Raising the Impact of Real World Evidence.
Authors: Kalra D Abstract In an environment in which most regulatory and authoritative health strategy decisions are made on the basis of randomised control trials, real-world evidence (RWE), primarily derived from electronic health records, remains a second-class citizen. Real world evidence is widely taken to include Pragmatic clinical trials and insights derived from the distributed analysis of large volumes of routinely collected health data and registry data (so called big data). This presentation will look at the growing scale and reputation of big health data, the ways in which good governance principles and...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

How to Harness Big Data for the Benefit of Patients.
Authors: Meulien P Abstract IMI is a large public private partnership which has committed Euro 5 Billion from the European Commission, the European Pharmaceutical sector and other partners, to enable and accelerate bringing medical innovation to patients. IMI is now 10 years old and already has changed the ecosystem and way of working in developing innovative medicines across the public/private divide. Big data represents a significant piece of this investment and projects in this area are attempting to provide solutions to major challenges including: 1. Data integration from many sources across many jurisdictions ...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Towards Interoperability in Clinical Research: Enabling FHIR on the Open Source Research Platform XNAT.
Authors: Khvastova M, Witt M, Krefting D PMID: 30942702 [PubMed - in process] (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Towards a Software Tool for Planning IHE-Compliant Information Systems.
Authors: Stäubert S, Strübing A, Drepper J, Bergh B, Winter A, Merzweiler A Abstract As hospital information systems are complex and the requirements for interoperability grow with the increasing networking in healthcare, careful planning becomes more and more necessary. The use of standards as described in IHE profiles, for example, are an important prerequisite for enabling interoperability. Enterprise Architecture Planning (EAP) methods should support this, but none of the currently available EAP methods offers the option of using IHE profiles. The 3LGM2IHE project wants to close this gap and implement...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Automated Verification of Structured Questionnaires Using HL7.
Authors: Lackerbauer AM, Krauss O, Helm E Abstract Informed consent of patients to research studies is a cornerstone to modern healthcare, which has lead to considerable administrative effort. The purpose of this paper is to show how forms and questionnaires and their respective answers can be captured in a standardized, structured way, in order to enable automated verification. The use of the HL7 FHIR resources Questionnaire and QuestionnaireResponse is discussed with respect to the different implementation options of Extensions, POST Interceptors, FHIR Operations, and CDS Hooks. These four approaches are describe...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Query Translation Between openEHR and i2b2.
Authors: Fette G, Kaspar M, Liman L, Dietrich G, Ertl M, Krebs J, Störk S, Puppe F Abstract Secondary use of electronic health records using data warehouses (DW) has become an attractive approach to support clinical research. In order to increase the volume of underlying patient data DWs at different institutions can be connected to research networks. Two obstacles to connect a DW to such a network are the syntactical differences between the involved DW technologies and differences in the data models of the connected DWs. The current work presents an approach to tackle both problems by translating queries from...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

An Extension of the i2b2 Data Warehouse to Support REDCap Dynamic Data Pull.
Authors: Gabetta M, Mirabelli M, Klersy C, Musella V, Rizzo G, Pedrazzoli P, Barbarini N, Bellazzi R, Larizza C Abstract i2b2 and REDCap are two widely adopted solutions respectively to facilitate data re-use for research purpose and to manage non-for-profit research studies. REDCap provides the design specifications to build a web service used to import data from an external source with a procedure called DDP. In this work we have developed a web service that implements these specifications in order to import data from i2b2. Our approach has been tested with a real REDCap study. PMID: 30942706 [PubMed - in pro...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

A REST Service for the Visualization of Clinical Time Series Data in the Context of Clinical Decision Support.
CONCLUSION: The new charting tool combines local preferences with best practices for visualization of clinical time series data. With its REST interface and reusable design it can be easily integrated in existing CDS platforms. PMID: 30942707 [PubMed - in process] (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

An Ontological Framework to Improve Surveillance of Adverse Childhood Experiences (ACEs).
Authors: Brenas JH, Shin EK, Shaban-Nejad A Abstract Adverse Childhood Experiences (ACEs) have been proven to be linked to increased risks of a multitude of negative health outcomes and conditions when children reach adulthood and beyond. To better understand the relationship between ACEs and the associated health outcomes and eventually to pan and implement preventive interventions, access to an integrated coherent actionable data set is crucial. In this paper, we introduce a formal reusable ontological framework to capture the knowledge in the domain of Adverse Childhood Experiences to improve ACEs surveillance a...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Complementing Medical Records with Precalculated Data Items to Facilitate Decision Support and Phenotyping.
Authors: Kraus S, Prokosch HU Abstract The Arden Syntax is a standard for clinical decision support functions in the form of Medical Logic Modules (MLMs). While the data type system of the early versions was limited to flat lists, later versions introduced an object type, supporting complex data structures, even up to entire electronic medical records (EMRs). Such objects are static insofar as their structure cannot be modified at MLM runtime. University Hospital Erlangen uses an experimental Arden Syntax version termed PLAIN, which provides an integrated mapper for arbitrary data structures, including entire EMRs....
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Investigation of Content Overlap in Proprietary Medical Mappings.
Authors: Lenivtseva Y, Kopanitsa G Abstract To manage medical information semantic interoperability is essential. Mapping of concepts and mapping of terminologies are two objectives to reach semantic interoperability. Russian proprietary health information system and FHIR overlaps (60%) were calculated to estimate possibility of standardization. Russian terminology directories and FHIR overlaps were calculated to estimate possibility of use Russian terminologies and codifications in FHIR-based information system. The result is promising, however, requires more wide investigation using automatic tools. PMID: 309...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Developing New Analysis Functions for a Translational Research Platform: Extending the cBioPortal for Cancer Genomics.
CONCLUSION: While extending the cBioPortal is possible, there are still some challenges to overcome. A plug-in concept and a more detailed documentation would greatly facilitate the development of own extensions. PMID: 30942711 [PubMed - in process] (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

On the Trustworthiness of Soft Computing in Medicine.
Authors: Wolff D, Marschollek M, Kupka T PMID: 30942712 [PubMed - in process] (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Electronic Prescriptions: Why Community Pharmacists Still Treat Them as Paper-Based?
In this study, the frequency of incorrect use of the paper proof was evaluated and possible reasons for incorrect use were hypothesized. In 10,000 prescriptions, 226 ePrescriptions (2.26 %) were handled incorrectly. Possible reasons for this handling are (1) non-compliance of the community pharmacist; (2) errors in software or handling of the community pharmacist; (3) errors at the prescriber side or patient tries to fraud; (4) incorrectly revoking the ePrescription; and (5) errors in prescriber's software. The presence of incentives and penalties might help in preventing this erroneous type of handling. PMID: 30942713...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

The Impact of Electronic Obstetric Records Using the ObsCare Software on Scientific Production.
CONCLUSION: Publications from hospitals that used an obstetric specific EHR (ObsCare), included a higher number of patients and longer study periods. PMID: 30942714 [PubMed - in process] (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Using the Recommendations Inferred by a Decision Support System to Compare Breast Cancer Clinical Practice Guidelines.
Authors: Seroussi B, Prebet C, Ngo C, Teixeira L, Guézennec G, Bouaud J Abstract Numerous studies have reported that inconsistencies exist between clinical practice guidelines (CPGs) elaborated on the same topic and at the same date. These results are usually established from the analyses handled on narrative CPGs or on their semi-structured version. In the context of the European-funded DESIREE project, we have developed a guideline-based decision support system embedding various contemporary CPGs on breast cancer management. We have run the GL-DSS on a sample of 571 retrospective clinical cases and specifi...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Views of Health Information Management Staff on Non-Technical Security Management Factors, Mashhad, Iran.
Authors: Sarbaz M, Manouchehri Monazah F, Banaye Yazdipour A, Kimiafar K Abstract Health care organizations are worried about information security because they generate important and valuable information in the field of health informatics. Therefore, the present study was conducted to investigate the health information management staff's viewpoint on non-technical security management factors. A descriptive cross-sectional study was conducted between Feb to Apr 2018 in 12 academic hospitals in Mashhad, north-eastern Iran. Data were collected through a paper-based questionnaire that was designed based on previous stu...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

An Analysis of Erlangen University Hospital's Billing Data on Utility-Based De-Identification.
CONCLUSION: To create k-anonymity with k > 1 while still maintaining a particular utility of the data, we need to apply further established strategies of de-identification. PMID: 30942717 [PubMed - in process] (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Adding Security and Privacy to Genomic Information Representation.
Authors: Delgado J, Llorente S, Naro D Abstract Provision of security and privacy to genomic data is a key issue in current genomic information representation. Existing formats do not give a solution to these issues (or they provide a partial one), so new solutions are demanded. MPEG-G (ISO/IEC 23092, Genomic Information Representation) is an International Standard for the representation of genomic information being defined by the MPEG Committee (Moving Pictures Expert Group, ISO/IEC JTC1 SC29/WG11). We provide flexible protection to the information stored inside the MPEG-G format with a combination of security tec...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Clinical Information Model Based Data Quality Checks: Theory and Example.
We describe principles of leveraging clinical information models (CIMs) for data quality (DQ) checks and present the exemplary application of these principles. METHODS: openEHR compliant CIMs are used to express DQ-checks as constraints. Test setting is the process of extracting, transforming and loading (ETL) assisted ventilation data from two patient data management systems (PDMS) of a pediatric intensive care unit into a local openEHR-based data repository. RESULTS: A generic component logs aggregated DQ-check results for ~28 million entries. DQ-issue types in the presented results are range-, format- and value ...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Approaching Clinical Data Transformation from Disparate Healthcare IT Systems Through a Modular Framework.
Authors: Phan-Vogtmann LA, Helhorn A, Kruse HM, Thomas E, Heidel AJ, Saleh K, Rissner F, Specht M, Henkel A, Scherag A, Ammon D Abstract Many healthcare IT systems in Germany are unable to interoperate with other systems through standardised data formats. Therefore it is difficult to store and retrieve data and to establish a systematic collection of data with provenance across systems and even healthcare institutions. We outline the concept for a Transformation Pipeline that can act as a processor for proprietary medical data formats from multiple sources. Through a modular construction, the pipeline relies on dif...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Reviving 30 Year Old Technology: Lessons Learned from Transferring Patient Data Using Data Matrix Codes.
Authors: Brix TJ, Neuhaus P, Storck M, Soto-Rey I, Dugas M Abstract In patient care and medical research patient data often has to be transferred between different electronic systems. These systems can be very heterogeneous, sometimes even legacy systems, and thus, often do not support standardized interfaces for data transfer. Since nowadays barcode scanners are commonly used in clinical routine and smartphones are accessible to most patients, we implemented different interfaces based on Data Matrix codes to transfer patient data between several medical applications. Objective of this work is to show different use...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Towards an Information System for Sickle Cell Neonatal Screening in Senegal.
Authors: Diallo AH, Camara G, Lamy JB, Lo M, Diagne I, Makalou D, Diop M, Doupa D Abstract Sickle cell disease is a major public health problem in Senegal. It is an inherited disease that affects about 300,000 births worldwide each year. There are 70 million people affected worldwide, 80% of whom live in sub-Saharan Africa. In Senegal, 1 in 10 people carries the sickle cell disease gene. This disease requires follow-up from birth and for life. The patient care requires the integration and the analysis of biological, clinical, social, economic data., etc. In this paper, we propose a health information system for dat...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Views of Users Towards the Quality of Picture Archiving and Communication System (PACS) in a Developing Country.
The objective of the study was to evaluate the PACS from the point of view of users in hospitals affiliated to Mashhad University of Medical Sciences. The study population consisted of the PACS' users (radiologists and the radiology technologists) in the radiology departments (103 staff). Data were collected through a questionnaire that was designed based on previous studies and published literature. From the views of users, quality of information of PACS had the highest average (Mean = 3.57±1.02), while quality of services had the lowest average (Mean = 2.99±0.19). About the quality of information, the highe...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Use of Social Networks for Learning Purposes Among Medical and Paramedical Sciences Students, Mashhad, Iran.
Authors: Sarbaz M, Banaye Yazdipour A, Kimiafar K Abstract Social networking sites are communication and information technologies which can facilitate the interaction between professors and students. The purpose of this study was to investigate the use of social networks for learning purposes among medical and paramedical sciences students in Mashhad University of Medical Sciences (northeastern Iran). A cross-sectional study was carried out in 2017 and the research tool was a researcher-made questionnaire based on a literature review. The results showed that social networks such as Telegram (3.44 ± 1.27 out ...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Privacy by Design for Integrated Case and Care Management: Receiver-Oriented Encryption in STROKE OWL.
Authors: Michelsen T, Lins C, Gudenkauf S, Hein A, Lüpkes C Abstract Research into new forms of care for complex chronic diseases requires substantial efforts in the collection, storage, and analysis of medical data. Additionally, providing practical support for those who coordinate the actual care management process within a diversified network of regional service providers is also necessary. For instance, for stroke units, rehabilitation partners, ambulatory actors, as well as health insurance funds. In this paper, we propose the concept of comprehensive and practical receiver-oriented encryption (ROE) as a ...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

A Queue-Poll Extension and DataSHIELD: Standardised, Monitored, Indirect and Secure Access to Sensitive Data.
Authors: Gruendner J, Prokosch HU, Schindler S, Lenz S, Binder H Abstract Analyzing data across hospitals and institutions without the data leaving the hospitals and adding institutions to a trusted network is an important part of privacy preserving data analysis. This work implements a queue-poll extension and integrates with DataSHIELD to allow for a standardized, monitored, indirect and secure access to data. The extension was created using the HTTP protocol and requests are not pushed into a participating institution but are sent to a server outside an institutional network. These requests are then pulled into ...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

International Standard Accident Number: A Master Case Index Linking Accident & Emergency with Medical Data.
International Standard Accident Number: A Master Case Index Linking Accident & Emergency with Medical Data. Stud Health Technol Inform. 2019;258:120-124 Authors: Le HP, Hackel S, Guenther A, Goldschmidt R, Daoud M, Deserno TM Abstract Unconnected data silos make it difficult to view a patient's accident and emergency case in a comprehensive way, i.e. across all sectors. This includes the emergency medical services (EMS), medical data in a hospital's electronic health record (EHR) as well as event data recorders (EDRs) collecting information about the circumstances of the accident and emergency even...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Prediction of Postoperative Hospital Stay with Deep Learning Based on 101 654 Operative Reports in Neurosurgery.
This study was aimed at testing the informativeness of neurosurgical operative reports for predicting the duration of postoperative stay in a hospital using deep learning techniques. The recurrent neuronal networks (GRU) were applied to the word-embedded texts in our experiments. The mean absolute error of prediction in 90% of cases was 2.8 days. These results demonstrate the potential utility of narrative medical texts as a substrate for decision support technologies in neurosurgery. PMID: 30942728 [PubMed - in process] (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

EEG Data Fusion for Improving Accuracy of Binary Classification.
Authors: Skarga-Bandurova I, Biloborodova T, Skarha-Bandurov I, Zagorodna N, Shumova L Abstract The paper refers to the problem of classification for multiple medical data. The proposed methodology for EEG data processing consists of seven stages and assumes different variations of the Dempster-Shafer technique as a base instrument for data fusion. Attained accuracy is comparable to other more popular algorithms and can be a promising further basis for real-time data classification. PMID: 30942729 [PubMed - in process] (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Predicting Blood Donations in a Tertiary Care Center Using Time Series Forecasting.
Authors: Bischoff F, Koch MDC, Rodrigues PP Abstract The current algorithm to support platelets stock management assumes that there are always sufficient whole blood donations (WBD) to produce the required amount of pooled platelets. Unfortunately, blood donation rate is uncertain so there is the need to backup pooled platelets productions with single-donor (apheresis) collections to compensate periods of low WBD. The aim of this work was to predict the daily number of WBD to a tertiary care center to preemptively account for a decrease of platelets production. We have collected 62,248 blood donations during 3 year...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Emotion Recognition Using Electrodermal Activity Signals and Multiscale Deep Convolution Neural Network.
Authors: Ganapathy N, Swaminathan R Abstract Automated emotion recognition plays a vital role in problem solving, decision making and social activities of human life. An emotion is a set of reactions and experience to a given conditions, which are modeled as a linear combination of arousal and valence dimensions. Emotional pattern recognition based on physiological signals is a relatively new and fast growing area of research. Several physiological signals such as ECG, EEG, and EMG have been used for emotion recognition. Analysis of Electrodermal Activity (EDA) signals is one of the popular technique for emotion st...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Interoperability Improvement of Mobile Patient Survey (MoPat) Implementing Fast Health Interoperability Resources (FHIR).
Authors: Storck M, Hollenberg L, Dugas M, Soto-Rey I Abstract Despite the advances in health information technology and the increasing usage of electronic systems, syntactic and semantic interoperability between different health information systems remains challenging. An emerging standard to tackle interoperability issues is HL7 FHIR, which uses modern web technologies for communication like Representational State Transfer. The electronic patient reported outcome system Mobile Patient Survey (MoPat) was adapted to support metadata import and clinical data export using HL7 FHIR. Thereby, the data models of HL7 FHIR...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

A Report on Archetype Modelling in a Nationwide Data Infrastructure Project.
CONCLUSIONS: The governance framework is valuable to make the activities manageable and to accelerate modelling. Combined with highly engaged data stewards and clinicians, a reasonable number of archetypes have already been developed. PMID: 30942733 [PubMed - in process] (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Standardizing Austrians Claims Data Using the OMOP Common Data Model: A Feasibility Study.
Authors: Haberson A, Rinner C, Gall W Abstract The suitability of the Observational Medical Outcomes Partnership (OMOP) common data model (CDM) for Austrian pseudonymized claims data from social security institutions and information about hospital stays is evaluated. 1,023 (99.7%) of ATC codes and 3,695 (98.6%) of ICD10 codes coincide with the OMOP vocabulary. Mappings for the local vocabularies like the Austrian pharmaceutical registration numbers, the Socio-Economic Index and professional groups, to the OMOP vocabulary do not exist. A standardization with the OMOP CDM is possible, however an initial, not negligib...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

From ObsCare Software to an OpenEHR Platform: Modelling Obstetric Archetypes.
CONCLUSIONS: Considering the potential to improve clinical research, we believe that more obstetric-gynecologic clinical statements should be modelled into openEHR. PMID: 30942735 [PubMed - in process] (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

A Concept for a Data Dictionary System Supporting for Clinical Research.
Authors: Strickler M, Zbinden C, Saccilotto R, Denecke K Abstract Clinical trials form the backbone of evidence-based medicine. They are indispensable tools that make it possible to compare medical interventions or test medical devices for their efficacy and safety. Each study design exactly defines which data is to be collected. Case report forms (CRFs) are used to document the collected data. Preparing CRFs is complicating, time consuming and requires extensive knowledge in the fields of medicine, data management and statistics. In addition, there are no global standards for CRF design, which means that each rese...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

StudyPortal - A Novel Method to Visualize Study Research Networks.
Authors: Varghese J, Fujarski M, Dugas M Abstract International trial databases as ClinicalTrials.gov or the EU Clinical Trials Register lack geographic visualization of clinical trials. Utilizing key requirements from patient support groups and clinical researchers, an interactive online platform called StudyPortal was designed. It enables patients, health providers and clinical researchers to find and localize suitable studies or whole research networks for selected diseases in a geographic proximity. A semantic layer enables multilingual disease input and autosuggestion. Trial information is pulled and processed...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Design and Implementation of a Single Source Multipurpose Hospital-Wide Clinical Trial Registry.
We describe the design and implementation of such a single source clinical trial registry serving multiple purposes at a university hospital. PMID: 30942738 [PubMed - in process] (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Registries for Research and Quality Management in Emergency Care.
This article provides a review of German emergency registries which follow the overall objective of quality improvement in emergency care. The various registry projects are briefly presented and compared with regard to their objectives and specific field of emergency care. The aim is to create a basis for future registry projects with reference to aspects of methodology, data sources, and scope. The results show that none of the projects cover the whole emergency care chain in a comprehensive way, i.e., across the prehospital and clinical sector. This reveals the need for the establishment of a registry that spans over a b...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Uncertainty-Adjusted Translation for Preference-Sensitive Decision Support.
Authors: Dowie J, Kaltoft MK Abstract In Multi-Criteria Decision Analysis-based decision support for person-centred care, the person's quantitative preferences (as criterion weightings) are combined with quantified evidence and expert assessments (as option performance ratings on all criteria) to produce a personalised quantified opinion (as a set of expected value option scores). In our current decision support tools, we use the best available (central point) estimates for option performance ratings. The uncertainty surrounding the performance rating estimates, routinely reported by researchers as intervals around...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Results of a Literature Review to Prepare Data Modelling in the Context of Kidney Transplant Rejection Diagnosis.
Authors: Katzensteiner M, Ludwig W, Marschollek M, Bott OJ Abstract Due to demographic change the number of serious kidney diseases and thus required transplantations will increase. The increased demand for donor organs and a decreasing supply of these organs underline the necessity for effective early rejection diagnostic measures to improve the lifetime of transplants. Expert systems might improve rejection diagnostics but for the development of such systems data models are needed that encompass the relevant information to enable optimal data aggregation and evaluation. Results of a literature review concerning p...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Supervised ICD Code Assignment to Short Clinical Problem List Entries.
In this study we investigate to what extent diagnosis codes using the disease classification system ICD-10 can be automatically post-assigned to patient-based short problem list entries, (50 characters maximum). Classifiers using random forest and Adaboost performed best with an F-measure of 0.87 and 0.85 running against an unbalanced data set, and an F-measure of 0.88 and 0.94 using a balanced data set, respectively. PMID: 30942742 [PubMed - in process] (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Discovering Monogenic Causes of Multi-Diseases by Mining Electronic Medical Records and Genetics Repositories.
We present a method called SMDG (Single Multi-Disease Genes) for systematic discovery of monogenic causes of multi-diseases. Multi-disease conditions, quite common in older populations, are difficult to treat due to missing their precise medical guidelines and need for attention of multiple health care providers. Finding monogenic causes of these diseases would enable introducing new therapeutic approaches, focused on the remediation of mutations of single genes. SMDG is based on the hierarchical divisive clustering of electronic medical records (EMR) that include genetic data, and on the analysis of the public gene-to-dis...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Evaluation of Patient's Attitude Towards Computer Supported History Taking.
Authors: Hauber R, Schirm M, Herrmann F, Puppe F Abstract We provide a highly integrated tool to conduct dynamic, multilingual anamnesis interviews with patients to enhance documentation and provide physicians with more time for patient interaction in an outpatient setting. A first analysis of patients' satisfaction with the user interface shows a high rate of acceptance and prompts further research. PMID: 30942744 [PubMed - in process] (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Organizations Towards "Big Data"-Driven Approaches in Personalized Medicine? An Empirical-Ethical Study in Health-Related IT.
Organizations Towards "Big Data"-Driven Approaches in Personalized Medicine? An Empirical-Ethical Study in Health-Related IT. Stud Health Technol Inform. 2019;258:199-200 Authors: Rauter CM, Wöhlke S, Schicktanz S Abstract Personalized medicine (PM) operates with sensitive biological data to optimize prevention and therapy. Therefore, ethical concerns by stakeholders such as patient organizations (POs) need to be reflected. We used an empirical-ethical approach including a website-analysis and 30 telephone-interviews for gaining in-depth insight into POs attitudes towards PM and Big Data...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Evaluation of a Patient-Facing Digital Prototype for Perioperative Risk Assessment.
Authors: Mang J, Schild S, Prokosch HU, Jeleazcov C, Heinrich A, Toddenroth D Abstract Preparations for anesthesiological management of patients build on preoperative patient self-reports concerning risk factors and comorbidities. In this setting, electronic documentation could facilitate innovative computerized functions, although patient-facing digital questionnaires require appropriate tools that patients can access effectively. To explore the feasibility of an electronic application for preoperative data acquisition directly from patients, a digital, tablet-based prototypical application has been developed with...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

The Vehicle as a Diagnostic Space: Efficient Placement of Accelerometers for Respiration Monitoring During Driving.
In conclusion, monitoring respiration on the seatbelt is possible with accelerometers while driving, if the right sensor position is chosen. In future, smart textiles will be used to integrate unobtrusive and inexpensive biomonitoring in the vehicle. PMID: 30942747 [PubMed - in process] (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Scenarios for Using OpenClinica in Academic Clinical Trials.
Authors: Löbe M, Meineke F, Winter A Abstract Clinical Data Management Systems (CDMS) are used to electronically capture and store data about study participants in clinical trials. CDMS tend to be superior compared to paper-based data capture with respect to data quality, consistency, completeness and traceability. Nevertheless, their application is not default - especially in small-scale, academic clinical studies. While clinical researchers can choose from many different software vendors, the vast requirements of data management and the growing need for integration with other systems make it hard to select t...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research

Establishing an Interoperable Clinical Trial Information System Within MIRACUM.
Authors: Hasselblatt H, Andrae J, Tassoni A, Fitzer K, Bahls T, Prokosch HU, Boeker M Abstract In the long-run we wish to demonstrate the power of linking clinical trial information to routine health records for straightforward patient recruitment - not only at each single hospital but in a large German consortium (called MIRACUM). In such architecture a hospital wide clinical trial registry (CTR) plays a major role. All such site specific CTR however, also need to be interoperable and support automated data provision for a central MIRACUM wide trial registry. Based on a survey of already existing trial information...
Source: Studies in Health Technology and Informatics - April 5, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research