Noninvasive Red Laser Intervention before Radiotherapy of Triple-negative Breast Cancer in a Murine Model
Radiat Res. 2023 Sep 13. doi: 10.1667/RADE-23-0005.1. Online ahead of print.ABSTRACTRadiotherapy is a well-established cancer treatment; it is estimated that approximately 52% of oncology patients will require this treatment modality at least once. However, some tumors, such as triple-negative breast cancer (TNBC), may present as radioresistant and thus require high doses of ionizing radiation and a prolonged period of treatment, which may result in more severe side effects. Moreover, such tumors show a high incidence of metastases and decreased survival expectancy of the patient. Thus, new strategies for radiosensitizing ...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: Camila R Silva Saulo T Pereira Daniela F T Silva Lucas R De Pretto Anderson Z Freitas Carlos A Zeituni Maria E C M Rostelato Martha S Ribeiro Source Type: research
Nicaraven Exerts a Limited Effect on Radiation-Induced Inhibition of Tumor Growth in a Subcutaneous Murine Tumor Model
Radiat Res. 2023 Sep 13. doi: 10.1667/RADE-22-00212.1. Online ahead of print.ABSTRACTNicaraven selectively protects normal tissue from radiation-induced injury. To further develop the clinical application of nicaraven for mitigating the side effects of cancer radiotherapy, we investigated the potential effect of nicaraven administration in radiation-induced inhibition of tumor growth. A subcutaneous tumor model was established in mice by the injection of Lewis lung cancer cells at the back of the chest. X-ray radiation was delivered to the thoracic area and different doses of nicaraven (0, 20, 50, 100 mg/kg) were administr...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: Lina Abdelghany Yong Xu Reiko Sekiya Chen Yan Keiichi Jingu Tao-Sheng Li Source Type: research
Dosimetry of the PIM1 Pion Beam at the Paul Scherrer Institute for Radiobiological Studies of Mice
Radiat Res. 2023 Sep 13. doi: 10.1667/RADE-23-00029.1. Online ahead of print.ABSTRACTSignificant past work has identified unexpected risks of central nervous system (CNS) exposure to the space radiation environment, where long-lasting functional decrements have been associated with multiple ion species delivered at low doses and dose rates. As shielding is the only established intervention capable of limiting exposure to the dangerous radiation fields in space, the recent discovery that pions, emanating from regions of enhanced shielding, can contribute significantly to the total absorbed dose on a deep space mission poses...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: L Desorgher A Stabilini T Rostomyan D Reggiani W Hajdas R M Marcinkowski M-C Vozenin C L Limoli E G Yukihara C Bailat Source Type: research
Dose-Dependent Testicular Injury and Recovery after Total-Body Irradiation in Rhesus Monkeys
We examined the testes from 143 irradiated and control male rhesus monkeys, who were part of the Radiation Late Effects Cohort over a four-year period. Irradiated animals were exposed to doses ranging from 3.5 to 8.5 Gy of total-body irradiation. The testes were assessed using computed tomography (CT) volumetry, serum testosterone, and histology for deceased members of the cohort. Irradiated animals exhibited dose-dependent testicular atrophy as well as decreased serum testosterone during the winter breeding season when compared to age-matched unirradiated controls. No significant difference in summer testosterone levels w...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: George W Schaaf John D Olson Greg O Dugan Betsy A Pray Jacob A Cleary J Mark Cline Source Type: research
Immune Dysfunction from Radiation Exposure
Radiat Res. 2023 Sep 13. doi: 10.1667/RADE-22-00197.1. Online ahead of print.ABSTRACTExposure to ionizing radiation causes acute damage and loss of bone marrow and peripheral immune cells that can result in high mortality due to reduced resistance to infections and hemorrhage. Besides these acute effects, tissue damage from radiation can trigger inflammatory responses, leading to progressive and chronic tissue damage by radiation-induced loss of immune cell types that are required for resolving tissue injuries. Understanding the mechanisms involved in radiation-induced immune system injury and repair will provide new insig...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: David R Cassatt Thomas A Winters Mercy PrabhuDas Source Type: research
Noninvasive Red Laser Intervention before Radiotherapy of Triple-negative Breast Cancer in a Murine Model
Radiat Res. 2023 Sep 13. doi: 10.1667/RADE-23-0005.1. Online ahead of print.ABSTRACTRadiotherapy is a well-established cancer treatment; it is estimated that approximately 52% of oncology patients will require this treatment modality at least once. However, some tumors, such as triple-negative breast cancer (TNBC), may present as radioresistant and thus require high doses of ionizing radiation and a prolonged period of treatment, which may result in more severe side effects. Moreover, such tumors show a high incidence of metastases and decreased survival expectancy of the patient. Thus, new strategies for radiosensitizing ...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: Camila R Silva Saulo T Pereira Daniela F T Silva Lucas R De Pretto Anderson Z Freitas Carlos A Zeituni Maria E C M Rostelato Martha S Ribeiro Source Type: research
Nicaraven Exerts a Limited Effect on Radiation-Induced Inhibition of Tumor Growth in a Subcutaneous Murine Tumor Model
Radiat Res. 2023 Sep 13. doi: 10.1667/RADE-22-00212.1. Online ahead of print.ABSTRACTNicaraven selectively protects normal tissue from radiation-induced injury. To further develop the clinical application of nicaraven for mitigating the side effects of cancer radiotherapy, we investigated the potential effect of nicaraven administration in radiation-induced inhibition of tumor growth. A subcutaneous tumor model was established in mice by the injection of Lewis lung cancer cells at the back of the chest. X-ray radiation was delivered to the thoracic area and different doses of nicaraven (0, 20, 50, 100 mg/kg) were administr...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: Lina Abdelghany Yong Xu Reiko Sekiya Chen Yan Keiichi Jingu Tao-Sheng Li Source Type: research
Dosimetry of the PIM1 Pion Beam at the Paul Scherrer Institute for Radiobiological Studies of Mice
Radiat Res. 2023 Sep 13. doi: 10.1667/RADE-23-00029.1. Online ahead of print.ABSTRACTSignificant past work has identified unexpected risks of central nervous system (CNS) exposure to the space radiation environment, where long-lasting functional decrements have been associated with multiple ion species delivered at low doses and dose rates. As shielding is the only established intervention capable of limiting exposure to the dangerous radiation fields in space, the recent discovery that pions, emanating from regions of enhanced shielding, can contribute significantly to the total absorbed dose on a deep space mission poses...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: L Desorgher A Stabilini T Rostomyan D Reggiani W Hajdas R M Marcinkowski M-C Vozenin C L Limoli E G Yukihara C Bailat Source Type: research
Dose-Dependent Testicular Injury and Recovery after Total-Body Irradiation in Rhesus Monkeys
We examined the testes from 143 irradiated and control male rhesus monkeys, who were part of the Radiation Late Effects Cohort over a four-year period. Irradiated animals were exposed to doses ranging from 3.5 to 8.5 Gy of total-body irradiation. The testes were assessed using computed tomography (CT) volumetry, serum testosterone, and histology for deceased members of the cohort. Irradiated animals exhibited dose-dependent testicular atrophy as well as decreased serum testosterone during the winter breeding season when compared to age-matched unirradiated controls. No significant difference in summer testosterone levels w...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: George W Schaaf John D Olson Greg O Dugan Betsy A Pray Jacob A Cleary J Mark Cline Source Type: research
Immune Dysfunction from Radiation Exposure
Radiat Res. 2023 Sep 13. doi: 10.1667/RADE-22-00197.1. Online ahead of print.ABSTRACTExposure to ionizing radiation causes acute damage and loss of bone marrow and peripheral immune cells that can result in high mortality due to reduced resistance to infections and hemorrhage. Besides these acute effects, tissue damage from radiation can trigger inflammatory responses, leading to progressive and chronic tissue damage by radiation-induced loss of immune cell types that are required for resolving tissue injuries. Understanding the mechanisms involved in radiation-induced immune system injury and repair will provide new insig...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: David R Cassatt Thomas A Winters Mercy PrabhuDas Source Type: research
Noninvasive Red Laser Intervention before Radiotherapy of Triple-negative Breast Cancer in a Murine Model
Radiat Res. 2023 Sep 13. doi: 10.1667/RADE-23-0005.1. Online ahead of print.ABSTRACTRadiotherapy is a well-established cancer treatment; it is estimated that approximately 52% of oncology patients will require this treatment modality at least once. However, some tumors, such as triple-negative breast cancer (TNBC), may present as radioresistant and thus require high doses of ionizing radiation and a prolonged period of treatment, which may result in more severe side effects. Moreover, such tumors show a high incidence of metastases and decreased survival expectancy of the patient. Thus, new strategies for radiosensitizing ...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: Camila R Silva Saulo T Pereira Daniela F T Silva Lucas R De Pretto Anderson Z Freitas Carlos A Zeituni Maria E C M Rostelato Martha S Ribeiro Source Type: research
Nicaraven Exerts a Limited Effect on Radiation-Induced Inhibition of Tumor Growth in a Subcutaneous Murine Tumor Model
Radiat Res. 2023 Sep 13. doi: 10.1667/RADE-22-00212.1. Online ahead of print.ABSTRACTNicaraven selectively protects normal tissue from radiation-induced injury. To further develop the clinical application of nicaraven for mitigating the side effects of cancer radiotherapy, we investigated the potential effect of nicaraven administration in radiation-induced inhibition of tumor growth. A subcutaneous tumor model was established in mice by the injection of Lewis lung cancer cells at the back of the chest. X-ray radiation was delivered to the thoracic area and different doses of nicaraven (0, 20, 50, 100 mg/kg) were administr...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: Lina Abdelghany Yong Xu Reiko Sekiya Chen Yan Keiichi Jingu Tao-Sheng Li Source Type: research
Dosimetry of the PIM1 Pion Beam at the Paul Scherrer Institute for Radiobiological Studies of Mice
Radiat Res. 2023 Sep 13. doi: 10.1667/RADE-23-00029.1. Online ahead of print.ABSTRACTSignificant past work has identified unexpected risks of central nervous system (CNS) exposure to the space radiation environment, where long-lasting functional decrements have been associated with multiple ion species delivered at low doses and dose rates. As shielding is the only established intervention capable of limiting exposure to the dangerous radiation fields in space, the recent discovery that pions, emanating from regions of enhanced shielding, can contribute significantly to the total absorbed dose on a deep space mission poses...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: L Desorgher A Stabilini T Rostomyan D Reggiani W Hajdas R M Marcinkowski M-C Vozenin C L Limoli E G Yukihara C Bailat Source Type: research
Dose-Dependent Testicular Injury and Recovery after Total-Body Irradiation in Rhesus Monkeys
We examined the testes from 143 irradiated and control male rhesus monkeys, who were part of the Radiation Late Effects Cohort over a four-year period. Irradiated animals were exposed to doses ranging from 3.5 to 8.5 Gy of total-body irradiation. The testes were assessed using computed tomography (CT) volumetry, serum testosterone, and histology for deceased members of the cohort. Irradiated animals exhibited dose-dependent testicular atrophy as well as decreased serum testosterone during the winter breeding season when compared to age-matched unirradiated controls. No significant difference in summer testosterone levels w...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: George W Schaaf John D Olson Greg O Dugan Betsy A Pray Jacob A Cleary J Mark Cline Source Type: research
Immune Dysfunction from Radiation Exposure
Radiat Res. 2023 Sep 13. doi: 10.1667/RADE-22-00197.1. Online ahead of print.ABSTRACTExposure to ionizing radiation causes acute damage and loss of bone marrow and peripheral immune cells that can result in high mortality due to reduced resistance to infections and hemorrhage. Besides these acute effects, tissue damage from radiation can trigger inflammatory responses, leading to progressive and chronic tissue damage by radiation-induced loss of immune cell types that are required for resolving tissue injuries. Understanding the mechanisms involved in radiation-induced immune system injury and repair will provide new insig...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: David R Cassatt Thomas A Winters Mercy PrabhuDas Source Type: research
