Iron Deposition in the Bone Marrow and Spleen of Nonhuman Primates with Acute Radiation Syndrome
Radiat Res. 2023 Nov 16. doi: 10.1667/RADE-23-00107.1. Online ahead of print.ABSTRACTThe risk of exposure to high levels of ionizing radiation from nuclear weapons or radiological accidents is an increasing world concern. Partial- or total-body exposure to high doses of radiation is potentially lethal through the induction of acute radiation syndrome (ARS). Hematopoietic cells are sensitive to radiation exposure; white blood cells primarily undergo apoptosis while red blood cells (RBCs) undergo hemolysis. Several laboratories demonstrated that the rapid hemolysis of RBCs results in the release of acellular iron into the bl...
Source: Radiation Research - November 15, 2023 Category: Physics Authors: Regina M Day W Bradley Rittase John E Slaven Sang-Ho Lee Grace V Brehm Dmitry T Bradfield Jeannie M Muir Stephen Y Wise Oluseyi O Fatanmi Vijay K Singh Source Type: research
Iron Deposition in the Bone Marrow and Spleen of Nonhuman Primates with Acute Radiation Syndrome
Radiat Res. 2023 Nov 16. doi: 10.1667/RADE-23-00107.1. Online ahead of print.ABSTRACTThe risk of exposure to high levels of ionizing radiation from nuclear weapons or radiological accidents is an increasing world concern. Partial- or total-body exposure to high doses of radiation is potentially lethal through the induction of acute radiation syndrome (ARS). Hematopoietic cells are sensitive to radiation exposure; white blood cells primarily undergo apoptosis while red blood cells (RBCs) undergo hemolysis. Several laboratories demonstrated that the rapid hemolysis of RBCs results in the release of acellular iron into the bl...
Source: Radiation Research - November 15, 2023 Category: Physics Authors: Regina M Day W Bradley Rittase John E Slaven Sang-Ho Lee Grace V Brehm Dmitry T Bradfield Jeannie M Muir Stephen Y Wise Oluseyi O Fatanmi Vijay K Singh Source Type: research
Chelation Modeling of a Plutonium-238 Inhalation Incident Treated with Delayed DTPA
Radiat Res. 2023 Nov 14. doi: 10.1667/RADE-23-00135.1. Online ahead of print.ABSTRACTThis work describes an analysis, using a previously established chelation model, of the bioassay data collected from a worker who received delayed chelation therapy following a plutonium-238 inhalation. The details of the case have already been described in two publications. The individual was treated with Ca-DTPA via multiple intravenous injections and then nebulizations beginning several months after the intake and continuing for four years. The exact date and circumstances of the intake are unknown. However, interviews with the worker s...
Source: Radiation Research - November 13, 2023 Category: Physics Authors: Sara Dumit Guthrie Miller Olivier Gr émy Deepesh Poudel Luiz Bertelli John A Klumpp Source Type: research
Chelation Modeling of a Plutonium-238 Inhalation Incident Treated with Delayed DTPA
Radiat Res. 2023 Nov 14. doi: 10.1667/RADE-23-00135.1. Online ahead of print.ABSTRACTThis work describes an analysis, using a previously established chelation model, of the bioassay data collected from a worker who received delayed chelation therapy following a plutonium-238 inhalation. The details of the case have already been described in two publications. The individual was treated with Ca-DTPA via multiple intravenous injections and then nebulizations beginning several months after the intake and continuing for four years. The exact date and circumstances of the intake are unknown. However, interviews with the worker s...
Source: Radiation Research - November 13, 2023 Category: Physics Authors: Sara Dumit Guthrie Miller Olivier Gr émy Deepesh Poudel Luiz Bertelli John A Klumpp Source Type: research
Chelation Modeling of a Plutonium-238 Inhalation Incident Treated with Delayed DTPA
Radiat Res. 2023 Nov 14. doi: 10.1667/RADE-23-00135.1. Online ahead of print.ABSTRACTThis work describes an analysis, using a previously established chelation model, of the bioassay data collected from a worker who received delayed chelation therapy following a plutonium-238 inhalation. The details of the case have already been described in two publications. The individual was treated with Ca-DTPA via multiple intravenous injections and then nebulizations beginning several months after the intake and continuing for four years. The exact date and circumstances of the intake are unknown. However, interviews with the worker s...
Source: Radiation Research - November 13, 2023 Category: Physics Authors: Sara Dumit Guthrie Miller Olivier Gr émy Deepesh Poudel Luiz Bertelli John A Klumpp Source Type: research
Thermoluminescence Characteristics of Copper and Terbium Co-Doped Lithium Tetraborate Glass
In this study, the preparation and characterization of copper (Cu) and terbium (Tb) co-doped lithium borate glass using spectroscopic and thermoluminescence techniques are reported. A thermal treatment was introduced to increase the degree of crystallinity. The thermoluminescence glow curve signal of the samples displayed upon exposure to beta radiation was measured and analyzed. It was found that the samples doped with 0.1% of copper and co-doped with 0.3% terbium showed the highest thermoluminescent (TL) signal in response to the irradiated dose. The analyses revealed that the glow curves of the doped samples were compos...
Source: Radiation Research - November 6, 2023 Category: Physics Authors: Nabil El-Faramawy Mohamed El-Kinawy Shrouk Farouk Mohamed Sabry Hassan F El-Nashar Alessia Mafodda Clemens Woda Source Type: research
Thermoluminescence Characteristics of Copper and Terbium Co-Doped Lithium Tetraborate Glass
In this study, the preparation and characterization of copper (Cu) and terbium (Tb) co-doped lithium borate glass using spectroscopic and thermoluminescence techniques are reported. A thermal treatment was introduced to increase the degree of crystallinity. The thermoluminescence glow curve signal of the samples displayed upon exposure to beta radiation was measured and analyzed. It was found that the samples doped with 0.1% of copper and co-doped with 0.3% terbium showed the highest thermoluminescent (TL) signal in response to the irradiated dose. The analyses revealed that the glow curves of the doped samples were compos...
Source: Radiation Research - November 6, 2023 Category: Physics Authors: Nabil El-Faramawy Mohamed El-Kinawy Shrouk Farouk Mohamed Sabry Hassan F El-Nashar Alessia Mafodda Clemens Woda Source Type: research
Thermoluminescence Characteristics of Copper and Terbium Co-Doped Lithium Tetraborate Glass
In this study, the preparation and characterization of copper (Cu) and terbium (Tb) co-doped lithium borate glass using spectroscopic and thermoluminescence techniques are reported. A thermal treatment was introduced to increase the degree of crystallinity. The thermoluminescence glow curve signal of the samples displayed upon exposure to beta radiation was measured and analyzed. It was found that the samples doped with 0.1% of copper and co-doped with 0.3% terbium showed the highest thermoluminescent (TL) signal in response to the irradiated dose. The analyses revealed that the glow curves of the doped samples were compos...
Source: Radiation Research - November 6, 2023 Category: Physics Authors: Nabil El-Faramawy Mohamed El-Kinawy Shrouk Farouk Mohamed Sabry Hassan F El-Nashar Alessia Mafodda Clemens Woda Source Type: research
Thermoluminescence Characteristics of Copper and Terbium Co-Doped Lithium Tetraborate Glass
In this study, the preparation and characterization of copper (Cu) and terbium (Tb) co-doped lithium borate glass using spectroscopic and thermoluminescence techniques are reported. A thermal treatment was introduced to increase the degree of crystallinity. The thermoluminescence glow curve signal of the samples displayed upon exposure to beta radiation was measured and analyzed. It was found that the samples doped with 0.1% of copper and co-doped with 0.3% terbium showed the highest thermoluminescent (TL) signal in response to the irradiated dose. The analyses revealed that the glow curves of the doped samples were compos...
Source: Radiation Research - November 6, 2023 Category: Physics Authors: Nabil El-Faramawy Mohamed El-Kinawy Shrouk Farouk Mohamed Sabry Hassan F El-Nashar Alessia Mafodda Clemens Woda Source Type: research
Thermoluminescence Characteristics of Copper and Terbium Co-Doped Lithium Tetraborate Glass
In this study, the preparation and characterization of copper (Cu) and terbium (Tb) co-doped lithium borate glass using spectroscopic and thermoluminescence techniques are reported. A thermal treatment was introduced to increase the degree of crystallinity. The thermoluminescence glow curve signal of the samples displayed upon exposure to beta radiation was measured and analyzed. It was found that the samples doped with 0.1% of copper and co-doped with 0.3% terbium showed the highest thermoluminescent (TL) signal in response to the irradiated dose. The analyses revealed that the glow curves of the doped samples were compos...
Source: Radiation Research - November 6, 2023 Category: Physics Authors: Nabil El-Faramawy Mohamed El-Kinawy Shrouk Farouk Mohamed Sabry Hassan F El-Nashar Alessia Mafodda Clemens Woda Source Type: research
Thermoluminescence Characteristics of Copper and Terbium Co-Doped Lithium Tetraborate Glass
In this study, the preparation and characterization of copper (Cu) and terbium (Tb) co-doped lithium borate glass using spectroscopic and thermoluminescence techniques are reported. A thermal treatment was introduced to increase the degree of crystallinity. The thermoluminescence glow curve signal of the samples displayed upon exposure to beta radiation was measured and analyzed. It was found that the samples doped with 0.1% of copper and co-doped with 0.3% terbium showed the highest thermoluminescent (TL) signal in response to the irradiated dose. The analyses revealed that the glow curves of the doped samples were compos...
Source: Radiation Research - November 6, 2023 Category: Physics Authors: Nabil El-Faramawy Mohamed El-Kinawy Shrouk Farouk Mohamed Sabry Hassan F El-Nashar Alessia Mafodda Clemens Woda Source Type: research
A New Method for Estimating Glomerular Filtration Rate in Rhesus Macaques (Macaca mulatta)
In this study, we aimed to determine if the Schwartz formula as used in human pediatric medicine can estimate GFR in rhesus macaques. We hypothesized that iohexol-GFR would correlate with the Schwartz formula-estimated GFR (eGFR) in irradiated and non-irradiated rhesus macaques. Twelve rhesus macaques [age 5-14 years (mean 7 years); 5 females, 7 males] with a range of BUN levels were selected for comparison to 4 non-irradiated controls (2 females, 2 males). Irradiated animals were divided by BUN into 3 groups: BUN ≤20 mg/dL (n = 4), BUN >20-24 mg/dL (n = 4), and BUN ≥25 mg/dL (n = 4). Baseline serum chemistry and ur...
Source: Radiation Research - October 30, 2023 Category: Physics Authors: Allison M Tomasino John D Olson George W Schaaf Anderson O Cox Cristina M Furdui J Mark Cline Eric P Cohen Source Type: research
Temporal Dynamic Regulation of Autophagy and Senescence Induction in Response to Radiation Exposure
Radiat Res. 2023 Oct 30. doi: 10.1667/RADE-23-00173.1. Online ahead of print.ABSTRACTAutophagy and senescence are closely related cellular responses to genotoxic stress, and play significant roles in the execution of cellular responses to radiation exposure. However, little is known about their interplay in the fate-decision of cells receiving lethal doses of radiation. Here, we report that autophagy precedes the establishment of premature senescence in normal human fibroblasts exposed to lethal doses of radiation. Activation of the p53-dependent DNA damage response caused sustained dephosphorylation of RB proteins and con...
Source: Radiation Research - October 30, 2023 Category: Physics Authors: Miho Noguchi Tomokazu Ihara Keiji Suzuki Akinari Yokoya Source Type: research
A New Method for Estimating Glomerular Filtration Rate in Rhesus Macaques (Macaca mulatta)
In this study, we aimed to determine if the Schwartz formula as used in human pediatric medicine can estimate GFR in rhesus macaques. We hypothesized that iohexol-GFR would correlate with the Schwartz formula-estimated GFR (eGFR) in irradiated and non-irradiated rhesus macaques. Twelve rhesus macaques [age 5-14 years (mean 7 years); 5 females, 7 males] with a range of BUN levels were selected for comparison to 4 non-irradiated controls (2 females, 2 males). Irradiated animals were divided by BUN into 3 groups: BUN ≤20 mg/dL (n = 4), BUN >20-24 mg/dL (n = 4), and BUN ≥25 mg/dL (n = 4). Baseline serum chemistry and ur...
Source: Radiation Research - October 30, 2023 Category: Physics Authors: Allison M Tomasino John D Olson George W Schaaf Anderson O Cox Cristina M Furdui J Mark Cline Eric P Cohen Source Type: research
Temporal Dynamic Regulation of Autophagy and Senescence Induction in Response to Radiation Exposure
Radiat Res. 2023 Oct 30. doi: 10.1667/RADE-23-00173.1. Online ahead of print.ABSTRACTAutophagy and senescence are closely related cellular responses to genotoxic stress, and play significant roles in the execution of cellular responses to radiation exposure. However, little is known about their interplay in the fate-decision of cells receiving lethal doses of radiation. Here, we report that autophagy precedes the establishment of premature senescence in normal human fibroblasts exposed to lethal doses of radiation. Activation of the p53-dependent DNA damage response caused sustained dephosphorylation of RB proteins and con...
Source: Radiation Research - October 30, 2023 Category: Physics Authors: Miho Noguchi Tomokazu Ihara Keiji Suzuki Akinari Yokoya Source Type: research
