Noninvasive Red Laser Intervention before Radiotherapy of Triple-negative Breast Cancer in a Murine Model
Radiat Res. 2023 Oct 1;200(4):366-373. doi: 10.1667/RADE-23-00050.1.ABSTRACTRadiotherapy is a well-established cancer treatment; it is estimated that approximately 52% of oncology patients will require this treatment modality at least once. However, some tumors, such as triple-negative breast cancer (TNBC), may present as radioresistant and thus require high doses of ionizing radiation and a prolonged period of treatment, which may result in more severe side effects. Moreover, such tumors show a high incidence of metastases and decreased survival expectancy of the patient. Thus, new strategies for radiosensitizing TNBC are...
Source: Radiation Research - September 29, 2023 Category: Physics Authors: Camila R Silva Saulo T Pereira Daniela F T Silva Lucas R De Pretto Anderson Z Freitas Carlos A Zeituni Maria E C M Rostelato Martha S Ribeiro Source Type: research
Noninvasive Red Laser Intervention before Radiotherapy of Triple-negative Breast Cancer in a Murine Model
Radiat Res. 2023 Oct 1;200(4):366-373. doi: 10.1667/RADE-23-00050.1.ABSTRACTRadiotherapy is a well-established cancer treatment; it is estimated that approximately 52% of oncology patients will require this treatment modality at least once. However, some tumors, such as triple-negative breast cancer (TNBC), may present as radioresistant and thus require high doses of ionizing radiation and a prolonged period of treatment, which may result in more severe side effects. Moreover, such tumors show a high incidence of metastases and decreased survival expectancy of the patient. Thus, new strategies for radiosensitizing TNBC are...
Source: Radiation Research - September 29, 2023 Category: Physics Authors: Camila R Silva Saulo T Pereira Daniela F T Silva Lucas R De Pretto Anderson Z Freitas Carlos A Zeituni Maria E C M Rostelato Martha S Ribeiro Source Type: research
Rapid Peroxide Removal Limits the Radiosensitization of Diffuse Intrinsic Pontine Glioma (DIPG) Cells by Pharmacologic Ascorbate
In this study we demonstrate that in contrast to adult glioma models, P-AscH- does not radiosensitize DIPG. DIPG cells were sensitive to bolus of H2O2 but have faster H2O2 removal rates than GBM models which are radiosensitized by P-AscH-. These data support the hypothesis that P-AscH- does not enhance DIPG radiosensitivity, likely due to a robust capacity to detoxify and remove hydroperoxides.PMID:37758035 | DOI:10.1667/RADE-23-00006.1 (Source: Radiation Research)
Source: Radiation Research - September 27, 2023 Category: Physics Authors: Shane R Solst Kranti A Mapuskar Claire H Graham Sarah A King Rana Rheem Kyle Current Bryan G Allen Joseph M Caster Douglas R Spitz Michelle E Howard Source Type: research
Effects of HZE-Particle Exposure Location and Energy on Brain Inflammation and Oxidative Stress in Rats
Radiat Res. 2023 Sep 27. doi: 10.1667/RADE-22-00041.1. Online ahead of print.ABSTRACTAstronauts on exploratory missions will be exposed to particle radiation of high energy and charge (HZE particles), which have been shown to produce neurochemical and performance deficits in animal models. Exposure to HZE particles can produce both targeted effects, resulting from direct ionization of atoms along the particle track, and non-targeted effects (NTEs) in cells that are distant from the track, extending the range of potential damage beyond the site of irradiation. While recent work suggests that NTEs are primarily responsible f...
Source: Radiation Research - September 27, 2023 Category: Physics Authors: Danielle S Cahoon Bernard M Rabin Derek R Fisher Barbara Shukitt-Hale Source Type: research
Hydrogen Peroxide Mediates Pharmacological Ascorbate Induced Radio-Sensitization of Pancreatic Cancer Cells by Enhancing G2-accumulation and Reducing Cyclin B1 Protein Levels
Radiat Res. 2023 Sep 27. doi: 10.1667/RADE-22-00182.1. Online ahead of print.ABSTRACTPharmacological ascorbate (P-AscH-, high dose, intravenous vitamin C) preferentially sensitizes human pancreas ductal adenocarcinoma (PDAC) cells to radiation-induced toxicity compared to non-tumorigenic epithelial cells. Radiation-induced G2-checkpoint activation contributes to the resistance of cancer cells to DNA damage induced toxicity. We hypothesized that P-AscH- induced radio-sensitization of PDAC cells is mediated by perturbations in the radiation induced activation of the G2-checkpoint pathway. Both non-tumorigenic pancreatic duct...
Source: Radiation Research - September 27, 2023 Category: Physics Authors: Brianne R O'Leary Amanda L Kalen Amanda N Pope Prabhat C Goswami Joseph J Cullen Source Type: research
A Data-Driven Variance Reduction Technique for Efficiently Modelling Astronaut Radiation Doses in Spacecraft in High-Energy Isotropic Radiation Fields
Radiat Res. 2023 Sep 27. doi: 10.1667/RADE-23-00027.1. Online ahead of print.ABSTRACTThe ionizing radiation exposure to crew on current and future space missions can significantly increase their health risks for cancers, degenerative diseases, and other acute and late effects. A common approach for estimating risk to crew is by completing stochastic (e.g., Monte Carlo) or deterministic particle transport simulations. Within the simulated environment, a small fraction of the particle histories tracked will interact with the astronaut or detector, particularly for larger spacecraft such as the International Space Station, Ti...
Source: Radiation Research - September 27, 2023 Category: Physics Authors: Liam D Moshovelis Gail N Iles Rick D Franich Source Type: research
Rapid Peroxide Removal Limits the Radiosensitization of Diffuse Intrinsic Pontine Glioma (DIPG) Cells by Pharmacologic Ascorbate
In this study we demonstrate that in contrast to adult glioma models, P-AscH- does not radiosensitize DIPG. DIPG cells were sensitive to bolus of H2O2 but have faster H2O2 removal rates than GBM models which are radiosensitized by P-AscH-. These data support the hypothesis that P-AscH- does not enhance DIPG radiosensitivity, likely due to a robust capacity to detoxify and remove hydroperoxides.PMID:37758035 | DOI:10.1667/RADE-23-00006.1 (Source: Radiation Research)
Source: Radiation Research - September 27, 2023 Category: Physics Authors: Shane R Solst Kranti A Mapuskar Claire H Graham Sarah A King Rana Rheem Kyle Current Bryan G Allen Joseph M Caster Douglas R Spitz Michelle E Howard Source Type: research
Effects of HZE-Particle Exposure Location and Energy on Brain Inflammation and Oxidative Stress in Rats
Radiat Res. 2023 Sep 27. doi: 10.1667/RADE-22-00041.1. Online ahead of print.ABSTRACTAstronauts on exploratory missions will be exposed to particle radiation of high energy and charge (HZE particles), which have been shown to produce neurochemical and performance deficits in animal models. Exposure to HZE particles can produce both targeted effects, resulting from direct ionization of atoms along the particle track, and non-targeted effects (NTEs) in cells that are distant from the track, extending the range of potential damage beyond the site of irradiation. While recent work suggests that NTEs are primarily responsible f...
Source: Radiation Research - September 27, 2023 Category: Physics Authors: Danielle S Cahoon Bernard M Rabin Derek R Fisher Barbara Shukitt-Hale Source Type: research
Hydrogen Peroxide Mediates Pharmacological Ascorbate Induced Radio-Sensitization of Pancreatic Cancer Cells by Enhancing G2-accumulation and Reducing Cyclin B1 Protein Levels
Radiat Res. 2023 Sep 27. doi: 10.1667/RADE-22-00182.1. Online ahead of print.ABSTRACTPharmacological ascorbate (P-AscH-, high dose, intravenous vitamin C) preferentially sensitizes human pancreas ductal adenocarcinoma (PDAC) cells to radiation-induced toxicity compared to non-tumorigenic epithelial cells. Radiation-induced G2-checkpoint activation contributes to the resistance of cancer cells to DNA damage induced toxicity. We hypothesized that P-AscH- induced radio-sensitization of PDAC cells is mediated by perturbations in the radiation induced activation of the G2-checkpoint pathway. Both non-tumorigenic pancreatic duct...
Source: Radiation Research - September 27, 2023 Category: Physics Authors: Brianne R O'Leary Amanda L Kalen Amanda N Pope Prabhat C Goswami Joseph J Cullen Source Type: research
A Data-Driven Variance Reduction Technique for Efficiently Modelling Astronaut Radiation Doses in Spacecraft in High-Energy Isotropic Radiation Fields
Radiat Res. 2023 Sep 27. doi: 10.1667/RADE-23-00027.1. Online ahead of print.ABSTRACTThe ionizing radiation exposure to crew on current and future space missions can significantly increase their health risks for cancers, degenerative diseases, and other acute and late effects. A common approach for estimating risk to crew is by completing stochastic (e.g., Monte Carlo) or deterministic particle transport simulations. Within the simulated environment, a small fraction of the particle histories tracked will interact with the astronaut or detector, particularly for larger spacecraft such as the International Space Station, Ti...
Source: Radiation Research - September 27, 2023 Category: Physics Authors: Liam D Moshovelis Gail N Iles Rick D Franich Source Type: research
Noninvasive Red Laser Intervention before Radiotherapy of Triple-negative Breast Cancer in a Murine Model
Radiat Res. 2023 Sep 13. doi: 10.1667/RADE-23-0005.1. Online ahead of print.ABSTRACTRadiotherapy is a well-established cancer treatment; it is estimated that approximately 52% of oncology patients will require this treatment modality at least once. However, some tumors, such as triple-negative breast cancer (TNBC), may present as radioresistant and thus require high doses of ionizing radiation and a prolonged period of treatment, which may result in more severe side effects. Moreover, such tumors show a high incidence of metastases and decreased survival expectancy of the patient. Thus, new strategies for radiosensitizing ...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: Camila R Silva Saulo T Pereira Daniela F T Silva Lucas R De Pretto Anderson Z Freitas Carlos A Zeituni Maria E C M Rostelato Martha S Ribeiro Source Type: research
Nicaraven Exerts a Limited Effect on Radiation-Induced Inhibition of Tumor Growth in a Subcutaneous Murine Tumor Model
Radiat Res. 2023 Sep 13. doi: 10.1667/RADE-22-00212.1. Online ahead of print.ABSTRACTNicaraven selectively protects normal tissue from radiation-induced injury. To further develop the clinical application of nicaraven for mitigating the side effects of cancer radiotherapy, we investigated the potential effect of nicaraven administration in radiation-induced inhibition of tumor growth. A subcutaneous tumor model was established in mice by the injection of Lewis lung cancer cells at the back of the chest. X-ray radiation was delivered to the thoracic area and different doses of nicaraven (0, 20, 50, 100 mg/kg) were administr...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: Lina Abdelghany Yong Xu Reiko Sekiya Chen Yan Keiichi Jingu Tao-Sheng Li Source Type: research
Dosimetry of the PIM1 Pion Beam at the Paul Scherrer Institute for Radiobiological Studies of Mice
Radiat Res. 2023 Sep 13. doi: 10.1667/RADE-23-00029.1. Online ahead of print.ABSTRACTSignificant past work has identified unexpected risks of central nervous system (CNS) exposure to the space radiation environment, where long-lasting functional decrements have been associated with multiple ion species delivered at low doses and dose rates. As shielding is the only established intervention capable of limiting exposure to the dangerous radiation fields in space, the recent discovery that pions, emanating from regions of enhanced shielding, can contribute significantly to the total absorbed dose on a deep space mission poses...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: L Desorgher A Stabilini T Rostomyan D Reggiani W Hajdas R M Marcinkowski M-C Vozenin C L Limoli E G Yukihara C Bailat Source Type: research
Dose-Dependent Testicular Injury and Recovery after Total-Body Irradiation in Rhesus Monkeys
We examined the testes from 143 irradiated and control male rhesus monkeys, who were part of the Radiation Late Effects Cohort over a four-year period. Irradiated animals were exposed to doses ranging from 3.5 to 8.5 Gy of total-body irradiation. The testes were assessed using computed tomography (CT) volumetry, serum testosterone, and histology for deceased members of the cohort. Irradiated animals exhibited dose-dependent testicular atrophy as well as decreased serum testosterone during the winter breeding season when compared to age-matched unirradiated controls. No significant difference in summer testosterone levels w...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: George W Schaaf John D Olson Greg O Dugan Betsy A Pray Jacob A Cleary J Mark Cline Source Type: research
Immune Dysfunction from Radiation Exposure
Radiat Res. 2023 Sep 13. doi: 10.1667/RADE-22-00197.1. Online ahead of print.ABSTRACTExposure to ionizing radiation causes acute damage and loss of bone marrow and peripheral immune cells that can result in high mortality due to reduced resistance to infections and hemorrhage. Besides these acute effects, tissue damage from radiation can trigger inflammatory responses, leading to progressive and chronic tissue damage by radiation-induced loss of immune cell types that are required for resolving tissue injuries. Understanding the mechanisms involved in radiation-induced immune system injury and repair will provide new insig...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: David R Cassatt Thomas A Winters Mercy PrabhuDas Source Type: research
