Enteric α-Defensin Contributes to Recovery of Radiation-Induced Intestinal Injury by Modulating Gut Microbiota and Fecal Metabolites
This study provides new insight into EαDs contribution to the recovery of radiation-induced intestinal damage, and suggests a potential novel target to prevent the adverse effects of radiotherapy.PMID:38124379 | DOI:10.1667/RADE-23-00071.1 (Source: Radiation Research)
Source: Radiation Research - December 21, 2023 Category: Physics Authors: Jie Wu Xi Ran Tao Wang Kun Xiong Shuang Long Yuhui Hao Peng Wang Aiping Wang Source Type: research

Enteric α-Defensin Contributes to Recovery of Radiation-Induced Intestinal Injury by Modulating Gut Microbiota and Fecal Metabolites
This study provides new insight into EαDs contribution to the recovery of radiation-induced intestinal damage, and suggests a potential novel target to prevent the adverse effects of radiotherapy.PMID:38124379 | DOI:10.1667/RADE-23-00071.1 (Source: Radiation Research)
Source: Radiation Research - December 21, 2023 Category: Physics Authors: Jie Wu Xi Ran Tao Wang Kun Xiong Shuang Long Yuhui Hao Peng Wang Aiping Wang Source Type: research

Enteric α-Defensin Contributes to Recovery of Radiation-Induced Intestinal Injury by Modulating Gut Microbiota and Fecal Metabolites
This study provides new insight into EαDs contribution to the recovery of radiation-induced intestinal damage, and suggests a potential novel target to prevent the adverse effects of radiotherapy.PMID:38124379 | DOI:10.1667/RADE-23-00071.1 (Source: Radiation Research)
Source: Radiation Research - December 21, 2023 Category: Physics Authors: Jie Wu Xi Ran Tao Wang Kun Xiong Shuang Long Yuhui Hao Peng Wang Aiping Wang Source Type: research

Enteric α-Defensin Contributes to Recovery of Radiation-Induced Intestinal Injury by Modulating Gut Microbiota and Fecal Metabolites
This study provides new insight into EαDs contribution to the recovery of radiation-induced intestinal damage, and suggests a potential novel target to prevent the adverse effects of radiotherapy.PMID:38124379 | DOI:10.1667/RADE-23-00071.1 (Source: Radiation Research)
Source: Radiation Research - December 21, 2023 Category: Physics Authors: Jie Wu Xi Ran Tao Wang Kun Xiong Shuang Long Yuhui Hao Peng Wang Aiping Wang Source Type: research

Enteric α-Defensin Contributes to Recovery of Radiation-Induced Intestinal Injury by Modulating Gut Microbiota and Fecal Metabolites
This study provides new insight into EαDs contribution to the recovery of radiation-induced intestinal damage, and suggests a potential novel target to prevent the adverse effects of radiotherapy.PMID:38124379 | DOI:10.1667/RADE-23-00071.1 (Source: Radiation Research)
Source: Radiation Research - December 21, 2023 Category: Physics Authors: Jie Wu Xi Ran Tao Wang Kun Xiong Shuang Long Yuhui Hao Peng Wang Aiping Wang Source Type: research

Modulation of Hematopoietic Injury by a Promising Radioprotector, Gamma-Tocotrienol, in Rhesus Macaques Exposed to Partial-Body Radiation
In this study, the ability of gamma-tocotrienol (GT3), a promising radioprotector and antioxidant, to ameliorate partial-body radiation-induced damage to the hematopoietic compartment was evaluated in a nonhuman primate (NHP) model. A total of 15 rhesus NHPs were divided into two groups, and were administered either GT3 or vehicle 24 h prior to 4 or 5.8 Gy partial-body irradiation (PBI), with 5% bone marrow (BM) sparing. Each group consisted of four NHPs, apart from the vehicle-treated group exposed to 5.8 Gy, which had only three NHPs. BM samples were collected 8 days prior to irradiation in addition to 2, 7, 14, and 30 d...
Source: Radiation Research - December 7, 2023 Category: Physics Authors: Tarun K Garg Sarita Garg Isabelle R Miousse Stephen Y Wise Alana D Carpenter Oluseyi O Fatanmi Frits van Rhee Vijay K Singh Martin Hauer-Jensen Source Type: research

Modulation of Hematopoietic Injury by a Promising Radioprotector, Gamma-Tocotrienol, in Rhesus Macaques Exposed to Partial-Body Radiation
In this study, the ability of gamma-tocotrienol (GT3), a promising radioprotector and antioxidant, to ameliorate partial-body radiation-induced damage to the hematopoietic compartment was evaluated in a nonhuman primate (NHP) model. A total of 15 rhesus NHPs were divided into two groups, and were administered either GT3 or vehicle 24 h prior to 4 or 5.8 Gy partial-body irradiation (PBI), with 5% bone marrow (BM) sparing. Each group consisted of four NHPs, apart from the vehicle-treated group exposed to 5.8 Gy, which had only three NHPs. BM samples were collected 8 days prior to irradiation in addition to 2, 7, 14, and 30 d...
Source: Radiation Research - December 7, 2023 Category: Physics Authors: Tarun K Garg Sarita Garg Isabelle R Miousse Stephen Y Wise Alana D Carpenter Oluseyi O Fatanmi Frits van Rhee Vijay K Singh Martin Hauer-Jensen Source Type: research

Modulation of Hematopoietic Injury by a Promising Radioprotector, Gamma-Tocotrienol, in Rhesus Macaques Exposed to Partial-Body Radiation
In this study, the ability of gamma-tocotrienol (GT3), a promising radioprotector and antioxidant, to ameliorate partial-body radiation-induced damage to the hematopoietic compartment was evaluated in a nonhuman primate (NHP) model. A total of 15 rhesus NHPs were divided into two groups, and were administered either GT3 or vehicle 24 h prior to 4 or 5.8 Gy partial-body irradiation (PBI), with 5% bone marrow (BM) sparing. Each group consisted of four NHPs, apart from the vehicle-treated group exposed to 5.8 Gy, which had only three NHPs. BM samples were collected 8 days prior to irradiation in addition to 2, 7, 14, and 30 d...
Source: Radiation Research - December 7, 2023 Category: Physics Authors: Tarun K Garg Sarita Garg Isabelle R Miousse Stephen Y Wise Alana D Carpenter Oluseyi O Fatanmi Frits van Rhee Vijay K Singh Martin Hauer-Jensen Source Type: research

Modulation of Hematopoietic Injury by a Promising Radioprotector, Gamma-Tocotrienol, in Rhesus Macaques Exposed to Partial-Body Radiation
In this study, the ability of gamma-tocotrienol (GT3), a promising radioprotector and antioxidant, to ameliorate partial-body radiation-induced damage to the hematopoietic compartment was evaluated in a nonhuman primate (NHP) model. A total of 15 rhesus NHPs were divided into two groups, and were administered either GT3 or vehicle 24 h prior to 4 or 5.8 Gy partial-body irradiation (PBI), with 5% bone marrow (BM) sparing. Each group consisted of four NHPs, apart from the vehicle-treated group exposed to 5.8 Gy, which had only three NHPs. BM samples were collected 8 days prior to irradiation in addition to 2, 7, 14, and 30 d...
Source: Radiation Research - December 7, 2023 Category: Physics Authors: Tarun K Garg Sarita Garg Isabelle R Miousse Stephen Y Wise Alana D Carpenter Oluseyi O Fatanmi Frits van Rhee Vijay K Singh Martin Hauer-Jensen Source Type: research

Modulation of Hematopoietic Injury by a Promising Radioprotector, Gamma-Tocotrienol, in Rhesus Macaques Exposed to Partial-Body Radiation
In this study, the ability of gamma-tocotrienol (GT3), a promising radioprotector and antioxidant, to ameliorate partial-body radiation-induced damage to the hematopoietic compartment was evaluated in a nonhuman primate (NHP) model. A total of 15 rhesus NHPs were divided into two groups, and were administered either GT3 or vehicle 24 h prior to 4 or 5.8 Gy partial-body irradiation (PBI), with 5% bone marrow (BM) sparing. Each group consisted of four NHPs, apart from the vehicle-treated group exposed to 5.8 Gy, which had only three NHPs. BM samples were collected 8 days prior to irradiation in addition to 2, 7, 14, and 30 d...
Source: Radiation Research - December 7, 2023 Category: Physics Authors: Tarun K Garg Sarita Garg Isabelle R Miousse Stephen Y Wise Alana D Carpenter Oluseyi O Fatanmi Frits van Rhee Vijay K Singh Martin Hauer-Jensen Source Type: research

Modulation of Hematopoietic Injury by a Promising Radioprotector, Gamma-Tocotrienol, in Rhesus Macaques Exposed to Partial-Body Radiation
In this study, the ability of gamma-tocotrienol (GT3), a promising radioprotector and antioxidant, to ameliorate partial-body radiation-induced damage to the hematopoietic compartment was evaluated in a nonhuman primate (NHP) model. A total of 15 rhesus NHPs were divided into two groups, and were administered either GT3 or vehicle 24 h prior to 4 or 5.8 Gy partial-body irradiation (PBI), with 5% bone marrow (BM) sparing. Each group consisted of four NHPs, apart from the vehicle-treated group exposed to 5.8 Gy, which had only three NHPs. BM samples were collected 8 days prior to irradiation in addition to 2, 7, 14, and 30 d...
Source: Radiation Research - December 7, 2023 Category: Physics Authors: Tarun K Garg Sarita Garg Isabelle R Miousse Stephen Y Wise Alana D Carpenter Oluseyi O Fatanmi Frits van Rhee Vijay K Singh Martin Hauer-Jensen Source Type: research

Modulation of Hematopoietic Injury by a Promising Radioprotector, Gamma-Tocotrienol, in Rhesus Macaques Exposed to Partial-Body Radiation
In this study, the ability of gamma-tocotrienol (GT3), a promising radioprotector and antioxidant, to ameliorate partial-body radiation-induced damage to the hematopoietic compartment was evaluated in a nonhuman primate (NHP) model. A total of 15 rhesus NHPs were divided into two groups, and were administered either GT3 or vehicle 24 h prior to 4 or 5.8 Gy partial-body irradiation (PBI), with 5% bone marrow (BM) sparing. Each group consisted of four NHPs, apart from the vehicle-treated group exposed to 5.8 Gy, which had only three NHPs. BM samples were collected 8 days prior to irradiation in addition to 2, 7, 14, and 30 d...
Source: Radiation Research - December 7, 2023 Category: Physics Authors: Tarun K Garg Sarita Garg Isabelle R Miousse Stephen Y Wise Alana D Carpenter Oluseyi O Fatanmi Frits van Rhee Vijay K Singh Martin Hauer-Jensen Source Type: research

Modulation of Hematopoietic Injury by a Promising Radioprotector, Gamma-Tocotrienol, in Rhesus Macaques Exposed to Partial-Body Radiation
In this study, the ability of gamma-tocotrienol (GT3), a promising radioprotector and antioxidant, to ameliorate partial-body radiation-induced damage to the hematopoietic compartment was evaluated in a nonhuman primate (NHP) model. A total of 15 rhesus NHPs were divided into two groups, and were administered either GT3 or vehicle 24 h prior to 4 or 5.8 Gy partial-body irradiation (PBI), with 5% bone marrow (BM) sparing. Each group consisted of four NHPs, apart from the vehicle-treated group exposed to 5.8 Gy, which had only three NHPs. BM samples were collected 8 days prior to irradiation in addition to 2, 7, 14, and 30 d...
Source: Radiation Research - December 7, 2023 Category: Physics Authors: Tarun K Garg Sarita Garg Isabelle R Miousse Stephen Y Wise Alana D Carpenter Oluseyi O Fatanmi Frits van Rhee Vijay K Singh Martin Hauer-Jensen Source Type: research

Modulation of Hematopoietic Injury by a Promising Radioprotector, Gamma-Tocotrienol, in Rhesus Macaques Exposed to Partial-Body Radiation
In this study, the ability of gamma-tocotrienol (GT3), a promising radioprotector and antioxidant, to ameliorate partial-body radiation-induced damage to the hematopoietic compartment was evaluated in a nonhuman primate (NHP) model. A total of 15 rhesus NHPs were divided into two groups, and were administered either GT3 or vehicle 24 h prior to 4 or 5.8 Gy partial-body irradiation (PBI), with 5% bone marrow (BM) sparing. Each group consisted of four NHPs, apart from the vehicle-treated group exposed to 5.8 Gy, which had only three NHPs. BM samples were collected 8 days prior to irradiation in addition to 2, 7, 14, and 30 d...
Source: Radiation Research - December 7, 2023 Category: Physics Authors: Tarun K Garg Sarita Garg Isabelle R Miousse Stephen Y Wise Alana D Carpenter Oluseyi O Fatanmi Frits van Rhee Vijay K Singh Martin Hauer-Jensen Source Type: research

Modulation of Hematopoietic Injury by a Promising Radioprotector, Gamma-Tocotrienol, in Rhesus Macaques Exposed to Partial-Body Radiation
In this study, the ability of gamma-tocotrienol (GT3), a promising radioprotector and antioxidant, to ameliorate partial-body radiation-induced damage to the hematopoietic compartment was evaluated in a nonhuman primate (NHP) model. A total of 15 rhesus NHPs were divided into two groups, and were administered either GT3 or vehicle 24 h prior to 4 or 5.8 Gy partial-body irradiation (PBI), with 5% bone marrow (BM) sparing. Each group consisted of four NHPs, apart from the vehicle-treated group exposed to 5.8 Gy, which had only three NHPs. BM samples were collected 8 days prior to irradiation in addition to 2, 7, 14, and 30 d...
Source: Radiation Research - December 7, 2023 Category: Physics Authors: Tarun K Garg Sarita Garg Isabelle R Miousse Stephen Y Wise Alana D Carpenter Oluseyi O Fatanmi Frits van Rhee Vijay K Singh Martin Hauer-Jensen Source Type: research