Dril influences short-term visual outcome after intravitreal corticosteroid injection for refractory diabetic macular edema.
DRIL INFLUENCES SHORT-TERM VISUAL OUTCOME AFTER INTRAVITREAL CORTICOSTEROID INJECTION FOR REFRACTORY DIABETIC MACULAR EDEMA. Curr Eye Res. 2021 Jan 19;: Authors: Luís ME, Sampaio F, Costa J, Cabral D, Teixeira C, Ferreira JT Abstract PURPOSE: : Intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF) are considered the gold standard for diabetic macular edema (DME). Despite adequate anti-VEGF treatments, many patients present persistent DME. The aim of this study is to identify systemic, ocular and anatomical characteristics influencing functional and anatomical outc...
Source: Current Eye Research - January 19, 2021 Category: Opthalmology Authors: Luís ME, Sampaio F, Costa J, Cabral D, Teixeira C, Ferreira JT Tags: Curr Eye Res Source Type: research

Rebound effect in the misight assessment study spain (mass).
CONCLUSIONS: Over a one-year period, neither myopia progression nor eye growth was faster for the subjects who discontinued MiSight contact lens wear compared to those who continued to wear MiSight contact lenses or those who continued to wear single vision spectacles, indicating no rebound effect with MiSight contact lenses for two years. PMID: 33460537 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - January 18, 2021 Category: Opthalmology Authors: Ruiz-Pomeda A, Prieto-Garrido FL, Hernández Verdejo JL, Villa-Collar C Tags: Curr Eye Res Source Type: research

Ganglion cell and retinal nerve fiver layers correlated with time disease of bipolar disorder using 64 cell grid OCT tool.
LE, Satue M Abstract PURPOSE OF THE STUDY: To assess the ability of the new Spectralis Optical Coherence Tomography (OCT) Posterior Pole protocol to detect degeneration of the inner retinal layers in patients with bipolar disorder (BD) and to assess the correlation between the neuroretinal thickness and disease duration. MATERIALS AND METHODS: Twenty-five eyes of 25 patients with bipolar disorder and 74 eyes of 74 healthy controls underwent retinal measurements of retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness. Measurements were obtained using the Spectralis-OCT device with the new P...
Source: Current Eye Research - January 17, 2021 Category: Opthalmology Authors: Orduna-Hospital E, Cordón B, Vilades E, Garcia-Martin E, Garcia-Campayo J, López-Del-Hoyo Y, Polo V, Larrosa JM, Pablo LE, Satue M Tags: Curr Eye Res Source Type: research

Clinical and demographic characteristics of tearing in patients after radioiodine ablation for differentiated thyroid cancer.
CONCLUSION: Finding risk factors for SALDO development after radioiodine therapy in the future will contribute to an individualized approach to the prevention of this complication. Development of preventive measures is one of the tasks facing researchers. PMID: 33455422 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - January 16, 2021 Category: Opthalmology Authors: Yartsev VD, Solodkiy VA, Fomin DK, Borisenko TE, Atkova EL Tags: Curr Eye Res Source Type: research

The Influence of Crescent-Shaped Selective Internal Limiting Membrane Staining on Vital Dye Toxicity in Temporal Inverted Flap Technique.
Abstract Purpose: To investigate the macular function and morphology after temporal inverted internal limiting membrane (ILM) flap technique with and without staining of the ILM flap in contact with the retinal pigment epithelium (RPE). Materials and Methods: This retrospective study included 30 patients with idiopathic macular hole (MH), who underwent 27G vitrectomy and temporal inverted ILM flap technique with brillant blue G (BBG) assisted ILM staining. In Group 1 (n=16), a large bubble of perfluorocarbon liquid (PFCL) measuring approximately 6-disc diameters was used to cover the hole and central part of the I...
Source: Current Eye Research - January 14, 2021 Category: Opthalmology Authors: Avci R, Mavi Yildiz A, Yilmaz S Tags: Curr Eye Res Source Type: research

Diagnosis of Dry Eye Disease Using Principal Component Analysis: A Study in Animal Models of the Disease.
CONCLUSIONS: PCA proved useful for evaluating DED providing a simpler, more comprehensive assessment than ICTP. PC 1 is a valuable, clinically relevant, and informative metric for DED status and severity having superior diagnostic value and statistical strength compared to ICTP. Spatial information on biplots of PC 1 vs PC 3 is also informative. PCA, and specifically PC 1, has the potential to serve as a biomarker for DED. PMID: 33445973 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - January 14, 2021 Category: Opthalmology Authors: Honkanen R, Nemesure B, Huang L, Rigas B Tags: Curr Eye Res Source Type: research

Evaluation of ocular hypoperfusion in patients with acromegaly by using optical coherence tomography angiography.
This study aimed to evaluate the retinal blood vessel parameters and the foveal avascular zone (FAZ) area using optical coherence tomography angiography (OCTA) in patients with acromegaly in comparison with healthy controls. METHODS: A total of 45 patients with acromegaly and 45 healthy controls were included in this study. In all patients, the vessel density (VD) of the deep and superficial macular vascular networks and the foveal avascular zone (FAZ) were measured using OCTA. The correlation of insulin-like growth factor 1 (IGF-1) level and disease duration with deep macular VD and FAZ values was analyzed. All param...
Source: Current Eye Research - January 14, 2021 Category: Opthalmology Authors: Karahan M, Demirtaş AA, Erdem S, Ava S, Pekkolay Z, Keklikçi U Tags: Curr Eye Res Source Type: research

The Association between Meibomian Gland Atrophy and Corneal Subbasal Nerve Loss in Patients with Chronic Ocular Graft-versus-host Disease.
Abstract Purpose: To investigate the association between meibomian gland (MG) loss and corneal subbasal nerve plexus density in patients with chronic graft-versus-host disease (GVHD) related dry eye disease (DED). Materials and Methods: This cross-sectional study included 22 adult patients with severe DED secondary to chronic GVHD. Control group comprised age- and sex-matched 28 healthy subjects with no evidence of ocular disease. All subjects underwent tear breakup time (TBUT), corneal staining, Schirmer I test without anesthesia, quantitative MG drop-out assessment using infrared meibography and corneal subbasal...
Source: Current Eye Research - January 11, 2021 Category: Opthalmology Authors: Dikmetas O, Kocabeyoglu S, Mocan MC Tags: Curr Eye Res Source Type: research

IL-1 α antibody inhibits dose-dependent exacerbation of eosinophilic inflammation by crude house-dust-mite antigen in the conjunctiva of an atopic keratoconjunctivitis mouse model.
Conclusions : The house-dust-mite antigen increased eosinophilic infiltration and Il13 mRNA expression in the conjunctiva of an atopic keratoconjunctivitis mouse model in a dose-dependent manner. These inflammatory alterations were partially alleviated by eyelid injection of anti-IL-1α antibody. These findings indicate that IL-1α-induced IL-13 production constitutes a major exacerbating factor for house-dust-mite antigen-induced atopic keratoconjunctivitis. PMID: 33428487 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - January 11, 2021 Category: Opthalmology Authors: Shiraki Y, Shoji J, Inada N, Tomioka A, Yamagami S Tags: Curr Eye Res Source Type: research

Retinal neurodegeneration in diabetic peripheral neuropathy by optical coherence tomography: a systematic review and meta-analysis.
CONCLUSIONS: Patients with DPN present with significant retinal neurodegeneration, with reduced pRNFL, mRNFL, mGCIPL, and mGCC thickness. Measurements of OCT parameters may serve as a biomarker for diagnosing and monitoring DPN. PMID: 33428500 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - January 11, 2021 Category: Opthalmology Authors: Liu B, Wang W, Zhou R, Zeng X, Zhu Z Tags: Curr Eye Res Source Type: research

Differences in visual working and mobile phone usage distance according to the job profile.
DIFFERENCES IN VISUAL WORKING AND MOBILE PHONE USAGE DISTANCE ACCORDING TO THE JOB PROFILE. Curr Eye Res. 2021 Jan 06;: Authors: Soler F, Sánchez-García A, Molina-Martin A, de Fez D, Díaz V, Piñero DP Abstract PURPOSE: To analyse and characterize the pattern of visual working distance (WD) and mobile phone usage distance (MPD) in a large population, analysing the differences in these parameters according to the job profile. METHODS: Cross-sectional study consisting of a screening campaign evaluating the visual status of professionals from seven different environments. ...
Source: Current Eye Research - January 6, 2021 Category: Opthalmology Authors: Soler F, Sánchez-García A, Molina-Martin A, de Fez D, Díaz V, Piñero DP Tags: Curr Eye Res Source Type: research

Ginsenoside Rg1 prevents H2O2-induced lens opacity.
Conclusions This study demonstrated that Rg1 might have the capability to protect lens against oxidative stress-induced cataract, at least by local administration. PMID: 33405968 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - January 6, 2021 Category: Opthalmology Authors: Zhang G, Zhang M, Yu J, Kang L, Guan H Tags: Curr Eye Res Source Type: research

Change and Recovery of Choroid Thickness after Short-term Application of 1% Atropine Gel and Its Influencing Factors in 6-7-year-old Children.
Conclusions: One-week application of 1% atropine gel may increase CT in 6-7-year-old Chinese children. Meanwhile, the recovery process after withdrawal lasts seven weeks. During the recovery process, the changes in structural parameters (AL, CT) and functional parameters (AA, SE) in both groups occurred synchronously. The SE, AA, and AL at baseline may not predict the extent of atropine's effect on CT. PMID: 33390025 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - January 4, 2021 Category: Opthalmology Authors: Jiang Y, Zhang Z, Wu Z, Sun S, Fu Y, Ke B Tags: Curr Eye Res Source Type: research

Clinical Analysis of Central Islands after Small Incision Lenticule Extraction (SMILE).
Conclusions: Central islands in SMILE, despite being a rare adverse event, can affect the safety of the procedure and are related to preoperative central steepness, not corrected by the spherical lenticule, which is clearly visible postoperatively. PMID: 33390036 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - January 4, 2021 Category: Opthalmology Authors: Fernández J, García-Montesinos J, Martínez J, Piñero DP, Rodríguez-Vallejo M Tags: Curr Eye Res Source Type: research

Heparanase Deficiency Is Associated with Disruption, Detachment, and Folding of the Retinal Pigment Epithelium.
Conclusions: Our results indicate that heparanase deficiency in the mice leads to RPE folds, choroidal thickening, and retinal disorganization. The presence of discrete hyperfluorescent foci, a key characteristic of the human disease, was not observed. However, it can be concluded that some of the observations in mice are similar to those seen after chronic use of PPS in humans. These findings indicate that the toxicity observed in the presence of heparanase inhibitors is target-related and will preclude the clinical use of heparanase inhibition as a therapeutic intervention. PMID: 33372561 [PubMed - as supplied by pu...
Source: Current Eye Research - December 29, 2020 Category: Opthalmology Authors: Van Bergen T, Etienne I, Jia J, Li JP, Vlodavsky I, Stitt A, Vermassen E, Feyen JHM Tags: Curr Eye Res Source Type: research

Prediction Error of Intraocular Lens Power Calculation in Very Elderly Patients over 90 Years Old.
Abstract Background: To investigate the influence of age on prediction error (PE) after cataract surgery in very elderly (VE) patients aged more than 90 years. Methods: We retrospectively analyzed 66 eyes of patients aged ≥90 years (VE group) who underwent phacoemulsification and intraocular lens (IOL) implantation. As the control group (CG), we investigated 121 eyes of patients aged 70-89 years who underwent the same surgery. PE was calculated 1 month post-surgery as the actual postoperative spherical equivalent minus the target diopter, which was calculated using the Sanders-Retzlaff-Kraff/T fo...
Source: Current Eye Research - December 26, 2020 Category: Opthalmology Authors: Koga Y, Kojima K, Yoshii K, Kusada N, Kagitani Y, Aoki T, Horiuchi N, Kitazawa K, Sotozono C Tags: Curr Eye Res Source Type: research

Determination of Neurodegeneration in Polycystic Ovary Syndrome with Retinal Segmentation Analysis.
Conclusion: The results of our retinal segmentation analysis indicate that patients with PCOS tend to have thinner GCL, IPL, and PRL than healthy, age-matched controls due to neurodegeneration likely caused by insulin resistance, or subclinical retinal inflammation. PMID: 33356631 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 26, 2020 Category: Opthalmology Authors: Sirakaya E, Sirakaya HA, Vural E, Duru Z, Aksoy H Tags: Curr Eye Res Source Type: research

A Single Low-Dose of Methylphenidate Improves Abnormal Visual Field Testing.
Conclusions: A single low dose of methylphenidate can improve visual field testing in subjects without ocular pathology, and even more in those with prior experience in perimetry. PMID: 33342320 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 21, 2020 Category: Opthalmology Authors: Sternfeld A, Bialer OY, Keidar D, Megiddo E, Budnik I, Stiebel-Kalish H, Livnat T Tags: Curr Eye Res Source Type: research

The role of plasma calprotectin in non-infectious uveitis.
CONCLUSIONS: Plasma calprotectin levels are elevated in uveitis patients and are influenced by age and anatomical location of uveitis. Further investigation is needed to assess the relationship between calprotectin and uveitis activity. PMID: 33349072 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 21, 2020 Category: Opthalmology Authors: Pascual EV, Martínez-Costa Pérez L, Hernández Pons A, López Ortega JM, Grau García E, Albert Fort M, Alegre Sancho JJ, Ivorra JAR Tags: Curr Eye Res Source Type: research

Comparative evaluation in Intense Pulsed Light therapy combined with or without meibomian gland expression for the treatment of meibomian gland dysfunction.
Abstract Objective: To determine whether the combination of meibomian gland expression (MGX) with intense pulsed light (IPL) has a better efficacy to treat meibomian gland dysfunction (MGD) than IPL alone. Methods: One hundred patients with MGD were randomly divided into three groups: MGX, IPL, and IPL+ MGX. Clinical parameters included the Ocular Surface Disease Index (OSDI), tear meniscus height (TMH), noninvasive keratograph tear breakup time (NIBUT),redness, meibomian gland dropout, tear breakup time (TBUT), corneal fluorescent staining (CFS), eyelid margin score, meibomian gland secretion function, and Schirm...
Source: Current Eye Research - December 19, 2020 Category: Opthalmology Authors: Chen Y, Li J, Wu Y, Lin X, Deng X, Yun-E Z Tags: Curr Eye Res Source Type: research

LncRNA-MALAT1/miRNA-204-5p/Smad4 Axis Regulates Epithelial-Mesenchymal Transition, Proliferation and Migration of Lens Epithelial Cells.
Conclusions: Our findings reveal that MALAT1 may regulate EMT, proliferation, and migration of LECs as a ceRNA by "sponging" miR-204-5p and targeting Smad4, and serve as a promising therapeutic target in preventing PCO. PMID: 33327804 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 17, 2020 Category: Opthalmology Authors: Peng C, Wang Y, Ji L, Kuang L, Yu Z, Li H, Zhang J, Zhao J Tags: Curr Eye Res Source Type: research

Effect of Intracameral Cefuroxime on Graft Endothelial Cells in Descemet Membrane Endothelial Keratoplasty: A Comparative Study.
Conclusion: The use of intracameral cefuroxime during simple or combined DMEK did not lead to higher graft endothelial cell loss. PMID: 33322945 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 16, 2020 Category: Opthalmology Authors: Ghazal W, Saad A, Courtin R, Gatinel D, Panthier C Tags: Curr Eye Res Source Type: research

Correlation between the Angiographic Choriocapillaris and the Structural Inner Choroid.
Conclusions: The angiographic CC FD was significantly correlated with the structural inner choroidal stromal index. These findings suggest that there may be an opportunity to use structural OCT data to analyze the CC, which may allow longitudinal assessment from historical structural OCT datasets. PMID: 33317343 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 15, 2020 Category: Opthalmology Authors: Corvi F, Corradetti G, Sadda SR Tags: Curr Eye Res Source Type: research

Prion protein on human leukocytes is reduced in iron deficiency - possible implications for age-related macular degeneration?
CONCLUSION: Our findings suggest a connection between the physiological function of the prion protein and iron metabolism in humans. PMID: 33317353 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 14, 2020 Category: Opthalmology Authors: Lindner E, Woltsche N, Merle D, Steinwender G, Strohmaier H, Nairz M, Ivastinovic D Tags: Curr Eye Res Source Type: research

Ophthalmic manifestations of Rathke's cleft cyst and its association to radiological characteristics.
Abstract PURPOSE: To evaluate the ophthalmic features of Rathke's cleft cyst (RCC) and its association to radiological characteristics. METHODS: In this retrospective single center study, patients who showed typical findings suggestive of RCC on magnetic resonance imaging (MRI) and underwent relevant ophthalmic examination were recruited retrospectively. Patients were stratified into two groups according to the presence or absence of ophthalmic symptoms related to RCC. We reviewed patients' demographic information, initial symptoms, endocrinological status, ophthalmic features, and characteristics on MRI. Hei...
Source: Current Eye Research - December 11, 2020 Category: Opthalmology Authors: Jeon H, Suh HB, Chung W, Choi HY Tags: Curr Eye Res Source Type: research

Critique of the study, "Five-Year Outcomes Prospective Study of Two First-Generation Trabecular Micro-Bypass Stents (iStent ®) in Open-Angle Glaucoma" by Hady Saheb et al.
Critique of the study, "Five-Year Outcomes Prospective Study of Two First-Generation Trabecular Micro-Bypass Stents (iStent®) in Open-Angle Glaucoma" by Hady Saheb et al. Curr Eye Res. 2020 Dec 10;: Authors: Mercer R, Alaghband P PMID: 33302706 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 10, 2020 Category: Opthalmology Authors: Mercer R, Alaghband P Tags: Curr Eye Res Source Type: research

Protective Effects of Nicotinamide Riboside on H2O2-induced Oxidative Damage in Lens Epithelial Cells.
Conclusions: NR may alleviate oxidative damage by targeting the MAPK and JAK2/Stat3 pathways in H2O2-treated SRA01/04 cells. NR may represent anovel drug for preventing or treating cataracts. PMID: 33297791 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 9, 2020 Category: Opthalmology Authors: Zhou B, Zhao G, Zhu Y, Chen X, Zhang N, Yang J, Lin H Tags: Curr Eye Res Source Type: research

High Myopia and Strabismus Induced by a Deep Intronic Mutation in COL2A1.
Conclusions: Stickler syndrome has several subtypes with variable clinical features. Therefore, predicting the genetic locus of the disease based on clinical characteristics is challenging. We present a rarely described intronic mutation in COL2A1. Genetic testing may aid in the early diagnosis of Stickler syndrome, which is important for genetic counselling, proper clinical management, and improved prognosis. PMID: 33295219 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 9, 2020 Category: Opthalmology Authors: Rossenwasser-Weiss S, Orenstein N, Zahavi A, Goldenberg-Cohen N Tags: Curr Eye Res Source Type: research

Efficacy and Safety of Sodium Hyaluronate/chondroitin Sulfate Preservative-free Ophthalmic Solution in the Treatment of Dry Eye: A Clinical Trial.
Conclusions: The topical application of SH/CS-PF is as effective, safe and well tolerated as that of PEG/PG or PEG/PG-PF. The results suggest that SH/CS-PF may lead to normalization of clinical parameters and symptom alleviation in patients treated for DED. PMID: 33289602 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 8, 2020 Category: Opthalmology Authors: Belalcázar-Rey S, Sánchez Huerta V, Ochoa-Tabares JC, Altamirano Vallejo S, Soto-Gómez A, Suárez-Velasco R, García-Félix F, Baiza-Durán L, Olvera-Montaño O, Muñoz-Villegas P Tags: Curr Eye Res Source Type: research

Incidence of Ultrathin Descemet Stripping Endothelial Keratoplasty Corneal Graft Rejection Following Steroid Discontinuation.
CONCLUSION: Discontinuation of topical steroid at approximately 1 year after uDSEK results in a low rate of corneal graft rejection and may prove extended use unnecessary. PMID: 33290663 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 8, 2020 Category: Opthalmology Authors: Walter KA, Hartel J, Hess JP, Joubert E, Lee RY Tags: Curr Eye Res Source Type: research

Influences of hypomagnesemia on optic nerve and retinal vascular structure determined using optical coherence tomography angiography.
Abstract PURPOSE: To evaluate the effects of low blood magnesium levels on the optic nerve, retina and retinal vascular structure. METHODS: This observational and cross-sectional study was conducted between June 2019 and May 2020 with participants aged 20-39 years, who had a visual acuity of ≥20/20, axial length of 22-24.5 mm, refractive defect spherical equivalent of ≤±3D and intraocular pressure of ≤21 mm Hg. All participants had a complaint of twitching in their eyes. The participants with normal serum magnesium levels constituted the control group, and patients with hypomagnesemia constitu...
Source: Current Eye Research - December 1, 2020 Category: Opthalmology Authors: Ugurlu A, Yılmaz H Tags: Curr Eye Res Source Type: research

Cat-12 Tool to reduce intraoperative complications for phacoemulsification and femtosecond laser assisted cataract surgery.
PMID: 33259754 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - December 1, 2020 Category: Opthalmology Authors: Low S, Tran J, McGurk C, Gupta A, Roberts HW, O'Brart D Tags: Curr Eye Res Source Type: research

Patterns of fundus autofluorescence in eyes with myopic atrophy maculopathy: a consecutive case series study.
Abstract PURPOSES: To investigate the patterns of fundus autofluorescence (FAF) in patients with different grades of myopic atrophy maculopathy (MAM). METHODS: Patients with MAM who visited Zhongshan Ophthalmic Center from January 2018 to December 2019 were screened. All patients received comprehensive ophthalmologic examinations as well as FAF imaging. The atrophic severity of each eye was identified based on the META-PM classification system, including no myopic retinal lesions (C0), tessellated fundus only (C1), diffuse chorioretinal atrophy (C2), patchy chorioretinal atrophy (C3), and macular atrophy (C4)...
Source: Current Eye Research - November 28, 2020 Category: Opthalmology Authors: Li J, Zhao X, Chen S, Liu B, Li Y, Lian P, Wang Y, Yu X, Lu L Tags: Curr Eye Res Source Type: research

Effect of congenital lower eyelid epiblepharon surgery on asymmetric margin reflex distance 1.
Abstract OBJECTIVES: To investigate the characteristics of margin reflex distance 1 (MRD1) asymmetry in congenital lower eyelid epiblepharon and its resolution after surgical correction of epiblepharon. METHODS: Among patients who underwent lower eyelid epiblepharon surgery from November 2015 to September 2017, patients with a preoperative MRD1 difference of more than 1.0 mm between the two eyes according to medical photographs were defined as having MRD1 asymmetry. A postoperative MRD1 difference of less than 1.0 mm between the two eyes was regarded as MRD1 asymmetry resolution. The preoperative MRD1 differe...
Source: Current Eye Research - November 28, 2020 Category: Opthalmology Authors: Yang MK, Kim N, Choung HK, Khwarg SI Tags: Curr Eye Res Source Type: research

Intraoperative Pain Sensation During Cataract Surgery: Why Does Timing Matter?
Conclusions : Patients undergoing cataract surgery in the afternoon showed more preoperative anxiety, which may have increased their relevant stress hormones. Both the patient's emotional state and hormone levels may together aggravate his/her perceived pain in the afternoon. Monitoring preoperative anxiety levels, blood pressure, and heart rate should help to identify patients at higher risk of perceived intraoperative pain. PMID: 33249933 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - November 28, 2020 Category: Opthalmology Authors: Zhu X, Lu Q, Yao Y, Xu X, Lu Y Tags: Curr Eye Res Source Type: research

A Comprehensive Review of the Clinical Trials Conducted for Dry Eye Disease and the Impact of the Vehicle Comparators in These Trials.
Abstract Dry eye disease (DED) is a multifactorial disease of the ocular surface characterized by loss of homeostasis of the tear film and accompanied by symptoms such as ocular discomfort and visual disturbance. DED is one of the most common reasons for seeking medical care in the United States and across the world. Despite this, there are a limited number of pharmacologic therapies for the treatment of DED in the United States and Europe. This review examines the different pivotal trials for DED medications and the impact the vehicle in each trial. In recent clinical trials, the vehicle of the active formulation...
Source: Current Eye Research - November 25, 2020 Category: Opthalmology Authors: Nichols KK, Evans DG, Karpecki PM Tags: Curr Eye Res Source Type: research

Comment on the reply: "Prospective Evaluation of Floppy Eyelid Syndrome at Baseline and After CPAP Therapy".
Comment on the reply: "Prospective Evaluation of Floppy Eyelid Syndrome at Baseline and After CPAP Therapy". Curr Eye Res. 2020 Nov 24;: Authors: Vieira MJ, Silva MJ, Lopes N, Moreira C, Carvalheira F, Sousa JP PMID: 33233957 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - November 24, 2020 Category: Opthalmology Authors: Vieira MJ, Silva MJ, Lopes N, Moreira C, Carvalheira F, Sousa JP Tags: Curr Eye Res Source Type: research

Analysis of Three-Dimensional Choroidal Volume with Enhanced Depth Imaging Findings in Patients with Recurrent Vogt-Koyanagi-Harada Disease.
Conclusions: In the recurrent stage of VKH, alteration in choroidal volume was evident by EDI-OCT even in an absence of anterior segment inflammation. Central choroidal volume may serve as a biomarker for detecting choroidal morphological change. PMID: 33215546 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - November 20, 2020 Category: Opthalmology Authors: Silpa-Archa S, Ittharat W, Chotcomwongse P, Preble JM, Foster CS Tags: Curr Eye Res Source Type: research

Safety and long-term scleral biomechanical stability of rhesus eyes after scleral cross-linking by blue light.
Conclusion: This study demonstrates that blue light scleral CXL could effectively increase the scleral stiffness of the rhesus eye for at least 1 year, but ultrastructural change was still observed in the retina of scleral CXL eye. Therefore, the long-term intraocular safety of the blue light scleral CXL technique for preventing myopia progression should be investigated further. PMID: 33213212 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - November 19, 2020 Category: Opthalmology Authors: Li Y, Zhang F, Sun M, Lai L, Lv X, Liu C, Wang M, Wang N Tags: Curr Eye Res Source Type: research

Correlation of retinal thickness and swept-source optical coherence tomography angiography derived vascular changes in patients with neovascular age-related macular degeneration.
Abstract PURPOSE: The aim of this study was to investigate whether structural OCT changes, in specific retinal thickness, is associated with the vascular response within the nAMD CNV lesion. In other words, whether SSOCTA derived parameters may prove suitable to assess CNV activity in future. METHODS: During the first 3 months patients were prospectively followed with visits at days 7, and 14 after each anti-VEGF treatment up to day 90. At baseline, day 30 and 60 Aflibercept was administered. OCT-derrived retinal thickness (RT) and OCTA-derived CNV lesion parameters (vessel area [VA]), total vessel length [TV...
Source: Current Eye Research - November 19, 2020 Category: Opthalmology Authors: Told R, Reiter GS, Schranz M, Reumueller A, Hacker V, Mittermueller TJ, Roberts PK, Sacu S, Schmidt-Erfurth U Tags: Curr Eye Res Source Type: research

The Change in Color Vision with Normal Aging Evaluated on Standard Pseudoisochromatic Plates Part-3.
Abstract Purpose: To evaluate the influence of aging on color vision in a large normal population using Standard Pseudoisochromatic Plates part-3 (SPP-3), which is a pseudoisochromatic plate test used to detect congenital or acquired color vision deficiency (CVD). Materials and methods: We retrospectively reviewed SPP-3 test results of 23,565 normal eyes of 23,565 subjects (women: 12,035; men: 11,530), who were examined between July 1993 and December 2010. The subjects had a mean age of 46.9 ± 18.5 years, ranging from 5 to 89 years, and they were evaluated following categorization into a...
Source: Current Eye Research - November 15, 2020 Category: Opthalmology Authors: Ichikawa K, Yokoyama S, Tanaka Y, Nakamura H, Smith RT, Tanabe S Tags: Curr Eye Res Source Type: research

Impact of Re-bubbling after Descemet Membrane Endothelial Keratoplasty on Long-term Results.
Abstract Purpose/Aim of the study: Graft detachment after DMEK can be treated easily with an additional air injection - re-bubbling. The aim of our study was to investigate the effect of a re-bubbling on the postoperative outcome. Materials and Methods: In this retrospective, comparative, cohort study we included eyes from patients that underwent DMEK surgery. A graft detachment was diagnosed by slit-lamp examination and OCT scan. All eyes were divided into three groups: no re-bubbling, one re-bubbling, more than one re-bubbling. We analyzed the visual acuity, endothelial cell density and rate of graft failure. Re...
Source: Current Eye Research - November 12, 2020 Category: Opthalmology Authors: Gundlach E, Pilger D, Dietrich-Ntoukas T, Joussen AM, Torun N, Maier AB Tags: Curr Eye Res Source Type: research

Clinical course of treated choroidal neovascularization in eyes with pre-existing geographic atrophy: case series and reappraisal of the literature.
Abstract Purpose : To report the clinical course of choroidal neovascularization (CNV) treated with anti-vascular endothelial growth factor (VEGF) treatment in eyes with preexisting geographic atrophy (GA). Material and Methods : Multicenter retrospective series. Electronic medical records, clinical notes and multimodal retinal imaging of patients attending four tertiary referring centers with a diagnosis of unilateral CNV in the context of preexisting diagnosis of GA were included. GA was assessed on multimodal retinal imaging including spectral-domain optical coherence tomography (SD-OCT) scan with simultaneous ...
Source: Current Eye Research - November 11, 2020 Category: Opthalmology Authors: Casalino G, Arrigo A, Introini U, Scialdone A, Coppola M, Bandello F, Chakravarthy U, Parodi MB Tags: Curr Eye Res Source Type: research

Association of ocular antihypertensive medications and the development and progression of age-related macular degeneration in a U.S. insurance claims database.
Abstract Purpose/Aim : To assess whether ocular antihypertensives are associated with development and progression of age-related macular degeneration (AMD). Materials and Methods : This retrospective, observational cohort study using healthcare claims data from a U.S. nationwide managed-care network between January 1, 2006 and December 31, 2016 included enrollees ≥40 years old with primary open angle glaucoma with or without a diagnosis of nonexudative AMD at the index date. Hazard ratios (HR) for developing AMD or progressing from nonexudative to exudative AMD with exposure to ocular antihypertensive medicatio...
Source: Current Eye Research - November 11, 2020 Category: Opthalmology Authors: Eton EA, Wubben TJ, Besirli CG, Wang SY Tags: Curr Eye Res Source Type: research

Quantification of retinal microvascular density using optic coherence tomography angiography in primary angle closure disease.
Abstract PURPOSE: : To evaluate the microvascular density of the peripapillary and parafoveal areas of the eyes with primary angle closure disease (PACD) using optical coherence tomography angiography (OCTA). MATERIALS AND METHODS: : An observational study was conducted with 76 PACD patients (29 eyes with primary angle closure suspect, 22 eyes with primary angle closure [PAC], and 25 eyes with primary angle closure glaucoma [PACG]) and 27 control eyes. OCTA was performed for all subjects to acquire a 4.5 × 4.5 mm scanning area centered on the optic discs and a 3 × 3 mm parafoveal cubes. Peripapill...
Source: Current Eye Research - November 10, 2020 Category: Opthalmology Authors: Wang X, Chen J, Kong X, Sun X Tags: Curr Eye Res Source Type: research

Macular Corneal Dystrophy: An Updated Review.
Abstract Macular Corneal Dystrophy is an autosomal recessive form of corneal dystrophy due to a mutation in CHST6 gene, which results in abnormal proteoglycan synthesis. There is accumulation of abnormal glycosaminoglycans in the corneal stroma and endothelium. The deposition results in progressive loss of corneal transparency and visual acuity. The histopathology shows characteristic alcian blue positive deposits. Management in the cases with visual loss requires keratoplasty either full thickness or lamellar. The decision about the ideal type of keratoplasty depends on age and pre-operative clinical features. Al...
Source: Current Eye Research - November 10, 2020 Category: Opthalmology Authors: Singh S, Das S, Kannabiran C, Jakati S, Chaurasia S Tags: Curr Eye Res Source Type: research

Alginate Oligosaccharide Prevents against D-galactose-mediated Cataract in C57BL/6J Mice via Regulating Oxidative Stress and Antioxidant System.
CONCLUSIONS: AOS prevents against D-gal-mediated cataract in C57BL/6 J mice via inhibiting oxidative stress and up-regulating antioxidant system. Consequently, our results suggest that AOS may be an effective therapeutic strategy against cataract. PMID: 33153341 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - November 6, 2020 Category: Opthalmology Authors: Feng W, Yang X, Feng M, Pan H, Liu J, Hu Y, Wang S, Zhang D, Ma F, Mao Y Tags: Curr Eye Res Source Type: research

Acanthamoeba Keratitis: Perspectives for Patients.
Abstract Purpose To unveil the long-term prognosis of Acanthamoeba keratitis based on clinical presentation and timing of diagnosis to better inform patients since first visit regarding their length of treatment, quality of life, and visual function. Methods Retrospective observational study enrolling patients with Acanthamoeba keratitis from 1994 to 2019. Patients with complete eye examination and medical records were analyzed. Severity of the disease, the time from onset of symptoms to the appropriate therapeutic regimen, the time until clinical resolution, visual function, and long-term follow-up were evaluated...
Source: Current Eye Research - November 5, 2020 Category: Opthalmology Authors: Bonini S, Di Zazzo A, Varacalli G, Coassin M Tags: Curr Eye Res Source Type: research

Quantitative Evaluation of Retinal Vessel Density in Central Serous Chorioretinopathy after Half-dose Photodynamic Therapy.
Abstract Purpose To determine vessel changes in retinochoroid with optical coherence tomographic angiography (OCT angiography) and spectral-domain OCT (SD-OCT) of patients with central serous chorioretinopathy (CSC) after half-dose photodynamic therapy (hd-PDT). Methods A prospective observational study of 62 eyes of 58 patients undergoing hd-PDT was followed for 3 months. Fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA) were performed at baseline; best corrected visual acuity (BCVA), fundus photography, OCT angiography and SD-OCT were performed at baseline, 1-month, and 3-month follow...
Source: Current Eye Research - November 3, 2020 Category: Opthalmology Authors: Xu F, Zhou L, Lai K, Gong Y, Li L, Lian P, Huang C, Ding X, Lu L, Jin C Tags: Curr Eye Res Source Type: research

Choroidal vascularity index in patients with type-1 diabetes mellitus without diabetic retinopathy.
This study aims to assess choroidal vascularity index (CVI) and choroidal thickness (CT) in patients diagnosed with type 1 diabetes mellitus (DM) and compare them with healthy control subjects. Methods This retrospective and cross-sectional study includes 43 patients diagnosed with type 1 DM and 43 healthy age/gender-matched subjects as the control group. Enhanced depth imaging optical coherence tomography (EDI-OCT; Spectralis, Heidelberg Engineering GmbH, Heidelberg, Germany) images of all participants were analyzed. CT measurements of five different points (subfoveal, 500 µm temporal, 1500 µm temporal, 500 &m...
Source: Current Eye Research - November 3, 2020 Category: Opthalmology Authors: Aksoy M, Simsek M, Apaydın M Tags: Curr Eye Res Source Type: research