Connexin 43 Prevents Radiation-Induced Intestinal Damage via the Ca2+-Dependent PI3K/Akt Signaling Pathway
This study aimed to investigate the expression and role of connexins in RIID and underlying mechanism. In this study, a calcein-AM fluorescence probe was used to detect changes in gap junctional intercellular communication in intestinal epithelial IEC-6 cells. Our results show that gap junctional intercellular communication of IEC-6 cells was reduced at 6, 12, 24, and 48 h after irradiation, with the most pronounced effect at 24 h. Western blotting and immunofluorescence results showed that the expression of Cx43, but not other connexins, was reduced in irradiated intestinal epithelial cells. Silencing of Cx43 reduced gap ...
Source: Radiation Research - February 20, 2024 Category: Physics Authors: Yue Zhu Jun Dai Bin Song Yuehua Zhang Tingyi Yang Hongwei Xu Xiaopeng Xu Yi Gao Tao Yan Weidong Shen Wenhao Zhang Shuyu Zhang Pengfei Liu Source Type: research
Development of a Radiation-induced Pulmonary Fibrosis Partial Body Irradiation Model in C57BL/6 Mice
In conclusion, a long-term model for radiation-induced pulmonary fibrosis was established, and countermeasures could be screened in this model for survival and protection/mitigation or recovery from radiation-induced pulmonary damage.PMID:38376474 | DOI:10.1667/RADE-23-00143.1 (Source: Radiation Research)
Source: Radiation Research - February 20, 2024 Category: Physics Authors: Vidya P Kumar Shalini Jaiswal Kefale Wuddie Jerrold M Ward Mark Lawrence Sanchita P Ghosh Source Type: research
Connexin 43 Prevents Radiation-Induced Intestinal Damage via the Ca2+-Dependent PI3K/Akt Signaling Pathway
This study aimed to investigate the expression and role of connexins in RIID and underlying mechanism. In this study, a calcein-AM fluorescence probe was used to detect changes in gap junctional intercellular communication in intestinal epithelial IEC-6 cells. Our results show that gap junctional intercellular communication of IEC-6 cells was reduced at 6, 12, 24, and 48 h after irradiation, with the most pronounced effect at 24 h. Western blotting and immunofluorescence results showed that the expression of Cx43, but not other connexins, was reduced in irradiated intestinal epithelial cells. Silencing of Cx43 reduced gap ...
Source: Radiation Research - February 20, 2024 Category: Physics Authors: Yue Zhu Jun Dai Bin Song Yuehua Zhang Tingyi Yang Hongwei Xu Xiaopeng Xu Yi Gao Tao Yan Weidong Shen Wenhao Zhang Shuyu Zhang Pengfei Liu Source Type: research
Development of a Radiation-induced Pulmonary Fibrosis Partial Body Irradiation Model in C57BL/6 Mice
In conclusion, a long-term model for radiation-induced pulmonary fibrosis was established, and countermeasures could be screened in this model for survival and protection/mitigation or recovery from radiation-induced pulmonary damage.PMID:38376474 | DOI:10.1667/RADE-23-00143.1 (Source: Radiation Research)
Source: Radiation Research - February 20, 2024 Category: Physics Authors: Vidya P Kumar Shalini Jaiswal Kefale Wuddie Jerrold M Ward Mark Lawrence Sanchita P Ghosh Source Type: research
Connexin 43 Prevents Radiation-Induced Intestinal Damage via the Ca2+-Dependent PI3K/Akt Signaling Pathway
This study aimed to investigate the expression and role of connexins in RIID and underlying mechanism. In this study, a calcein-AM fluorescence probe was used to detect changes in gap junctional intercellular communication in intestinal epithelial IEC-6 cells. Our results show that gap junctional intercellular communication of IEC-6 cells was reduced at 6, 12, 24, and 48 h after irradiation, with the most pronounced effect at 24 h. Western blotting and immunofluorescence results showed that the expression of Cx43, but not other connexins, was reduced in irradiated intestinal epithelial cells. Silencing of Cx43 reduced gap ...
Source: Radiation Research - February 20, 2024 Category: Physics Authors: Yue Zhu Jun Dai Bin Song Yuehua Zhang Tingyi Yang Hongwei Xu Xiaopeng Xu Yi Gao Tao Yan Weidong Shen Wenhao Zhang Shuyu Zhang Pengfei Liu Source Type: research
Development of a Radiation-induced Pulmonary Fibrosis Partial Body Irradiation Model in C57BL/6 Mice
In conclusion, a long-term model for radiation-induced pulmonary fibrosis was established, and countermeasures could be screened in this model for survival and protection/mitigation or recovery from radiation-induced pulmonary damage.PMID:38376474 | DOI:10.1667/RADE-23-00143.1 (Source: Radiation Research)
Source: Radiation Research - February 20, 2024 Category: Physics Authors: Vidya P Kumar Shalini Jaiswal Kefale Wuddie Jerrold M Ward Mark Lawrence Sanchita P Ghosh Source Type: research
Connexin 43 Prevents Radiation-Induced Intestinal Damage via the Ca2+-Dependent PI3K/Akt Signaling Pathway
This study aimed to investigate the expression and role of connexins in RIID and underlying mechanism. In this study, a calcein-AM fluorescence probe was used to detect changes in gap junctional intercellular communication in intestinal epithelial IEC-6 cells. Our results show that gap junctional intercellular communication of IEC-6 cells was reduced at 6, 12, 24, and 48 h after irradiation, with the most pronounced effect at 24 h. Western blotting and immunofluorescence results showed that the expression of Cx43, but not other connexins, was reduced in irradiated intestinal epithelial cells. Silencing of Cx43 reduced gap ...
Source: Radiation Research - February 20, 2024 Category: Physics Authors: Yue Zhu Jun Dai Bin Song Yuehua Zhang Tingyi Yang Hongwei Xu Xiaopeng Xu Yi Gao Tao Yan Weidong Shen Wenhao Zhang Shuyu Zhang Pengfei Liu Source Type: research
Development of a Radiation-induced Pulmonary Fibrosis Partial Body Irradiation Model in C57BL/6 Mice
In conclusion, a long-term model for radiation-induced pulmonary fibrosis was established, and countermeasures could be screened in this model for survival and protection/mitigation or recovery from radiation-induced pulmonary damage.PMID:38376474 | DOI:10.1667/RADE-23-00143.1 (Source: Radiation Research)
Source: Radiation Research - February 20, 2024 Category: Physics Authors: Vidya P Kumar Shalini Jaiswal Kefale Wuddie Jerrold M Ward Mark Lawrence Sanchita P Ghosh Source Type: research
Connexin 43 Prevents Radiation-Induced Intestinal Damage via the Ca2+-Dependent PI3K/Akt Signaling Pathway
This study aimed to investigate the expression and role of connexins in RIID and underlying mechanism. In this study, a calcein-AM fluorescence probe was used to detect changes in gap junctional intercellular communication in intestinal epithelial IEC-6 cells. Our results show that gap junctional intercellular communication of IEC-6 cells was reduced at 6, 12, 24, and 48 h after irradiation, with the most pronounced effect at 24 h. Western blotting and immunofluorescence results showed that the expression of Cx43, but not other connexins, was reduced in irradiated intestinal epithelial cells. Silencing of Cx43 reduced gap ...
Source: Radiation Research - February 20, 2024 Category: Physics Authors: Yue Zhu Jun Dai Bin Song Yuehua Zhang Tingyi Yang Hongwei Xu Xiaopeng Xu Yi Gao Tao Yan Weidong Shen Wenhao Zhang Shuyu Zhang Pengfei Liu Source Type: research
Development of a Radiation-induced Pulmonary Fibrosis Partial Body Irradiation Model in C57BL/6 Mice
In conclusion, a long-term model for radiation-induced pulmonary fibrosis was established, and countermeasures could be screened in this model for survival and protection/mitigation or recovery from radiation-induced pulmonary damage.PMID:38376474 | DOI:10.1667/RADE-23-00143.1 (Source: Radiation Research)
Source: Radiation Research - February 20, 2024 Category: Physics Authors: Vidya P Kumar Shalini Jaiswal Kefale Wuddie Jerrold M Ward Mark Lawrence Sanchita P Ghosh Source Type: research
Connexin 43 Prevents Radiation-Induced Intestinal Damage via the Ca2+-Dependent PI3K/Akt Signaling Pathway
This study aimed to investigate the expression and role of connexins in RIID and underlying mechanism. In this study, a calcein-AM fluorescence probe was used to detect changes in gap junctional intercellular communication in intestinal epithelial IEC-6 cells. Our results show that gap junctional intercellular communication of IEC-6 cells was reduced at 6, 12, 24, and 48 h after irradiation, with the most pronounced effect at 24 h. Western blotting and immunofluorescence results showed that the expression of Cx43, but not other connexins, was reduced in irradiated intestinal epithelial cells. Silencing of Cx43 reduced gap ...
Source: Radiation Research - February 20, 2024 Category: Physics Authors: Yue Zhu Jun Dai Bin Song Yuehua Zhang Tingyi Yang Hongwei Xu Xiaopeng Xu Yi Gao Tao Yan Weidong Shen Wenhao Zhang Shuyu Zhang Pengfei Liu Source Type: research
Development of a Radiation-induced Pulmonary Fibrosis Partial Body Irradiation Model in C57BL/6 Mice
In conclusion, a long-term model for radiation-induced pulmonary fibrosis was established, and countermeasures could be screened in this model for survival and protection/mitigation or recovery from radiation-induced pulmonary damage.PMID:38376474 | DOI:10.1667/RADE-23-00143.1 (Source: Radiation Research)
Source: Radiation Research - February 20, 2024 Category: Physics Authors: Vidya P Kumar Shalini Jaiswal Kefale Wuddie Jerrold M Ward Mark Lawrence Sanchita P Ghosh Source Type: research
FSL-1: A Synthetic Peptide Increases Survival in a Murine Model of Hematopoietic Acute Radiation Syndrome
Radiat Res. 2024 Feb 19. doi: 10.1667/RADE-23-00142.1. Online ahead of print.ABSTRACTIn the current geopolitical climate there is an unmet need to identify and develop prophylactic radiation countermeasures, particularly to ensure the well-being of warfighters and first responders that may be required to perform on radiation-contaminated fields for operational or rescue missions. Currently, no countermeasures have been approved by the U.S. FDA for prophylactic administration. Here we report on the efficacious nature of FSL-1 (toll-like receptor 2/6 agonist) and the protection from acute radiation syndrome (ARS) in a murine...
Source: Radiation Research - February 19, 2024 Category: Physics Authors: Gregory P Holmes-Hampton Vidya P Kumar Kaylee Valenzia Sanchita P Ghosh Source Type: research
Consumption of Apigenin Prevents Radiation-induced Gut Dysbiosis in Male C57BL/6J Mice Exposed to Silicon Ions
In conclusion, our results demonstrate the potential of dietary apigenin as a countermeasure against radiation-induced gut injuries due to its anti-inflammatory activity, reduction of gut microbiota dysbiosis, and increase in probiotic bacteria (e.g., Lachnospiraceae, Muribaculaceae and Bifidobacteriaceae).PMID:38373016 | DOI:10.1667/RADE-23-00110.1 (Source: Radiation Research)
Source: Radiation Research - February 19, 2024 Category: Physics Authors: Kanokporn Noy Rithidech Tanat Peanlikhit Louise Honikel Jinyu Li Jingxuan Liu Tobias Karakach Thomas Zimmerman James Welsh Source Type: research
CPNE1, A Potential Therapeutic Target in Nasopharyngeal Carcinoma, Affects Cell Growth and Radiation Resistance
In conclusion, these results demonstrated that CPNE1 expression is elevated in nasopharyngeal carcinoma cells, and its silencing could attenuate nasopharyngeal carcinoma advancement and improve radiosensitivity to radiation therapy by controlling Akt activation.PMID:38355101 | DOI:10.1667/RADE-23-00220.1 (Source: Radiation Research)
Source: Radiation Research - February 14, 2024 Category: Physics Authors: Shujuan Zhu Rui Li Kun Yin Liming Wu Source Type: research
