Immune Dysfunction from Radiation Exposure
Radiat Res. 2023 Oct;200(4):396-416. doi: 10.1667/rade-22-00004.1. Epub 2023 Sep 13.ABSTRACTThe hematopoietic system is highly sensitive to ionizing radiation. Damage to the immune system may result in opportunistic infections and hemorrhage, which could lead to mortality. Inflammation triggered by tissue damage can also lead to additional local or widespread tissue damage. The immune system is responsible for tissue repair and restoration, which is made more challenging when it is in the process of self-recovery. Because of these challenges, the Radiation and Nuclear Countermeasures Program (RNCP) and the Basic Immunology...
Source: Radiation Research - December 28, 2023 Category: Physics Authors: Brynn A Hollingsworth Jennifer T Aldrich Cullen M Case Andrea L DiCarlo Corey M Hoffman Ann A Jakubowski Qian Liu Shannon G Loelius Mercy PrabhuDas Thomas A Winters David R Cassatt Source Type: research
Alleviation of Splenic Injury by CB001 after Low-Dose Irradiation Mediated by NLRP3/Caspase-1-BAX/Caspase-3 Axis
Radiat Res. 2023 Dec 29. doi: 10.1667/RADE-22-00053.1. Online ahead of print.ABSTRACTLow-dose radiation has been extensively employed in clinical practice, including tumor immunotherapy, chronic inflammation treatment and nidus screening. However, the damage on the spleen caused by low-dose radiation significantly increases the risk of late infection-related mortality, and there is currently no corresponding protective strategy. In the present study, a novel compound preparation named CB001 mainly constituted of Acanthopanax senticosus (AS) and Oldenlandia diffusa (OD) was developed to alleviate splenic injury caused by fr...
Source: Radiation Research - December 28, 2023 Category: Physics Authors: Changkun Hu Zebin Liao Liangliang Zhang Zengchun Ma Chengrong Xiao Shuai Shao Yue Gao Source Type: research
Proximity Estimation and Quantification of Ionizing Radiation-induced DNA Lesions in Aqueous Media using Fluorescence Spectroscopy
Radiat Res. 2023 Dec 29. doi: 10.1667/RADE-23-00145.1. Online ahead of print.ABSTRACTClustered DNA damage (cluster) or a multiply damaged site, which is a region with two or more lesions within one or two helical turns, has a high mutagenic potential and causes cell death. We quantified fluorophore-labeled lesions and estimated their proximity through fluorescence anisotropy measurements depending on Förster resonance energy transfer (FRET) among the fluorophores close to each other. pUC19 plasmid DNA (2,686 base pairs) dissolved in water or 0.2 M Tris-HCl buffer at a concentration of 10 μg/μL was irradiated by several ...
Source: Radiation Research - December 28, 2023 Category: Physics Authors: Ken Akamatsu Katsuya Satoh Naoya Shikazono Takeshi Saito Source Type: research
Immune Dysfunction from Radiation Exposure
Radiat Res. 2023 Oct;200(4):396-416. doi: 10.1667/rade-22-00004.1. Epub 2023 Sep 13.ABSTRACTThe hematopoietic system is highly sensitive to ionizing radiation. Damage to the immune system may result in opportunistic infections and hemorrhage, which could lead to mortality. Inflammation triggered by tissue damage can also lead to additional local or widespread tissue damage. The immune system is responsible for tissue repair and restoration, which is made more challenging when it is in the process of self-recovery. Because of these challenges, the Radiation and Nuclear Countermeasures Program (RNCP) and the Basic Immunology...
Source: Radiation Research - December 28, 2023 Category: Physics Authors: Brynn A Hollingsworth Jennifer T Aldrich Cullen M Case Andrea L DiCarlo Corey M Hoffman Ann A Jakubowski Qian Liu Shannon G Loelius Mercy PrabhuDas Thomas A Winters David R Cassatt Source Type: research
Alleviation of Splenic Injury by CB001 after Low-Dose Irradiation Mediated by NLRP3/Caspase-1-BAX/Caspase-3 Axis
Radiat Res. 2023 Dec 29. doi: 10.1667/RADE-22-00053.1. Online ahead of print.ABSTRACTLow-dose radiation has been extensively employed in clinical practice, including tumor immunotherapy, chronic inflammation treatment and nidus screening. However, the damage on the spleen caused by low-dose radiation significantly increases the risk of late infection-related mortality, and there is currently no corresponding protective strategy. In the present study, a novel compound preparation named CB001 mainly constituted of Acanthopanax senticosus (AS) and Oldenlandia diffusa (OD) was developed to alleviate splenic injury caused by fr...
Source: Radiation Research - December 28, 2023 Category: Physics Authors: Changkun Hu Zebin Liao Liangliang Zhang Zengchun Ma Chengrong Xiao Shuai Shao Yue Gao Source Type: research
Proximity Estimation and Quantification of Ionizing Radiation-induced DNA Lesions in Aqueous Media using Fluorescence Spectroscopy
Radiat Res. 2023 Dec 29. doi: 10.1667/RADE-23-00145.1. Online ahead of print.ABSTRACTClustered DNA damage (cluster) or a multiply damaged site, which is a region with two or more lesions within one or two helical turns, has a high mutagenic potential and causes cell death. We quantified fluorophore-labeled lesions and estimated their proximity through fluorescence anisotropy measurements depending on Förster resonance energy transfer (FRET) among the fluorophores close to each other. pUC19 plasmid DNA (2,686 base pairs) dissolved in water or 0.2 M Tris-HCl buffer at a concentration of 10 μg/μL was irradiated by several ...
Source: Radiation Research - December 28, 2023 Category: Physics Authors: Ken Akamatsu Katsuya Satoh Naoya Shikazono Takeshi Saito Source Type: research
Immune Dysfunction from Radiation Exposure
Radiat Res. 2023 Oct;200(4):396-416. doi: 10.1667/rade-22-00004.1. Epub 2023 Sep 13.ABSTRACTThe hematopoietic system is highly sensitive to ionizing radiation. Damage to the immune system may result in opportunistic infections and hemorrhage, which could lead to mortality. Inflammation triggered by tissue damage can also lead to additional local or widespread tissue damage. The immune system is responsible for tissue repair and restoration, which is made more challenging when it is in the process of self-recovery. Because of these challenges, the Radiation and Nuclear Countermeasures Program (RNCP) and the Basic Immunology...
Source: Radiation Research - December 28, 2023 Category: Physics Authors: Brynn A Hollingsworth Jennifer T Aldrich Cullen M Case Andrea L DiCarlo Corey M Hoffman Ann A Jakubowski Qian Liu Shannon G Loelius Mercy PrabhuDas Thomas A Winters David R Cassatt Source Type: research
Alleviation of Splenic Injury by CB001 after Low-Dose Irradiation Mediated by NLRP3/Caspase-1-BAX/Caspase-3 Axis
Radiat Res. 2023 Dec 29. doi: 10.1667/RADE-22-00053.1. Online ahead of print.ABSTRACTLow-dose radiation has been extensively employed in clinical practice, including tumor immunotherapy, chronic inflammation treatment and nidus screening. However, the damage on the spleen caused by low-dose radiation significantly increases the risk of late infection-related mortality, and there is currently no corresponding protective strategy. In the present study, a novel compound preparation named CB001 mainly constituted of Acanthopanax senticosus (AS) and Oldenlandia diffusa (OD) was developed to alleviate splenic injury caused by fr...
Source: Radiation Research - December 28, 2023 Category: Physics Authors: Changkun Hu Zebin Liao Liangliang Zhang Zengchun Ma Chengrong Xiao Shuai Shao Yue Gao Source Type: research
Proximity Estimation and Quantification of Ionizing Radiation-induced DNA Lesions in Aqueous Media using Fluorescence Spectroscopy
Radiat Res. 2023 Dec 29. doi: 10.1667/RADE-23-00145.1. Online ahead of print.ABSTRACTClustered DNA damage (cluster) or a multiply damaged site, which is a region with two or more lesions within one or two helical turns, has a high mutagenic potential and causes cell death. We quantified fluorophore-labeled lesions and estimated their proximity through fluorescence anisotropy measurements depending on Förster resonance energy transfer (FRET) among the fluorophores close to each other. pUC19 plasmid DNA (2,686 base pairs) dissolved in water or 0.2 M Tris-HCl buffer at a concentration of 10 μg/μL was irradiated by several ...
Source: Radiation Research - December 28, 2023 Category: Physics Authors: Ken Akamatsu Katsuya Satoh Naoya Shikazono Takeshi Saito Source Type: research
Immune Dysfunction from Radiation Exposure
Radiat Res. 2023 Oct;200(4):396-416. doi: 10.1667/rade-22-00004.1. Epub 2023 Sep 13.ABSTRACTThe hematopoietic system is highly sensitive to ionizing radiation. Damage to the immune system may result in opportunistic infections and hemorrhage, which could lead to mortality. Inflammation triggered by tissue damage can also lead to additional local or widespread tissue damage. The immune system is responsible for tissue repair and restoration, which is made more challenging when it is in the process of self-recovery. Because of these challenges, the Radiation and Nuclear Countermeasures Program (RNCP) and the Basic Immunology...
Source: Radiation Research - December 28, 2023 Category: Physics Authors: Brynn A Hollingsworth Jennifer T Aldrich Cullen M Case Andrea L DiCarlo Corey M Hoffman Ann A Jakubowski Qian Liu Shannon G Loelius Mercy PrabhuDas Thomas A Winters David R Cassatt Source Type: research
Alleviation of Splenic Injury by CB001 after Low-Dose Irradiation Mediated by NLRP3/Caspase-1-BAX/Caspase-3 Axis
Radiat Res. 2023 Dec 29. doi: 10.1667/RADE-22-00053.1. Online ahead of print.ABSTRACTLow-dose radiation has been extensively employed in clinical practice, including tumor immunotherapy, chronic inflammation treatment and nidus screening. However, the damage on the spleen caused by low-dose radiation significantly increases the risk of late infection-related mortality, and there is currently no corresponding protective strategy. In the present study, a novel compound preparation named CB001 mainly constituted of Acanthopanax senticosus (AS) and Oldenlandia diffusa (OD) was developed to alleviate splenic injury caused by fr...
Source: Radiation Research - December 28, 2023 Category: Physics Authors: Changkun Hu Zebin Liao Liangliang Zhang Zengchun Ma Chengrong Xiao Shuai Shao Yue Gao Source Type: research
Proximity Estimation and Quantification of Ionizing Radiation-induced DNA Lesions in Aqueous Media using Fluorescence Spectroscopy
Radiat Res. 2023 Dec 29. doi: 10.1667/RADE-23-00145.1. Online ahead of print.ABSTRACTClustered DNA damage (cluster) or a multiply damaged site, which is a region with two or more lesions within one or two helical turns, has a high mutagenic potential and causes cell death. We quantified fluorophore-labeled lesions and estimated their proximity through fluorescence anisotropy measurements depending on Förster resonance energy transfer (FRET) among the fluorophores close to each other. pUC19 plasmid DNA (2,686 base pairs) dissolved in water or 0.2 M Tris-HCl buffer at a concentration of 10 μg/μL was irradiated by several ...
Source: Radiation Research - December 28, 2023 Category: Physics Authors: Ken Akamatsu Katsuya Satoh Naoya Shikazono Takeshi Saito Source Type: research
Immune Dysfunction from Radiation Exposure
Radiat Res. 2023 Oct;200(4):396-416. doi: 10.1667/rade-22-00004.1. Epub 2023 Sep 13.ABSTRACTThe hematopoietic system is highly sensitive to ionizing radiation. Damage to the immune system may result in opportunistic infections and hemorrhage, which could lead to mortality. Inflammation triggered by tissue damage can also lead to additional local or widespread tissue damage. The immune system is responsible for tissue repair and restoration, which is made more challenging when it is in the process of self-recovery. Because of these challenges, the Radiation and Nuclear Countermeasures Program (RNCP) and the Basic Immunology...
Source: Radiation Research - December 28, 2023 Category: Physics Authors: Brynn A Hollingsworth Jennifer T Aldrich Cullen M Case Andrea L DiCarlo Corey M Hoffman Ann A Jakubowski Qian Liu Shannon G Loelius Mercy PrabhuDas Thomas A Winters David R Cassatt Source Type: research
Alleviation of Splenic Injury by CB001 after Low-Dose Irradiation Mediated by NLRP3/Caspase-1-BAX/Caspase-3 Axis
Radiat Res. 2023 Dec 29. doi: 10.1667/RADE-22-00053.1. Online ahead of print.ABSTRACTLow-dose radiation has been extensively employed in clinical practice, including tumor immunotherapy, chronic inflammation treatment and nidus screening. However, the damage on the spleen caused by low-dose radiation significantly increases the risk of late infection-related mortality, and there is currently no corresponding protective strategy. In the present study, a novel compound preparation named CB001 mainly constituted of Acanthopanax senticosus (AS) and Oldenlandia diffusa (OD) was developed to alleviate splenic injury caused by fr...
Source: Radiation Research - December 28, 2023 Category: Physics Authors: Changkun Hu Zebin Liao Liangliang Zhang Zengchun Ma Chengrong Xiao Shuai Shao Yue Gao Source Type: research
Proximity Estimation and Quantification of Ionizing Radiation-induced DNA Lesions in Aqueous Media using Fluorescence Spectroscopy
Radiat Res. 2023 Dec 29. doi: 10.1667/RADE-23-00145.1. Online ahead of print.ABSTRACTClustered DNA damage (cluster) or a multiply damaged site, which is a region with two or more lesions within one or two helical turns, has a high mutagenic potential and causes cell death. We quantified fluorophore-labeled lesions and estimated their proximity through fluorescence anisotropy measurements depending on Förster resonance energy transfer (FRET) among the fluorophores close to each other. pUC19 plasmid DNA (2,686 base pairs) dissolved in water or 0.2 M Tris-HCl buffer at a concentration of 10 μg/μL was irradiated by several ...
Source: Radiation Research - December 28, 2023 Category: Physics Authors: Ken Akamatsu Katsuya Satoh Naoya Shikazono Takeshi Saito Source Type: research
