Validating a Four-gene Set for H-ARS Severity Prediction in Peripheral Blood Samples of Irradiated Rhesus Macaques
In conclusion, the diagnostic significance for radiation-induced H-ARS severity prediction of FDXR, DDB2, and POU2AF1 was confirmed in this Rhesus macaques model. However, DDB2 showed higher GE values than FDXR. As shown in previous studies, the diagnostic significance of WNT3 could not be reproduced in Rhesus macaques; this could be due to the choice of animal model and methodological challenges.PMID:38471521 | DOI:10.1667/RADE-23-00162.1 (Source: Radiation Research)
Source: Radiation Research - March 12, 2024 Category: Physics Authors: D Schwanke S Sch üle S Stewart O O Fatanmi S Y Wise C Hackenbroch T Wiegel V K Singh M Port M Abend P Ostheim Source Type: research
Emission of Parasitic X Rays of Vacuum-electron Tubes with Glass Housings: Implications for the Evaluation of Occupational Doses
Radiat Res. 2024 Mar 13. doi: 10.1667/RADE-23-00161.1. Online ahead of print.ABSTRACTDespite the large variety of high-voltage semiconductor components for medium and high voltage switching and pulse-forming applications as well as for high-power high-frequency generation, the use of vacuum electron tubes still prevails to a considerable degree. Due to the common design incorporating a high energy electron beam which finally is dumped into an anode or a resonator cavity, these tubes are also considered as sources of X rays produced as bremsstrahlung and characteristic radiation, which are referred to as parasitic X rays. H...
Source: Radiation Research - March 12, 2024 Category: Physics Authors: H P öttgen A Schirmer M Port R Nusshardt Source Type: research
PUM1 and PGK1 are Favorable Housekeeping Genes over Established Biodosimetry-related Housekeeping Genes such as HPRT1, ITFG1, DPM1, MRPS5, 18S rRNA and Others after Radiation Exposure
This study was conducted to identify the most promising HKGs showing the least radiation-induced GE variance after radiation exposure. In the screening stage of this study, 35 HKGs were analyzed. This included selected HKGs (ITFG1, MRPS5, and DPM1) used in large-scale biodosimetry studies which were not covered on an additionally employed pre-designed 96-well platform comprising another 32 HKGs used for different exposures. Altogether 41 samples were examined, including 27 ex vivo X-ray irradiated blood samples (0, 0.5, 4 Gy), six X-irradiated samples (0, 0.5, 5 Gy) from two cell lines (U118, A549), as well as eight non-ir...
Source: Radiation Research - March 12, 2024 Category: Physics Authors: R Muhtadi S Stewart F Bunert O O Fatanmi S Y Wise C G ärtner S Motzke C Ruf P Ostheim S Sch üle D Schwanke V K Singh M Port M Abend Source Type: research
Advanced Technologies in Radiation Research
Radiat Res. 2024 Mar 8. doi: 10.1667/RADE-24-00003.1. Online ahead of print.ABSTRACTThe U.S. Government is committed to maintaining a robust research program that supports a portfolio of scientific experts who are investigating the biological effects of radiation exposure. On August 17 and 18, 2023, the Radiation and Nuclear Countermeasures Program, within the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), partnered with the National Cancer Institute, NIH, the National Aeronautics and Space Administration, and the Radiation Injury Treatment Network to convene a workshop titled, ...
Source: Radiation Research - March 7, 2024 Category: Physics Authors: Carmen I Rios Andrea L DiCarlo Lynn Harrison Pataje G S Prasanna Jeffery C Buchsbaum Michael W Rudokas Lauren Gomes Thomas A Winters Source Type: research
Investigation of the Impact of Temporal Dose Delivery Patterns of Ion Irradiation with the Local Effect Model
We present an extension of the Local Effect Model (LEM) to include time-dose relationships for predicting effects of protracted and split-dose ion irradiation at arbitrary LET. With this kinetic extension, the spatial and temporal induction and processing of DNA double strand breaks (DSB) in cellular nuclei can be simulated for a wide range of ion radiation qualities, doses and dose rates. The key concept of the extension is based on the joint spatial and temporal coexistence of initial DSB, leading to the formation of clustered DNA damage on the µm scale (as defined e.g., by the size scale of Mbp chromatin loops), which ...
Source: Radiation Research - March 7, 2024 Category: Physics Authors: Lisa Herr Thomas Friedrich Marco Durante Michael Scholz Source Type: research
Advanced Technologies in Radiation Research
Radiat Res. 2024 Mar 8. doi: 10.1667/RADE-24-00003.1. Online ahead of print.ABSTRACTThe U.S. Government is committed to maintaining a robust research program that supports a portfolio of scientific experts who are investigating the biological effects of radiation exposure. On August 17 and 18, 2023, the Radiation and Nuclear Countermeasures Program, within the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), partnered with the National Cancer Institute, NIH, the National Aeronautics and Space Administration, and the Radiation Injury Treatment Network to convene a workshop titled, ...
Source: Radiation Research - March 7, 2024 Category: Physics Authors: Carmen I Rios Andrea L DiCarlo Lynn Harrison Pataje G S Prasanna Jeffery C Buchsbaum Michael W Rudokas Lauren Gomes Thomas A Winters Source Type: research
Investigation of the Impact of Temporal Dose Delivery Patterns of Ion Irradiation with the Local Effect Model
We present an extension of the Local Effect Model (LEM) to include time-dose relationships for predicting effects of protracted and split-dose ion irradiation at arbitrary LET. With this kinetic extension, the spatial and temporal induction and processing of DNA double strand breaks (DSB) in cellular nuclei can be simulated for a wide range of ion radiation qualities, doses and dose rates. The key concept of the extension is based on the joint spatial and temporal coexistence of initial DSB, leading to the formation of clustered DNA damage on the µm scale (as defined e.g., by the size scale of Mbp chromatin loops), which ...
Source: Radiation Research - March 7, 2024 Category: Physics Authors: Lisa Herr Thomas Friedrich Marco Durante Michael Scholz Source Type: research
Advanced Technologies in Radiation Research
Radiat Res. 2024 Mar 8. doi: 10.1667/RADE-24-00003.1. Online ahead of print.ABSTRACTThe U.S. Government is committed to maintaining a robust research program that supports a portfolio of scientific experts who are investigating the biological effects of radiation exposure. On August 17 and 18, 2023, the Radiation and Nuclear Countermeasures Program, within the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), partnered with the National Cancer Institute, NIH, the National Aeronautics and Space Administration, and the Radiation Injury Treatment Network to convene a workshop titled, ...
Source: Radiation Research - March 7, 2024 Category: Physics Authors: Carmen I Rios Andrea L DiCarlo Lynn Harrison Pataje G S Prasanna Jeffery C Buchsbaum Michael W Rudokas Lauren Gomes Thomas A Winters Source Type: research
Investigation of the Impact of Temporal Dose Delivery Patterns of Ion Irradiation with the Local Effect Model
We present an extension of the Local Effect Model (LEM) to include time-dose relationships for predicting effects of protracted and split-dose ion irradiation at arbitrary LET. With this kinetic extension, the spatial and temporal induction and processing of DNA double strand breaks (DSB) in cellular nuclei can be simulated for a wide range of ion radiation qualities, doses and dose rates. The key concept of the extension is based on the joint spatial and temporal coexistence of initial DSB, leading to the formation of clustered DNA damage on the µm scale (as defined e.g., by the size scale of Mbp chromatin loops), which ...
Source: Radiation Research - March 7, 2024 Category: Physics Authors: Lisa Herr Thomas Friedrich Marco Durante Michael Scholz Source Type: research
Advanced Technologies in Radiation Research
Radiat Res. 2024 Mar 8. doi: 10.1667/RADE-24-00003.1. Online ahead of print.ABSTRACTThe U.S. Government is committed to maintaining a robust research program that supports a portfolio of scientific experts who are investigating the biological effects of radiation exposure. On August 17 and 18, 2023, the Radiation and Nuclear Countermeasures Program, within the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), partnered with the National Cancer Institute, NIH, the National Aeronautics and Space Administration, and the Radiation Injury Treatment Network to convene a workshop titled, ...
Source: Radiation Research - March 7, 2024 Category: Physics Authors: Carmen I Rios Andrea L DiCarlo Lynn Harrison Pataje G S Prasanna Jeffery C Buchsbaum Michael W Rudokas Lauren Gomes Thomas A Winters Source Type: research
Investigation of the Impact of Temporal Dose Delivery Patterns of Ion Irradiation with the Local Effect Model
We present an extension of the Local Effect Model (LEM) to include time-dose relationships for predicting effects of protracted and split-dose ion irradiation at arbitrary LET. With this kinetic extension, the spatial and temporal induction and processing of DNA double strand breaks (DSB) in cellular nuclei can be simulated for a wide range of ion radiation qualities, doses and dose rates. The key concept of the extension is based on the joint spatial and temporal coexistence of initial DSB, leading to the formation of clustered DNA damage on the µm scale (as defined e.g., by the size scale of Mbp chromatin loops), which ...
Source: Radiation Research - March 7, 2024 Category: Physics Authors: Lisa Herr Thomas Friedrich Marco Durante Michael Scholz Source Type: research
Product Development within the National Institutes of Health Radiation and Nuclear Countermeasures Program
Radiat Res. 2024 Feb 26. doi: 10.1667/RADE-23-00144.1. Online ahead of print.ABSTRACTThe Radiation and Nuclear Countermeasures Program (RNCP) at the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) was established to facilitate the development of medical countermeasures (MCMs) and diagnostic approaches for use in a radiation public health emergency. Approvals for MCMs can be very challenging but are made possible under the United States Food and Drug Administration (FDA) Animal Rule, which is designed to enable licensure of drugs or biologics when clinical efficacy studies ...
Source: Radiation Research - February 26, 2024 Category: Physics Authors: David R Cassatt Andrea L DiCarlo Olivia Molinar-Inglis Source Type: research
Induction of Chromosomal Aberrations after Exposure to the Auger Electron Emitter Iodine-125, the β--emitter Tritium and Cesium-137 γ rays
In this study, we investigated whether DNA lesions induced at different cell cycle stages and by different radiation types [Auger-electrons (125I), β- particles (3H), or γ radiation (137Cs)] have an impact on the number of CA induced after induction of the same number of DSB as determined by the γ-H2AX foci assay. Cells were synchronized and pulse-labeled in S phase with low activities of 125I-UdR or tritiated thymidine. For decay accumulation, cells were cryopreserved either after pulse-labeling in S phase or after progression to G2/M or G1 phase. Experiments with γ irradiation (137Cs) were performed with synchronized...
Source: Radiation Research - February 26, 2024 Category: Physics Authors: M Unverricht-Yeboah M Von Ameln R Kriehuber Source Type: research
Dose Rate Effects on Hydrated Electrons, Hydrogen Peroxide, and a OH Radical Molecular Probe Under Clinical Energy Protons
We report the dose rate dependence of radiation chemical yields (G value) of water radiolysis products under clinical energy protons (230 MeV) to understand mechanisms of the FLASH radiotherapy performed at ultra-high dose rate (>40 Gy/s). The G value of 7-hydoroxy-coumarin-3-carboxylic acid (7OH-C3CA) produced by reactions of coumarin-3-carboxylic acid (C3CA) with OH radicals and oxygen is evaluated by fluorescence method. Also, those of hydrated electrons and hydrogen peroxide are derived by absorption method using Saltzman and Ghomley techniques, respectively. Both G values of 7OH-C3CA and hydrated electrons decrease...
Source: Radiation Research - February 26, 2024 Category: Physics Authors: Tamon Kusumoto Antoine Danvin Taisei Mamiya Aurelia Arnone Severine Chefson Catherine Galindo Philippe Peaupardin Quentin Raffy Nagaaki Kamiguchi Daizo Amano Kenzo Sasai Teruaki Konishi Satoshi Kodaira Source Type: research
Product Development within the National Institutes of Health Radiation and Nuclear Countermeasures Program
Radiat Res. 2024 Feb 26. doi: 10.1667/RADE-23-00144.1. Online ahead of print.ABSTRACTThe Radiation and Nuclear Countermeasures Program (RNCP) at the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) was established to facilitate the development of medical countermeasures (MCMs) and diagnostic approaches for use in a radiation public health emergency. Approvals for MCMs can be very challenging but are made possible under the United States Food and Drug Administration (FDA) Animal Rule, which is designed to enable licensure of drugs or biologics when clinical efficacy studies ...
Source: Radiation Research - February 26, 2024 Category: Physics Authors: David R Cassatt Andrea L DiCarlo Olivia Molinar-Inglis Source Type: research
