A liquid biopsy assay for the noninvasive detection of lymph node metastases in T1 lung adenocarcinoma
ConclusionsWe have established a new risk prediction model using serum samples from T1 LUAD patients, enabling noninvasive identification of those with positive lymph node metastases. (Source: Thoracic Cancer)
Source: Thoracic Cancer - April 29, 2024 Category: Cancer & Oncology Authors: Xin Li,
Yang Gu,
Bin Hu,
Ming ‐Ming Shao,
Hui Li Tags: ORIGINAL ARTICLE Source Type: research
Understanding IT in Healthcare: Relevance and Training Needs of IT in Private Medical Practice
CONCLUSION: The findings underscore a significant need for targeted IT training and support in medical practices, particularly in areas related to the medical practice and security. Addressing these needs could lead to improved healthcare delivery and better management of technological resources in the healthcare sector.PMID:38682526 | DOI:10.3233/SHTI240033 (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 29, 2024 Category: Information Technology Authors: Marco Schweitzer Werner O Hackl Sabrina B Neururer Bernhard Pfeifer Source Type: research
Neither Amphetamine nor Sub-Anesthetic Ketamine Treatment during Adolescence Impairs Devaluation in Rats Tested during Adulthood
CONCLUSIONS: We discuss possible reasons for this discrepancy with the prior literature, including (1) the age of exposure and (2) the pattern in the previous literature that most previous demonstrations of drug exposure impairing devaluation in laboratory animals may be attributed to either drug-associated cues present in the testing environment and/or accelerated habit learning in tasks that predispose laboratory animals towards habit formation with extended training (with training procedures that should resist the formation of habits in the current experiment). However, additional research is needed to examine the effec...
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Ian R Davis Hayley Fisher Caitlin McLean Jackson Murray Charles L Pickens Source Type: research
Preparing Medical Students to Care for Patients with Opioid Use Disorder: Buprenorphine Waiver Training in Undergraduate Medical Education
Acad Psychiatry. 2024 Apr 29. doi: 10.1007/s40596-024-01968-w. Online ahead of print.NO ABSTRACTPMID:38684575 | DOI:10.1007/s40596-024-01968-w (Source: The Journal of American Association of Directors of Psychiatric Residency Training)
Source: The Journal of American Association of Directors of Psychiatric Residency Training - April 29, 2024 Category: Psychiatry Authors: Elly Riser Amanda G Kennedy Leigh Ann Holterman John Brooklyn Sanchit Maruti Halle G Sobel Source Type: research
A temporal enhanced semi-supervised training framework for needle segmentation in 3D ultrasound images
Phys Med Biol. 2024 Apr 29. doi: 10.1088/1361-6560/ad450b. Online ahead of print.ABSTRACTAutomated biopsy needle segmentation in 3D ultrasound images can be used for biopsy navigation, but it is quite challenging due to the low ultrasound image resolution and interference similar to the needle appearance. For 3D medical image segmentation, such deep learning (DL) networks as convolutional neural network (CNN) and transformer have been investigated. However, these segmentation methods require numerous labeled data for training, have difficulty in meeting the real-time segmentation requirement and involve high memory consump...
Source: Physics in Medicine and Biology - April 29, 2024 Category: Physics Authors: Mingwei Wen Pavel Shcherbakov Yang Xu Jing Li Yi Hu Quan Zhou Huageng Liang Li Yuan Xuming Zhang Source Type: research
Token Sparsification for Faster Medical Image Segmentation
Inf Process Med Imaging. 2023 Jun;13939:743-754. doi: 10.1007/978-3-031-34048-2_57. Epub 2023 Jun 8.ABSTRACTCan we use sparse tokens for dense prediction, e.g., segmentation? Although token sparsification has been applied to Vision Transformers (ViT) to accelerate classification, it is still unknown how to perform segmentation from sparse tokens. To this end, we reformulate segmentation as a sparse encoding → token completion → dense decoding (SCD) pipeline. We first empirically show that naïvely applying existing approaches from classification token pruning and masked image modeling (MIM) leads to failure and ineffic...
Source: Inf Process Med Imaging - April 29, 2024 Category: Radiology Authors: Lei Zhou Huidong Liu Joseph Bae Junjun He Dimitris Samaras Prateek Prasanna Source Type: research
The false promise of firearms examination validation studies: Lay controls, simplistic comparisons, and the failure to soundly measure misidentification rates
This article therefore utilizes such a group, specifically 82 attorneys, as a post hoc control and juxtaposes their performance on a comparison set of cartridge case images from one commonly cited study (Duez et al. in J Forensic Sci. 2018;63:1069-1084) with that of the original participant pool of professionals. Despite lacking the kind of formalized training and experience common to the latter, our lay participants displayed an ability, generally, to distinguish between cartridge cases fired by the same versus different guns in the 327 comparisons they performed. And while their accuracy rates lagged substantially behind...
Source: Journal of Forensic Sciences - April 29, 2024 Category: Forensic Medicine Authors: Richard E Gutierrez Emily J Prokesch Source Type: research
Association between opioid use disorder and palliative care: a cohort study using linked health administrative data in Ontario, Canada
CMAJ. 2024 Apr 28;196(16):E547-E557. doi: 10.1503/cmaj.231419.ABSTRACTBACKGROUND: People with opioid use disorder (OUD) are at risk of premature death and can benefit from palliative care. We sought to compare palliative care provision for decedents with and without OUD.METHODS: We conducted a cohort study using health administrative databases in Ontario, Canada, to identify people who died between July 1, 2015, and Dec. 31, 2021. The exposure was OUD, defined as having emergency department visits, hospital admissions, or pharmacologic treatments suggestive of OUD within 3 years of death. Our primary outcome was receipt of...
Source: Canadian Medical Association Journal - April 29, 2024 Category: General Medicine Authors: Jenny Lau Mary M Scott Karl Everett Tara Gomes Peter Tanuseputro Sheila Jennings Rebecca Bagnarol Camilla Zimmermann Sarina R Isenberg Source Type: research
Comparison of Novel Proteomic Expression Profiles for Radiation Exposure in Male and Female C57BL6 Mice
Radiat Res. 2024 Apr 30. doi: 10.1667/RADE-23-00180.1. Online ahead of print.ABSTRACTThere is a need for point-of-care diagnostics for future mass casualty events involving radiation exposure. The development of radiation exposure and dose prediction algorithms for biodosimetry is needed for screening of large populations during these scenarios, and exploration of the potential effects which sex, age, genetic heterogeneity, and physiological comorbidities may have on the utility of biodosimetry diagnostics is needed. In the current study, proteomic profiling was used to examine sex-specific differences in age-matched C57BL...
Source: Radiation Research - April 29, 2024 Category: Physics Authors: M Sproull Y Fan Q Chen D Meerzaman K Camphausen Source Type: research
The Tools for Integrated Management of Childhood Illness (TIMCI) study protocol: a multi-country mixed-method evaluation of pulse oximetry and clinical decision support algorithms
Glob Health Action. 2024 Dec 31;17(1):2326253. doi: 10.1080/16549716.2024.2326253. Epub 2024 Apr 29.ABSTRACTEffective and sustainable strategies are needed to address the burden of preventable deaths among children under-five in resource-constrained settings. The Tools for Integrated Management of Childhood Illness (TIMCI) project aims to support healthcare providers to identify and manage severe illness, whilst promoting resource stewardship, by introducing pulse oximetry and clinical decision support algorithms (CDSAs) to primary care facilities in India, Kenya, Senegal and Tanzania. Health impact is assessed through: a ...
Source: Global Health Action - April 29, 2024 Category: International Medicine & Public Health Authors: Fenella Beynon H élène Langet Leah F Bohle Shally Awasthi Ousmane Ndiaye James Machoki M'Imunya Honorati Masanja Susan Horton Maymouna Ba Silvia Cicconi Mira Emmanuel-Fabula Papa Moctar Faye Tracy R Glass Kristina Keitel Divas Kumar Gaurav Kumar Gillian Source Type: research
Structurally diverse oxygen-containing aromatic compounds with anti-inflammatory activity from < em > Aspergillus < /em > sp. LY-1-2
Nat Prod Res. 2024 Apr 29:1-9. doi: 10.1080/14786419.2024.2347451. Online ahead of print.ABSTRACTThree isocoumarins, ascoisocoumarin A (1), embeurekol (2), and sclerotinin A (3), and five biosynthetically related derivatives, ascospinols A-C (4, 6, and 7), and talaflavuols C and B (5 and 8), together with twelve polyketides or terpenes (9-20) were isolated from the fungus Aspergillus sp. LY-1-2 inhabited in a sample of Cordyceps sp. Most of them belong to the family of oxygen-containing aromatic compounds and compounds 1, 4, 6, and 7 are previously undescribed compounds. Their planar structures were established by a combin...
Source: Natural Product Research - April 29, 2024 Category: Biochemistry Authors: Chu-Qiao Wang Jinzhi Pan Shuang-Zhi Yuan Chao Yuan Fei-Xiang Ji Dan Feng Xiao-Ping Peng Qian Luo Hong-Xiang Lou Gang Li Source Type: research
Task-similarity is a crucial factor for few-shot meta-learning of structure-activity relationships
In this study, we assessed the effectiveness of two different meta-learning methods, namely model-agnostic meta-learning (MAML) and adaptive deep kernel fitting (ADKF), specifically in the regression setting. We investigated how factors such as dataset size and the similarity of training tasks impact predictability. The results indicate that ADKF significantly outperformed both MAML and a single-task baseline model on the inhibition data. However, the performance of ADKF varied across different test tasks. Our findings suggest that considerable enhancements in performance can be anticipated primarily when the task of inter...
Source: Chembiochem - April 29, 2024 Category: Biochemistry Authors: Alexander K ötter Stephan Allenspach Christoph Grebner Hans Matter Jan Hiss Gisbert Schneider Gerhard Hessler Source Type: research
Bioinformatics Analysis Identifies Key Genes in the Effect of Resistance Training on Female Skeletal Muscle Aging
J Aging Phys Act. 2024 Apr 29:1-10. doi: 10.1123/japa.2023-0178. Online ahead of print.ABSTRACTResistance training is used to combat skeletal muscle function decline in older adults. Few studies have been designed specific for females, resulting in very limited treatment options for skeletal muscle atrophy in aging women. Here, we analyzed the gene expression profiles of skeletal muscle samples from sedentary young women, sedentary older women, and resistance-trained older women, using microarray data from public database. A total of 45 genes that were differentially expressed during female muscle aging and reversed by res...
Source: Journal of Aging and Physical Activity - April 29, 2024 Category: Geriatrics Authors: Jiacheng Ma Xiaoli Pang Ismail Laher Shunchang Li Source Type: research
Choriocapillaris Perfusion after 8 Weeks of High-Speed Circuit Training in Older Healthy Adults
CONCLUSION: CCD appeared to remain stable after 8 weeks of HSCT in healthy older individuals, possibly due to autoregulation. Further research with extended training may be necessary to verify these findings.PMID:38679899 | DOI:10.1080/02713683.2024.2346538 (Source: Current Eye Research)
Source: Current Eye Research - April 29, 2024 Category: Opthalmology Authors: Ava-Gaye Simms Joseph F Signorile Gustavo Rosa Gameiro Abdulrahman Mamoon Allaf Jianhua Wang Hong Jiang Source Type: research
Best practices for the dissemination and implementation of neuromuscular training injury prevention warm-ups in youth team sport: a systematic review
CONCLUSIONS: Workshops including supplementary resources supported the success of NMT programme implementation, however, few studies examined effectiveness. High-quality D&I studies are needed to optimise the translation of NMT programmes into routine practice in youth sport.PMID:38684329 | DOI:10.1136/bjsports-2023-106906 (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - April 29, 2024 Category: Sports Medicine Authors: Destiny Lutz Carla van den Berg Anu M R äisänen Isla J Shill Jemma Kim Kenzie Vaandering Alix Hayden Kati Pasanen Kathryn J Schneider Carolyn A Emery Oluwatoyosi B A Owoeye Source Type: research
