Ivermectin: potential candidate for the treatment of Covid 19.
PMID: 32615072 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - June 28, 2020 Category: Infectious Diseases Authors: Gupta D, Sahoo AK, Singh A Tags: Braz J Infect Dis Source Type: research

Mild and asymptomatic cases of COVID-19 are potential threat for faecal-oral transmission.
PMID: 32615073 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - June 28, 2020 Category: Infectious Diseases Authors: Teixeira SC Tags: Braz J Infect Dis Source Type: research

Calcineurin inhibitors revisited: A new paradigm for COVID-19?
Abstract The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can cause mild, moderate or severe disease (COVID-19). In severe disease, there is hyperinflammation causing severe symptoms. Severe COVID-19 is an immunological phenomenon, rather than viral load. Therapies for COVID-19 are investigational therapies. In case of severe disease, treatment with a calcineurin inhibitor could be promising. In this article we explain the mechanisms of calcineurin inhibitor treatment in COVID-19, based on the experience seen in solid organ transplant recipients who suffered from COVID-19. PMID: 32603679 [PubM...
Source: Braz J Infect Dis - June 27, 2020 Category: Infectious Diseases Authors: Hage R, Steinack C, Schuurmans MM Tags: Braz J Infect Dis Source Type: research

Pediatric bacterial meningitis and meningococcal disease profile in a Brazilian General Hospital.
CONCLUSION: Morbidity and mortality rates from bacterial meningitis and meningococcal disease remain high, requiring hospitalization and leading to sequelae. Our study observed a reduced incidence of bacterial disease over the last decade, possibly reflecting the impact of vaccination. PMID: 32598866 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - June 26, 2020 Category: Infectious Diseases Authors: Blanco BP, Branas PCAA, Yoshioka CRM, Ferronato AE Tags: Braz J Infect Dis Source Type: research

Association between NDO-LID and PGL-1 for leprosy and class I and II HLA alleles in an indigenous community in Southwest Amazon.
Abstract The frequencies of the HLA alleles in the Puyanawa indigenous reserve population and their association with the NDO-LID and ELISA PGL-1 rapid serological test was assessed. This was a cross-sectional study with an epidemiological clinical design conducted in two indigenous communities in the state of Acre, Brazil. Blood was collected in a tube with EDTA to identify HLA alleles and perform serological tests. DNA was obtained using the salting out procedure. The LabType™ technique (One-Lambda-USA) was used for HLA class I (loci A*, B* and C*) and II (loci DRB1*, DQA1* and DQB1*) typing. Allele frequen...
Source: Braz J Infect Dis - June 23, 2020 Category: Infectious Diseases Authors: Teles SF, Silva EA, Souza RM, Tomimori J, Florian MC, Souza RO, Marcos EVC, Souza-Santana FC, Gamba MA Tags: Braz J Infect Dis Source Type: research

First molecular detection of Coxiella burnetii in Brazilian artisanal cheese: a neglected food safety hazard in ready-to-eat raw-milk product Coxiella burnetii in raw-milk cheese.
CONCLUSION: To our knowledge, this is the first report of highly heat-resistant zoonotic pathogen in raw-milk Brazilian artisanal cheese. This food safety hazard has been completely neglected in ready-to-eat raw-milk Brazilian artisanal cheese and could imply potential threats to consumers, since C. burnetii survives in artisanal cheese submitted to long ripening periods. Thus, this work established random and representative baseline prevalence of C. burnetii in this food product in Brazil. Further epidemiological studies, monitoring trends and setting control targets are warranted. Finally, these results point out the imp...
Source: Braz J Infect Dis - June 18, 2020 Category: Infectious Diseases Authors: Rozental T, Faria LS, Forneas D, Guterres A, Ribeiro JB, Araújo FR, Lemos ERS, Silva MR Tags: Braz J Infect Dis Source Type: research

Osteopenia and osteoporosis among treatment-experienced people living with HIV.
CONCLUSIONS: This study showed a high frequency of bone changes, especially in PLHIV older than 50 years. This information is useful to stimulate the screening and timely intervention of this comorbidity of PLHIV on prolonged use of ART in order to prevent or minimize complications and new demands on the healthcare system. PMID: 32553468 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - June 15, 2020 Category: Infectious Diseases Authors: Lara BMC, Pádua CM, Mendicino CCP, Rocha GM Tags: Braz J Infect Dis Source Type: research

First lung transplantation in a HIV patient in Brazil.
PMID: 32553467 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - June 14, 2020 Category: Infectious Diseases Authors: Reis FPD, Camargo LFA, Junior JEA, Samano MN, Pego-Fernandes PM Tags: Braz J Infect Dis Source Type: research

Can diabetes mellitus modify the plasma concentrations of rifampicin in patients under treatment for tuberculosis?
Vieira JLF Abstract Rifampicin is a key component of treatment for tuberculosis and its efficacy is determined by the blood levels attained after therapeutic doses. However, there is a high variability of rifampicin blood levels that is related to both the patient and the formulation used. To date, the effect of diabetes mellitus on the plasma levels of rifampicin was low exploited, which could be relevant either by the significant increase of the comorbidity worldwide as by the probable influence of diabetes on the rifampicin exposure. The study aims to evaluate whether diabetes mellitus contribute to the variat...
Source: Braz J Infect Dis - June 11, 2020 Category: Infectious Diseases Authors: Fonseca AAD, Pinto ACG, Paixão TPD, Albério CAA, Vieira JLF Tags: Braz J Infect Dis Source Type: research

A broad-spectrum beta-lactam-sparing stewardship program in a middle-income country public hospital: antibiotic use and expenditure outcomes and antimicrobial susceptibility profiles.
Abstract BACKGROUND: Antimicrobial stewardship programs (ASP) are an efficient way to reduce inappropriate use of antimicrobials and costs; however, supporting data are scarce in middle-income countries. The aim of this study was to evaluate antibiotic use, bacterial susceptibility profiles, and the economic impact following implementation of a broad-spectrum beta-lactam-sparing ASP. METHODS: An interrupted time-series (ITS) analysis was performed to evaluate antibiotic use and expenditure over a 24-month period (12 months before the ASP and in the 12 months after implementation of the ASP). Antibiotics were ...
Source: Braz J Infect Dis - June 3, 2020 Category: Infectious Diseases Authors: Zequinao T, Gasparetto J, Oliveira DDS, Silva GT, Telles JP, Tuon FF Tags: Braz J Infect Dis Source Type: research

Telemedicine as a tool for PrEP delivery during the COVID-19 pandemic in a large HIV prevention service in Rio de Janeiro-Brazil.
Abstract COVID-19 public health responses such as social distancing and community containment measures protocols are critical to preventing and containing the spread of coronavirus. Brazil accounts for almost half of Latin American HIV cases and Rio de Janeiro is the city with the second largest number of AIDS. Clinical appointments and pharmacy antiretroviral refills may be impaired due to restricted traffic and possible lockdowns, preventing people living with HIV and those using PrEP from accessing needed antiretrovirals. We hereby describe the telemedicine procedures implemented in a large PrEP delivery in Rio...
Source: Braz J Infect Dis - May 31, 2020 Category: Infectious Diseases Authors: Hoagland B, Torres TS, Bezerra DRB, Geraldo K, Pimenta C, Veloso VG, Grinsztejn B Tags: Braz J Infect Dis Source Type: research

Analysis of clinical and demographic heterogeneity of patients dying from COVID-19 in Brazil versus China and Italy.
PMID: 32479748 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - May 29, 2020 Category: Infectious Diseases Authors: Oliveira MHS, Wong J, Lippi G, Henry BM Tags: Braz J Infect Dis Source Type: research

Seroprevalence and factors associated with HIV-1, HTLV and Hepatitis B/C infections in parturient women of Salvador - Bahia, Brazil.
CONCLUSIONS: The seroprevalence rates for HIV, HCV, HBV, and HTLV were similar to that found in previous studies in other Brazilian regions. The high individual, socioeconomic, and social vulnerability detected in seropositive parturient women indicates the need to improve coverage and effectiveveness of STDs control with prevention, detection and monitoring strategies, focusing in pregnant women exposed to high biopsychosocial risk. PMID: 32464116 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - May 25, 2020 Category: Infectious Diseases Authors: Vargas L, Bastos F, Guimarães A, Amaral S, Fausto T, Arriaga M, Sarno M, Brites C Tags: Braz J Infect Dis Source Type: research

Cost minimization analysis and validation of a cytomegalovirus quantitative in-house real time PCR assay in relation to m2000 RealTime System.
CONCLUSIONS: These results demonstrated that in-house qPCR testing is a possible alternative in comparison to automated platforms, being considerably less expensive and as efficacious as the commercial methods. PMID: 32450055 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - May 23, 2020 Category: Infectious Diseases Authors: Caurio CFB, Allende OS, Kist R, Vasconcellos ICS, Rozales FP, Reck-Kortmann M, DallaLana DF, Alegretti AP, Neto GB, Pasqualotto AC Tags: Braz J Infect Dis Source Type: research

High prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae at an STI clinic in Western French Guiana.
Abstract The purpose of this study was to estimate the prevalence of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections in western French Guiana and to analyze associated factors with both infections. A retrospective study was conducted in a sexually transmitted infections (STI) clinic in 2017. Women (n=338) were tested by real-time PCR for vaginal, anal and throat CT and NG infections. Men (n=192) were evaluated using urine specimens. Socio-demographic and sexual behaviour data were collected by nurses with a structured questionnaire. The prevalence of CT and NG infections among women were 24.3%...
Source: Braz J Infect Dis - May 19, 2020 Category: Infectious Diseases Authors: Manca MF, Stettler LR, Carod JF, Agostini C, Jolivet A Tags: Braz J Infect Dis Source Type: research

Nontuberculous mycobacterial infection in a tertiary care center in Mexico, 2001-2017.
CONCLUSIONS: Our results show a significant increase in the number of NTM infections in our setting. Patients with SGM infections were mainly persons living with HIV. Older patients with chronic diseases were common among those with RGM infections. For NTM lung infection, antibiotic therapy should be carefully individualized. PMID: 32428442 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - May 16, 2020 Category: Infectious Diseases Authors: Lopez-Luis BA, Sifuentes-Osornio J, Pérez-Gutiérrez MT, Chávez-Mazari B, Bobadilla-Del-Valle M, Ponce-de-León A Tags: Braz J Infect Dis Source Type: research

Clinical utilization of bacteriophages: a new perspective to combat the antimicrobial resistance in Brazil.
Abstract Due to the emergence of multi-drug resistant bacteria, and the evident limitation in therapeutic options, alternatives to combat bacterial infections have been sought. One of these is phage therapy, which is the use of bacterial viruses to kill pathogenic bacteria responsible for the infection. These viruses called bacteriophages are very abundant organisms in the world and are harmless to humans. There are several advantages in using phage therapy, especially against multi-drug resistant pathogens, which tend to be dominated by individual strains. The advantages include fewer collateral effects such as l...
Source: Braz J Infect Dis - May 15, 2020 Category: Infectious Diseases Authors: Martins WMBS, Toleman MA, Gales AC Tags: Braz J Infect Dis Source Type: research

Viral metagenomics performed in patients with acute febrile syndrome during Toxoplasma gondii outbreak in south Brazil.
In conclusion, our findings show the importance of mNGS use to help characterize the outbreak more completely and in the management of the affected patients. PMID: 32422120 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - May 15, 2020 Category: Infectious Diseases Authors: Bezerra RDS, Diefenbach CF, Pereira DV, Kashima S, Slavov SN Tags: Braz J Infect Dis Source Type: research

Real-world evidence in antiretroviral therapy: drug safety data.
to B PMID: 32417161 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - May 14, 2020 Category: Infectious Diseases Authors: Silva AM, Pereira M, Dias CC, Ventura Â, Sousa-Pinto B Tags: Braz J Infect Dis Source Type: research

The 2019-2020 coronavirus pandemic in Italy: immunologic and cultural hurdles on the road to a cure.
PMID: 32404266 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - May 6, 2020 Category: Infectious Diseases Authors: Virgilio E Tags: Braz J Infect Dis Source Type: research

An infant with a mild SARS-CoV-2 infection detected only by anal swabs: a case report.
We present a mild SARS-CoV-2 infection in a baby with non-productive cough and normal chest computed tomography, in whom only anal swabs tested positive by real-time PCR testing for SARS-CoV-2. She was given atomization inhalation therapy with recombinant human interferon alfa-1b for 10 days. Her anal swabs remained positive for eight days, whereas her throat swabs were persistently negative by real-time PCR testing. Mild and asymptomatic cases, especially in children, might present with PCR negative pharyngeal/nasal swabs and PCR positive anal swabs. Those patients are potential sources of infection via fecal-oral transmi...
Source: Braz J Infect Dis - May 6, 2020 Category: Infectious Diseases Authors: Li J, Feng J, Liu TH, Xu FC, Song GQ Tags: Braz J Infect Dis Source Type: research

Will environmental changes in temperature affect the course of COVID-19?
Abstract While the outbreak has reached every region of the world, it is undeniable that countries in the southern hemisphere seem to be less affected, where cases have been reported, these have been imported and travel related. We analyzed the climate temperature from various regions according to their current ongoing human-to-human transmission (OHHT) status. We studied 3 groups; Group 1, 10 provinces from China with majority of COVID-19 cases; Group 2, areas where continuous horizontal transmission outside of China had been reported; and group 3, areas where imported cases had been detected and no horizontal tr...
Source: Braz J Infect Dis - May 4, 2020 Category: Infectious Diseases Authors: Del Rio C, Camacho-Ortiz A Tags: Braz J Infect Dis Source Type: research

Joint report of SBI (Brazilian Society of Infectious Diseases), FEBRASGO (Brazilian Federation of Gynecology and Obstetrics Associations), SBU (Brazilian Society of Urology) and SBPC/ML (Brazilian Society of Clinical Pathology/Laboratory Medicine): recommendations for the clinical management of lower urinary tract infections in pregnant and non-pregnant women.
Abstract Urinary tract infection (UTI) is a common condition in women and there is an increased concern of reduction of bacterial susceptibility resulting from wrongly prescribing antimicrobials. This paper summarizes the recommendations of four Brazilian medical societies (SBI - Brazilian Society of Infectious Diseases, FEBRASGO - Brazilian Federation of Gynecology and Obstetrics Associations, SBU - Brazilian Society of Urology, and SBPC/ML - Brazilian Society of Clinical Pathology/Laboratory Medicine) on the management of urinary tract infection in women. Asymptomatic bacteriuria should be screened at least twic...
Source: Braz J Infect Dis - April 30, 2020 Category: Infectious Diseases Authors: de Rossi P, Cimerman S, Truzzi JC, Cunha CAD, Mattar R, Martino MDV, Hachul M, Andriolo A, Neto JAV, Pereira-Correia JA, Machado AMO, Gales AC Tags: Braz J Infect Dis Source Type: research

Profile of drug-drug interactions (DIs) and impact on the effectiveness of antiretroviral therapy among patients living with HIV followed at an Infectious Diseases Referral Center in Belo Horizonte, Brazil.
The objectives of this study were to describe the profile of these interactions, their prevalence and their classification according to the potential for significant or non-significant DIs. From June 2015 to July 2016, PLWH on follow-up at an Infectious Diseases Referral Center in Belo Horizonte, Brazil have been investigated for the presence of DIs. A total of 304 patients were included and the majority (75%) had less than 50 years of age, male (66.4%), and 37.8% self-defined as brown skinned. Approximately 24% were on five or more medications and half of them presented with DIs. Patients older than 50 years had a higher ...
Source: Braz J Infect Dis - April 29, 2020 Category: Infectious Diseases Authors: Pontelo BM, Greco DB, Guimarães NS, Rotsen N, Braga VAR, Pimentel PHN, Barbosa H, Barroso TM, Tupinambás U Tags: Braz J Infect Dis Source Type: research

Evaluation of in vitro activity of ceftolozane-tazobactam against recent clinical bacterial isolates from Brazil - the EM200 study.
CONCLUSIONS: Ceftolozane-tazobactam has shown relevant activity against a large variety of the analyzed microorganisms collected from multiple centers in Brazil, showing promising results even in multidrug resistant strains. PMID: 32360070 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - April 28, 2020 Category: Infectious Diseases Authors: Tuon FF, Cieslinski J, Rodrigues SDS, Serra FB, Paula MD Tags: Braz J Infect Dis Source Type: research

"Penumbra sign" of Brodie's abscess.
"Penumbra sign" of Brodie's abscess. Braz J Infect Dis. 2020 Apr 25;: Authors: Wright WF PMID: 32343951 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - April 25, 2020 Category: Infectious Diseases Authors: Wright WF Tags: Braz J Infect Dis Source Type: research

Reactivity of sera from dogs living in a leishmaniasis-endemic area to the COOH-terminal region of cysteine proteinase B.
Abstract Cysteine proteinases are well-known virulence factors of Leishmania spp. with demonstrated actions in both experimental mouse infection and human infection. However, studies on these enzymes in canine leishmaniasis are scarce. Here, we show, for the first time, the reactivity of sera from dogs living in an endemic area to a recombinant protein from the COOH-terminal region of cysteine B protease (rcyspep). In this work, enzyme-linked immunosorbent assays were performed using a 14-kDa rcyspep protein obtained through a pET28-a expression system in Escherichia coli. First, 96-well plates were coated with rc...
Source: Braz J Infect Dis - April 25, 2020 Category: Infectious Diseases Authors: Barral-Veloso L, Melo BCA, Santos-de-Souza R, Cysne-Finkelstein L, Silva FS, Santos FN, Sousa JF, Alves CR Tags: Braz J Infect Dis Source Type: research

Deep impact of COVID-19 in the healthcare of Latin America: the case of Brazil.
es AJ PMID: 32335078 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - April 23, 2020 Category: Infectious Diseases Authors: Cimerman S, Chebabo A, Cunha CAD, Rodríguez-Morales AJ Tags: Braz J Infect Dis Source Type: research

New laboratory perspectives for evaluation of vivax malaria infected patients: a useful tool for infection monitoring.
Abstract In recent years, the number of cases with severe Plasmodium vivax malaria has shown an increasing trend. It is, therefore, important to identify routine laboratory markers that best characterize the acute disease phase and can serve as a tool for clinical follow-up of patients. In a cohort study, we followed 87 patients with acute P. vivax monoinfection acquired in an endemic region of the Brazilian Amazon. Forty-two different biochemical and hematological parameters frequently tested in clinical routine were evaluated at the acute phase and the convalescent phase. A total of 42 laboratory tests were perf...
Source: Braz J Infect Dis - April 23, 2020 Category: Infectious Diseases Authors: Alves-Junior ER, Gomes LT, Dombroski TCD, Nery AF, Filho SV, Nakazato L, Fontes CJF, Rios-Santos F Tags: Braz J Infect Dis Source Type: research

Mobile genetic elements associated with carbapenemase genes in South American Enterobacterales.
CONCLUSION: This review indicates that, like in other parts of the world, the most commonly reported carbapenemases in Enterobacterales from South America are being disseminated through clones, plasmids, and transposons which have been previously reported in other parts of the world. PMID: 32325019 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - April 20, 2020 Category: Infectious Diseases Authors: Reyes JA, Melano R, Cárdenas PA, Trueba G Tags: Braz J Infect Dis Source Type: research

Tuberculosis associated with diabetes mellitus by age group in Brazil: a retrospective cohort study, 2007-2014.
This study analyzed the association between TB and DM (TBDM) in Brazil from 2007 to 2014. This was a retrospective cohort study carried out in 709,429 new cases of TB reported to the national disease notification system of the Brazilian Ministry of Health. Sociodemographic and clinical data, test results, and treatment outcomes were analyzed. TBDM was found in 6.0% of TB cases, mostly in men aged 18-59 years. The lethality rate was 5.1% higher in all age groups with diabetes, except in those older than 60 years of age. The frequency of multi-drug-resistant tuberculosis (MDR-TB) in patients with DM was higher in those witho...
Source: Braz J Infect Dis - April 13, 2020 Category: Infectious Diseases Authors: Evangelista MDSN, Maia R, Toledo JP, Abreu RG Tags: Braz J Infect Dis Source Type: research

Pulmonary involvement in patients with measles.
PMID: 32278677 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - April 9, 2020 Category: Infectious Diseases Authors: Hochhegger B, Zanetti G, Marchiori E Tags: Braz J Infect Dis Source Type: research

Serum levels of matrix metalloproteinase-2, -9, and vitamin D in patients with multiple sclerosis with or without herpesvirus-6 seropositivity.
In this study, we measured the serum levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), and vitamin D levels in MS patients with HHV-6 infection and MS patients without HHV-6 infection. Five hundred sixty (including 300 females and 260 males) MS patients along with 560 healthy subjects were analyzed for HHV-6 seropositivity using enzyme-linked immunosorbent assay (ELISA). Subsequently, we measured the serum levels of MMP-2, MMP-9, and vitamin D levels in MS patients with HHV-6 infection and MS patients without HHV-6 infection by ELISA. About 90.7% of MS patients (508/560) were seropositive fo...
Source: Braz J Infect Dis - March 31, 2020 Category: Infectious Diseases Authors: Amini R, Karampoor S, Zahednasab H, Keyvani H, Gheiasian M, Jalilian FA Tags: Braz J Infect Dis Source Type: research

Infectious complications associated with parenteral nutrition in intensive care unit and non-intensive care unit patients.
This study aimed at analyzing associations between PN characteristics and infectious complications in hospitalized patients. MATERIAL AND METHODS: This was a retrospective cohort study conducted in a tertiarycare university hospital. Data from consecutive adult patients submitted to PN (January 2016 to December 2017; ICU and ward) were reviewed by means of an electronic database. Patient's clinical characteristics, PN prescription and catheter insertion procedure data were extracted and analyzed. The main outcome was the development of central line-associated bloodstream infection (CLABSI). The secondary outcomes were...
Source: Braz J Infect Dis - March 20, 2020 Category: Infectious Diseases Authors: Comerlato PH, Stefani J, Viana MV, Viana LV Tags: Braz J Infect Dis Source Type: research

Novel coronavirus pneumonia.
PMID: 32201125 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - March 19, 2020 Category: Infectious Diseases Authors: Na W, Yi Z, Yong-Sheng Y Tags: Braz J Infect Dis Source Type: research

Nicotinamide activates latent HIV-1 ex vivo in ART suppressed individuals, revealing higher potency than the association of two methyltransferase inhibitors, chaetocin and BIX01294.
CONCLUSION: NAM alone was more potent HIV-1 activator of than combination of MTIs, with potential of clinical use. PMID: 32105620 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - February 24, 2020 Category: Infectious Diseases Authors: Samer S, Arif MS, Giron LB, Zukurov JPL, Hunter J, Santillo BT, Namiyama G, Galinskas J, Komninakis SV, Oshiro TM, Sucupira MC, Janini LM, Diaz RS Tags: Braz J Infect Dis Source Type: research

Efficacy and safety of dimeticones in the treatment of epidermal parasitic skin diseases with special emphasis on tungiasis: an evidence-based critical review.
Abstract Epidermal parasitic skin diseases encompass scabies, pediculosis, cutaneous larva migrans, myiasis, and tungiasis. Tungiasis is probably the most neglected of all Neglected Tropical Diseases (NTD). It occurs in South America, the Caribbean and Sub-Saharan Africa and affects marginalized populations where people live in extreme poverty. In endemic communities the prevalence can be up to 30% in general population and 85% in children. Over time, chronic pathology develops characterized by hyperkeratosis, edema around the nail rim, fissures, ulcers, deformation and loss of nails. This leads to a pattern of di...
Source: Braz J Infect Dis - February 24, 2020 Category: Infectious Diseases Authors: Miller H, Trujillo-Trujillo J, Mutebi F, Feldmeier H Tags: Braz J Infect Dis Source Type: research

Coagulase-negative staphylococci: a 20-year study on the antimicrobial resistance profile of blood culture isolates from a teaching hospital.
Abstract The increasing rates of nosocomial infection associated with coagulase-negative staphylococci (CoNS) were the rationale for this study, aiming to categorize oxacillin-resistant CoNS species recovered from blood culture specimens of inpatients at the UNESP Hospital das Clínicas in Botucatu, Brazil, over a 20-year period, and determine their sensitivity to other antimicrobial agents. The mecA gene was detected in 222 (74%) CoNS samples, and the four types of staphylococcal chromosomal cassette mec (SCCmec) were characterized in 19.4%, 3.6%, 54.5%, and 14.4% of specimens, respectively, for types I, II...
Source: Braz J Infect Dis - February 18, 2020 Category: Infectious Diseases Authors: Pereira VC, Romero LC, Pinheiro-Hubinger L, Oliveira A, Martins KB, Cunha MLRSD Tags: Braz J Infect Dis Source Type: research

Seroprevalence of chikungunya virus infection in five hospitals within anyigba, kogi State of Nigeria.
This study determined seroprevalence of active and past CHIKV infection among febrile patients who tested negative for malaria and typhoid fever. Sera from 243 febrile patients were screened for CHIKV IgG and IgM using an immunochromatographic test kit. Clinical and socio-demographic variables were collected using a structured questionnaire. Recent CHIKV infection was observed in 5.8% of the study participants while 25.1% had IgG antibodies demonstrating previous infection. Significant associations were observed between seropositivity and age of participants (p 
Source: Braz J Infect Dis - January 27, 2020 Category: Infectious Diseases Authors: Omatola CA, Onoja BA, Fassan PK, Osaruyi SA, Iyeh M, Samuel MA, Haruna PU Tags: Braz J Infect Dis Source Type: research

Thermotolerance of Histoplasma capsulatum at 40  °C predominates among clinical isolates from different Latin American regions.
Thermotolerance of Histoplasma capsulatum at 40 °C predominates among clinical isolates from different Latin American regions. Braz J Infect Dis. 2020 Jan 24;: Authors: Sahaza JH, Rodríguez-Arellanez G, Canteros CE, Reyes-Montes MDR, Taylor ML Abstract The yeast phase of 22 Histoplasma capsulatum clinical isolates from Mexico, Argentina, Colombia, and Guatemala and three reference strains, one from Panama and two from the United States of America (USA), were screened for thermosensitivity characteristics using different analyses. Growth curves at 0, 3, 6, 12, 24, and 30 h of incubation ...
Source: Braz J Infect Dis - January 24, 2020 Category: Infectious Diseases Authors: Sahaza JH, Rodríguez-Arellanez G, Canteros CE, Reyes-Montes MDR, Taylor ML Tags: Braz J Infect Dis Source Type: research

Diagnostic parameters and reliability of four rapid immunochromatographic tests for dengue 4.
YHM Abstract BACKGROUND: Although performance of rapid immunochromatographic tests (RITs) for dengue virus (DENV) serotypes 1, 2 and 3 is relatively settled, evidence on accuracy of RITs for DENV-4 are based on studies with small sample sizes and with discrepant results. OBJECTIVES: To assess accuracy and inter-observer agreement of RITs targeting dengue nonstructural protein-1 (NS1) antigen - Dengue NS1-Bioeasy™, Dengue NS1 Ag Strip-Bio-Rad™, IVB Dengue Ag NS1-Orangelife™ and Dengue NS1-K130-Bioclin™ in DENV-4 samples. METHODS: Study sample (n = 324) included adults presentin...
Source: Braz J Infect Dis - January 16, 2020 Category: Infectious Diseases Authors: Mata VE, Passos SRL, Santos MABD, Buonora SN, de Andrade CAF, Lima MDRQ, Costa BM, Hökerberg YHM Tags: Braz J Infect Dis Source Type: research

Influenza A and B in a cohort of outpatient children and adolescent with influenza like-illness during two consecutive influenza seasons.
CONCLUSIONS: Influenza A and B are often detected in children and adolescents with ILI episodes, with similar and mild presentation in outpatients. The mismatch between the circulating influenza viruses and the trivalent vaccine offered in Brazil may have contributed to the high frequency of influenza A and B in this population. PMID: 31951818 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - January 14, 2020 Category: Infectious Diseases Authors: Machado CM, de Souza ACMF, Romano CM, Dos Santos Freire W, Costa ÂA, Figueiredo WM, Pannuti CS, Luna EJA Tags: Braz J Infect Dis Source Type: research

Sporadic human cutaneous anthrax outbreak in Shaanxi Province, China: report of two cases from 2018.
Abstract China's compulsory annual livestock anthrax vaccination policy has remarkably reduced but not completely eradicated human anthrax infections. Herein we describe a sporadic human cutaneous anthrax outbreak involving two cases in 2018 in Shaanxi Province, both involving herdsman who dealt with unvaccinated and potentially sick cattle. Both patients showed Bacillus anthracis-positive blister smear and blood culture. Treatment with penicillin was followed by uneventful recovery for both. The prompt performance of the prophylactic measures successfully interrupted the further transmission of this sporadic huma...
Source: Braz J Infect Dis - January 9, 2020 Category: Infectious Diseases Authors: Liu Y, Li Y, Wang Q, Fu J, Ji F Tags: Braz J Infect Dis Source Type: research

Septicemia in an immunocompetent adult in the Czech Republic caused by Corynebacterium diphtheriae nontoxigenic strain biotype mitis: emergence of invasive cases in Western Europe.
;ková D, Fiksa J PMID: 31926899 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - January 9, 2020 Category: Infectious Diseases Authors: Massmann R, Zavadilová J, Smíšková D, Fiksa J Tags: Braz J Infect Dis Source Type: research

Corrigendum to "Gastrointestinal mucormycosis post lung transplantation" [Braz J Infect Dis 23 (2019) 368-370].
Corrigendum to "Gastrointestinal mucormycosis post lung transplantation" [Braz J Infect Dis 23 (2019) 368-370]. Braz J Infect Dis. 2020 Jan 02;: Authors: Dos Reis FP, Campos SV, Aiello VD, Duarte MIS, Samano MN, Pego-Fernandes PM PMID: 31904349 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - January 2, 2020 Category: Infectious Diseases Authors: Dos Reis FP, Campos SV, Aiello VD, Duarte MIS, Samano MN, Pego-Fernandes PM Tags: Braz J Infect Dis Source Type: research

Clinical and microbiological characteristics of cryptococcosis at an university hospital in China from 2013 to 2017.
CONCLUSIONS: Most of the patients with cryptococcosis were not HIV-infected in this study, while patients with HIV had a higher mortality. Reduced susceptibility to fluconazole was observed among C. neoformans isolates, most of them belonged to ST5 genotype VNI having an impact on the effective dose of fluconazole. PMID: 31870760 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - December 20, 2019 Category: Infectious Diseases Authors: Fang LF, Zhang PP, Wang J, Yang Q, Qu TT Tags: Braz J Infect Dis Source Type: research

Measles, rubella, mumps and Toxoplasma gondii antibodies in saliva of vaccinated students of schools and universities in S ão Paulo City, Brazil.
DISCUSSION: The prevalence of antibodies against mumps and rubella after 6-8 years of vaccination was lower than against measles among students. The findings of this study demonstrate the feasibility of saliva sampling for follow-up of vaccine immune status in teenagers. This useful approach allows for IgG detection for vaccine control or epidemiological studies. PMID: 31866191 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - December 19, 2019 Category: Infectious Diseases Authors: Sampaio BCF, Rodrigues JP, Meireles LR, Junior HFA Tags: Braz J Infect Dis Source Type: research

Proposal of a clinical score to stratify the risk of multidrug-resistant gram-negative rods bacteraemia in cancer patients.
OCAS) Abstract INTRODUCTION: Multidrug-resistant Gram-negative rods (MDR GNR) represent a growing threat for patients with cancer. Our objective was to determine the characteristics of and risk factors for MDR GNR bacteremia in patients with cancer and to develop a clinical score to predict MDR GNR bacteremia. MATERIAL AND METHODS: Multicenter prospective study analyzing initial episodes of MDR GNR bacteremia. Risk factors were evaluated using a multiple logistic regression (forward-stepwise selection) analysis including variables with a p 
Source: Braz J Infect Dis - December 15, 2019 Category: Infectious Diseases Authors: Carena AA, Laborde A, Roccia-Rossi I, Palacios CJ, Jordán R, Valledor A, Nenna A, Costantini P, Dictar M, Herrera F, Argentine Group for the Study of Bacteraemias in Cancer, Stem Cell Transplant, (ROCAS) Tags: Braz J Infect Dis Source Type: research

Differential replicative fitness of the four dengue virus serotypes circulating in Colombia in human liver Huh7 cells.
This study aimed to compare the replicative fitness of the four dengue virus serotypes and understand the association between the serotypes, their in vitro infection ability, and their replication in target cells. We used three isolates of each DENV serotype to infect Huh-7 cells at an MOI of 0.5. The percentage of infected cells was evaluated by flow cytometry, cell viability was evaluated by MTT assay, and the pathogenicity index was calculated as a ratio of both parameters. The replicative fitness was measured by the number of viral genome copies produced using quantitative PCR and the production of infectious viral pro...
Source: Braz J Infect Dis - December 13, 2019 Category: Infectious Diseases Authors: Gutiérrez-Barbosa H, Castañeda NY, Castellanos JE Tags: Braz J Infect Dis Source Type: research

Factors associated to modification of first-line antiretroviral therapy due to adverse events in people living with HIV/AIDS.
Abstract Antiretroviral therapy (ART) has modified the outcome of patients with HIV infection, providing virological control and reducing mortality. However, there are several reasons as to why patients may discontinue their antiretroviral therapy, with adverse events being one of the main reasons reported in the literature. This is a case-control nested in a cohort of people living with HIV/AIDS, conducted to identify the incidence of ART modification due to adverse events and the associated factors, in two referral services in Recife, Brazil, between 2011 and 2014. Of the modifications occurred in the first year...
Source: Braz J Infect Dis - December 10, 2019 Category: Infectious Diseases Authors: Azevedo LN, Ximenes RAA, Monteiro P, Montarroyos UR, Miranda-Filho DB Tags: Braz J Infect Dis Source Type: research