Thermoluminescence Characteristics of Copper and Terbium Co-Doped Lithium Tetraborate Glass
In this study, the preparation and characterization of copper (Cu) and terbium (Tb) co-doped lithium borate glass using spectroscopic and thermoluminescence techniques are reported. A thermal treatment was introduced to increase the degree of crystallinity. The thermoluminescence glow curve signal of the samples displayed upon exposure to beta radiation was measured and analyzed. It was found that the samples doped with 0.1% of copper and co-doped with 0.3% terbium showed the highest thermoluminescent (TL) signal in response to the irradiated dose. The analyses revealed that the glow curves of the doped samples were compos...
Source: Radiation Research - November 6, 2023 Category: Physics Authors: Nabil El-Faramawy Mohamed El-Kinawy Shrouk Farouk Mohamed Sabry Hassan F El-Nashar Alessia Mafodda Clemens Woda Source Type: research
A New Method for Estimating Glomerular Filtration Rate in Rhesus Macaques (Macaca mulatta)
In this study, we aimed to determine if the Schwartz formula as used in human pediatric medicine can estimate GFR in rhesus macaques. We hypothesized that iohexol-GFR would correlate with the Schwartz formula-estimated GFR (eGFR) in irradiated and non-irradiated rhesus macaques. Twelve rhesus macaques [age 5-14 years (mean 7 years); 5 females, 7 males] with a range of BUN levels were selected for comparison to 4 non-irradiated controls (2 females, 2 males). Irradiated animals were divided by BUN into 3 groups: BUN ≤20 mg/dL (n = 4), BUN >20-24 mg/dL (n = 4), and BUN ≥25 mg/dL (n = 4). Baseline serum chemistry and ur...
Source: Radiation Research - October 30, 2023 Category: Physics Authors: Allison M Tomasino John D Olson George W Schaaf Anderson O Cox Cristina M Furdui J Mark Cline Eric P Cohen Source Type: research
Temporal Dynamic Regulation of Autophagy and Senescence Induction in Response to Radiation Exposure
Radiat Res. 2023 Oct 30. doi: 10.1667/RADE-23-00173.1. Online ahead of print.ABSTRACTAutophagy and senescence are closely related cellular responses to genotoxic stress, and play significant roles in the execution of cellular responses to radiation exposure. However, little is known about their interplay in the fate-decision of cells receiving lethal doses of radiation. Here, we report that autophagy precedes the establishment of premature senescence in normal human fibroblasts exposed to lethal doses of radiation. Activation of the p53-dependent DNA damage response caused sustained dephosphorylation of RB proteins and con...
Source: Radiation Research - October 30, 2023 Category: Physics Authors: Miho Noguchi Tomokazu Ihara Keiji Suzuki Akinari Yokoya Source Type: research
A New Method for Estimating Glomerular Filtration Rate in Rhesus Macaques (Macaca mulatta)
In this study, we aimed to determine if the Schwartz formula as used in human pediatric medicine can estimate GFR in rhesus macaques. We hypothesized that iohexol-GFR would correlate with the Schwartz formula-estimated GFR (eGFR) in irradiated and non-irradiated rhesus macaques. Twelve rhesus macaques [age 5-14 years (mean 7 years); 5 females, 7 males] with a range of BUN levels were selected for comparison to 4 non-irradiated controls (2 females, 2 males). Irradiated animals were divided by BUN into 3 groups: BUN ≤20 mg/dL (n = 4), BUN >20-24 mg/dL (n = 4), and BUN ≥25 mg/dL (n = 4). Baseline serum chemistry and ur...
Source: Radiation Research - October 30, 2023 Category: Physics Authors: Allison M Tomasino John D Olson George W Schaaf Anderson O Cox Cristina M Furdui J Mark Cline Eric P Cohen Source Type: research
Temporal Dynamic Regulation of Autophagy and Senescence Induction in Response to Radiation Exposure
Radiat Res. 2023 Oct 30. doi: 10.1667/RADE-23-00173.1. Online ahead of print.ABSTRACTAutophagy and senescence are closely related cellular responses to genotoxic stress, and play significant roles in the execution of cellular responses to radiation exposure. However, little is known about their interplay in the fate-decision of cells receiving lethal doses of radiation. Here, we report that autophagy precedes the establishment of premature senescence in normal human fibroblasts exposed to lethal doses of radiation. Activation of the p53-dependent DNA damage response caused sustained dephosphorylation of RB proteins and con...
Source: Radiation Research - October 30, 2023 Category: Physics Authors: Miho Noguchi Tomokazu Ihara Keiji Suzuki Akinari Yokoya Source Type: research
A New Method for Estimating Glomerular Filtration Rate in Rhesus Macaques (Macaca mulatta)
In this study, we aimed to determine if the Schwartz formula as used in human pediatric medicine can estimate GFR in rhesus macaques. We hypothesized that iohexol-GFR would correlate with the Schwartz formula-estimated GFR (eGFR) in irradiated and non-irradiated rhesus macaques. Twelve rhesus macaques [age 5-14 years (mean 7 years); 5 females, 7 males] with a range of BUN levels were selected for comparison to 4 non-irradiated controls (2 females, 2 males). Irradiated animals were divided by BUN into 3 groups: BUN ≤20 mg/dL (n = 4), BUN >20-24 mg/dL (n = 4), and BUN ≥25 mg/dL (n = 4). Baseline serum chemistry and ur...
Source: Radiation Research - October 30, 2023 Category: Physics Authors: Allison M Tomasino John D Olson George W Schaaf Anderson O Cox Cristina M Furdui J Mark Cline Eric P Cohen Source Type: research
Temporal Dynamic Regulation of Autophagy and Senescence Induction in Response to Radiation Exposure
Radiat Res. 2023 Oct 30. doi: 10.1667/RADE-23-00173.1. Online ahead of print.ABSTRACTAutophagy and senescence are closely related cellular responses to genotoxic stress, and play significant roles in the execution of cellular responses to radiation exposure. However, little is known about their interplay in the fate-decision of cells receiving lethal doses of radiation. Here, we report that autophagy precedes the establishment of premature senescence in normal human fibroblasts exposed to lethal doses of radiation. Activation of the p53-dependent DNA damage response caused sustained dephosphorylation of RB proteins and con...
Source: Radiation Research - October 30, 2023 Category: Physics Authors: Miho Noguchi Tomokazu Ihara Keiji Suzuki Akinari Yokoya Source Type: research
A New Method for Estimating Glomerular Filtration Rate in Rhesus Macaques (Macaca mulatta)
In this study, we aimed to determine if the Schwartz formula as used in human pediatric medicine can estimate GFR in rhesus macaques. We hypothesized that iohexol-GFR would correlate with the Schwartz formula-estimated GFR (eGFR) in irradiated and non-irradiated rhesus macaques. Twelve rhesus macaques [age 5-14 years (mean 7 years); 5 females, 7 males] with a range of BUN levels were selected for comparison to 4 non-irradiated controls (2 females, 2 males). Irradiated animals were divided by BUN into 3 groups: BUN ≤20 mg/dL (n = 4), BUN >20-24 mg/dL (n = 4), and BUN ≥25 mg/dL (n = 4). Baseline serum chemistry and ur...
Source: Radiation Research - October 30, 2023 Category: Physics Authors: Allison M Tomasino John D Olson George W Schaaf Anderson O Cox Cristina M Furdui J Mark Cline Eric P Cohen Source Type: research
Temporal Dynamic Regulation of Autophagy and Senescence Induction in Response to Radiation Exposure
Radiat Res. 2023 Oct 30. doi: 10.1667/RADE-23-00173.1. Online ahead of print.ABSTRACTAutophagy and senescence are closely related cellular responses to genotoxic stress, and play significant roles in the execution of cellular responses to radiation exposure. However, little is known about their interplay in the fate-decision of cells receiving lethal doses of radiation. Here, we report that autophagy precedes the establishment of premature senescence in normal human fibroblasts exposed to lethal doses of radiation. Activation of the p53-dependent DNA damage response caused sustained dephosphorylation of RB proteins and con...
Source: Radiation Research - October 30, 2023 Category: Physics Authors: Miho Noguchi Tomokazu Ihara Keiji Suzuki Akinari Yokoya Source Type: research
A New Method for Estimating Glomerular Filtration Rate in Rhesus Macaques (Macaca mulatta)
In this study, we aimed to determine if the Schwartz formula as used in human pediatric medicine can estimate GFR in rhesus macaques. We hypothesized that iohexol-GFR would correlate with the Schwartz formula-estimated GFR (eGFR) in irradiated and non-irradiated rhesus macaques. Twelve rhesus macaques [age 5-14 years (mean 7 years); 5 females, 7 males] with a range of BUN levels were selected for comparison to 4 non-irradiated controls (2 females, 2 males). Irradiated animals were divided by BUN into 3 groups: BUN ≤20 mg/dL (n = 4), BUN >20-24 mg/dL (n = 4), and BUN ≥25 mg/dL (n = 4). Baseline serum chemistry and ur...
Source: Radiation Research - October 30, 2023 Category: Physics Authors: Allison M Tomasino John D Olson George W Schaaf Anderson O Cox Cristina M Furdui J Mark Cline Eric P Cohen Source Type: research
Temporal Dynamic Regulation of Autophagy and Senescence Induction in Response to Radiation Exposure
Radiat Res. 2023 Oct 30. doi: 10.1667/RADE-23-00173.1. Online ahead of print.ABSTRACTAutophagy and senescence are closely related cellular responses to genotoxic stress, and play significant roles in the execution of cellular responses to radiation exposure. However, little is known about their interplay in the fate-decision of cells receiving lethal doses of radiation. Here, we report that autophagy precedes the establishment of premature senescence in normal human fibroblasts exposed to lethal doses of radiation. Activation of the p53-dependent DNA damage response caused sustained dephosphorylation of RB proteins and con...
Source: Radiation Research - October 30, 2023 Category: Physics Authors: Miho Noguchi Tomokazu Ihara Keiji Suzuki Akinari Yokoya Source Type: research
A New Method for Estimating Glomerular Filtration Rate in Rhesus Macaques (Macaca mulatta)
In this study, we aimed to determine if the Schwartz formula as used in human pediatric medicine can estimate GFR in rhesus macaques. We hypothesized that iohexol-GFR would correlate with the Schwartz formula-estimated GFR (eGFR) in irradiated and non-irradiated rhesus macaques. Twelve rhesus macaques [age 5-14 years (mean 7 years); 5 females, 7 males] with a range of BUN levels were selected for comparison to 4 non-irradiated controls (2 females, 2 males). Irradiated animals were divided by BUN into 3 groups: BUN ≤20 mg/dL (n = 4), BUN >20-24 mg/dL (n = 4), and BUN ≥25 mg/dL (n = 4). Baseline serum chemistry and ur...
Source: Radiation Research - October 30, 2023 Category: Physics Authors: Allison M Tomasino John D Olson George W Schaaf Anderson O Cox Cristina M Furdui J Mark Cline Eric P Cohen Source Type: research
Temporal Dynamic Regulation of Autophagy and Senescence Induction in Response to Radiation Exposure
Radiat Res. 2023 Oct 30. doi: 10.1667/RADE-23-00173.1. Online ahead of print.ABSTRACTAutophagy and senescence are closely related cellular responses to genotoxic stress, and play significant roles in the execution of cellular responses to radiation exposure. However, little is known about their interplay in the fate-decision of cells receiving lethal doses of radiation. Here, we report that autophagy precedes the establishment of premature senescence in normal human fibroblasts exposed to lethal doses of radiation. Activation of the p53-dependent DNA damage response caused sustained dephosphorylation of RB proteins and con...
Source: Radiation Research - October 30, 2023 Category: Physics Authors: Miho Noguchi Tomokazu Ihara Keiji Suzuki Akinari Yokoya Source Type: research
Regulation of Circulating miR-342-3p Alleviates the Radiation-Induced Immune System Injury
In this study, we found that mmu-miR-342-3p (miR-342) in mouse serum presents a stable and significant decrease after X-ray total-body irradiation (TBI). Focusing on this miRNA, we investigated the influences of circulating miR-342 on the radiation-induced injury. Through tail vein injection of Cy5-labeled synthetic miR-342, we found the exogenous miR-342-Cy5 was mainly enriched in metabolic and immune organs. Besides, the bioinformatic analysis predicted that miR-342 might involve in immune-related processes or pathways. Further, mice were tail vein injected with synthetic miR-342 mimetics (Ago-miR-342) after irradiation ...
Source: Radiation Research - October 24, 2023 Category: Physics Authors: Wenjun Wei Hao Bai Tianyi Zhang Shufan Cai Yumeng Zhou Min Liu Yanan Zhang Yaxiong Chen Junrui Hua Jinpeng He Nan Ding GuoYing Miao Jufang Wang Source Type: research
Regulation of Circulating miR-342-3p Alleviates the Radiation-Induced Immune System Injury
In this study, we found that mmu-miR-342-3p (miR-342) in mouse serum presents a stable and significant decrease after X-ray total-body irradiation (TBI). Focusing on this miRNA, we investigated the influences of circulating miR-342 on the radiation-induced injury. Through tail vein injection of Cy5-labeled synthetic miR-342, we found the exogenous miR-342-Cy5 was mainly enriched in metabolic and immune organs. Besides, the bioinformatic analysis predicted that miR-342 might involve in immune-related processes or pathways. Further, mice were tail vein injected with synthetic miR-342 mimetics (Ago-miR-342) after irradiation ...
Source: Radiation Research - October 24, 2023 Category: Physics Authors: Wenjun Wei Hao Bai Tianyi Zhang Shufan Cai Yumeng Zhou Min Liu Yanan Zhang Yaxiong Chen Junrui Hua Jinpeng He Nan Ding GuoYing Miao Jufang Wang Source Type: research
