Task-similarity is a crucial factor for few-shot meta-learning of structure-activity relationships
In this study, we assessed the effectiveness of two different meta-learning methods, namely model-agnostic meta-learning (MAML) and adaptive deep kernel fitting (ADKF), specifically in the regression setting. We investigated how factors such as dataset size and the similarity of training tasks impact predictability. The results indicate that ADKF significantly outperformed both MAML and a single-task baseline model on the inhibition data. However, the performance of ADKF varied across different test tasks. Our findings suggest that considerable enhancements in performance can be anticipated primarily when the task of inter...
Source: Chembiochem - April 29, 2024 Category: Biochemistry Authors: Alexander K ötter Stephan Allenspach Christoph Grebner Hans Matter Jan Hiss Gisbert Schneider Gerhard Hessler Source Type: research
Bioinformatics Analysis Identifies Key Genes in the Effect of Resistance Training on Female Skeletal Muscle Aging
J Aging Phys Act. 2024 Apr 29:1-10. doi: 10.1123/japa.2023-0178. Online ahead of print.ABSTRACTResistance training is used to combat skeletal muscle function decline in older adults. Few studies have been designed specific for females, resulting in very limited treatment options for skeletal muscle atrophy in aging women. Here, we analyzed the gene expression profiles of skeletal muscle samples from sedentary young women, sedentary older women, and resistance-trained older women, using microarray data from public database. A total of 45 genes that were differentially expressed during female muscle aging and reversed by res...
Source: Journal of Aging and Physical Activity - April 29, 2024 Category: Geriatrics Authors: Jiacheng Ma Xiaoli Pang Ismail Laher Shunchang Li Source Type: research
Choriocapillaris Perfusion after 8 Weeks of High-Speed Circuit Training in Older Healthy Adults
CONCLUSION: CCD appeared to remain stable after 8 weeks of HSCT in healthy older individuals, possibly due to autoregulation. Further research with extended training may be necessary to verify these findings.PMID:38679899 | DOI:10.1080/02713683.2024.2346538 (Source: Current Eye Research)
Source: Current Eye Research - April 29, 2024 Category: Opthalmology Authors: Ava-Gaye Simms Joseph F Signorile Gustavo Rosa Gameiro Abdulrahman Mamoon Allaf Jianhua Wang Hong Jiang Source Type: research
Best practices for the dissemination and implementation of neuromuscular training injury prevention warm-ups in youth team sport: a systematic review
CONCLUSIONS: Workshops including supplementary resources supported the success of NMT programme implementation, however, few studies examined effectiveness. High-quality D&I studies are needed to optimise the translation of NMT programmes into routine practice in youth sport.PMID:38684329 | DOI:10.1136/bjsports-2023-106906 (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - April 29, 2024 Category: Sports Medicine Authors: Destiny Lutz Carla van den Berg Anu M R äisänen Isla J Shill Jemma Kim Kenzie Vaandering Alix Hayden Kati Pasanen Kathryn J Schneider Carolyn A Emery Oluwatoyosi B A Owoeye Source Type: research
"Emergency Room Incision and Drainage of Perirectal Abscess is Equivalent to Incision and Drainage in the Operating Room"
In this study, for patients presenting to the ED, bedside drainage was found to be an adequate management strategy to achieve complete drainage without a significant increase in the rate of complications when compared to operative drainage.PMID:38684322 | DOI:10.1177/00031348241248785 (Source: The American Surgeon)
Source: The American Surgeon - April 29, 2024 Category: Surgery Authors: Seija A Maniskas Mallory I Jebbia Dena Nasir Gabriel Akopian Howard S Kaufman Juliane Y Golan Source Type: research
Association between opioid use disorder and palliative care: a cohort study using linked health administrative data in Ontario, Canada
CMAJ. 2024 Apr 28;196(16):E547-E557. doi: 10.1503/cmaj.231419.ABSTRACTBACKGROUND: People with opioid use disorder (OUD) are at risk of premature death and can benefit from palliative care. We sought to compare palliative care provision for decedents with and without OUD.METHODS: We conducted a cohort study using health administrative databases in Ontario, Canada, to identify people who died between July 1, 2015, and Dec. 31, 2021. The exposure was OUD, defined as having emergency department visits, hospital admissions, or pharmacologic treatments suggestive of OUD within 3 years of death. Our primary outcome was receipt of...
Source: cmaj - April 29, 2024 Category: General Medicine Authors: Jenny Lau Mary M Scott Karl Everett Tara Gomes Peter Tanuseputro Sheila Jennings Rebecca Bagnarol Camilla Zimmermann Sarina R Isenberg Source Type: research
Computed tomography-based radiomics to predict early recurrence of hepatocellular carcinoma post-hepatectomy in patients background on cirrhosis
CONCLUSION: The combined model, integrating both radiomics and clinical-radiologic characteristics, exhibited excellent performance in HCC with cirrhosis. The K-M curves assessing OS revealed statistically significant differences.PMID:38681988 | PMC:PMC11045480 | DOI:10.3748/wjg.v30.i15.2128 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Gui-Xiang Qian Zi-Ling Xu Yong-Hai Li Jian-Lin Lu Xiang-Yi Bu Ming-Tong Wei Wei-Dong Jia Source Type: research
A Reproducible Peritonsillar Abscess Incision and Drainage Model for Junior Trainees
CONCLUSIONS: Our model offers an affordable and efficient training opportunity for residents to enhance their competence in managing PTAs. This approach, with its simple yet effective design and low production cost, shows potential for scalability on a broader scale.PMID:38682302 | DOI:10.1177/00034894241249611 (Source: The Annals of Otology, Rhinology, and Laryngology)
Source: The Annals of Otology, Rhinology, and Laryngology - April 29, 2024 Category: ENT & OMF Authors: Azmi Marouf Samuel Doty Humzah A Quereshy Benjamin R Johnson Claudia I Cabrera Sarah Mowry Akina Tamaki Source Type: research
Computed tomography-based radiomics to predict early recurrence of hepatocellular carcinoma post-hepatectomy in patients background on cirrhosis
CONCLUSION: The combined model, integrating both radiomics and clinical-radiologic characteristics, exhibited excellent performance in HCC with cirrhosis. The K-M curves assessing OS revealed statistically significant differences.PMID:38681988 | PMC:PMC11045480 | DOI:10.3748/wjg.v30.i15.2128 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Gui-Xiang Qian Zi-Ling Xu Yong-Hai Li Jian-Lin Lu Xiang-Yi Bu Ming-Tong Wei Wei-Dong Jia Source Type: research
Learning motivation and self-assessment in health economics: a survey on overconfidence in healthcare providers
DISCUSSION: We could show the presence of overconfidence in health economics, which is consistent with studies in healthcare and the economy. The subjective perception of some medical educators, being role models to students and having a superior 'attitude' (eg, morality) concerning the economy may foster prejudice against economists as students might believe them. It also may aggravate moral distress and disrupts interactions between healthcare providers managers and leaders. Considering the study's limitations, lifelong interprofessional and reflective training and train-the-trainer programmes may be mandatory to address...
Source: Pain Physician - April 29, 2024 Category: Anesthesiology Authors: Stefan Bushuven Michael Bentele Milena Trifunovic-Koenig Bianka Gerber Stefanie Bentele Fritz Hagen Oliver Schoeffski Hartwig Marung Reinhard Strametz Source Type: research
Emergency Physician Performed Ultrasound-Guided Abdominal Paracentesis: A Retrospective Analysis
CONCLUSIONS: Emergency physicians with training in real-time needle guidance with ultrasound were able to use POCUS to perform ultrasound-guided paracentesis in the emergency department with a high success rate and no fatal complications. Based on our experience, we recommend performing ultrasound-guided paracentesis using a linear transducer, with attention to identifying vessels near the procedure site and maintaining sterile technique.PMID:38681156 | PMC:PMC11044928 | DOI:10.24908/pocus.v9i1.16668 (Source: Pain Physician)
Source: Pain Physician - April 29, 2024 Category: Anesthesiology Authors: Brandon M Wubben Jad Dandashi Omar Rizvi Srikar Adhikari Source Type: research
Understanding IT in Healthcare: Relevance and Training Needs of IT in Private Medical Practice
CONCLUSION: The findings underscore a significant need for targeted IT training and support in medical practices, particularly in areas related to the medical practice and security. Addressing these needs could lead to improved healthcare delivery and better management of technological resources in the healthcare sector.PMID:38682526 | DOI:10.3233/SHTI240033 (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 29, 2024 Category: Information Technology Authors: Marco Schweitzer Werner O Hackl Sabrina B Neururer Bernhard Pfeifer Source Type: research
The Tools for Integrated Management of Childhood Illness (TIMCI) study protocol: a multi-country mixed-method evaluation of pulse oximetry and clinical decision support algorithms
Glob Health Action. 2024 Dec 31;17(1):2326253. doi: 10.1080/16549716.2024.2326253. Epub 2024 Apr 29.ABSTRACTEffective and sustainable strategies are needed to address the burden of preventable deaths among children under-five in resource-constrained settings. The Tools for Integrated Management of Childhood Illness (TIMCI) project aims to support healthcare providers to identify and manage severe illness, whilst promoting resource stewardship, by introducing pulse oximetry and clinical decision support algorithms (CDSAs) to primary care facilities in India, Kenya, Senegal and Tanzania. Health impact is assessed through: a ...
Source: Global Health Action - April 29, 2024 Category: International Medicine & Public Health Authors: Fenella Beynon H élène Langet Leah F Bohle Shally Awasthi Ousmane Ndiaye James Machoki M'Imunya Honorati Masanja Susan Horton Maymouna Ba Silvia Cicconi Mira Emmanuel-Fabula Papa Moctar Faye Tracy R Glass Kristina Keitel Divas Kumar Gaurav Kumar Gillian Source Type: research
Neither Amphetamine nor Sub-Anesthetic Ketamine Treatment during Adolescence Impairs Devaluation in Rats Tested during Adulthood
CONCLUSIONS: We discuss possible reasons for this discrepancy with the prior literature, including (1) the age of exposure and (2) the pattern in the previous literature that most previous demonstrations of drug exposure impairing devaluation in laboratory animals may be attributed to either drug-associated cues present in the testing environment and/or accelerated habit learning in tasks that predispose laboratory animals towards habit formation with extended training (with training procedures that should resist the formation of habits in the current experiment). However, additional research is needed to examine the effec...
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Ian R Davis Hayley Fisher Caitlin McLean Jackson Murray Charles L Pickens Source Type: research
Preparing Medical Students to Care for Patients with Opioid Use Disorder: Buprenorphine Waiver Training in Undergraduate Medical Education
Acad Psychiatry. 2024 Apr 29. doi: 10.1007/s40596-024-01968-w. Online ahead of print.NO ABSTRACTPMID:38684575 | DOI:10.1007/s40596-024-01968-w (Source: The Journal of American Association of Directors of Psychiatric Residency Training)
Source: The Journal of American Association of Directors of Psychiatric Residency Training - April 29, 2024 Category: Psychiatry Authors: Elly Riser Amanda G Kennedy Leigh Ann Holterman John Brooklyn Sanchit Maruti Halle G Sobel Source Type: research
