The Association between Fourier Parameters and Clinical Parameters in Myopic Children Undergoing Orthokeratology
Curr Eye Res. 2021 Jun 6:1-9. doi: 10.1080/02713683.2021.1917619. Online ahead of print.ABSTRACTPurpose: To explore how Fourier parameters are associated with axial length growth (ALG) and clinical parameters in children who underwent orthokeratology.Materials and Methods: A total of 267 children received orthokeratology. Baseline cycloplegic autorefraction was performed. Axial length was measured at baseline and one year after the lens dispatch, and the difference was defined as ALG. Corneal topography was performed at the same two visits. Central treatment zone (CTZ) was identified from the difference between the two tan...
Source: Current Eye Research - June 7, 2021 Category: Opthalmology Authors: Di Wang Dejia Wen Bin Zhang Weiping Lin Guihua Liu Bei Du Fang Lin Xiaorong Li Ruihua Wei Source Type: research

The Association between Fourier Parameters and Clinical Parameters in Myopic Children Undergoing Orthokeratology
Curr Eye Res. 2021 Jun 6:1-9. doi: 10.1080/02713683.2021.1917619. Online ahead of print.ABSTRACTPurpose: To explore how Fourier parameters are associated with axial length growth (ALG) and clinical parameters in children who underwent orthokeratology.Materials and Methods: A total of 267 children received orthokeratology. Baseline cycloplegic autorefraction was performed. Axial length was measured at baseline and one year after the lens dispatch, and the difference was defined as ALG. Corneal topography was performed at the same two visits. Central treatment zone (CTZ) was identified from the difference between the two tan...
Source: Current Eye Research - June 7, 2021 Category: Opthalmology Authors: Di Wang Dejia Wen Bin Zhang Weiping Lin Guihua Liu Bei Du Fang Lin Xiaorong Li Ruihua Wei Source Type: research

Acquired Monocular Blindness Associated with Retinitis and Optic Neuritis in COVID-19
Curr Eye Res. 2021 May 30:1-2. doi: 10.1080/02713683.2021.1925699. Online ahead of print.NO ABSTRACTPMID:34056996 | DOI:10.1080/02713683.2021.1925699 (Source: Current Eye Research)
Source: Current Eye Research - May 31, 2021 Category: Opthalmology Authors: Ling Liu Danrui Cai Xin Huang Yin Shen Source Type: research

Acquired Monocular Blindness Associated with Retinitis and Optic Neuritis in COVID-19
Curr Eye Res. 2021 May 30:1-2. doi: 10.1080/02713683.2021.1925699. Online ahead of print.NO ABSTRACTPMID:34056996 | DOI:10.1080/02713683.2021.1925699 (Source: Current Eye Research)
Source: Current Eye Research - May 31, 2021 Category: Opthalmology Authors: Ling Liu Danrui Cai Xin Huang Yin Shen Source Type: research

Acquired Monocular Blindness Associated with Retinitis and Optic Neuritis in COVID-19
Curr Eye Res. 2021 May 30:1-2. doi: 10.1080/02713683.2021.1925699. Online ahead of print.NO ABSTRACTPMID:34056996 | DOI:10.1080/02713683.2021.1925699 (Source: Current Eye Research)
Source: Current Eye Research - May 31, 2021 Category: Opthalmology Authors: Ling Liu Danrui Cai Xin Huang Yin Shen Source Type: research

Acquired Monocular Blindness Associated with Retinitis and Optic Neuritis in COVID-19
Curr Eye Res. 2021 May 30:1-2. doi: 10.1080/02713683.2021.1925699. Online ahead of print.NO ABSTRACTPMID:34056996 | DOI:10.1080/02713683.2021.1925699 (Source: Current Eye Research)
Source: Current Eye Research - May 31, 2021 Category: Opthalmology Authors: Ling Liu Danrui Cai Xin Huang Yin Shen Source Type: research

Acquired Monocular Blindness Associated with Retinitis and Optic Neuritis in COVID-19
Curr Eye Res. 2021 May 30:1-2. doi: 10.1080/02713683.2021.1925699. Online ahead of print.NO ABSTRACTPMID:34056996 | DOI:10.1080/02713683.2021.1925699 (Source: Current Eye Research)
Source: Current Eye Research - May 31, 2021 Category: Opthalmology Authors: Ling Liu Danrui Cai Xin Huang Yin Shen Source Type: research

Acquired Monocular Blindness Associated with Retinitis and Optic Neuritis in COVID-19
Curr Eye Res. 2021 May 30:1-2. doi: 10.1080/02713683.2021.1925699. Online ahead of print.NO ABSTRACTPMID:34056996 | DOI:10.1080/02713683.2021.1925699 (Source: Current Eye Research)
Source: Current Eye Research - May 31, 2021 Category: Opthalmology Authors: Ling Liu Danrui Cai Xin Huang Yin Shen Source Type: research

Corneal Crosslinking Biomechanics Evaluated by a Novel and Easily Implemented Differential Tonometry Method
Discussion: Differential tonometry between standard GAT and corneal biomechanical compensating CATS prisms indicates findings consistent with increased corneal rigidity following CXL and may demonstrate a simple and sensitive method for measurement of relative corneal biomechanical changes due to pharmacologic agents and procedures.PMID:34039182 | DOI:10.1080/02713683.2021.1916039 (Source: Current Eye Research)
Source: Current Eye Research - May 27, 2021 Category: Opthalmology Authors: Mingwu Wang John Berdahl Sean McCafferty Source Type: research

Effects of Mechanical Compression on Cell Morphology and Function in Human Corneal Fibroblasts
Conclusions: Mechanical compression alters cell morphology, inhibits proliferation, induces apoptosis, upregulates genes related to extracellular matrix degradation, and downregulates corneal structural genes in human corneal fibroblasts. This study provides evidence that compressive stress significantly influences corneal keratocytes. Our findings suggest that this mechanical effect may be related to keratoconus associated with chronic eye rubbing.PMID:34039223 | DOI:10.1080/02713683.2021.1904510 (Source: Current Eye Research)
Source: Current Eye Research - May 27, 2021 Category: Opthalmology Authors: Jing Zhang Shu Yang Youhua Tan Yan Wang Source Type: research

Corneal Crosslinking Biomechanics Evaluated by a Novel and Easily Implemented Differential Tonometry Method
Discussion: Differential tonometry between standard GAT and corneal biomechanical compensating CATS prisms indicates findings consistent with increased corneal rigidity following CXL and may demonstrate a simple and sensitive method for measurement of relative corneal biomechanical changes due to pharmacologic agents and procedures.PMID:34039182 | DOI:10.1080/02713683.2021.1916039 (Source: Current Eye Research)
Source: Current Eye Research - May 27, 2021 Category: Opthalmology Authors: Mingwu Wang John Berdahl Sean McCafferty Source Type: research

Effects of Mechanical Compression on Cell Morphology and Function in Human Corneal Fibroblasts
Conclusions: Mechanical compression alters cell morphology, inhibits proliferation, induces apoptosis, upregulates genes related to extracellular matrix degradation, and downregulates corneal structural genes in human corneal fibroblasts. This study provides evidence that compressive stress significantly influences corneal keratocytes. Our findings suggest that this mechanical effect may be related to keratoconus associated with chronic eye rubbing.PMID:34039223 | DOI:10.1080/02713683.2021.1904510 (Source: Current Eye Research)
Source: Current Eye Research - May 27, 2021 Category: Opthalmology Authors: Jing Zhang Shu Yang Youhua Tan Yan Wang Source Type: research

Corneal Crosslinking Biomechanics Evaluated by a Novel and Easily Implemented Differential Tonometry Method
Discussion: Differential tonometry between standard GAT and corneal biomechanical compensating CATS prisms indicates findings consistent with increased corneal rigidity following CXL and may demonstrate a simple and sensitive method for measurement of relative corneal biomechanical changes due to pharmacologic agents and procedures.PMID:34039182 | DOI:10.1080/02713683.2021.1916039 (Source: Current Eye Research)
Source: Current Eye Research - May 27, 2021 Category: Opthalmology Authors: Mingwu Wang John Berdahl Sean McCafferty Source Type: research

Effects of Mechanical Compression on Cell Morphology and Function in Human Corneal Fibroblasts
Conclusions: Mechanical compression alters cell morphology, inhibits proliferation, induces apoptosis, upregulates genes related to extracellular matrix degradation, and downregulates corneal structural genes in human corneal fibroblasts. This study provides evidence that compressive stress significantly influences corneal keratocytes. Our findings suggest that this mechanical effect may be related to keratoconus associated with chronic eye rubbing.PMID:34039223 | DOI:10.1080/02713683.2021.1904510 (Source: Current Eye Research)
Source: Current Eye Research - May 27, 2021 Category: Opthalmology Authors: Jing Zhang Shu Yang Youhua Tan Yan Wang Source Type: research

Corneal Crosslinking Biomechanics Evaluated by a Novel and Easily Implemented Differential Tonometry Method
Discussion: Differential tonometry between standard GAT and corneal biomechanical compensating CATS prisms indicates findings consistent with increased corneal rigidity following CXL and may demonstrate a simple and sensitive method for measurement of relative corneal biomechanical changes due to pharmacologic agents and procedures.PMID:34039182 | DOI:10.1080/02713683.2021.1916039 (Source: Current Eye Research)
Source: Current Eye Research - May 27, 2021 Category: Opthalmology Authors: Mingwu Wang John Berdahl Sean McCafferty Source Type: research

Effects of Mechanical Compression on Cell Morphology and Function in Human Corneal Fibroblasts
Conclusions: Mechanical compression alters cell morphology, inhibits proliferation, induces apoptosis, upregulates genes related to extracellular matrix degradation, and downregulates corneal structural genes in human corneal fibroblasts. This study provides evidence that compressive stress significantly influences corneal keratocytes. Our findings suggest that this mechanical effect may be related to keratoconus associated with chronic eye rubbing.PMID:34039223 | DOI:10.1080/02713683.2021.1904510 (Source: Current Eye Research)
Source: Current Eye Research - May 27, 2021 Category: Opthalmology Authors: Jing Zhang Shu Yang Youhua Tan Yan Wang Source Type: research

Endothelial Cell Viability after DMEK Graft Preparation
Conclusion: Cell viability of most of the grafts will not be affected by preparation and storage. Endothelial cell damage may be observed for some grafts within hours after preparation, with insignificant additional ECD changes during 3-7 days of graft storage. Implementing an additional post-preparation step in the eye bank to evaluate cell density before graft release for transplantation may help to reduce postoperative DMEK complications.PMID:34027768 | DOI:10.1080/02713683.2021.1927111 (Source: Current Eye Research)
Source: Current Eye Research - May 24, 2021 Category: Opthalmology Authors: Alina Miron Anita Sajet Esther A Groeneveld-van Beek Jet S Kok Mehtap Dedeci Maloeke de Jong Vicky Amo-Addae Gerrit R J Melles Silke Oellerich Jacqueline van der Wees Source Type: research

Development of allergic conjunctivitis induced by < em > Acanthamoeba < /em > excretory-secretory protein and the effect of resolvin D1 on treatment
CONCLUSIONS: Acanthamoeba could be used to establish an animal model of AC, which could be effectively treated with RvD1 or topical antiallergic agents.PMID:34029500 | DOI:10.1080/02713683.2021.1934878 (Source: Current Eye Research)
Source: Current Eye Research - May 24, 2021 Category: Opthalmology Authors: Min Seung Kang Lee JongSoo Sung Hee Park Hak Sun Yu Jieun Lee Source Type: research

Endothelial Cell Viability after DMEK Graft Preparation
Conclusion: Cell viability of most of the grafts will not be affected by preparation and storage. Endothelial cell damage may be observed for some grafts within hours after preparation, with insignificant additional ECD changes during 3-7 days of graft storage. Implementing an additional post-preparation step in the eye bank to evaluate cell density before graft release for transplantation may help to reduce postoperative DMEK complications.PMID:34027768 | DOI:10.1080/02713683.2021.1927111 (Source: Current Eye Research)
Source: Current Eye Research - May 24, 2021 Category: Opthalmology Authors: Alina Miron Anita Sajet Esther A Groeneveld-van Beek Jet S Kok Mehtap Dedeci Maloeke de Jong Vicky Amo-Addae Gerrit R J Melles Silke Oellerich Jacqueline van der Wees Source Type: research

Development of allergic conjunctivitis induced by < em > Acanthamoeba < /em > excretory-secretory protein and the effect of resolvin D1 on treatment
CONCLUSIONS: Acanthamoeba could be used to establish an animal model of AC, which could be effectively treated with RvD1 or topical antiallergic agents.PMID:34029500 | DOI:10.1080/02713683.2021.1934878 (Source: Current Eye Research)
Source: Current Eye Research - May 24, 2021 Category: Opthalmology Authors: Min Seung Kang Lee JongSoo Sung Hee Park Hak Sun Yu Jieun Lee Source Type: research

Endothelial Cell Viability after DMEK Graft Preparation
Conclusion: Cell viability of most of the grafts will not be affected by preparation and storage. Endothelial cell damage may be observed for some grafts within hours after preparation, with insignificant additional ECD changes during 3-7 days of graft storage. Implementing an additional post-preparation step in the eye bank to evaluate cell density before graft release for transplantation may help to reduce postoperative DMEK complications.PMID:34027768 | DOI:10.1080/02713683.2021.1927111 (Source: Current Eye Research)
Source: Current Eye Research - May 24, 2021 Category: Opthalmology Authors: Alina Miron Anita Sajet Esther A Groeneveld-van Beek Jet S Kok Mehtap Dedeci Maloeke de Jong Vicky Amo-Addae Gerrit R J Melles Silke Oellerich Jacqueline van der Wees Source Type: research

Start and end with genetics: < em > RCBTB1 < /em > and beyond
Curr Eye Res. 2021 May 20. doi: 10.1080/02713683.2021.1933060. Online ahead of print.NO ABSTRACTPMID:34011215 | DOI:10.1080/02713683.2021.1933060 (Source: Current Eye Research)
Source: Current Eye Research - May 20, 2021 Category: Opthalmology Authors: Junxing Yang Wenmin Sun Qingjiong Zhang Source Type: research

CircPAG1 inhibits the high glucose-induced lens epithelial cell injury by sponging miR-630 and upregulating EPHA2
CONCLUSION: : Our evidence suggested that circPAG1 alleviated cell damages in HG-treated human lens epithelial cells by regulating the miR-630/EPHA2 axis.PMID:34011217 | DOI:10.1080/02713683.2021.1933058 (Source: Current Eye Research)
Source: Current Eye Research - May 20, 2021 Category: Opthalmology Authors: Youyi Yang Qianqian Li Xin Zhang Gangfeng Cui Source Type: research

Clinical Accuracy of 18 IOL Power Formulas in 241 Short Eyes
Curr Eye Res. 2021 May 20. doi: 10.1080/02713683.2021.1933056. Online ahead of print.ABSTRACTPURPOSE: To analyze the accuracy of 18 intraocular lens (IOL) power calculation formulas in eyes with axial length (AL) ≤ 22 mm.METHODS: We analyzed 241 eyes of 241 patients. Eighteen formulas were evaluated: Barrett Universal II (BUII), EVO 2.0, Haigis, Hoffer Q, Holladay 1 and 2, Cooke K6, Kane, LadasSuperFormula AI, Naeser 2, Olsen, Panacea, Pearl-DGS, RBF 2.0, SRK/T, T2, VRF and VRF-G. Optical biometry was performed with an IOLMaster 700 (Carl Zeiss Meditec, Jena, Germany). With lens constants optimized for the whole range o...
Source: Current Eye Research - May 20, 2021 Category: Opthalmology Authors: Oleksiy V Voytsekhivskyy Kenneth J Hoffer Giacomo Savini Larysa P Tutchenko Diogo Fernandes Source Type: research

Start and end with genetics: < em > RCBTB1 < /em > and beyond
Curr Eye Res. 2021 May 20. doi: 10.1080/02713683.2021.1933060. Online ahead of print.NO ABSTRACTPMID:34011215 | DOI:10.1080/02713683.2021.1933060 (Source: Current Eye Research)
Source: Current Eye Research - May 20, 2021 Category: Opthalmology Authors: Junxing Yang Wenmin Sun Qingjiong Zhang Source Type: research

CircPAG1 inhibits the high glucose-induced lens epithelial cell injury by sponging miR-630 and upregulating EPHA2
CONCLUSION: : Our evidence suggested that circPAG1 alleviated cell damages in HG-treated human lens epithelial cells by regulating the miR-630/EPHA2 axis.PMID:34011217 | DOI:10.1080/02713683.2021.1933058 (Source: Current Eye Research)
Source: Current Eye Research - May 20, 2021 Category: Opthalmology Authors: Youyi Yang Qianqian Li Xin Zhang Gangfeng Cui Source Type: research

Clinical Accuracy of 18 IOL Power Formulas in 241 Short Eyes
Curr Eye Res. 2021 May 20. doi: 10.1080/02713683.2021.1933056. Online ahead of print.ABSTRACTPURPOSE: To analyze the accuracy of 18 intraocular lens (IOL) power calculation formulas in eyes with axial length (AL) ≤ 22 mm.METHODS: We analyzed 241 eyes of 241 patients. Eighteen formulas were evaluated: Barrett Universal II (BUII), EVO 2.0, Haigis, Hoffer Q, Holladay 1 and 2, Cooke K6, Kane, LadasSuperFormula AI, Naeser 2, Olsen, Panacea, Pearl-DGS, RBF 2.0, SRK/T, T2, VRF and VRF-G. Optical biometry was performed with an IOLMaster 700 (Carl Zeiss Meditec, Jena, Germany). With lens constants optimized for the whole range o...
Source: Current Eye Research - May 20, 2021 Category: Opthalmology Authors: Oleksiy V Voytsekhivskyy Kenneth J Hoffer Giacomo Savini Larysa P Tutchenko Diogo Fernandes Source Type: research

Start and end with genetics: < em > RCBTB1 < /em > and beyond
Curr Eye Res. 2021 May 20. doi: 10.1080/02713683.2021.1933060. Online ahead of print.NO ABSTRACTPMID:34011215 | DOI:10.1080/02713683.2021.1933060 (Source: Current Eye Research)
Source: Current Eye Research - May 20, 2021 Category: Opthalmology Authors: Junxing Yang Wenmin Sun Qingjiong Zhang Source Type: research

CircPAG1 inhibits the high glucose-induced lens epithelial cell injury by sponging miR-630 and upregulating EPHA2
CONCLUSION: : Our evidence suggested that circPAG1 alleviated cell damages in HG-treated human lens epithelial cells by regulating the miR-630/EPHA2 axis.PMID:34011217 | DOI:10.1080/02713683.2021.1933058 (Source: Current Eye Research)
Source: Current Eye Research - May 20, 2021 Category: Opthalmology Authors: Youyi Yang Qianqian Li Xin Zhang Gangfeng Cui Source Type: research

Clinical Accuracy of 18 IOL Power Formulas in 241 Short Eyes
Curr Eye Res. 2021 May 20. doi: 10.1080/02713683.2021.1933056. Online ahead of print.ABSTRACTPURPOSE: To analyze the accuracy of 18 intraocular lens (IOL) power calculation formulas in eyes with axial length (AL) ≤ 22 mm.METHODS: We analyzed 241 eyes of 241 patients. Eighteen formulas were evaluated: Barrett Universal II (BUII), EVO 2.0, Haigis, Hoffer Q, Holladay 1 and 2, Cooke K6, Kane, LadasSuperFormula AI, Naeser 2, Olsen, Panacea, Pearl-DGS, RBF 2.0, SRK/T, T2, VRF and VRF-G. Optical biometry was performed with an IOLMaster 700 (Carl Zeiss Meditec, Jena, Germany). With lens constants optimized for the whole range o...
Source: Current Eye Research - May 20, 2021 Category: Opthalmology Authors: Oleksiy V Voytsekhivskyy Kenneth J Hoffer Giacomo Savini Larysa P Tutchenko Diogo Fernandes Source Type: research

Start and end with genetics: < em > RCBTB1 < /em > and beyond
Curr Eye Res. 2021 May 20. doi: 10.1080/02713683.2021.1933060. Online ahead of print.NO ABSTRACTPMID:34011215 | DOI:10.1080/02713683.2021.1933060 (Source: Current Eye Research)
Source: Current Eye Research - May 20, 2021 Category: Opthalmology Authors: Junxing Yang Wenmin Sun Qingjiong Zhang Source Type: research

CircPAG1 inhibits the high glucose-induced lens epithelial cell injury by sponging miR-630 and upregulating EPHA2
CONCLUSION: : Our evidence suggested that circPAG1 alleviated cell damages in HG-treated human lens epithelial cells by regulating the miR-630/EPHA2 axis.PMID:34011217 | DOI:10.1080/02713683.2021.1933058 (Source: Current Eye Research)
Source: Current Eye Research - May 20, 2021 Category: Opthalmology Authors: Youyi Yang Qianqian Li Xin Zhang Gangfeng Cui Source Type: research

Clinical Accuracy of 18 IOL Power Formulas in 241 Short Eyes
Curr Eye Res. 2021 May 20. doi: 10.1080/02713683.2021.1933056. Online ahead of print.ABSTRACTPURPOSE: To analyze the accuracy of 18 intraocular lens (IOL) power calculation formulas in eyes with axial length (AL) ≤ 22 mm.METHODS: We analyzed 241 eyes of 241 patients. Eighteen formulas were evaluated: Barrett Universal II (BUII), EVO 2.0, Haigis, Hoffer Q, Holladay 1 and 2, Cooke K6, Kane, LadasSuperFormula AI, Naeser 2, Olsen, Panacea, Pearl-DGS, RBF 2.0, SRK/T, T2, VRF and VRF-G. Optical biometry was performed with an IOLMaster 700 (Carl Zeiss Meditec, Jena, Germany). With lens constants optimized for the whole range o...
Source: Current Eye Research - May 20, 2021 Category: Opthalmology Authors: Oleksiy V Voytsekhivskyy Kenneth J Hoffer Giacomo Savini Larysa P Tutchenko Diogo Fernandes Source Type: research

Comparison of Keratoconus Cone Location of Different Topo/tomographical Parameters
Curr Eye Res. 2021 May 17. doi: 10.1080/02713683.2021.1931343. Online ahead of print.ABSTRACTPURPOSE: To compare the corneal cone location on different maps and instruments and their agreements with elevation maps.METHODS: In 90 left eyes with bilateral keratoconus, the apex of cone location was determined based on the maximum simulated keratometry (Kmax) location on the anterior sagittal curvature map by Pentacam HR, the maximum curvature on the mean curvature map by ATLAS 9000, most elevated point of the island of positive elevation relative to the best fit sphere on the front and back corneal elevation maps by Pentacam ...
Source: Current Eye Research - May 17, 2021 Category: Opthalmology Authors: Mohammad-Reza Sedaghat Hamed Momeni-Moghaddam Abbas Azimi Khorasani Michael W Belin Naeemeh Monfared James S W Wolffsohn Maryam Pakdel Majid Farrokh Ghate Zahra Hemmatian Source Type: research

Effect of long-term anti-VEGF treatment on viability and function of RPE cells
CONCLUSIONS: Long term treatment with anti VEGF may affect viability of RPE cells, and treatment with bevacizumab may have effects on RPE function in long term treatment.PMID:33998943 | DOI:10.1080/02713683.2021.1931344 (Source: Current Eye Research)
Source: Current Eye Research - May 17, 2021 Category: Opthalmology Authors: Anna Brinkmann Katrin Winkelmann Tom K äckenmeister Johann Roider Alexa Klettner Source Type: research

Comparison of Keratoconus Cone Location of Different Topo/tomographical Parameters
Curr Eye Res. 2021 May 17. doi: 10.1080/02713683.2021.1931343. Online ahead of print.ABSTRACTPURPOSE: To compare the corneal cone location on different maps and instruments and their agreements with elevation maps.METHODS: In 90 left eyes with bilateral keratoconus, the apex of cone location was determined based on the maximum simulated keratometry (Kmax) location on the anterior sagittal curvature map by Pentacam HR, the maximum curvature on the mean curvature map by ATLAS 9000, most elevated point of the island of positive elevation relative to the best fit sphere on the front and back corneal elevation maps by Pentacam ...
Source: Current Eye Research - May 17, 2021 Category: Opthalmology Authors: Mohammad-Reza Sedaghat Hamed Momeni-Moghaddam Abbas Azimi Khorasani Michael W Belin Naeemeh Monfared James S W Wolffsohn Maryam Pakdel Majid Farrokh Ghate Zahra Hemmatian Source Type: research

Effect of long-term anti-VEGF treatment on viability and function of RPE cells
CONCLUSIONS: Long term treatment with anti VEGF may affect viability of RPE cells, and treatment with bevacizumab may have effects on RPE function in long term treatment.PMID:33998943 | DOI:10.1080/02713683.2021.1931344 (Source: Current Eye Research)
Source: Current Eye Research - May 17, 2021 Category: Opthalmology Authors: Anna Brinkmann Katrin Winkelmann Tom K äckenmeister Johann Roider Alexa Klettner Source Type: research

Comparison of Keratoconus Cone Location of Different Topo/tomographical Parameters
Curr Eye Res. 2021 May 17. doi: 10.1080/02713683.2021.1931343. Online ahead of print.ABSTRACTPURPOSE: To compare the corneal cone location on different maps and instruments and their agreements with elevation maps.METHODS: In 90 left eyes with bilateral keratoconus, the apex of cone location was determined based on the maximum simulated keratometry (Kmax) location on the anterior sagittal curvature map by Pentacam HR, the maximum curvature on the mean curvature map by ATLAS 9000, most elevated point of the island of positive elevation relative to the best fit sphere on the front and back corneal elevation maps by Pentacam ...
Source: Current Eye Research - May 17, 2021 Category: Opthalmology Authors: Mohammad-Reza Sedaghat Hamed Momeni-Moghaddam Abbas Azimi Khorasani Michael W Belin Naeemeh Monfared James S W Wolffsohn Maryam Pakdel Majid Farrokh Ghate Zahra Hemmatian Source Type: research

Effect of long-term anti-VEGF treatment on viability and function of RPE cells
CONCLUSIONS: Long term treatment with anti VEGF may affect viability of RPE cells, and treatment with bevacizumab may have effects on RPE function in long term treatment.PMID:33998943 | DOI:10.1080/02713683.2021.1931344 (Source: Current Eye Research)
Source: Current Eye Research - May 17, 2021 Category: Opthalmology Authors: Anna Brinkmann Katrin Winkelmann Tom K äckenmeister Johann Roider Alexa Klettner Source Type: research

CircMKLN1 Suppresses the Progression of Human Retinoblastoma by Modulation of miR-425-5p/PDCD4 Axis
Conclusions: CircMKLN1 overexpression decelerated the progression of RB through sponging miR-425-5p and elevating PDCD4.PMID:33988065 | DOI:10.1080/02713683.2021.1927110 (Source: Current Eye Research)
Source: Current Eye Research - May 14, 2021 Category: Opthalmology Authors: Le Xu Hua Long Bo Zhou Haibo Jiang Mingfang Cai Source Type: research

CircMKLN1 Suppresses the Progression of Human Retinoblastoma by Modulation of miR-425-5p/PDCD4 Axis
Conclusions: CircMKLN1 overexpression decelerated the progression of RB through sponging miR-425-5p and elevating PDCD4.PMID:33988065 | DOI:10.1080/02713683.2021.1927110 (Source: Current Eye Research)
Source: Current Eye Research - May 14, 2021 Category: Opthalmology Authors: Le Xu Hua Long Bo Zhou Haibo Jiang Mingfang Cai Source Type: research

CircMKLN1 Suppresses the Progression of Human Retinoblastoma by Modulation of miR-425-5p/PDCD4 Axis
Conclusions: CircMKLN1 overexpression decelerated the progression of RB through sponging miR-425-5p and elevating PDCD4.PMID:33988065 | DOI:10.1080/02713683.2021.1927110 (Source: Current Eye Research)
Source: Current Eye Research - May 14, 2021 Category: Opthalmology Authors: Le Xu Hua Long Bo Zhou Haibo Jiang Mingfang Cai Source Type: research

Optical coherence tomography angiography and structural analyses of the pale optic discs: is it possible to differentiate the cause?
CONCLUSION: There was a positive correlation between the RNFL thickness and peripapillary RPC vessel density regardless of the cause of optic disc pallor. Structural evaluation of the ONH seems to be a better way to differentiate the cause of optic nerve head atrophy than the microangiographic changes.PMID:33980086 | DOI:10.1080/02713683.2021.1929331 (Source: Current Eye Research)
Source: Current Eye Research - May 13, 2021 Category: Opthalmology Authors: Kaveh Abri Aghdam Ali Aghajani Marjan Razi-Khosroshahi Mostafa Soltan Sanjari Samira Chaibakhsh Khalil Ghasemi Falavarjani Source Type: research

Optical coherence tomography angiography and structural analyses of the pale optic discs: is it possible to differentiate the cause?
CONCLUSION: There was a positive correlation between the RNFL thickness and peripapillary RPC vessel density regardless of the cause of optic disc pallor. Structural evaluation of the ONH seems to be a better way to differentiate the cause of optic nerve head atrophy than the microangiographic changes.PMID:33980086 | DOI:10.1080/02713683.2021.1929331 (Source: Current Eye Research)
Source: Current Eye Research - May 13, 2021 Category: Opthalmology Authors: Kaveh Abri Aghdam Ali Aghajani Marjan Razi-Khosroshahi Mostafa Soltan Sanjari Samira Chaibakhsh Khalil Ghasemi Falavarjani Source Type: research

Cultured human uveal melanocytes express/secrete CXCL1 and CXCL2 constitutively and increased by lipopolysaccharide via activation of Toll-like receptor 4
CONCLUSIONS: : This is the first report on the LPS-induced expression of CXCL1 and CXCL2 by uveal melanocytes via the activation of TLR4. These results suggest that uveal melanocytes may play a role in the immune reaction that eliminates the invading pathogens. Conversely, an excessive LPS-induced inflammatory reaction may also lead to the development of inflammatory ocular disorders, such as non-infectious uveitis.PMID:33979551 | DOI:10.1080/02713683.2021.1929326 (Source: Current Eye Research)
Source: Current Eye Research - May 12, 2021 Category: Opthalmology Authors: Dan-Ning Hu Ruihua Zhang Shen Yao Codrin E Iacob Wei-En Yang Richard B Rosen Shun-Fa Yang Source Type: research

Acyclovir-Loaded Nanoemulsions: Preparation, Characterization and Irritancy Studies for Ophthalmic Delivery
Curr Eye Res. 2021 May 12. doi: 10.1080/02713683.2021.1929328. Online ahead of print.ABSTRACTOBJECTIVE: The main goal of the present work was to develop and evaluate nanoemulsions (NEs) containing acyclovir (ACV) for ophthalmic drug delivery.METHOD: Firstly, component screening was performed by determining ACV solubility in various oils, surfactants, and co-surfactants. Different NE formulations were developed based on pseudo-ternary phase diagrams, and physicochemical assets were evaluated. Selected formulations were subjected to the drug release efficacy, stability studies, and ex-vivo trans-corneal permeation test. The ...
Source: Current Eye Research - May 12, 2021 Category: Opthalmology Authors: Mojdeh Mohammadi Zohreh Elahimehr Mohammad Mehdi Mahboobian Source Type: research

Risk factors for presence of cystoid macular edema following rhegmatogenous retinal detachment surgery
Curr Eye Res. 2021 May 12. doi: 10.1080/02713683.2021.1929330. Online ahead of print.ABSTRACTPURPOSE: Cystoid macular edema (CME) following cataract surgery is a well-known entity. Less is known regarding the risk factors of developing CME following repair of rhegmatogenous retinal detachments (RRD).METHODS: This was a multi-institutional study of primary RRD surgeries from 1/1/2015 through 12/31/2015. The primary outcome was development of post-operative CME following RRD surgery. Post-operative optical coherence tomography imaging and 3 months of follow up following RRD repair were required.RESULTS: There were 1,466 eyes...
Source: Current Eye Research - May 12, 2021 Category: Opthalmology Authors: Matthew R Starr Louis Cai Anthony Obeid Edwin H Ryan Dean Eliott Claire Ryan Nora J Forbes Michael Ammar Luv G Patel Antonio Capone Geoffrey G Emerson Daniel P Joseph Omesh P Gupta Carl D Regillo Jason Hsu Yoshihiro Yonekawa Source Type: research

Effect of ECG-gating retinal photographs on retinal vessel caliber measurements in subjects with and without type 2 diabetes
Curr Eye Res. 2021 May 7. doi: 10.1080/02713683.2021.1927112. Online ahead of print.ABSTRACTPurpose/Aim of this study:Retinal vessel caliber is an independent risk marker of cardiovascular disease risk. However, variable mechanical delays in capturing retinal photographs and cardiac cycle-induced retinal vascular changes have shown to reduce the accuracy of retinal vessel caliber measurements, but this has only ever been investigated in healthy subjects. This cross-sectional study is the first study to investigate this issue in type 2 diabetes. The aim of this study was to determine whether ECG-gating retinal photographs r...
Source: Current Eye Research - May 7, 2021 Category: Opthalmology Authors: Anchal Lal Neha Dave Oliver J Gibbs Michael Anthony Tony Barry Annika Sood Paul Mitchell Aravinda Thiagalingam Source Type: research

Effect of ECG-gating retinal photographs on retinal vessel caliber measurements in subjects with and without type 2 diabetes
Curr Eye Res. 2021 May 7. doi: 10.1080/02713683.2021.1927112. Online ahead of print.ABSTRACTPurpose/Aim of this study:Retinal vessel caliber is an independent risk marker of cardiovascular disease risk. However, variable mechanical delays in capturing retinal photographs and cardiac cycle-induced retinal vascular changes have shown to reduce the accuracy of retinal vessel caliber measurements, but this has only ever been investigated in healthy subjects. This cross-sectional study is the first study to investigate this issue in type 2 diabetes. The aim of this study was to determine whether ECG-gating retinal photographs r...
Source: Current Eye Research - May 7, 2021 Category: Opthalmology Authors: Anchal Lal Neha Dave Oliver J Gibbs Michael Anthony Tony Barry Annika Sood Paul Mitchell Aravinda Thiagalingam Source Type: research

Effect of ECG-gating retinal photographs on retinal vessel caliber measurements in subjects with and without type 2 diabetes
Curr Eye Res. 2021 May 7. doi: 10.1080/02713683.2021.1927112. Online ahead of print.ABSTRACTPurpose/Aim of this study:Retinal vessel caliber is an independent risk marker of cardiovascular disease risk. However, variable mechanical delays in capturing retinal photographs and cardiac cycle-induced retinal vascular changes have shown to reduce the accuracy of retinal vessel caliber measurements, but this has only ever been investigated in healthy subjects. This cross-sectional study is the first study to investigate this issue in type 2 diabetes. The aim of this study was to determine whether ECG-gating retinal photographs r...
Source: Current Eye Research - May 7, 2021 Category: Opthalmology Authors: Anchal Lal Neha Dave Oliver J Gibbs Michael Anthony Tony Barry Annika Sood Paul Mitchell Aravinda Thiagalingam Source Type: research