Hematopoietic Recovery using Multi-Cytokine Therapy in 8 Patients Presenting Radiation-Induced Myelosuppression after Radiological Accidents
Radiat Res. 2021 Sep 23. doi: 10.1667/RADE-21-00169.1. Online ahead of print.ABSTRACTTreatment of accidental radiation-induced myelosuppression is primarily based on supportive care and requires specific treatment based on hematopoietic growth factors injection or hematopoietic cell transplantation for the most severe cases. The cytokines used consisted of pegylated erythropoietin (darbepoetin alfa) 500 IU once per week, pegylated G-CSF (pegfilgrastim) 6 mg × 2 once, stem cell factor 20 μg.kg-1 for five days, and romiplostim (TPO analog) 10 μg.kg-1 once per week, with different combinations depending on the acc...
Source: Radiation Research - September 23, 2021 Category: Physics Authors: Marc Benderitter Eduardo Herrera-Reyes Yvan Gigov Bertrand Souleau Jean Christelle Huet Fran çois Trompier Thierry Fagot Eric Gr égoire Jean Val ère Malfuson Johanna Konopacki-Potet Elena Buglova Jean-Jacques Lataillade Radia Tamarat Patrick Gourmelon Source Type: research

Hematopoietic Recovery using Multi-Cytokine Therapy in 8 Patients Presenting Radiation-Induced Myelosuppression after Radiological Accidents
Radiat Res. 2021 Sep 23. doi: 10.1667/RADE-21-00169.1. Online ahead of print.ABSTRACTTreatment of accidental radiation-induced myelosuppression is primarily based on supportive care and requires specific treatment based on hematopoietic growth factors injection or hematopoietic cell transplantation for the most severe cases. The cytokines used consisted of pegylated erythropoietin (darbepoetin alfa) 500 IU once per week, pegylated G-CSF (pegfilgrastim) 6 mg × 2 once, stem cell factor 20 μg.kg-1 for five days, and romiplostim (TPO analog) 10 μg.kg-1 once per week, with different combinations depending on the acc...
Source: Radiation Research - September 23, 2021 Category: Physics Authors: Marc Benderitter Eduardo Herrera-Reyes Yvan Gigov Bertrand Souleau Jean Christelle Huet Fran çois Trompier Thierry Fagot Eric Gr égoire Jean Val ère Malfuson Johanna Konopacki-Potet Elena Buglova Jean-Jacques Lataillade Radia Tamarat Patrick Gourmelon Source Type: research

Hematopoietic Recovery using Multi-Cytokine Therapy in 8 Patients Presenting Radiation-Induced Myelosuppression after Radiological Accidents
Radiat Res. 2021 Sep 23. doi: 10.1667/RADE-21-00169.1. Online ahead of print.ABSTRACTTreatment of accidental radiation-induced myelosuppression is primarily based on supportive care and requires specific treatment based on hematopoietic growth factors injection or hematopoietic cell transplantation for the most severe cases. The cytokines used consisted of pegylated erythropoietin (darbepoetin alfa) 500 IU once per week, pegylated G-CSF (pegfilgrastim) 6 mg × 2 once, stem cell factor 20 μg.kg-1 for five days, and romiplostim (TPO analog) 10 μg.kg-1 once per week, with different combinations depending on the acc...
Source: Radiation Research - September 23, 2021 Category: Physics Authors: Marc Benderitter Eduardo Herrera-Reyes Yvan Gigov Bertrand Souleau Jean Christelle Huet Fran çois Trompier Thierry Fagot Eric Gr égoire Jean Val ère Malfuson Johanna Konopacki-Potet Elena Buglova Jean-Jacques Lataillade Radia Tamarat Patrick Gourmelon Source Type: research

Observation of Unique Circulating miRNA Signatures in Non-Human Primates Exposed to Total-Body vs. Whole Thorax Lung Irradiation
Radiat Res. 2021 Sep 15. doi: 10.1667/RADE-21-00043.1. Online ahead of print.ABSTRACTA radiological/nuclear (RAD-NUC) incident, especially in an urban setting, results in diverse radiation-induced injuries due to heterogeneities in dose, the extent of partial-body shielding, human biodiversity and pre-existing health conditions. For example, acute radiation syndrome (ARS) can result in death within days to weeks of exposure to 0.7-10 Gy doses and is associated with destruction of the bone marrow, known as hematopoietic ARS (H-ARS). However, partial-body shielding that spares a portion of the bone marrow from exposure can s...
Source: Radiation Research - September 15, 2021 Category: Physics Authors: Claude J Rogers Espoir M Kyubwa Agnes I Lukaszewicz Mark A Starbird Michelle Nguyen Ben T Copeland Jason Yamada-Hanff Naresh Menon Source Type: research

Observation of Unique Circulating miRNA Signatures in Non-Human Primates Exposed to Total-Body vs. Whole Thorax Lung Irradiation
Radiat Res. 2021 Sep 15. doi: 10.1667/RADE-21-00043.1. Online ahead of print.ABSTRACTA radiological/nuclear (RAD-NUC) incident, especially in an urban setting, results in diverse radiation-induced injuries due to heterogeneities in dose, the extent of partial-body shielding, human biodiversity and pre-existing health conditions. For example, acute radiation syndrome (ARS) can result in death within days to weeks of exposure to 0.7-10 Gy doses and is associated with destruction of the bone marrow, known as hematopoietic ARS (H-ARS). However, partial-body shielding that spares a portion of the bone marrow from exposure can s...
Source: Radiation Research - September 15, 2021 Category: Physics Authors: Claude J Rogers Espoir M Kyubwa Agnes I Lukaszewicz Mark A Starbird Michelle Nguyen Ben T Copeland Jason Yamada-Hanff Naresh Menon Source Type: research

Observation of Unique Circulating miRNA Signatures in Non-Human Primates Exposed to Total-Body vs. Whole Thorax Lung Irradiation
Radiat Res. 2021 Sep 15. doi: 10.1667/RADE-21-00043.1. Online ahead of print.ABSTRACTA radiological/nuclear (RAD-NUC) incident, especially in an urban setting, results in diverse radiation-induced injuries due to heterogeneities in dose, the extent of partial-body shielding, human biodiversity and pre-existing health conditions. For example, acute radiation syndrome (ARS) can result in death within days to weeks of exposure to 0.7-10 Gy doses and is associated with destruction of the bone marrow, known as hematopoietic ARS (H-ARS). However, partial-body shielding that spares a portion of the bone marrow from exposure can s...
Source: Radiation Research - September 15, 2021 Category: Physics Authors: Claude J Rogers Espoir M Kyubwa Agnes I Lukaszewicz Mark A Starbird Michelle Nguyen Ben T Copeland Jason Yamada-Hanff Naresh Menon Source Type: research

Observation of Unique Circulating miRNA Signatures in Non-Human Primates Exposed to Total-Body vs. Whole Thorax Lung Irradiation
Radiat Res. 2021 Sep 15. doi: 10.1667/RADE-21-00043.1. Online ahead of print.ABSTRACTA radiological/nuclear (RAD-NUC) incident, especially in an urban setting, results in diverse radiation-induced injuries due to heterogeneities in dose, the extent of partial-body shielding, human biodiversity and pre-existing health conditions. For example, acute radiation syndrome (ARS) can result in death within days to weeks of exposure to 0.7-10 Gy doses and is associated with destruction of the bone marrow, known as hematopoietic ARS (H-ARS). However, partial-body shielding that spares a portion of the bone marrow from exposure can s...
Source: Radiation Research - September 15, 2021 Category: Physics Authors: Claude J Rogers Espoir M Kyubwa Agnes I Lukaszewicz Mark A Starbird Michelle Nguyen Ben T Copeland Jason Yamada-Hanff Naresh Menon Source Type: research

Observation of Unique Circulating miRNA Signatures in Non-Human Primates Exposed to Total-Body vs. Whole Thorax Lung Irradiation
Radiat Res. 2021 Sep 15. doi: 10.1667/RADE-21-00043.1. Online ahead of print.ABSTRACTA radiological/nuclear (RAD-NUC) incident, especially in an urban setting, results in diverse radiation-induced injuries due to heterogeneities in dose, the extent of partial-body shielding, human biodiversity and pre-existing health conditions. For example, acute radiation syndrome (ARS) can result in death within days to weeks of exposure to 0.7-10 Gy doses and is associated with destruction of the bone marrow, known as hematopoietic ARS (H-ARS). However, partial-body shielding that spares a portion of the bone marrow from exposure can s...
Source: Radiation Research - September 15, 2021 Category: Physics Authors: Claude J Rogers Espoir M Kyubwa Agnes I Lukaszewicz Mark A Starbird Michelle Nguyen Ben T Copeland Jason Yamada-Hanff Naresh Menon Source Type: research

Observation of Unique Circulating miRNA Signatures in Non-Human Primates Exposed to Total-Body vs. Whole Thorax Lung Irradiation
Radiat Res. 2021 Sep 15. doi: 10.1667/RADE-21-00043.1. Online ahead of print.ABSTRACTA radiological/nuclear (RAD-NUC) incident, especially in an urban setting, results in diverse radiation-induced injuries due to heterogeneities in dose, the extent of partial-body shielding, human biodiversity and pre-existing health conditions. For example, acute radiation syndrome (ARS) can result in death within days to weeks of exposure to 0.7-10 Gy doses and is associated with destruction of the bone marrow, known as hematopoietic ARS (H-ARS). However, partial-body shielding that spares a portion of the bone marrow from exposure can s...
Source: Radiation Research - September 15, 2021 Category: Physics Authors: Claude J Rogers Espoir M Kyubwa Agnes I Lukaszewicz Mark A Starbird Michelle Nguyen Ben T Copeland Jason Yamada-Hanff Naresh Menon Source Type: research

CytoRADx: A High-Throughput, Standardized Biodosimetry Diagnostic System Based on the Cytokinesis-Block Micronucleus Assay
Radiat Res. 2021 Sep 13. doi: 10.1667/RADE-20-00030.1. Online ahead of print.ABSTRACTIn a large-scale catastrophe, such as a nuclear detonation in a major city, it will be crucial to accurately diagnose large numbers of people to direct scarce medical resources to those in greatest need. Currently no FDA-cleared tests are available to diagnose radiation exposures, which can lead to complex, life-threatening injuries. To address this gap, we have achieved substantial advancements in radiation biodosimetry through refinement and adaptation of the cytokinesis-block micronucleus (CBMN) assay as a high throughput, quantitative ...
Source: Radiation Research - September 13, 2021 Category: Physics Authors: Chris Capaccio Jay R Perrier L ídia Cunha Ryan C Mahnke Thomas L örch Michael Porter Chris L Smith Ken Damer J Daniel Bourland Bart Frizzell Jennifer Torelli Marie Vasquez Jeremy B Brower Melanie Doyle-Eisele Maria Taveras Helen Turner David J Brenner R Source Type: research

CytoRADx: A High-Throughput, Standardized Biodosimetry Diagnostic System Based on the Cytokinesis-Block Micronucleus Assay
Radiat Res. 2021 Sep 13. doi: 10.1667/RADE-20-00030.1. Online ahead of print.ABSTRACTIn a large-scale catastrophe, such as a nuclear detonation in a major city, it will be crucial to accurately diagnose large numbers of people to direct scarce medical resources to those in greatest need. Currently no FDA-cleared tests are available to diagnose radiation exposures, which can lead to complex, life-threatening injuries. To address this gap, we have achieved substantial advancements in radiation biodosimetry through refinement and adaptation of the cytokinesis-block micronucleus (CBMN) assay as a high throughput, quantitative ...
Source: Radiation Research - September 13, 2021 Category: Physics Authors: Chris Capaccio Jay R Perrier L ídia Cunha Ryan C Mahnke Thomas L örch Michael Porter Chris L Smith Ken Damer J Daniel Bourland Bart Frizzell Jennifer Torelli Marie Vasquez Jeremy B Brower Melanie Doyle-Eisele Maria Taveras Helen Turner David J Brenner R Source Type: research

CytoRADx: A High-Throughput, Standardized Biodosimetry Diagnostic System Based on the Cytokinesis-Block Micronucleus Assay
Radiat Res. 2021 Sep 13. doi: 10.1667/RADE-20-00030.1. Online ahead of print.ABSTRACTIn a large-scale catastrophe, such as a nuclear detonation in a major city, it will be crucial to accurately diagnose large numbers of people to direct scarce medical resources to those in greatest need. Currently no FDA-cleared tests are available to diagnose radiation exposures, which can lead to complex, life-threatening injuries. To address this gap, we have achieved substantial advancements in radiation biodosimetry through refinement and adaptation of the cytokinesis-block micronucleus (CBMN) assay as a high throughput, quantitative ...
Source: Radiation Research - September 13, 2021 Category: Physics Authors: Chris Capaccio Jay R Perrier L ídia Cunha Ryan C Mahnke Thomas L örch Michael Porter Chris L Smith Ken Damer J Daniel Bourland Bart Frizzell Jennifer Torelli Marie Vasquez Jeremy B Brower Melanie Doyle-Eisele Maria Taveras Helen Turner David J Brenner R Source Type: research

Stem Cell Migration: A Possible Mechanism for the Tissue-Sparing Effect of Spatially Fractionated Radiation
Radiat Res. 2021 Sep 8. doi: 10.1667/RADE-21-00134.1. Online ahead of print.ABSTRACTStem cell responses in tissues after exposure to radiation are of significance for maintaining tissue functions. From the point of view of stem cell characteristics, this article seeks to illustrate some contributions of microbeam research to spatially fractionated radiotherapy (SFRT), such as grid radiotherapy and microbeam radiotherapy. Although the tissue-sparing response after SFRT was first reported more than a century ago, current radiation dose-volume metrics are still unable to accurately predict such tissue-level changes in respons...
Source: Radiation Research - September 8, 2021 Category: Physics Authors: Hisanori Fukunaga Source Type: research

Stem Cell Migration: A Possible Mechanism for the Tissue-Sparing Effect of Spatially Fractionated Radiation
Radiat Res. 2021 Sep 8. doi: 10.1667/RADE-21-00134.1. Online ahead of print.ABSTRACTStem cell responses in tissues after exposure to radiation are of significance for maintaining tissue functions. From the point of view of stem cell characteristics, this article seeks to illustrate some contributions of microbeam research to spatially fractionated radiotherapy (SFRT), such as grid radiotherapy and microbeam radiotherapy. Although the tissue-sparing response after SFRT was first reported more than a century ago, current radiation dose-volume metrics are still unable to accurately predict such tissue-level changes in respons...
Source: Radiation Research - September 8, 2021 Category: Physics Authors: Hisanori Fukunaga Source Type: research

Stem Cell Migration: A Possible Mechanism for the Tissue-Sparing Effect of Spatially Fractionated Radiation
Radiat Res. 2021 Sep 8. doi: 10.1667/RADE-21-00134.1. Online ahead of print.ABSTRACTStem cell responses in tissues after exposure to radiation are of significance for maintaining tissue functions. From the point of view of stem cell characteristics, this article seeks to illustrate some contributions of microbeam research to spatially fractionated radiotherapy (SFRT), such as grid radiotherapy and microbeam radiotherapy. Although the tissue-sparing response after SFRT was first reported more than a century ago, current radiation dose-volume metrics are still unable to accurately predict such tissue-level changes in respons...
Source: Radiation Research - September 8, 2021 Category: Physics Authors: Hisanori Fukunaga Source Type: research

Stem Cell Migration: A Possible Mechanism for the Tissue-Sparing Effect of Spatially Fractionated Radiation
Radiat Res. 2021 Sep 8. doi: 10.1667/RADE-21-00134.1. Online ahead of print.ABSTRACTStem cell responses in tissues after exposure to radiation are of significance for maintaining tissue functions. From the point of view of stem cell characteristics, this article seeks to illustrate some contributions of microbeam research to spatially fractionated radiotherapy (SFRT), such as grid radiotherapy and microbeam radiotherapy. Although the tissue-sparing response after SFRT was first reported more than a century ago, current radiation dose-volume metrics are still unable to accurately predict such tissue-level changes in respons...
Source: Radiation Research - September 8, 2021 Category: Physics Authors: Hisanori Fukunaga Source Type: research

The LD50 for Low-Energy Ultrashort-Pulsed Laser Driven Electron Beam Whole-Body Irradiation of Wistar Rats
Radiat Res. 2021 Sep 3. doi: 10.1667/RADE-20-00198.1. Online ahead of print.ABSTRACTRecently, a new technology of low-energy ultrashort-pulsed electron beam (UPEB) accelerators has been developed opening new directions for radiobiology and biomedical research. The purpose of this study was to reveal the lethal dose, LD50 (lethal dose, 50%) delivered by low-energy UPEB whole-body exposure on an organismal level. Wistar rats were exposed to low-energy UPEB whole-body irradiation with different doses and pulse repetition rates to find the LD50 and in silico computer simulations were performed to conduct numerical dose calcula...
Source: Radiation Research - September 3, 2021 Category: Physics Authors: Gohar Tsakanova Elina Arakelova Violetta Ayvazyan Zaven Karalyan Lusine Matevosyan Arsen Arakelyan Zohrab Amirkhanyan Hakob Davtyan Vitali Khachatryan Bagrat Grigoryan Source Type: research

The LD50 for Low-Energy Ultrashort-Pulsed Laser Driven Electron Beam Whole-Body Irradiation of Wistar Rats
Radiat Res. 2021 Sep 3. doi: 10.1667/RADE-20-00198.1. Online ahead of print.ABSTRACTRecently, a new technology of low-energy ultrashort-pulsed electron beam (UPEB) accelerators has been developed opening new directions for radiobiology and biomedical research. The purpose of this study was to reveal the lethal dose, LD50 (lethal dose, 50%) delivered by low-energy UPEB whole-body exposure on an organismal level. Wistar rats were exposed to low-energy UPEB whole-body irradiation with different doses and pulse repetition rates to find the LD50 and in silico computer simulations were performed to conduct numerical dose calcula...
Source: Radiation Research - September 3, 2021 Category: Physics Authors: Gohar Tsakanova Elina Arakelova Violetta Ayvazyan Zaven Karalyan Lusine Matevosyan Arsen Arakelyan Zohrab Amirkhanyan Hakob Davtyan Vitali Khachatryan Bagrat Grigoryan Source Type: research

Response of Canine Soft Tissue Sarcoma to Stereotactic Body Radiotherapy
Radiat Res. 2021 Sep 2. doi: 10.1667/RADE-20-00271.1. Online ahead of print.ABSTRACTCanine soft tissue sarcoma (STS) has served as a preclinical model for radiation, hyperthermia, experimental therapeutics, and tumor microenvironmental research for decades. Stereotactic body radiotherapy (SBRT) demonstrates promising results for the control of various tumors in human and veterinary medicine; however, there is limited clinical data for the management of STS with SBRT. In this retrospective study, we aimed to define overall efficacy and toxicity of SBRT for the treatment of macroscopic canine STS to establish this preclinica...
Source: Radiation Research - September 2, 2021 Category: Physics Authors: Rebecca Tierce Tiffany Martin Kelly L Hughes Lauren Harrison Katy L Swancutt Sangeeta Rao Del Leary Susan M LaRue Mary-Keara Boss Source Type: research

Protective Effect of Sirt1 against Radiation-Induced Damage
Radiat Res. 2021 Aug 30. doi: 10.1667/RADE-20-00139.1. Online ahead of print.ABSTRACTRadiotherapy is an important method for the treatment of malignant tumors. It can directly or indirectly lead to the formation of free radicals and DNA damage, resulting in a series of biological effects, including tumor cell death and normal tissue damage. These radiation effects are typically accompanied by the abnormal expression of sirtuin 1 (Sirt1), which deacetylates histones and non-histones. These Sirt1 substrates, including transcription factors and some catalytic enzymes, play a crucial role in anti-oxidative stress, DNA damage r...
Source: Radiation Research - August 30, 2021 Category: Physics Authors: Haoren Qin Heng Zhang Shiwu Zhang Siwei Zhu Hui Wang Source Type: research

Protective Effect of Sirt1 against Radiation-Induced Damage
Radiat Res. 2021 Aug 30. doi: 10.1667/RADE-20-00139.1. Online ahead of print.ABSTRACTRadiotherapy is an important method for the treatment of malignant tumors. It can directly or indirectly lead to the formation of free radicals and DNA damage, resulting in a series of biological effects, including tumor cell death and normal tissue damage. These radiation effects are typically accompanied by the abnormal expression of sirtuin 1 (Sirt1), which deacetylates histones and non-histones. These Sirt1 substrates, including transcription factors and some catalytic enzymes, play a crucial role in anti-oxidative stress, DNA damage r...
Source: Radiation Research - August 30, 2021 Category: Physics Authors: Haoren Qin Heng Zhang Shiwu Zhang Siwei Zhu Hui Wang Source Type: research

Alpha-Particle Exposure Induces Mainly Unstable Complex Chromosome Aberrations which do not Contribute to Radiation-Associated Cytogenetic Risk
Radiat Res. 2021 Aug 19. doi: 10.1667/RADE-21-00116.1. Online ahead of print.ABSTRACTThe mechanism underlying the carcinogenic potential of α radiation is not fully understood, considering that cell inactivation (e.g., mitotic cell death) as a main consequence of exposure efficiently counteracts the spreading of heritable DNA damage. The aim of this study is to improve our understanding of the effectiveness of α particles in inducing different types of chromosomal aberrations, to determine the respective values of the relative biological effectiveness (RBE) and to interpret the results with respect to exposure ...
Source: Radiation Research - August 19, 2021 Category: Physics Authors: C Hartel E Nasonova S Ritter T Friedrich Source Type: research

Alpha-Particle Exposure Induces Mainly Unstable Complex Chromosome Aberrations which do not Contribute to Radiation-Associated Cytogenetic Risk
Radiat Res. 2021 Aug 19. doi: 10.1667/RADE-21-00116.1. Online ahead of print.ABSTRACTThe mechanism underlying the carcinogenic potential of α radiation is not fully understood, considering that cell inactivation (e.g., mitotic cell death) as a main consequence of exposure efficiently counteracts the spreading of heritable DNA damage. The aim of this study is to improve our understanding of the effectiveness of α particles in inducing different types of chromosomal aberrations, to determine the respective values of the relative biological effectiveness (RBE) and to interpret the results with respect to exposure ...
Source: Radiation Research - August 19, 2021 Category: Physics Authors: C Hartel E Nasonova S Ritter T Friedrich Source Type: research

Alpha-Particle Exposure Induces Mainly Unstable Complex Chromosome Aberrations which do not Contribute to Radiation-Associated Cytogenetic Risk
Radiat Res. 2021 Aug 19. doi: 10.1667/RADE-21-00116.1. Online ahead of print.ABSTRACTThe mechanism underlying the carcinogenic potential of α radiation is not fully understood, considering that cell inactivation (e.g., mitotic cell death) as a main consequence of exposure efficiently counteracts the spreading of heritable DNA damage. The aim of this study is to improve our understanding of the effectiveness of α particles in inducing different types of chromosomal aberrations, to determine the respective values of the relative biological effectiveness (RBE) and to interpret the results with respect to exposure ...
Source: Radiation Research - August 19, 2021 Category: Physics Authors: C Hartel E Nasonova S Ritter T Friedrich Source Type: research

Alpha-Particle Exposure Induces Mainly Unstable Complex Chromosome Aberrations which do not Contribute to Radiation-Associated Cytogenetic Risk
Radiat Res. 2021 Aug 19. doi: 10.1667/RADE-21-00116.1. Online ahead of print.ABSTRACTThe mechanism underlying the carcinogenic potential of α radiation is not fully understood, considering that cell inactivation (e.g., mitotic cell death) as a main consequence of exposure efficiently counteracts the spreading of heritable DNA damage. The aim of this study is to improve our understanding of the effectiveness of α particles in inducing different types of chromosomal aberrations, to determine the respective values of the relative biological effectiveness (RBE) and to interpret the results with respect to exposure ...
Source: Radiation Research - August 19, 2021 Category: Physics Authors: C Hartel E Nasonova S Ritter T Friedrich Source Type: research

Alpha-Particle Exposure Induces Mainly Unstable Complex Chromosome Aberrations which do not Contribute to Radiation-Associated Cytogenetic Risk
Radiat Res. 2021 Aug 19. doi: 10.1667/RADE-21-00116.1. Online ahead of print.ABSTRACTThe mechanism underlying the carcinogenic potential of α radiation is not fully understood, considering that cell inactivation (e.g., mitotic cell death) as a main consequence of exposure efficiently counteracts the spreading of heritable DNA damage. The aim of this study is to improve our understanding of the effectiveness of α particles in inducing different types of chromosomal aberrations, to determine the respective values of the relative biological effectiveness (RBE) and to interpret the results with respect to exposure ...
Source: Radiation Research - August 19, 2021 Category: Physics Authors: C Hartel E Nasonova S Ritter T Friedrich Source Type: research

Alpha-Particle Exposure Induces Mainly Unstable Complex Chromosome Aberrations which do not Contribute to Radiation-Associated Cytogenetic Risk
Radiat Res. 2021 Aug 19. doi: 10.1667/RADE-21-00116.1. Online ahead of print.ABSTRACTThe mechanism underlying the carcinogenic potential of α radiation is not fully understood, considering that cell inactivation (e.g., mitotic cell death) as a main consequence of exposure efficiently counteracts the spreading of heritable DNA damage. The aim of this study is to improve our understanding of the effectiveness of α particles in inducing different types of chromosomal aberrations, to determine the respective values of the relative biological effectiveness (RBE) and to interpret the results with respect to exposure ...
Source: Radiation Research - August 19, 2021 Category: Physics Authors: C Hartel E Nasonova S Ritter T Friedrich Source Type: research

Alpha-Particle Exposure Induces Mainly Unstable Complex Chromosome Aberrations which do not Contribute to Radiation-Associated Cytogenetic Risk
Radiat Res. 2021 Aug 19. doi: 10.1667/RADE-21-00116.1. Online ahead of print.ABSTRACTThe mechanism underlying the carcinogenic potential of α radiation is not fully understood, considering that cell inactivation (e.g., mitotic cell death) as a main consequence of exposure efficiently counteracts the spreading of heritable DNA damage. The aim of this study is to improve our understanding of the effectiveness of α particles in inducing different types of chromosomal aberrations, to determine the respective values of the relative biological effectiveness (RBE) and to interpret the results with respect to exposure ...
Source: Radiation Research - August 19, 2021 Category: Physics Authors: C Hartel E Nasonova S Ritter T Friedrich Source Type: research

Effects of Microwave 10 GHz Radiation Exposure in the Skin of Rats: An Insight on Molecular Responses
Radiat Res. 2021 Aug 18. doi: 10.1667/RADE-20-00155.1. Online ahead of print.ABSTRACTMicrowave (MW) radiation poses the risk of potential hazards on human health. The present study investigated the effects of MW 10 GHz exposure for 3 h/day for 30 days at power densities of 5.23 ± 0.25 and 10.01 ± 0.15 mW/cm2 in the skin of rats. The animals exposed to 10 mW/cm2 (corresponded to twice the ICNIRP-2020 occupational reference level of MW exposure for humans) exhibited significant biophysical, biochemical, molecular and histological alterations compared to sham-irradiated animals. Infrared thermography revealed an...
Source: Radiation Research - August 18, 2021 Category: Physics Authors: Saurabh Verma Gaurav K Keshri Santanu Karmakar Kumar Vyonkesh Mani Satish Chauhan Anju Yadav Manish Sharma Asheesh Gupta Source Type: research

Effects of Microwave 10 GHz Radiation Exposure in the Skin of Rats: An Insight on Molecular Responses
Radiat Res. 2021 Aug 18. doi: 10.1667/RADE-20-00155.1. Online ahead of print.ABSTRACTMicrowave (MW) radiation poses the risk of potential hazards on human health. The present study investigated the effects of MW 10 GHz exposure for 3 h/day for 30 days at power densities of 5.23 ± 0.25 and 10.01 ± 0.15 mW/cm2 in the skin of rats. The animals exposed to 10 mW/cm2 (corresponded to twice the ICNIRP-2020 occupational reference level of MW exposure for humans) exhibited significant biophysical, biochemical, molecular and histological alterations compared to sham-irradiated animals. Infrared thermography revealed an...
Source: Radiation Research - August 18, 2021 Category: Physics Authors: Saurabh Verma Gaurav K Keshri Santanu Karmakar Kumar Vyonkesh Mani Satish Chauhan Anju Yadav Manish Sharma Asheesh Gupta Source Type: research

Dual Roles of Nicotinamide Phosphoribosyltransferase as a Promising Target for Cancer Radiotherapy
Radiat Res. 2021 Aug 16. doi: 10.1667/RADE-20-00273.1. Online ahead of print.ABSTRACTNicotinamide phosphoribosyltransferase (NAMPT) is the key rate-limiting enzyme in the regulation of nicotinamide adenine dinucleotide (NAD) biosynthesis, and its activity is critical for the replenishment of NAD level as well as cell survival or death. As one of the most important components in the electron transport chain of complex I in mitochondrion, sustained supply of NAD is essential to the maintenance of energy metabolism both in normal and cancer cells. Recent research shown that X-ray radiation sharply downregulated the expression...
Source: Radiation Research - August 16, 2021 Category: Physics Authors: Bin Xiang Xin Yue Wang Ke Jian Liu Source Type: research

Letters to the Editor
Radiat Res. 2021 Aug 16. doi: 10.1667/RADE-21-00106.1. Online ahead of print.NO ABSTRACTPMID:34399424 | DOI:10.1667/RADE-21-00106.1 (Source: Radiation Research)
Source: Radiation Research - August 16, 2021 Category: Physics Authors: Steven L Simon F Owen Hoffman Eduard Hofer Daniel O Stram Dale L Preston Source Type: research

The Threshold Effects of Low-Dose-Rate Radiation on miRNA-Mediated Neurodevelopment of Zebrafish
In conclusion, the effect of low-dose and low-dose-rate radiation on neurodevelopment follows the threshold model, under the regulation of miRNAs, excitatory effects occurred at a dose rate of 0.1 mGy/h and toxic effects occurred at a dose rate of 0.2 mGy/h and 0.4 mGy/h.PMID:34399425 | DOI:10.1667/RADE-20-00265.1 (Source: Radiation Research)
Source: Radiation Research - August 16, 2021 Category: Physics Authors: Chu-Qi He Liang Mao Jin Yao Wei-Chao Zhao Bo Huang Nan Hu Ding-Xin Long Source Type: research

Dual Roles of Nicotinamide Phosphoribosyltransferase as a Promising Target for Cancer Radiotherapy
Radiat Res. 2021 Aug 16. doi: 10.1667/RADE-20-00273.1. Online ahead of print.ABSTRACTNicotinamide phosphoribosyltransferase (NAMPT) is the key rate-limiting enzyme in the regulation of nicotinamide adenine dinucleotide (NAD) biosynthesis, and its activity is critical for the replenishment of NAD level as well as cell survival or death. As one of the most important components in the electron transport chain of complex I in mitochondrion, sustained supply of NAD is essential to the maintenance of energy metabolism both in normal and cancer cells. Recent research shown that X-ray radiation sharply downregulated the expression...
Source: Radiation Research - August 16, 2021 Category: Physics Authors: Bin Xiang Xin Yue Wang Ke Jian Liu Source Type: research

Letters to the Editor
Radiat Res. 2021 Aug 16. doi: 10.1667/RADE-21-00106.1. Online ahead of print.NO ABSTRACTPMID:34399424 | DOI:10.1667/RADE-21-00106.1 (Source: Radiation Research)
Source: Radiation Research - August 16, 2021 Category: Physics Authors: Steven L Simon F Owen Hoffman Eduard Hofer Daniel O Stram Dale L Preston Source Type: research

The Threshold Effects of Low-Dose-Rate Radiation on miRNA-Mediated Neurodevelopment of Zebrafish
In conclusion, the effect of low-dose and low-dose-rate radiation on neurodevelopment follows the threshold model, under the regulation of miRNAs, excitatory effects occurred at a dose rate of 0.1 mGy/h and toxic effects occurred at a dose rate of 0.2 mGy/h and 0.4 mGy/h.PMID:34399425 | DOI:10.1667/RADE-20-00265.1 (Source: Radiation Research)
Source: Radiation Research - August 16, 2021 Category: Physics Authors: Chu-Qi He Liang Mao Jin Yao Wei-Chao Zhao Bo Huang Nan Hu Ding-Xin Long Source Type: research

Tomotherapy Applied Total Lymphoid Irradiation and Allogeneic Hematopoietic Cell Transplantation Generates Mixed Chimerism in the Rhesus Macaque Model
Radiat Res. 2021 Aug 13. doi: 10.1667/RADE-20-00246.1. Online ahead of print.ABSTRACTDevelopment of a new methodology to induce immunological chimerism after allogeneic hematopoietic cell (HC) transplantation in a rhesus macaque model is described. The chimeric state was achieved using a non-myeloablative, helical tomotherapy-based total lymphoid irradiation (TomoTLI) conditioning regimen followed by donor HC infusions between 1-haplotype matched donor/recipient pairs. The technique was tested as a feasibility study in an experimental group of seven rhesus macaques that received the novel TomoTLI tolerance protocol and HC ...
Source: Radiation Research - August 13, 2021 Category: Physics Authors: Lisa Forrest John Fechner Jennifer Post Nathaniel Van Asselt Kevin Kvasnica Lynn D Haynes Jenny Coonen Kevin Brunner W John Haynes Christopher Little William J Burlingham Peiman Hematti Samuel Strober Dixon B Kaufman Source Type: research

Local Irradiation of Mouse Tooth Germ Gives Insight into the Direct Effects of Irradiation on Root Development
Radiat Res. 2021 Aug 13. doi: 10.1667/RADE-20-00081.1. Online ahead of print.ABSTRACTTo elucidate the mechanism underlying the failure of root formation after irradiation, we established a method of local irradiation of the molar tooth germ and demonstrated that radiation directly affected dental root development. In the current study, to locally irradiate the lower first molars of 5-day-old C57BL/6J mice, we used lead glass containing a hole as a collimator. We confirmed that our local irradiation method targeted only the tooth germ. The irradiated root was immature in terms of apical growth, and dentin formation was irre...
Source: Radiation Research - August 13, 2021 Category: Physics Authors: Yoshiaki Ide Taka Nakahara Tetsuya Fukada Masanori Nasu Source Type: research

Tomotherapy Applied Total Lymphoid Irradiation and Allogeneic Hematopoietic Cell Transplantation Generates Mixed Chimerism in the Rhesus Macaque Model
Radiat Res. 2021 Aug 13. doi: 10.1667/RADE-20-00246.1. Online ahead of print.ABSTRACTDevelopment of a new methodology to induce immunological chimerism after allogeneic hematopoietic cell (HC) transplantation in a rhesus macaque model is described. The chimeric state was achieved using a non-myeloablative, helical tomotherapy-based total lymphoid irradiation (TomoTLI) conditioning regimen followed by donor HC infusions between 1-haplotype matched donor/recipient pairs. The technique was tested as a feasibility study in an experimental group of seven rhesus macaques that received the novel TomoTLI tolerance protocol and HC ...
Source: Radiation Research - August 13, 2021 Category: Physics Authors: Lisa Forrest John Fechner Jennifer Post Nathaniel Van Asselt Kevin Kvasnica Lynn D Haynes Jenny Coonen Kevin Brunner W John Haynes Christopher Little William J Burlingham Peiman Hematti Samuel Strober Dixon B Kaufman Source Type: research

Local Irradiation of Mouse Tooth Germ Gives Insight into the Direct Effects of Irradiation on Root Development
Radiat Res. 2021 Aug 13. doi: 10.1667/RADE-20-00081.1. Online ahead of print.ABSTRACTTo elucidate the mechanism underlying the failure of root formation after irradiation, we established a method of local irradiation of the molar tooth germ and demonstrated that radiation directly affected dental root development. In the current study, to locally irradiate the lower first molars of 5-day-old C57BL/6J mice, we used lead glass containing a hole as a collimator. We confirmed that our local irradiation method targeted only the tooth germ. The irradiated root was immature in terms of apical growth, and dentin formation was irre...
Source: Radiation Research - August 13, 2021 Category: Physics Authors: Yoshiaki Ide Taka Nakahara Tetsuya Fukada Masanori Nasu Source Type: research

Tomotherapy Applied Total Lymphoid Irradiation and Allogeneic Hematopoietic Cell Transplantation Generates Mixed Chimerism in the Rhesus Macaque Model
Radiat Res. 2021 Aug 13. doi: 10.1667/RADE-20-00246.1. Online ahead of print.ABSTRACTDevelopment of a new methodology to induce immunological chimerism after allogeneic hematopoietic cell (HC) transplantation in a rhesus macaque model is described. The chimeric state was achieved using a non-myeloablative, helical tomotherapy-based total lymphoid irradiation (TomoTLI) conditioning regimen followed by donor HC infusions between 1-haplotype matched donor/recipient pairs. The technique was tested as a feasibility study in an experimental group of seven rhesus macaques that received the novel TomoTLI tolerance protocol and HC ...
Source: Radiation Research - August 13, 2021 Category: Physics Authors: Lisa Forrest John Fechner Jennifer Post Nathaniel Van Asselt Kevin Kvasnica Lynn D Haynes Jenny Coonen Kevin Brunner W John Haynes Christopher Little William J Burlingham Peiman Hematti Samuel Strober Dixon B Kaufman Source Type: research

Local Irradiation of Mouse Tooth Germ Gives Insight into the Direct Effects of Irradiation on Root Development
Radiat Res. 2021 Aug 13. doi: 10.1667/RADE-20-00081.1. Online ahead of print.ABSTRACTTo elucidate the mechanism underlying the failure of root formation after irradiation, we established a method of local irradiation of the molar tooth germ and demonstrated that radiation directly affected dental root development. In the current study, to locally irradiate the lower first molars of 5-day-old C57BL/6J mice, we used lead glass containing a hole as a collimator. We confirmed that our local irradiation method targeted only the tooth germ. The irradiated root was immature in terms of apical growth, and dentin formation was irre...
Source: Radiation Research - August 13, 2021 Category: Physics Authors: Yoshiaki Ide Taka Nakahara Tetsuya Fukada Masanori Nasu Source Type: research

Quantitative Bias Analysis of the Association between Occupational Radiation Exposure and Ischemic Heart Disease Mortality in UK Nuclear Workers
Radiat Res. 2021 Aug 9. doi: 10.1667/RADE-21-00078.1. Online ahead of print.ABSTRACTThe scientific question of whether protracted low-dose or low-dose-rate exposure to external radiation is causally related to the risk of circulatory disease continues to be an important issue for radiation protection. Previous analyses of a matched case-control dataset nested in a large cohort of UK nuclear fuel cycle workers indicated that there was little evidence that observed associations between external radiation dose and ischemic heart disease (IHD) mortality risk [OR = 1.35 (95% CI: 0.99-184) for 15-year-lagged exposure] could alte...
Source: Radiation Research - August 9, 2021 Category: Physics Authors: Frank de Vocht Richard M Martin Mira Hidajat Richard Wakeford Source Type: research

Quantitative Bias Analysis of the Association between Occupational Radiation Exposure and Ischemic Heart Disease Mortality in UK Nuclear Workers
Radiat Res. 2021 Aug 9. doi: 10.1667/RADE-21-00078.1. Online ahead of print.ABSTRACTThe scientific question of whether protracted low-dose or low-dose-rate exposure to external radiation is causally related to the risk of circulatory disease continues to be an important issue for radiation protection. Previous analyses of a matched case-control dataset nested in a large cohort of UK nuclear fuel cycle workers indicated that there was little evidence that observed associations between external radiation dose and ischemic heart disease (IHD) mortality risk [OR = 1.35 (95% CI: 0.99-184) for 15-year-lagged exposure] could alte...
Source: Radiation Research - August 9, 2021 Category: Physics Authors: Frank de Vocht Richard M Martin Mira Hidajat Richard Wakeford Source Type: research

Quantitative Bias Analysis of the Association between Occupational Radiation Exposure and Ischemic Heart Disease Mortality in UK Nuclear Workers
Radiat Res. 2021 Aug 9. doi: 10.1667/RADE-21-00078.1. Online ahead of print.ABSTRACTThe scientific question of whether protracted low-dose or low-dose-rate exposure to external radiation is causally related to the risk of circulatory disease continues to be an important issue for radiation protection. Previous analyses of a matched case-control dataset nested in a large cohort of UK nuclear fuel cycle workers indicated that there was little evidence that observed associations between external radiation dose and ischemic heart disease (IHD) mortality risk [OR = 1.35 (95% CI: 0.99-184) for 15-year-lagged exposure] could alte...
Source: Radiation Research - August 9, 2021 Category: Physics Authors: Frank de Vocht Richard M Martin Mira Hidajat Richard Wakeford Source Type: research

A Trans-Agency Workshop on the Pathophysiology of Radiation-Induced Lung Injury
Radiat Res. 2021 Aug 3. doi: 10.1667/RADE-21-00127.1. Online ahead of print.ABSTRACTResearch and development of medical countermeasures (MCMs) for radiation-induced lung injury relies on the availability of animal models with well-characterized pathophysiology, allowing effective bridging to humans. To develop useful animal models, it is important to understand the clinical condition, advantages and limitations of individual models, and how to properly apply these models to demonstrate MCM efficacy. On March 20, 2019, a meeting sponsored by the Radiation and Nuclear Countermeasures Program (RNCP) within the National Instit...
Source: Radiation Research - August 3, 2021 Category: Physics Authors: David R Cassatt Alex Gorovets Banu Karimi-Shah Rosemary Roberts Paul W Price Merriline M Satyamitra Nushin Todd Sue-Jane Wang Libero Marzella Source Type: research

A Trans-Agency Workshop on the Pathophysiology of Radiation-Induced Lung Injury
Radiat Res. 2021 Aug 3. doi: 10.1667/RADE-21-00127.1. Online ahead of print.ABSTRACTResearch and development of medical countermeasures (MCMs) for radiation-induced lung injury relies on the availability of animal models with well-characterized pathophysiology, allowing effective bridging to humans. To develop useful animal models, it is important to understand the clinical condition, advantages and limitations of individual models, and how to properly apply these models to demonstrate MCM efficacy. On March 20, 2019, a meeting sponsored by the Radiation and Nuclear Countermeasures Program (RNCP) within the National Instit...
Source: Radiation Research - August 3, 2021 Category: Physics Authors: David R Cassatt Alex Gorovets Banu Karimi-Shah Rosemary Roberts Paul W Price Merriline M Satyamitra Nushin Todd Sue-Jane Wang Libero Marzella Source Type: research

A Trans-Agency Workshop on the Pathophysiology of Radiation-Induced Lung Injury
Radiat Res. 2021 Aug 3. doi: 10.1667/RADE-21-00127.1. Online ahead of print.ABSTRACTResearch and development of medical countermeasures (MCMs) for radiation-induced lung injury relies on the availability of animal models with well-characterized pathophysiology, allowing effective bridging to humans. To develop useful animal models, it is important to understand the clinical condition, advantages and limitations of individual models, and how to properly apply these models to demonstrate MCM efficacy. On March 20, 2019, a meeting sponsored by the Radiation and Nuclear Countermeasures Program (RNCP) within the National Instit...
Source: Radiation Research - August 3, 2021 Category: Physics Authors: David R Cassatt Alex Gorovets Banu Karimi-Shah Rosemary Roberts Paul W Price Merriline M Satyamitra Nushin Todd Sue-Jane Wang Libero Marzella Source Type: research

A Trans-Agency Workshop on the Pathophysiology of Radiation-Induced Lung Injury
Radiat Res. 2021 Aug 3. doi: 10.1667/RADE-21-00127.1. Online ahead of print.ABSTRACTResearch and development of medical countermeasures (MCMs) for radiation-induced lung injury relies on the availability of animal models with well-characterized pathophysiology, allowing effective bridging to humans. To develop useful animal models, it is important to understand the clinical condition, advantages and limitations of individual models, and how to properly apply these models to demonstrate MCM efficacy. On March 20, 2019, a meeting sponsored by the Radiation and Nuclear Countermeasures Program (RNCP) within the National Instit...
Source: Radiation Research - August 3, 2021 Category: Physics Authors: David R Cassatt Alex Gorovets Banu Karimi-Shah Rosemary Roberts Paul W Price Merriline M Satyamitra Nushin Todd Sue-Jane Wang Libero Marzella Source Type: research

A Trans-Agency Workshop on the Pathophysiology of Radiation-Induced Lung Injury
Radiat Res. 2021 Aug 3. doi: 10.1667/RADE-21-00127.1. Online ahead of print.ABSTRACTResearch and development of medical countermeasures (MCMs) for radiation-induced lung injury relies on the availability of animal models with well-characterized pathophysiology, allowing effective bridging to humans. To develop useful animal models, it is important to understand the clinical condition, advantages and limitations of individual models, and how to properly apply these models to demonstrate MCM efficacy. On March 20, 2019, a meeting sponsored by the Radiation and Nuclear Countermeasures Program (RNCP) within the National Instit...
Source: Radiation Research - August 3, 2021 Category: Physics Authors: David R Cassatt Alex Gorovets Banu Karimi-Shah Rosemary Roberts Paul W Price Merriline M Satyamitra Nushin Todd Sue-Jane Wang Libero Marzella Source Type: research