Novel Liquid Interface for Femtosecond Laser-Assisted Penetrating Keratoplasty.
Conclusion: We could show in this first pilot study that a hand-held liquid patient interface in combination with a femtosecond laser has a preliminary safety and reliability in penetrating keratoplasty. PMID: 31964191 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - January 22, 2020 Category: Opthalmology Authors: Boden KT, Schlosser R, Boden K, Januschowski K, Szurman P, Rickmann A Tags: Curr Eye Res Source Type: research

Response of retinal sensitivity to intravitreal anti-angiogenic bevacizumab and triamcinolone acetonide for patients with diabetic macular edema over one year.
Conclusion: Central macular function as measured by microperimetry in patients with acute DME improved in addition to anatomical restoration after intravitreal bevacizumab and triamcinolone injection. In our clinical study, the measures of the variables in patients receiving bevacizumab were superior to those receiving triamcinolone throughout the one-year observation period. PMID: 31961224 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - January 21, 2020 Category: Opthalmology Authors: Mylonas G, Markus S, Christoph S, Sonja K, Gregor R, Lukas B, Schmidt-Erfurth U, Kriechbaum K Tags: Curr Eye Res Source Type: research

APX-115A, a pan-NADPH oxidase inhibitor, induces caspase-dependent cell death by suppressing NOX4-ROS signaling in EBV-infected retinal epithelial cells.
Conclusion Taken together, these our results suggest that APX-115A could be a therapeutic agent for treating EBV-infected retinal cells or diseases by inhibiting LMP1-NOX4-ROS signaling. PMID: 31951764 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - January 17, 2020 Category: Opthalmology Authors: Hong SW, Noh MH, Kim YS, Jin DH, Moon SH, Yang JW, Hur DY Tags: Curr Eye Res Source Type: research

The necessity for second-eye cataract surgery in bilateral highly myopic patients with good visual acuity in the unoperated fellow eye.
Abstract Purpose: To evaluate the necessity for second-eye cataract surgery in bilateral highly myopic patients with good visual acuity in the unoperated fellow eye.Materials and Methods: Seventy-five bilateral highly myopic patients who underwent uneventful sequential cataract surgery (the eye with worse visual acuity operated first) were included in this prospective study. The preoperative BCVA of the eye with better visual acuity in these patients was ≤0.3 (logMAR, or Snellen ≥ 20/40). Binocular single vision examinations were performed 1 month after the first-eye and second-eye surgery, respectively. The...
Source: Current Eye Research - January 16, 2020 Category: Opthalmology Authors: Rong X, Du Y, He W, Zhu X, Lu Y Tags: Curr Eye Res Source Type: research

Open-angle glaucoma and sensorineural hearing impairment in the Korean population.
This study identifies the prevalence and risk factors of sensorineural hearing loss and primary open-angle glaucoma (POAG).Materials and methods: Patients aged 19 years or older who had undergone both ophthalmologic examination and audiometry as part of the Korea National Health and Nutrition Examination Survey V (2010-2012) were analyzed. Hearing loss was defined as the pure-tone average over 40 decibels based on the automatic hearing test to determine the threshold of airway hearing for each frequency. We investigated the prevalence of glaucoma and hearing loss when they occurred alone or simultaneously. The risk factors...
Source: Current Eye Research - January 14, 2020 Category: Opthalmology Authors: Kim JM, Lee MY, Kim JW, Lee J, Kim HJ, Cha SC, Kim NR Tags: Curr Eye Res Source Type: research

Occurrence of retinal ganglion cell loss via autophagy and apoptotic pathways in an autoimmune glaucoma model.
Conclusions: Due to the novel results from this study, we conclude that IgG antibodies are involved in RGC loss in this model leading to apoptotic and autophagic cell loss. These results could help to develop new therapy strategies for glaucoma patients. PMID: 31935132 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - January 14, 2020 Category: Opthalmology Authors: Reinehr S, Buschhorn V, Mueller-Buehl AM, Goldmann T, Grus FH, Wolfrum U, Dick HB, Joachim SC Tags: Curr Eye Res Source Type: research

Are there funduscopic and optical coherence tomography preoperative characteristics to predict surgical difficulty of epiretinal membrane removal?
Conclusion: The presence of fibrillary changes between the ERM and RNFL, severe retinal vascular tortuosity and severe glinting reflex are preoperative findings that have a strong association with the difficulty in ERM peeling. PMID: 31935135 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - January 14, 2020 Category: Opthalmology Authors: Mylonas G, Markus S, Georgopoulos M, Sacu S, Deak G, Reumueller A, Lukas B, Schmidt-Erfurth U Tags: Curr Eye Res Source Type: research

Cytokine and chemokine concentration in the tear of patients with age-related cataract.
Conclusions: Our results suggest that ocular aging is accompanied by increased production of IL-6 and MCP-1, which can be measured in tear fluid. PMID: 31928443 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - January 13, 2020 Category: Opthalmology Authors: Engelbrecht C, Sardinha LR, Rizzo LV Tags: Curr Eye Res Source Type: research

Incidence and Risk for Developing Proliferative Diabetic Retinopathy after Photocoagulation for Diabetic Maculopathy.
Conclusions: In patients treated with retinal photocoagulation for DM, a tight metabolic control is accompanied with a reduced risk for subsequent progression to PDR. In the treated patients who do not develop PDR, the control interval can be gradually increased with time. PMID: 31920110 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - January 10, 2020 Category: Opthalmology Authors: Bek T Tags: Curr Eye Res Source Type: research

O-GlcNAc Signaling Augmentation Protects Human Corneal Endothelial Cells from Oxidative Stress via AKT Pathway Activation.
Abstract Purpose: To investigate the effect of inhibitor of O-glycosylation on human corneal endothelial cells (HCECs) under oxidative stress.Methods: HCECs were cultured and treated with 10 mM tert-butyl hydroperoxide (tBHP) with or without PUGNAc, a known inhibitor of OGA. Cell viability was assessed. Mitochondrial membrane potential (ΔΨm) was measured. Intracellular Ca2+ levels and mitochondrial Ca2+ levels were measured. Intracellular reactive oxygen species formation was measured. Levels of O-linked β-N-acetylglucosamine (O-GlcNAc), AKT, and pAKT were evaluated by Western blotting.Results: O-Gl...
Source: Current Eye Research - January 10, 2020 Category: Opthalmology Authors: Yoon CK, Yoon SY, Hwang JS, Shin YJ Tags: Curr Eye Res Source Type: research

Eye Socket Regeneration and Reconstruction.
Abstract When an eye has become irreversibly blind or painful it is removed by enucleation or evisceration. The resulting anophthalmic socket usually receives a volume replacing implant and is subsequently fitted with a prosthetic shell for adequate cosmesis. Trauma, tumour or immunological pathomechanisms can result in loss of bone, orbital soft tissue volume, conjunctival contraction or implant exposure and make wearing a prosthesis impossible. In this situation as well as in numerous diseases limited to the conjunctiva (e.g. Pterygium, or cicatrizing conjunctivitis) strategies to substitute the lost tissue are ...
Source: Current Eye Research - January 8, 2020 Category: Opthalmology Authors: Borrelli M, Geerling G, Spaniol K, Witt J Tags: Curr Eye Res Source Type: research

Diabetes-induced inflammation and vascular alterations in the Goto-Kakizaki rat retina.
CONCLUSIONS: Data suggest retinal vascular bed alterations in spontaneous type 2 diabetic retinas at 30 weeks. Lipid and collagen accumulation in the retina and choroid, in addition to retinal upregulation of VEGF and B1R, microgliosis, and Müller cell reactivity, may contribute to vascular alterations and inflammatory processes. PMID: 31902231 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - January 6, 2020 Category: Opthalmology Authors: Hachana S, Pouliot M, Couture R, Vaucher E Tags: Curr Eye Res Source Type: research

ICare Pro: Age Dependent Effect of Central Corneal Thickness on Intraocular Pressure in Glaucoma and Ocular Hypertension Patients.
Abstract Purpose: Measurement of the exact intraocular pressure (IOP) is essential in glaucoma diagnosis and follow-up, thus all therapeutic options affect IOP in order to win sighted lifetime. As it is known that corneal properties of glaucoma patients differ from normal subjects, the present study aimed to investigate the influence of CCT on rebound tonometry (ICT, ICare Pro) in glaucoma and ocular hypertension patients in dependency of age additionally considering different times of day.Methods: Three hundred sixty-two eyes of 190 subjects were included: 339 open-angle glaucoma and 23 ocular hypertension. IOP w...
Source: Current Eye Research - January 6, 2020 Category: Opthalmology Authors: Hohberger B, Sommerfeld C, Lucio M, Bergua A Tags: Curr Eye Res Source Type: research

Tear Film Dynamics of Soft Contact Lens-Induced Dry Eye.
Conclusions: soft contact lens-induced dry eye was associated with tear dynamics only while wearing soft contact lenses. Observation of tear film dynamics in eyes with soft contact lenses could facilitate the understanding of dry eye-related symptoms. PMID: 31899962 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - January 3, 2020 Category: Opthalmology Authors: Kaido M, Kawashima M, Ishida R, Tsubota K Tags: Curr Eye Res Source Type: research

Evaluation of Choroidal Thickness in Patients with Proliferative and Non-Proliferative Macular Telangiectasia Using Enhanced Depth Imaging Optical Coherence Tomography.
Abstract Purpose: To compare subfoveal choroidal thickness (SFCT) in eyes with non-proliferative macular telangiectasia (MacTel) type 2 with or without subretinal neovascularization (SRNV) and healthy control eyes.Methods: Consecutive patients with non-proliferative and proliferative MacTel type 2 were included in the current study. For comparisons subjects with no ocular pathology were recruited and used as controls. Best corrected visual acuity (BCVA), central macular thickness (CMT), and subfoveal choroidal thickness (SFCT) were evaluated. Since axial length (AL) may affect choroidal thickness, AL measurements ...
Source: Current Eye Research - January 3, 2020 Category: Opthalmology Authors: Demir G, Cakir I, Alkin Z, Demircan A, Tulu B, Fazıl K Tags: Curr Eye Res Source Type: research

Characterization of an Electronic Corneal Prosthesis System.
ConclusionThis is the first study to demonstrate and characterize fully functional intraocular projection systems. This technology has the potential to be an important new tool in the treatment of intractable corneal blindness. PMID: 31886728 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 30, 2019 Category: Opthalmology Authors: Shim SY, Gong S, Fan VH, Rosenblatt MI, Al-Qahtani AF, Sun MG, Zhou Q, Kanu L, Vieira IV, Yu CQ Tags: Curr Eye Res Source Type: research

Evaluation of Papillomacular Nerve Fiber Bundle Thickness in Glaucoma Patients with Visual Acuity Disturbance.
This study included 347 eyes of 205 open-angle glaucoma (OAG) patients. Patients were excluded if they had best-corrected decimal visual acuity 28 mm, non-glaucoma ocular disease, or systemic disease affecting the visual field. We obtained vertical 12.0 × 9.0 mm 3D volume scans covering both the macular and optic disc regions with SS-OCT (DRI OCT Triton, Topcon), and measured the thickness of the PMB, as well as average macular retinal nerve fiber layer thickness (mRNFLT) and macular ganglion cell complex thickness (mGCCT) in the macular map and temporal-quadrant circumpapillary RNFL thickness (tcpRNFLT). W...
Source: Current Eye Research - December 27, 2019 Category: Opthalmology Authors: Naoki T, Kazuko O, Kyongsun P, Tsutomu K, Wataru K, Masahiro A, Toru N Tags: Curr Eye Res Source Type: research

How big is the hole? Measuring intra- and inter- individual agreement in macular hole size measurements.
CONCLUSIONS: Manual OCT FTMH diameter measurements show poor intra- and inter-individual repeatability. Future work should aim to develop an automated method for measuring macular holes. PMID: 31880476 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 27, 2019 Category: Opthalmology Authors: Antonopoulou PG, Baumann C, Jalil A, Dhawahir-Scala F, Muñoz-Sanz N, Lu VHJ, Park D, Patton N Tags: Curr Eye Res Source Type: research

Evaluating the impact of information and support for people with nystagmus in the digital age: A patient and carer questionnaire study.
Conclusions: This study highlights a significant variation in the support and information received by people in the UK with nystagmus. It also supports the role of charities and increasingly, social media in the provision of patient information. The study also highlights the need for standardized guidelines for the management of patients with nystagmus, particularly with regard to support and information. PMID: 31876191 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 26, 2019 Category: Opthalmology Authors: Gummer SL, Evans M, Cygan A, Osborne D, Griffiths HJ, Lee H, Self JE Tags: Curr Eye Res Source Type: research

Optical quality assessment in branch retinal vein occlusion after monthly intravitreal ranibizumab injection: a prospective, case-control study.
Conclusions: BRVO resulted in declined visual acuity and optical quality. It is suggested that the optical quality parameters are affected by the inner layers of the retina in BRVO. PMID: 31873038 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 24, 2019 Category: Opthalmology Authors: Li L, Hu X, Yang Z, Chen X, Guo L, Zhu C, Zhang Z, Pan Q Tags: Curr Eye Res Source Type: research

TNFSF15 polymorphisms are associated with Graves' disease and Graves' ophthalmopathy in a Han Chinese population.
Conclusions: Our results suggest that TNFSF15 rs3810936 and rs4979462 polymorphisms are associated with the susceptibility of GD and GO in a Han Chinese population. Additionally, rs3810936 may affect the activity of GO, and rs4979462 may correlate with the sexual dimorphism observed in GD and GO. PMID: 31869260 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 23, 2019 Category: Opthalmology Authors: Zhang M, Liu S, Xu J, Lv S, Fan Y, Zhang Y, Zhang Y, Wu Y, Su Y, Yu H, Song S, He J, Li H Tags: Curr Eye Res Source Type: research

Effectiveness of the Goldmann Applanation Tonometer, the Dynamic Contour Tonometer, the Ocular Response Analyzer and the Corvis ST in measuring intraocular pressure following FS-LASIK.
Conclusions: The biomechanically-corrected bIOP from the Corvis ST provided post-FS-LASIK measurements that were in closest agreement with those obtained before surgery. In comparison, GAT-IOP, ORA-IOPg, ORA-IOPcc and CVS-IOP appeared to be more influenced by the changes in corneal biomechanics caused by FS-LASIK. PMID: 31869261 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 23, 2019 Category: Opthalmology Authors: Bao F, Huang W, Zhu R, Lu N, Wang Y, Li H, Wu S, Lin H, Wang J, Zheng X, JinHai H, Li Y, Wang Q, Elsheikh A Tags: Curr Eye Res Source Type: research

Upregulation of miR-630 induced by oxidative damage resists cell migration through targeting ALCAM in human lens epithelium cells.
Conclusion-miR-630 is one of the miRNAs increased by oxidative stimulation in human lens epithelium cells. Its up regulation may inhibit cell migration by targeting on ALCAM, which is important for HLECs to resist behavioral changes induced by oxidative damage and may delay the progression of cataract. PMID: 31869263 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 23, 2019 Category: Opthalmology Authors: Mei L, Yan H, Wang S, Guo C, Zheng X, Yan B, Zhao J, Yang A Tags: Curr Eye Res Source Type: research

Infectious Keratitis Caused by Rare and Emerging Micro-Organisms.
ConclusionKeratitis caused by rare and emerging micro-organisms must be suspected in cases where the infection runs an unusual course or shows poor response to standard anti-microbial drugs. Early diagnosis and timely treatment hold the key for good outcome. PMID: 31870176 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 23, 2019 Category: Opthalmology Authors: Sahay P, Goel S, Nagpal R, Maharana PK, Sinha R, Agarwal T, Sharma N, Titiyal JS Tags: Curr Eye Res Source Type: research

Patterns of Choroidal Deepening in Highly Myopic Eyes with Dome-Shaped Macula.
Abstract Purpose: To investigate the patterns and characteristics of choroidal deepening (CD) in highly myopic eyes with a dome-shaped macula (DSM).Methods: A retrospective analysis of vertical and horizontal optical coherence tomography (OCT) scans across the central fovea was conducted. An inward bulge greater than 50μm at either the vertical or horizontal OCT images of the macula was defined as DSM and was analyzed.Results: Among the 155 eyes, a vertical oval-shaped DSM was present in eight eyes (5.16%), a horizontal oval-shaped in 102 eyes (65.81%), and a round DSM in 45 eyes (29.03%). Vertical oval-shaped ...
Source: Current Eye Research - December 21, 2019 Category: Opthalmology Authors: Zhao X, Lian P, Li S, Liu B, Ding X, Lu L Tags: Curr Eye Res Source Type: research

MiRNA-155-5p reduces corneal epithelial permeability by remodeling epithelial tight junctions during corneal wound healing.
Conclusions: Our results suggest that miR-155-5p reduced corneal permeability and accelerated the recovery of corneal epithelial wounds by decreasing the expression of MLCK and phosphorylation of MLC and by remodeling tight junctions. PMID: 31852252 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 18, 2019 Category: Opthalmology Authors: Wang F, Wang D, Song M, Zhou Q, Liao R, Wang Y Tags: Curr Eye Res Source Type: research

Effect of UV-absorbing Contact Lenses on Conjunctival Ultraviolet Autofluorescence.
CONCLUSIONS: Contact lens materials have conjunctival effects, with increased UVAF in both UV-absorbing and minimally UV-absorbing contact lens wearers compared with non-lens wearers. UV-absorbing and minimally UV-absorbing contact lens materials appear to influence nasal and temporal areas of the ocular surface equally. PMID: 31852305 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 18, 2019 Category: Opthalmology Authors: Haworth K, Belair C Tags: Curr Eye Res Source Type: research

G öttingen minipig is not a suitable animal model for in vivo testing of tissue-engineered corneal endothelial cell-carrier sheets and for endothelial keratoplasty.
Göttingen minipig is not a suitable animal model for in vivo testing of tissue-engineered corneal endothelial cell-carrier sheets and for endothelial keratoplasty. Curr Eye Res. 2019 Dec 18;: Authors: Telinius N, Spinozzi D, Rasic D, Dapena I, Baandrup U, Miron A, Oellerich S, Hjortdal J Abstract AIM: To test the feasibility of implanting human anterior lens capsules (HALCs) with porcine corneal endothelial cells (pCEC)) in vivo in Göttingen minipigs and at the same time test the suitability of Göttingen minipig as model for endothelial keratoplasty. MATERIALS AND METHODS: Cell-car...
Source: Current Eye Research - December 18, 2019 Category: Opthalmology Authors: Telinius N, Spinozzi D, Rasic D, Dapena I, Baandrup U, Miron A, Oellerich S, Hjortdal J Tags: Curr Eye Res Source Type: research

Preparation, characterization and evaluation of zinc oxide nanoparticles suspension as an antimicrobial media for daily use soft contact lenses.
CONCLUSIONS: In vitro antimicrobial activity showed that the suspension of ZNPs with 250 ppm concentration could effectively cause a proper reduction and inhibition in the growth of both Gram-positive and Gram-negative microorganisms. Therefore, the results revealed the efficacy of the antibacterial properties of synthesized ZNPs suspension in aqueous media. PMID: 31847595 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 17, 2019 Category: Opthalmology Authors: Shayani Rad M, Sabeti Z, Mohajeri SA, Fazly Bazzaz BS Tags: Curr Eye Res Source Type: research

Structural and functional abnormalities in early-stage diabetic retinopathy.
Conclusions: The results support previous findings of early retinal neurodegeneration in diabetics who have NDR or MDR. Interestingly, the structural and functional deficits appear to be only weakly associated, suggesting that mechanisms in addition to retinal thinning underlie the functional defects in early stage DR. PMID: 31847599 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 17, 2019 Category: Opthalmology Authors: Park JC, Chen YF, Liu M, Liu K, McAnany JJ Tags: Curr Eye Res Source Type: research

A comparative study on the diagnostic utility of corneal confocal microscopy and tear neuromediator levels in diabetic peripheral neuropathy.
Abstract Aims: To determine the utility of corneal confocal microscopy and tear neuromediator analysis in the diagnosis of diabetic peripheral neuropathy (DPN) as a result of type 1 and type 2 diabetes.Methods: Seventy individuals with either type 1 diabetes or type 2 diabetes (T1D/T2D) underwent corneal confocal microscopy to assess the corneal nerve morphology. The concentration of substance P and calcitonin gene-related peptide (CGRP) in tears was measured by enzyme-linked immunosorbent assay. Motor excitability studies were conducted on the median nerve to assess axonal ion channel function. Based on total ...
Source: Current Eye Research - December 14, 2019 Category: Opthalmology Authors: Tummanapalli SS, Issar T, Kwai N, Pisarcikova J, Poynten AM, Krishnan AV, Willcox MDP, Markoulli M Tags: Curr Eye Res Source Type: research

Neuroprotective Effect of Brazilian Green Propolis on Retinal Ganglion Cells in Ischemic Mouse Retina.
Conclusions: Our results suggest that BGP has a neuroprotective effect on RGCs through the upregulation of histone acetylation, downregulation of apoptotic stimuli, and suppression of NF-κB mediated inflammatory pathway in ischemic retina. These findings suggest that BGP is a potential neuroprotective agent against RGC loss under oxidative stress. PMID: 31842625 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 14, 2019 Category: Opthalmology Authors: Park JW, Sung MS, Ha JY, Guo Y, Piao H, Heo H, Park SW Tags: Curr Eye Res Source Type: research

Endogenous toll-like receptor 2 modulates Th1/Treg-promoting dendritic cells in mice corneal transplantation model.
Conclusions: Endogenous TLR2 may contribute to allogeneic corneal rejection via Th1 immunity by activating Th1-promoting DCs and suppressing Treg-promoting DCs. PMID: 31842628 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 14, 2019 Category: Opthalmology Authors: Su YR, Chen MT, Xiong K, Bai L Tags: Curr Eye Res Source Type: research

Real-world outcomes among eyes with center-involving diabetic macular edema and good visual acuity.
Conclusions: After an average of 1.7 years of follow-up, there were no significant differences in final vision or central foveal thickness irrespective of whether patients received or did not receive treatment with anti-vascular endothelial growth factor injections. PMID: 31829753 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 12, 2019 Category: Opthalmology Authors: Zafar S, Smith K, Boland MV, Weng CY, Solomon S, Channa R Tags: Curr Eye Res Source Type: research

Bupivacaine Injection in the Extra Ocular Muscle of Rabbits: Analysis of Global and Orbital Layers.
Conclusion: This study revealed that 60 days after BUP injection, the extra ocular muscle of rabbits presented an increase in the CSA of myosin 1 type fibers in the global layer. PMID: 31820656 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 10, 2019 Category: Opthalmology Authors: Hopker LM, de Moraes MAS, Nitsch R, Pasqual GW, Cavagnari P, Kusma SZ, Moreira L, Zanoteli E, Allemann N Tags: Curr Eye Res Source Type: research

Bilaminar Mechanics of the Human Optic Nerve Sheath.
Conclusions: We conclude that maximum tensile stiffness occurs in the elastin-rich optic nerve sheath inner layer that inserts near the lamina cribrosa where tension in the sheath exerted during adduction tethering may be concentrated adjacent the optic nerve head. PMID: 31821056 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 10, 2019 Category: Opthalmology Authors: Shin A, Park J, Le A, Poukens V, Demer JL Tags: Curr Eye Res Source Type: research

Pattern of axial length growth in children myopic anisometropes with orthokeratology treatment.
Abstract Purpose: To compare the pattern of growth in axial length (AL) between children with anisometropia who wear orthokeratology (OK) lenses and those who wear spectacles (SP).Methods:A retrospective study was conducted. Data of baseline and one year from 252 children (8-14 years old) anisomyopes who sought refraction corrections at the Zhongshan Ophthalmic Center between October 2013 and June 2017 were reviewed. Seventy-nine unilateral myopic anisometropes (UMA) and 98 bilateral myopic anisometropes (BMA) treated with OK lenses were set as study groups (OK-UMA and OK-BMA groups). Age, refraction, and AL-match...
Source: Current Eye Research - December 10, 2019 Category: Opthalmology Authors: Long W, Li Z, Hu Y, Cui D, Zhai Z, Yang X Tags: Curr Eye Res Source Type: research

Regeneration of the corneal endothelium.
Abstract Penetrating keratoplasty was the only therapeutic choice for the treatment of corneal endothelial decompensation until the introduction of evolutional endothelial keratoplasties, namely Descemet's stripping automated endothelial keratoplasty (DSAEK) and Descemet's membrane endothelial keratoplasty (DMEK). Although now in widespread use, DSAEK and DMEK still have associated problems, such as difficulty of the surgical technique, acute and chronic cell loss, and shortage of donor corneas. Therefore, regeneration of the corneal endothelium by tissue engineering techniques is being researched to overcome thes...
Source: Current Eye Research - December 6, 2019 Category: Opthalmology Authors: Okumura N, Koizumi N Tags: Curr Eye Res Source Type: research

Impact of patient interface diameter and vacuum level on suction stability using a flat applanating interface for femtosecond laser-assisted LASIK.
Abstract Purpose: To investigate the impact of different patient interface (PI) diameters and different vacuum levels on the suction stability during vacuum application for femtosecond laser-assisted LASIK.Methods: Break-away forces as a marker for suction stability were measured by an automated test bench set-up. The test bench was based on a customized stamp connected to a digital load cell. Three flat applanating PI with different diameters (8.5, 9.5 and 10.0mm) and 4 different vacuum levels (500, 600, 700 and 800mbar) were investigated using the FEMTO LDV Z8 (Ziemer Ophthalmic Systems AG, Switzerland).Results:...
Source: Current Eye Research - December 6, 2019 Category: Opthalmology Authors: Mariacher S, Mariacher M, Seuthe AM, Szurman P, Seitz B, Boden KT Tags: Curr Eye Res Source Type: research

Risk Factors Associated with Failure of Direct Cyclopexy in the Treatment of Small to Moderate Tramatic Cyclodialysis Clefts.
Conclusion: Exceeding the threshold of 5 clock hour in anterior chamber angle closure may impede accurate cleft location and, thus, present a higher risk of failure to correct hypotony using direct cyclopexy. These patients may need injection of a viscoelastic agent into the anterior chamber by paracentesis to deepen the anterior chamber and to delineate the clefts using gonioscopy pre- or intraoperatively. PMID: 31797695 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 4, 2019 Category: Opthalmology Authors: Zhao R, Lou B, Yang Y, Duan F, Lin L, Yuan M, Wang Z, He L, Long C, Lin X Tags: Curr Eye Res Source Type: research

Comparative Study of Implantable Collamer Lens Implantation in Treating Four Degrees of Myopia: Six-Month Observation of Visual Results, Higher Order Aberrations, and Amplitude of Accommodation.
Abstract Purpose to compare the visual and refractive outcomes, higher order aberrations (HOAs), and amplitude of accommodation (AA) after implantable collamer lens (ICL) model V4c implantation in 4 degrees of myopia.Methods One hundred and forty-two myopic eyes (142 patients) undergoing ICL implantation were included and divided into 4 groups: Group 1 with spherical equivalent (SE) ≤ -6.0 D, Group 2 with SE from -6.13 D to -9.0D, Group 3 with SE from -9.13D to -12.0 D, and Group 4 with SE from -12.13D to -18.0D. The postoperative visits were scheduled at 1 day, 1 week, 1 month, 3 months, and 6 months. Visual a...
Source: Current Eye Research - December 4, 2019 Category: Opthalmology Authors: Wan T, Yin H, Wu Z, Yang Y Tags: Curr Eye Res Source Type: research

Anti-inflammatory medication of cataract surgery in pseudoexfoliation syndrome - NSAID is needed.
Conclusions: Routine cataract surgery of PXF eyes with nonsteroidal anti-inflammatory drugs (NSAID) alone, or in combination with steroids resulted in faster recovery from surgery and avoidance of PCME compared to steroids alone. PMID: 31801388 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 4, 2019 Category: Opthalmology Authors: Ilveskoski L, Taipale C, Tuuminen R Tags: Curr Eye Res Source Type: research

Understanding the complexity of retina and pluripotent stem cell derived retinal organoids with single cell RNA sequencing: current progress, remaining challenges and future prospective.
Abstract Single cell sequencing technologies have emerged as a revolutionary tool with transformative new methods to profile genetic, epigenetic, spatial, and lineage information in individual cells. Single cell RNA sequencing (scRNA-Seq) allows researchers to collect large datasets detailing the transcriptomes of individual cells in space and time and is increasingly being applied to reveal cellular heterogeneity in retinal development, normal physiology and disease, and provide new insights into cell type specific markers and signalling pathways. In the recent years, scRNA-Seq datasets have been generated from r...
Source: Current Eye Research - December 3, 2019 Category: Opthalmology Authors: Zerti D, Collin J, Queen R, Cockell SJ, Lako M Tags: Curr Eye Res Source Type: research

Treatment of Age-Related Macular Degeneration with Pluripotent Stem Cell-Derived Retinal Pigment Epithelium.
Abstract Retinal pigment epithelium (RPE) degradation is central to the onset and progression of age-related macular degeneration (AMD), a growing and currently incurable form of blindness.Due to its key role in maintaining the retinal structure and homeostasis, cell replacement of the RPE monolayer has emerged as a promising therapy to rescue visual acuity in AMD patients.Thanks to the tremendous progress of pluripotent stem cell technologies over the last decade, a potentially unlimited new source for RPE transplantation has reached clinical trials. This review summarizes the methods by which pluripotent stem ce...
Source: Current Eye Research - November 28, 2019 Category: Opthalmology Authors: Vitillo L, Tovell VE, Coffey P Tags: Curr Eye Res Source Type: research

Accuracy of modified axial length adjustment for intraocular lens power calculation in Chinese axial myopic eyes.
Conclusions: The modified Wang-Koch adjustment had better performance than constant optimization for Holladay 1 but not for SRK/T. Holladay 1 with Wang-Koch adjustment was more accurate than Barrett for ALs between 25.0 mm and 27.0 mm. PMID: 31769715 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - November 26, 2019 Category: Opthalmology Authors: Cheng H, Liu L, Sun A, Wu M Tags: Curr Eye Res Source Type: research

Evaluation of the putative efficacy of a methanolic extract of Ocimum basilicum in preventing disruption of structural proteins in an in vitro system of selenite-induced cataractogenesis.
Conclusions: The methanolic extract of OB leaves prevented alterations in lenticular protein sulfhydryl and carbonyl content, calcium level, insoluble to soluble protein ratio, SDS-PAGE patterns of lenticular proteins, and expression of αA-crystallin and βB1-crystallin gene and proteins in cultured selenite-challenged lenses. OB may be further evaluated as a promising agent for prevention of cataract. PMID: 31770036 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - November 26, 2019 Category: Opthalmology Authors: Thiraviyam A, Muniyandi A, Archana T, Thomas PA, Geraldine P Tags: Curr Eye Res Source Type: research

Black carbon induces cytotoxicity and NLRP3 inflammasome activation in human corneal epithelial cells.
Abstract Purpose: To investigate the cytotoxic effects of fresh black carbon (FBC) particles and ozone-oxidized BC (OBC) particles on human corneal epithelial cells (HCECs), and the role of the NLRP3 inflammasome signal pathway in the process.Methods: HCECs were treated with different doses of FBC and OBC particles, the cell inhibitory effect was observed by MTS assay and the inhibitory concentration 50 (IC50) was calculated; the effect of FBC and OBC particles on cell apoptosis was assessed using flow cytometry-based annexin V/7AAD assay; the mRNA levels of NLRP3 inflammasome signal pathway components (NLRP3, ASC...
Source: Current Eye Research - November 25, 2019 Category: Opthalmology Authors: Long Q, Huang Y, Shang J, Liu Y, Chen C Tags: Curr Eye Res Source Type: research

Intraoperative Dexamethasone Intravitreal Implant (Ozurdex) in Vitrectomy Surgery for Epiretinal Membrane.
Abstract ObjectiveTo study the effectiveness and safety of the intravitreal dexamethasone implant 0.7mg (Ozurdex®) in vitrectomy surgery for epiretinal membrane.MethodsThis is a prospective, multicenter, pilot study. Inclusion criteria included visually significant (
Source: Current Eye Research - November 25, 2019 Category: Opthalmology Authors: Hostovsky A, Muni RH, Eng KT, Mulhall D, Leung C, Kertes PJ Tags: Curr Eye Res Source Type: research

Evaluation of Tear Fluid and Aqueous Humor Concentration of Clusterin as Biomarkers for Early Diagnosis of Pseudoexfoliation Syndrome and Pseudoexfoliative Glaucoma.
Conclusions: In conclusion, tear fluid clusterin level in patients with PEG and PEX was determined for the first time, which showed no difference between study groups. Aqueous humor clusterin level was markedly higher in patients with PEG. PMID: 31765245 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - November 25, 2019 Category: Opthalmology Authors: Can Demirdöğen B, Demirkaya-Budak S, Özge G, Mumcuoğlu T Tags: Curr Eye Res Source Type: research

Immediate Changes in Peripapillary Retinal Vasculature after Intraocular Pressure Elevation -an Optical Coherence Tomography Angiography Study.
Abstract Purpose: To investigate changes in peripapillary retinal vessel density after acute intraocular pressure (IOP) elevation caused by laser peripheral iridotomy (LPI) in primary angle-closure suspects (PACS) by optical coherence tomography angiography (OCTA).Materials and Methods: Ninety-seven participants with PACS were included in this cross-sectional observational study. OCTA and IOP measurement were performed at baseline and 1 hour after LPI. PACS eyes were further divided into three groups according to IOP increase 1 hour after LPI (group 1 = IOP elevation
Source: Current Eye Research - November 21, 2019 Category: Opthalmology Authors: Wang X, Chen J, Kong X, Sun X Tags: Curr Eye Res Source Type: research