Radiation Biological Toximetry Using Circulating Cell-Free DNA (cfDNA) for Rapid Radiation/Nuclear Triage
Radiat Res. 2024 Apr 25. doi: 10.1667/RADE-23-00159.1. Online ahead of print.ABSTRACTOptimal triage biodosimetry would include risk stratification within minutes, and it would provide useful triage despite heterogeneous dosimetry, cytokine therapy, mixed radiation quality, race, and age. For regulatory approval, the U.S. Food and Drug Administration (FDA) Biodosimetry Guidance requires suitability for purpose and a validated species-independent mechanism. Circulating cell-free DNA (cfDNA) concentration assays may provide such triage information. To test this hypothesis, cfDNA concentrations were measured in unprocessed mon...
Source: Radiation Research - April 25, 2024 Category: Physics Authors: Paul Okunieff Steven G Swarts Bruce Fenton Stephen B Zhang Zhenhuan Zhang Lori Rice Daohong Zhou France Carrier Lurong Zhang Source Type: research
Living Donor Ethics and Uterus Transplantation
This article provides an in-depth ethical analysis of living donor uterus transplantation, incorporating clinical, psychological, and qualitative study data into the discussion. Although the concept of living organ donors as patients in their own right has not always been present in the field of transplantation, this conceptualization informs the framework for living donor ethics that we apply to living uterus donation. This framework takes root in the principles of research ethics, which include respect for persons, beneficence, and justice. It incorporates an analysis based on eight potential vulnerabilities of living do...
Source: Perspectives in Biology and Medicine - April 25, 2024 Category: Medical Ethics Authors: Anji E Wall Giuliano Testa Source Type: research
Glutamine supplementation improves the activity and immunosuppressive action of induced regulatory T cells in vitro and in vivo
CONCLUSION: Glutamine supplementation can improve the activity and immunosuppressive action of iTregs, and the possible mechanisms by which this occurs are related to cell proliferation, apoptosis, and OXPHOS.PMID:38663757 | DOI:10.1016/j.trim.2024.102044 (Source: Transplant Immunology)
Source: Transplant Immunology - April 25, 2024 Category: Transplant Surgery Authors: Li Zhang Zhongya Xu Yuanjiu Li Ke-Jia Wu Chongyuan Yu Wenjie Zhu Dong-Lin Sun Li Zhu Jun Zhou Source Type: research
Cellular strategies to induce immune tolerance after liver transplantation: Clinical perspectives
World J Gastroenterol. 2024 Apr 7;30(13):1791-1800. doi: 10.3748/wjg.v30.i13.1791.ABSTRACTLiver transplantation (LT) has become the most efficient treatment for pediatric and adult end-stage liver disease and the survival time after transplantation is becoming longer due to the development of surgical techniques and perioperative management. However, long-term side-effects of immunosuppressants, like infection, metabolic disorders and malignant tumor are gaining more attention. Immune tolerance is the status in which LT recipients no longer need to take any immunosuppressants, but the liver function and intrahepatic histol...
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Ai-Wei Zhou Jing Jin Yuan Liu Source Type: research
Cellular strategies to induce immune tolerance after liver transplantation: Clinical perspectives
World J Gastroenterol. 2024 Apr 7;30(13):1791-1800. doi: 10.3748/wjg.v30.i13.1791.ABSTRACTLiver transplantation (LT) has become the most efficient treatment for pediatric and adult end-stage liver disease and the survival time after transplantation is becoming longer due to the development of surgical techniques and perioperative management. However, long-term side-effects of immunosuppressants, like infection, metabolic disorders and malignant tumor are gaining more attention. Immune tolerance is the status in which LT recipients no longer need to take any immunosuppressants, but the liver function and intrahepatic histol...
Source: World Journal of Gastroenterology : WJG - April 25, 2024 Category: Gastroenterology Authors: Ai-Wei Zhou Jing Jin Yuan Liu Source Type: research
Bazedoxifene attenuates dextran sodium sulfate-induced colitis in mice through gut microbiota modulation and inhibition of STAT3 and NF- κB pathways
This study highlights gut microbiota's role in IBD drug development, offering insights for BZA's future development and its clinical applications.PMID:38663540 | DOI:10.1016/j.ejphar.2024.176611 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 25, 2024 Category: Drugs & Pharmacology Authors: Liumei Liang Jingdan Zhang Junxiong Chen Yu Tian Weiqian Li Mengchen Shi Sijing Cheng Yinhai Zheng Chen Wang Huanliang Liu Xiangling Yang Weibiao Ye Source Type: research
Low-risk delisting strategy in highly sensitized patients without donor offers included in exchange donation programs. One single-center experience
Hum Immunol. 2024 Apr 24:110806. doi: 10.1016/j.humimm.2024.110806. Online ahead of print.ABSTRACTDonor exchange programs were designed to allocate organs for highly sensitized (HS) patients. The allocation algorithm differs slightly among countries and includes different strategies to improve access to transplants in HS patients. However, many HS patients with a calculated panel reactive of antibodies (cPRA) of 100 % remain on the waiting list for a long time. Some allocation algorithms assume immunological risk, including Imlifidase treatment, to increase the chance of transplantation in very HS patients. Here, we descri...
Source: Human Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Alejandra Comins-Boo Juan Irure-Ventura Maria O Valentin Lara Belmar-Vega Covadonga L ópez Del Moral Cuesta Rosal ía Valero San Cecilio Emilio Rodrigo Calabia M ónica Renuncio-García Carolina Castro Hern ández Dzmitry Mikhalkovich Nerea Mota P érez Source Type: research
Cope with copper: From molecular mechanisms of cuproptosis to copper-related kidney diseases
Int Immunopharmacol. 2024 Apr 24;133:112075. doi: 10.1016/j.intimp.2024.112075. Online ahead of print.ABSTRACTCuproptosis has recently been identified as a novel regulatory mechanism of cell death. It is characterized by the accumulation of copper in mitochondria and its binding to acylated proteins. These characteristics lead to the downregulation of iron-sulfur cluster proteins and protein toxicity stress, ultimately resulting in cell death. Cuproptosis is distinct from other types of cell death, including necrosis, apoptosis, ferroptosis, and pyroptosis. Cu induces oxidative stress damage, protein acylation, and the oli...
Source: International Immunopharmacology - April 25, 2024 Category: Allergy & Immunology Authors: Yurong Zou Shukun Wu Xingli Xu Xiaoqiu Tan Shuang Yang Tangting Chen Jiong Zhang Shengqiang Li Wei Li Fang Wang Source Type: research
Systematic Review and Meta-Analysis of Health-Related Quality of Life in Patients with β-Thalassemia that Underwent Hematopoietic Stem Cell Transplantation
CONCLUSION: HRQoL is generally good in β-TM transplanted patients and may significantly contribute in deciding whether or not to transplant a β-TM patient treated with conventional therapy.PMID:38659631 | PMC:PMC11037551 | DOI:10.2174/17450179-v17-e211208-2021-HT2-1910-4 (Source: Clinical Practice and Epidemiology in Mental Health)
Source: Clinical Practice and Epidemiology in Mental Health - April 25, 2024 Category: Psychiatry Authors: Olga Mulas Ilaria Pili Marco Sanna Giorgio La Nasa Source Type: research
Alpha-1 Antitrypsin Augmentation Therapy in Chronic Pancreatitis Patients Undergoing Total Pancreatectomy and Islet Autotransplantation: A Randomized, Controlled Study
Cell Transplant. 2024 Jan-Dec;33:9636897241243014. doi: 10.1177/09636897241243014.ABSTRACTStress-induced islet graft loss during the peri-transplantation period reduces the efficacy of islet transplantation. In this prospective, randomized, double-blind clinical trial, we evaluated the safety and efficacy of 60 mg/kg human alpha-1 antitrypsin (AAT) or placebo infusion weekly for four doses beginning before surgery in chronic pancreatitis (CP) patients undergoing total pancreatectomy and islet autotransplantation (TP-IAT). Subjects were followed for 12 months post-TP-IAT. The dose of AAT was safe, as there was no difference...
Source: Cell Transplantation - April 25, 2024 Category: Cytology Authors: Hongjun Wang Wenyu Gou Paul J Nietert Jason Hirsch Jingjing Wang Ahmed Allawi Abd S Mortadha Kelsey Cook Morgan Overstreet Hua Wei David Adams William P Lancaster Katherine A Morgan Charlie Strange Source Type: research
Radiation Biological Toximetry Using Circulating Cell-Free DNA (cfDNA) for Rapid Radiation/Nuclear Triage
Radiat Res. 2024 Apr 25. doi: 10.1667/RADE-23-00159.1. Online ahead of print.ABSTRACTOptimal triage biodosimetry would include risk stratification within minutes, and it would provide useful triage despite heterogeneous dosimetry, cytokine therapy, mixed radiation quality, race, and age. For regulatory approval, the U.S. Food and Drug Administration (FDA) Biodosimetry Guidance requires suitability for purpose and a validated species-independent mechanism. Circulating cell-free DNA (cfDNA) concentration assays may provide such triage information. To test this hypothesis, cfDNA concentrations were measured in unprocessed mon...
Source: Radiation Research - April 25, 2024 Category: Physics Authors: Paul Okunieff Steven G Swarts Bruce Fenton Stephen B Zhang Zhenhuan Zhang Lori Rice Daohong Zhou France Carrier Lurong Zhang Source Type: research
Living Donor Ethics and Uterus Transplantation
This article provides an in-depth ethical analysis of living donor uterus transplantation, incorporating clinical, psychological, and qualitative study data into the discussion. Although the concept of living organ donors as patients in their own right has not always been present in the field of transplantation, this conceptualization informs the framework for living donor ethics that we apply to living uterus donation. This framework takes root in the principles of research ethics, which include respect for persons, beneficence, and justice. It incorporates an analysis based on eight potential vulnerabilities of living do...
Source: Perspectives in Biology and Medicine - April 25, 2024 Category: Medical Ethics Authors: Anji E Wall Giuliano Testa Source Type: research
Glutamine supplementation improves the activity and immunosuppressive action of induced regulatory T cells in vitro and in vivo
CONCLUSION: Glutamine supplementation can improve the activity and immunosuppressive action of iTregs, and the possible mechanisms by which this occurs are related to cell proliferation, apoptosis, and OXPHOS.PMID:38663757 | DOI:10.1016/j.trim.2024.102044 (Source: Transplant Immunology)
Source: Transplant Immunology - April 25, 2024 Category: Transplant Surgery Authors: Li Zhang Zhongya Xu Yuanjiu Li Ke-Jia Wu Chongyuan Yu Wenjie Zhu Dong-Lin Sun Li Zhu Jun Zhou Source Type: research
Cellular strategies to induce immune tolerance after liver transplantation: Clinical perspectives
World J Gastroenterol. 2024 Apr 7;30(13):1791-1800. doi: 10.3748/wjg.v30.i13.1791.ABSTRACTLiver transplantation (LT) has become the most efficient treatment for pediatric and adult end-stage liver disease and the survival time after transplantation is becoming longer due to the development of surgical techniques and perioperative management. However, long-term side-effects of immunosuppressants, like infection, metabolic disorders and malignant tumor are gaining more attention. Immune tolerance is the status in which LT recipients no longer need to take any immunosuppressants, but the liver function and intrahepatic histol...
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Ai-Wei Zhou Jing Jin Yuan Liu Source Type: research
Cope with copper: From molecular mechanisms of cuproptosis to copper-related kidney diseases
Int Immunopharmacol. 2024 Apr 24;133:112075. doi: 10.1016/j.intimp.2024.112075. Online ahead of print.ABSTRACTCuproptosis has recently been identified as a novel regulatory mechanism of cell death. It is characterized by the accumulation of copper in mitochondria and its binding to acylated proteins. These characteristics lead to the downregulation of iron-sulfur cluster proteins and protein toxicity stress, ultimately resulting in cell death. Cuproptosis is distinct from other types of cell death, including necrosis, apoptosis, ferroptosis, and pyroptosis. Cu induces oxidative stress damage, protein acylation, and the oli...
Source: International Immunopharmacology - April 25, 2024 Category: Allergy & Immunology Authors: Yurong Zou Shukun Wu Xingli Xu Xiaoqiu Tan Shuang Yang Tangting Chen Jiong Zhang Shengqiang Li Wei Li Fang Wang Source Type: research
