, has the potential to reduce opioid use and opioid prescriptions after herniorrhaphy without compromising patient satisfaction.Trial RegistrationClinicalTrials.gov, NCT03237481. (Source: Pain and Therapy)
Source: Pain and Therapy - July 27, 2021 Category: Anesthesiology Source Type: research

Correction to: Complex Regional Pain Syndrome: A Comprehensive Review
(Source: Pain and Therapy)
Source: Pain and Therapy - July 26, 2021 Category: Anesthesiology Source Type: research

The Effect of Preoperative Anxiety and Pain Sensitivity on Preoperative Hemodynamics, Propofol Consumption, and Postoperative Recovery and Pain in Endoscopic Ultrasonography
ConclusionThe significant linear correlation between preoperative anxiety and pain sensitivity and anesthesia need can facilitate better preoperative management by predicting individual anesthetic consumption.Trial RegistrationThe study was registered with the number NCT03114735 on ClinicalTrials.gov. (Source: Pain and Therapy)
Source: Pain and Therapy - July 22, 2021 Category: Anesthesiology Source Type: research

Microglia in the Pathophysiology of Hemorrhagic Stroke and the Relationship Between Microglia and Pain After Stroke: A Narrative Review
AbstractStroke is a leading cause of death worldwide, and about a quarter of stroke patients are dead within 1 month. The prognosis is even worse for those with hemorrhagic stroke because the 1-month mortality approaches 50%. Besides, most patients who survive experience complications such as nausea, vomiting, and chronic pain. These adverse experiences, especially the existence of chronic pain, can lead to a decline in the patient ’s quality of life. In order to improve the treatment and prognosis of hemorrhagic stroke, there is an urgent need to understand its pathophysiological mechanism as well as the chronic pai...
Source: Pain and Therapy - July 18, 2021 Category: Anesthesiology Source Type: research