Refractory hypercalcemia owing to vitamin A toxicity in a 4-year-old boy.
PMID: 32571883 [PubMed - in process] (Source: cmaj)
Source: cmaj - June 22, 2020 Category: General Medicine Authors: Lorenzo M, Nadeau M, Harrington J, Gill PJ Tags: CMAJ Source Type: research

Ensuring adequate capital investment in Canadian health care.
PMID: 32571884 [PubMed - in process] (Source: cmaj)
Source: cmaj - June 22, 2020 Category: General Medicine Authors: Teja B, Daniel I, Pink GH, Brown A, Klein DJ Tags: CMAJ Source Type: research

Vestibular neuritis.
PMID: 32571885 [PubMed - in process] (Source: cmaj)
Source: cmaj - June 22, 2020 Category: General Medicine Authors: Walter AJ Tags: CMAJ Source Type: research

Need caring, compassion or comfort? Sorry, I'm a doctor.
PMID: 32571886 [PubMed - in process] (Source: cmaj)
Source: cmaj - June 22, 2020 Category: General Medicine Authors: Dale C, Webster F Tags: CMAJ Source Type: research

Should triage guidelines be revisited ahead of a second wave of COVID-19?
PMID: 32571887 [PubMed - in process] (Source: cmaj)
Source: cmaj - June 22, 2020 Category: General Medicine Authors: Owens B Tags: CMAJ Source Type: research

Organ transplants drop dramatically during pandemic.
PMID: 32571888 [PubMed - in process] (Source: cmaj)
Source: cmaj - June 22, 2020 Category: General Medicine Authors: Owens B Tags: CMAJ Source Type: research

Immune checkpoint inhibitors in cancer immunotherapy.
PMID: 32540906 [PubMed - in process] (Source: cmaj)
Source: cmaj - June 15, 2020 Category: General Medicine Authors: Himmel ME, Saibil SD, Saltman AP Tags: CMAJ Source Type: research

Disseminated gonococcal infection: the importance of testing all mucosal sites.
PMID: 32540907 [PubMed - in process] (Source: cmaj)
Source: cmaj - June 15, 2020 Category: General Medicine Authors: Gunaratne K, Gold WL, Wu PE Tags: CMAJ Source Type: research

Protecting rural Canadians from extreme heat.
PMID: 32540908 [PubMed - in process] (Source: cmaj)
Source: cmaj - June 15, 2020 Category: General Medicine Authors: Liang KE, Kosatsky T Tags: CMAJ Source Type: research

Centralized referral systems can both shorten wait times and preserve patient autonomy.
PMID: 32540909 [PubMed - in process] (Source: cmaj)
Source: cmaj - June 15, 2020 Category: General Medicine Authors: McAlister CN Tags: CMAJ Source Type: research

Psychological support for health care workers during the COVID-19 pandemic.
PMID: 32540910 [PubMed - in process] (Source: cmaj)
Source: cmaj - June 15, 2020 Category: General Medicine Authors: Leszcz M, Maunder R, Hunter J Tags: CMAJ Source Type: research

New Canadian guideline is wrong to say acetylsalicylic acid is only for patients with symptomatic vascular disease.
PMID: 32540911 [PubMed - in process] (Source: cmaj)
Source: cmaj - June 15, 2020 Category: General Medicine Authors: Spence JD Tags: CMAJ Source Type: research

Quiet rooms.
PMID: 32540912 [PubMed - in process] (Source: cmaj)
Source: cmaj - June 15, 2020 Category: General Medicine Authors: Ding J Tags: CMAJ Source Type: research

Is Canada ready for the second wave of COVID-19?
PMID: 32540913 [PubMed - in process] (Source: cmaj)
Source: cmaj - June 15, 2020 Category: General Medicine Authors: Vogel L Tags: CMAJ Source Type: research

Reporting of financial conflicts of interest by Canadian clinical practice guideline producers: a descriptive study.
Abstract BACKGROUND: The producers of clinical practice guidelines (CPGs) may not disclose industry funding in their CPGs. We reviewed Canadian national CPGs to examine the existence and disclosure of industry-related organizational funding in the CPGs, financial conflicts of interest of committee members and organizational procedures for managing financial conflicts of interest. METHODS: For this descriptive study, we searched the asset map of the Strategy for Patient-Oriented Research Evidence Alliance and the CPG Infobase for CPGs published between Jan. 1, 2016, and Nov. 30, 2018. Eligible guidelines had t...
Source: cmaj - June 8, 2020 Category: General Medicine Authors: Elder K, Turner KA, Cosgrove L, Lexchin J, Shnier A, Moore A, Straus S, Thombs BD Tags: CMAJ Source Type: research

Incidental COVID-19 on PET/CT imaging.
PMID: 32444479 [PubMed - as supplied by publisher] (Source: cmaj)
Source: cmaj - May 22, 2020 Category: General Medicine Authors: Amin R, Grinblat L, Husain M Tags: CMAJ Source Type: research

Chest imaging in patients with suspected COVID-19.
PMID: 32444480 [PubMed - as supplied by publisher] (Source: cmaj)
Source: cmaj - May 22, 2020 Category: General Medicine Authors: Adams SJ, Dennie C Tags: CMAJ Source Type: research

Temporal estimates of case-fatality rate for COVID-19 outbreaks in Canada and the United States.
Abstract BACKGROUND: Estimates of the casefatality rate (CFR) associated with coronavirus disease 2019 (COVID-19) vary widely in different population settings. We sought to estimate and compare the COVID-19 CFR in Canada and the United States while adjusting for 2 potential biases in crude CFR. METHODS: We used the daily incidence of confirmed COVID-19 cases and deaths in Canada and the US from Jan. 31 to Apr. 22, 2020. We applied a statistical method to minimize bias in the crude CFR by accounting for the survival interval as the lag time between disease onset and death, while considering reporting rates of ...
Source: cmaj - May 22, 2020 Category: General Medicine Authors: Abdollahi E, Champredon D, Langley JM, Galvani AP, Moghadas SM Tags: CMAJ Source Type: research

Efficacy and safety of convalescent plasma for severe COVID-19 based on evidence in other severe respiratory viral infections: a systematic review and meta-analysis.
att G Abstract BACKGROUND: The safety and efficacy of convalescent plasma in severe coronavirus disease 2019 (COVID-19) remain uncertain. To support a guideline on COVID-19 management, we conducted a systematic review and meta-analysis of convalescent plasma in COVID-19 and other severe respiratory viral infections. METHODS: In March 2020, we searched international and Chinese biomedical literature databases, clinical trial registries and prepublication sources for randomized controlled trials (RCTs) and nonrandomized studies comparing patients receiving and not receiving convalescent plasma. We included pati...
Source: cmaj - May 22, 2020 Category: General Medicine Authors: Devasenapathy N, Ye Z, Loeb M, Fang F, Najafabadi BT, Xiao Y, Couban R, B├ęgin P, Guyatt G Tags: CMAJ Source Type: research

Postpartum exacerbation of antenatal COVID-19 pneumonia in 3 women.
PMID: 32376643 [PubMed - as supplied by publisher] (Source: cmaj)
Source: cmaj - May 6, 2020 Category: General Medicine Authors: An P, Wood BJ, Li W, Zhang M, Ye Y Tags: CMAJ Source Type: research

Confronting the COVID-19 surgery crisis: time for transformational change.
PMID: 32376644 [PubMed - as supplied by publisher] (Source: cmaj)
Source: cmaj - May 6, 2020 Category: General Medicine Authors: Urbach DR, Martin D Tags: CMAJ Source Type: research

Treatment of patients with nonsevere and severe coronavirus disease 2019: an evidence-based guideline.
PMID: 32350002 [PubMed - as supplied by publisher] (Source: cmaj)
Source: cmaj - April 29, 2020 Category: General Medicine Authors: Ye Z, Rochwerg B, Wang Y, Adhikari NK, Murthy S, Lamontagne F, Fowler RA, Qiu H, Wei L, Sang L, Loeb M, Shen N, Huang M, Jiang Z, Arabi YM, Colunga-Lozano LE, Jiang L, Koh Y, Liu D, Liu F, Phua J, Shen A, Huo T, Du B, Zhai S, Guyatt GH Tags: CMAJ Source Type: research

Mitigating the psychological effects of COVID-19 on health care workers.
PMID: 32295761 [PubMed - as supplied by publisher] (Source: cmaj)
Source: cmaj - April 15, 2020 Category: General Medicine Authors: Wu PE, Styra R, Gold WL Tags: CMAJ Source Type: research

Chest CT imaging of an early Canadian case of COVID-19 in a 28-year-old man.
PMID: 32295762 [PubMed - as supplied by publisher] (Source: cmaj)
Source: cmaj - April 15, 2020 Category: General Medicine Authors: Singh N, Fratesi J Tags: CMAJ Source Type: research

Mathematical modelling of COVID-19 transmission and mitigation strategies in the population of Ontario, Canada.
We present medians and credible intervals from 100 replicates per scenario using a 2-year time horizon. RESULTS: We estimated that 56% (95% credible interval 42%-63%) of the Ontario population would be infected over the course of the epidemic in the base case. At the epidemic peak, we projected 107 000 (95% credible interval 60 760-149 000) cases in hospital (non-ICU) and 55 500 (95% credible interval 32 700-75 200) cases in ICU. For fixed-duration scenarios, all interventions were projected to delay and reduce the height of the epidemic peak relative to the base case, with restrictive physical distancing estimated to...
Source: cmaj - April 8, 2020 Category: General Medicine Authors: Tuite AR, Fisman DN, Greer AL Tags: CMAJ Source Type: research

Social distancing to combat COVID-19: We are all on the front line.
PMID: 32269019 [PubMed - as supplied by publisher] (Source: cmaj)
Source: cmaj - April 8, 2020 Category: General Medicine Authors: Patrick K, Stanbrook MB, Laupacis A Tags: CMAJ Source Type: research

Projecting demand for critical care beds during COVID-19 outbreaks in Canada.
Abstract BACKGROUND: Increasing numbers of coronavirus disease 2019 (COVID-19) cases in Canada may create substantial demand for hospital admission and critical care. We evaluated the extent to which self-isolation of mildly ill people delays the peak of outbreaks and reduces the need for this care in each Canadian province. METHODS: We developed a computational model and simulated scenarios for COVID-19 outbreaks within each province. Using estimates of COVID-19 characteristics, we projected the hospital and intensive care unit (ICU) bed requirements without self-isolation, assuming an average number of 2.5 ...
Source: cmaj - April 8, 2020 Category: General Medicine Authors: Shoukat A, Wells CR, Langley JM, Singer BH, Galvani AP Tags: CMAJ Source Type: research

Safety considerations with chloroquine, hydroxychloroquine and azithromycin in the management of SARS-CoV-2 infection.
PMID: 32269021 [PubMed - as supplied by publisher] (Source: cmaj)
Source: cmaj - April 8, 2020 Category: General Medicine Authors: Juurlink DN Tags: CMAJ Source Type: research

Proportion of female recipients of resident-selected awards across Canada from 2000 to 2018: a retrospective observational study.
We examined the sex distribution of recipients of Canadian residency association awards. METHODS: We conducted a retrospective observational study of the sex of staff and resident physician recipients of resident-selected awards from provincial and national residency associations using data from 2000-2018. We classified awards into professionalism, advocacy and wellness awards, and education and teaching awards based on award names and descriptions, and compared the proportion of male and female recipients in these categories. RESULTS: We identified 314 recipients of staff physician awards and 129 recipients of r...
Source: cmaj - April 1, 2020 Category: General Medicine Authors: Silverberg S, Ruzycki SM Tags: CMAJ Open Source Type: research

Perspectives of specialists and family physicians in interprofessional teams in caring for patients with multimorbidity: a qualitative study.
Abstract BACKGROUND: Patients with multimorbidity often require services across different health care settings, yet team processes among settings are rarely implemented. We explored perceptions of specialists and family physicians collaborating in a telemedicine interprofessional consultation for patients with multimorbidity to better understand the value of bringing physicians together across the boundaries of health care settings. METHODS: This was a descriptive qualitative, interview-based study. Physicians who had previously participated in the Telemedicine Interprofessional Model of Practice for Aging an...
Source: cmaj - April 1, 2020 Category: General Medicine Authors: Boeckxstaens P, Brown JB, Reichert SM, Smith CNC, Stewart M, Fortin M Tags: CMAJ Open Source Type: research

Quarantine.
PMID: 32198177 [PubMed - as supplied by publisher] (Source: cmaj)
Source: cmaj - March 20, 2020 Category: General Medicine Authors: Coomes EA, Leis JA, Gold WL Tags: CMAJ Source Type: research

Working together to contain and manage COVID-19.
PMID: 32184199 [PubMed - as supplied by publisher] (Source: cmaj)
Source: cmaj - March 17, 2020 Category: General Medicine Authors: Laupacis A Tags: CMAJ Source Type: research

Association between Chinese or South Asian ethnicity and end-of-life care in Ontario, Canada.
Abstract BACKGROUND: Ethnicity may be associated with important aspects of end-of-life care, such as what treatments are received, access to palliative care and where people die. However, most studies have focused on end-of-life care of white, Hispanic and black patients. We sought to compare end-of-life care delivered to people of Chinese and South Asian ethnicity with that delivered to others from the general population, in Ontario, Canada. METHODS: In this population-based cohort study, we included all people who died in Ontario, Canada, between Apr. 1, 2004, and Mar. 31, 2015. People were identified as ha...
Source: cmaj - March 16, 2020 Category: General Medicine Authors: Yarnell CJ, Fu L, Bonares MJ, Nayfeh A, Fowler RA Tags: CMAJ Source Type: research

An approach to the care of patients with irritable bowel syndrome.
PMID: 32179536 [PubMed - in process] (Source: cmaj)
Source: cmaj - March 16, 2020 Category: General Medicine Authors: Farmer AD, Wood E, Ruffle JK Tags: CMAJ Source Type: research

Acute aortic dissection presenting as status epilepticus.
PMID: 32179537 [PubMed - in process] (Source: cmaj)
Source: cmaj - March 16, 2020 Category: General Medicine Authors: Eikelboom R, Katz N Tags: CMAJ Source Type: research

Cutaneous contact allergy to a glucose monitor.
PMID: 32179538 [PubMed - in process] (Source: cmaj)
Source: cmaj - March 16, 2020 Category: General Medicine Authors: DeKoven JG, Shear NH Tags: CMAJ Source Type: research

Ethnicity and "aggressive" end-of-life care.
Ethnicity and "aggressive" end-of-life care. CMAJ. 2020 Mar 16;192(11):E287-E288 Authors: Sheikh A, Dhami S PMID: 32179539 [PubMed - in process] (Source: cmaj)
Source: cmaj - March 16, 2020 Category: General Medicine Authors: Sheikh A, Dhami S Tags: CMAJ Source Type: research

A broader perspective needed in Canadian guideline for Parkinson disease.
PMID: 32179540 [PubMed - in process] (Source: cmaj)
Source: cmaj - March 16, 2020 Category: General Medicine Authors: Sack J Tags: CMAJ Source Type: research

Artificial intelligence isn't.
PMID: 32179541 [PubMed - in process] (Source: cmaj)
Source: cmaj - March 16, 2020 Category: General Medicine Authors: Burns DM Tags: CMAJ Source Type: research

New dawn.
PMID: 32179542 [PubMed - in process] (Source: cmaj)
Source: cmaj - March 16, 2020 Category: General Medicine Authors: Sivanand A Tags: CMAJ Source Type: research

Ontario ponders expanded prescribing by midwives.
PMID: 32179543 [PubMed - in process] (Source: cmaj)
Source: cmaj - March 16, 2020 Category: General Medicine Authors: Varner C Tags: CMAJ Source Type: research

Screening strategies to identify sepsis in the prehospital setting: a validation study.
Abstract BACKGROUND: In the prehospital setting, differentiating patients who have sepsis from those who have infection but no organ dysfunction is important to initiate sepsis treatments appropriately. We aimed to identify which published screening strategies for paramedics to use in identifying patients with sepsis provide the most certainty for prehospital diagnosis. METHODS: We identified published strategies for screening by paramedics through a literature search. We then conducted a validation study in Alberta, Canada, from April 2015 to March 2016. For adult patients (≥ 18 yr) who were transferred b...
Source: cmaj - March 9, 2020 Category: General Medicine Authors: Lane DJ, Wunsch H, Saskin R, Cheskes S, Lin S, Morrison LJ, Scales DC Tags: CMAJ Source Type: research

Clinical guideline for homeless and vulnerably housed people, and people with lived homelessness experience.
der M, Guenter D, Muckle W, Hwang S, Stergiopoulos V, Tugwell P PMID: 32152052 [PubMed - in process] (Source: cmaj)
Source: cmaj - March 9, 2020 Category: General Medicine Authors: Pottie K, Kendall CE, Aubry T, Magwood O, Andermann A, Salvalaggio G, Ponka D, Bloch G, Brcic V, Agbata E, Thavorn K, Hannigan T, Bond A, Crouse S, Goel R, Shoemaker E, Wang JZJ, Mott S, Kaur H, Mathew C, Hashmi SS, Saad A, Piggott T, Arya N, Kozloff N, B Tags: CMAJ Source Type: research

HIV diagnosed after 50 years of age.
PMID: 32152053 [PubMed - in process] (Source: cmaj)
Source: cmaj - March 9, 2020 Category: General Medicine Authors: McMillan JM, Rubin LH, Gill MJ Tags: CMAJ Source Type: research

Pulmonary tumour thrombotic microangiopathy.
PMID: 32152054 [PubMed - in process] (Source: cmaj)
Source: cmaj - March 9, 2020 Category: General Medicine Authors: Fujikawa H, Wakabayashi T Tags: CMAJ Source Type: research

Pekiwewin (coming home): advancing good relations with Indigenous people experiencing homelessness.
PMID: 32152055 [PubMed - in process] (Source: cmaj)
Source: cmaj - March 9, 2020 Category: General Medicine Authors: Thistle J, Smylie J Tags: CMAJ Source Type: research

Disclosing breast density empowers women to make informed decisions about their health.
PMID: 32152056 [PubMed - in process] (Source: cmaj)
Source: cmaj - March 9, 2020 Category: General Medicine Authors: Ewart E Tags: CMAJ Source Type: research

Responses to "Health Canada needs to act on laboratory-developed diagnostics".
Responses to "Health Canada needs to act on laboratory-developed diagnostics". CMAJ. 2020 Mar 09;192(10):E261 Authors: Holloway K, Miller FA, Rousseau F, Gutierrez A, Hogarth S PMID: 32152057 [PubMed - in process] (Source: cmaj)
Source: cmaj - March 9, 2020 Category: General Medicine Authors: Holloway K, Miller FA, Rousseau F, Gutierrez A, Hogarth S Tags: CMAJ Source Type: research

Aphasia: Bob, Felicity and I.
PMID: 32152058 [PubMed - in process] (Source: cmaj)
Source: cmaj - March 9, 2020 Category: General Medicine Authors: Finestone HM Tags: CMAJ Source Type: research

Proposed protocol to keep COVID-19 out of hospitals.
PMID: 32152059 [PubMed - in process] (Source: cmaj)
Source: cmaj - March 9, 2020 Category: General Medicine Authors: Glauser W Tags: CMAJ Source Type: research