Correlation of Staphylococcus epidermidis Phenotype and its Corneal Virulence.
CONCLUSION: Hemolysins and proteases seem to be important in corneal pathology caused by S. epidermidis infections. The Esp protease mediates significant corneal damage. S. epidermidis Esp and S. aureus V8 protease caused similar and extensive edema in rabbit corneas. PMID: 32938252 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - September 17, 2020 Category: Opthalmology Authors: Caballero AR, Tang A, Bierdeman M, O'Callaghan R, Marquart M Tags: Curr Eye Res Source Type: research

Process Mapping and Activity-Based Costing of the Intravitreal Injection Procedure.
Conclusions Our study provides an objective and accurate cost estimate of the IVI procedure and illustrates how ABC may be applied in a clinical context. Our findings suggest that IVIs may currently be undervalued by payors. PMID: 32940071 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - September 17, 2020 Category: Opthalmology Authors: Go JA, Weng CY Tags: Curr Eye Res Source Type: research

Comparison of the Visual Performance after Implantation of Three Aberration-correcting Aspherical Intraocular Lens.
Abstract PURPOSE: To compare the visual performance after implantation of three aberration-correcting aspherical intraocular lens (IOL). MATERIALS AND METHODS: Seventy-seven eyes of 77 cataract patients were divided into three groups: 26 eyes implanted with a non-constant aberration IOL (LUCIA 601P IOL, Zeiss Company, Germany); 26 eyes implanted with a spherical aberration -0.18μm IOL (CT ASPHINA 509M, Zeiss Company, Germany) and 27 eyes implanted with a spherical aberration -0.27μm IOL (AMO Tecnis ZCB00, Johnson & Johnson Surgical Vision, USA). Three months after operation, the distance visual acui...
Source: Current Eye Research - September 16, 2020 Category: Opthalmology Authors: Liu Y, Zhao J, Hu Y, Li B, Wang J, Zhang J Tags: Curr Eye Res Source Type: research

Adduction-Induced Strain on the Optic Nerve in Primary Open Angle Glaucoma at Normal Intraocular Pressure.
Abstract PURPOSE/AIM: The optic nerve (ON) becomes taut during adduction beyond ~26° in healthy people and patients with primary open angle glaucoma (POAG), but only retracts the globe in POAG. We used magnetic resonance imaging (MRI) to investigate this difference. MATERIALS AND METHODS: MRI was obtained in 2-mm quasi-coronal planes in central gaze, and smaller (~23-25°) and larger (~30-31°) adduction and abduction in 21 controls and 12 POAG subjects whose intraocular pressure never exceeded 21 mmHg. ON cross-sections were analyzed from the globe to 10 mm posteriorly. Area centroids were use...
Source: Current Eye Research - September 11, 2020 Category: Opthalmology Authors: Clark RA, Suh SY, Caprioli J, Giaconi JA, Nouri-Mahdavi K, Law SK, Bonelli L, Coleman AL, Demer JL Tags: Curr Eye Res Source Type: research

Visual and refractive outcomes with a new topography-integrated wavefront-guided lasik procedure.
VISUAL AND REFRACTIVE OUTCOMES WITH A NEW TOPOGRAPHY-INTEGRATED WAVEFRONT-GUIDED LASIK PROCEDURE. Curr Eye Res. 2020 Sep 09;: Authors: Uceda-Montañés A, Rogers M, Piñero DP Abstract PURPOSE: To evaluate the clinical outcomes of laser in situ keratomileusis (LASIK) using a new approach for the calculation of the ablation profile based on wavefront vertexing from pupil plane to corneal. METHODS: One hundred eyes of 50 patients (age, 21-41 years) with low and moderate myopia were enrolled in this prospective case series. All of them underwent topography-integrated wavefront-guid...
Source: Current Eye Research - September 9, 2020 Category: Opthalmology Authors: Uceda-Montañés A, Rogers M, Piñero DP Tags: Curr Eye Res Source Type: research

Reply to Prospective Evaluation of Floppy Eyelid Syndrome at Baseline and After CPAP Therapy.
PMID: 32905715 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - September 9, 2020 Category: Opthalmology Authors: Acar M, Firat H Tags: Curr Eye Res Source Type: research

Neuroprotective Effect of Intravitreal Single-Dose Lithium Chloride after Optic Nerve Injury in Rats.
Abstract OBJECTIVE: Lithium is an old drug to control bipolar disorder. Moreover, it presents neuroprotective effects and supports neuronal plasticity. The aim of this study was to evaluate neuroprotective effect of intravitreal lithium after optic nerve injury. METHODS: Three dosages of lithium chloride, including 2 pmol, 200 pmol, and 2 nmol, were injected intravitreally after rat optic nerve injury. Proteins expression were assessed by western blot. Nitric oxide (NO) metabolites were measured by Griess test. Visual evoked potential (VEP) and optical coherence tomography (OCT) measurement were performe...
Source: Current Eye Research - September 4, 2020 Category: Opthalmology Authors: Ala M, Mohammad Jafari R, Nematian H, Ganjedanesh MR, Naderi A, Akbariani M, Sanatkar M, Satarian L, Aghsaei Fard M, Dehpour AR Tags: Curr Eye Res Source Type: research

Color Doppler Imaging Features of the Lacrimal Sac in Health and Diseased States.
CONCLUSION: Characteristic Color Doppler flow parameters can be demonstrated in patients with PANDO and acute dacryocystitis. Color Doppler techniques has the potential to enhance the understanding of lacrimal drainage pathophysiology. PMID: 32886568 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - September 4, 2020 Category: Opthalmology Authors: Ali MJ, Ponnaganti S, Barla K, Varma DR, Bothra N Tags: Curr Eye Res Source Type: research

Beneficial effects of hypercapnic acidosis on the inhibition of transforming growth factor β-1-induced corneal fibrosis in vitro.
CONCLUSIONS: Hypercapnic acidosis inhibits transforming growth factor β-1-induced corneal fibroblast migration, collagen gel contraction capacity, and alpha smooth muscle actin expression, potentially through the Smad and NF-κB pathways. Therefore, hypercapnic acidosis may be a potentially useful anti-fibrotic therapy for corneal scarring. PMID: 32886570 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - September 4, 2020 Category: Opthalmology Authors: Chang YM, Cian AA, Weng TH, Liang CM, Pao SI, Chen YJ Tags: Curr Eye Res Source Type: research

Ischemia Modified Albumin Levels and Thiol-Disulphide Homeostasis in Diabetic Macular Edema in Patients with Diabetes Mellitus Type 2.
ml; Abstract PURPOSE: It was aimed to assess the role of thiol-disulphide homeostasis and ischemia-modified albumin (IMA) level in the development of diabetic macular edema (DME) in patients with diabetes mellitus type 2 (T2DM). MATERIALS AND METHODS: Sixty-six study patients were divided into two groups. Group I included 43 patients with T2DM and DME, and Group 2 included 23 patients with T2DM without eye involvement. A novel colorimetric method was used to assess thiol-disulphide homeostasis. Between the two groups IMA, total anti-oxidant, and total oxidant levels were measured and compared. RESULTS: I...
Source: Current Eye Research - September 2, 2020 Category: Opthalmology Authors: Kalayci M, Cetinkaya E, Yigit K, Sabaner MC, Duman R, Balik AR, Erel Ö Tags: Curr Eye Res Source Type: research

Incidence and outcomes of cystoid macular edema after Descemet Membrane Endothelial Keratoplasty (DMEK) and DMEK combined with cataract surgery.
Conclusions The incidence of CME after DMEK was low and not associated with decreased long-term visual acuity. Most cases of CME occurred between 1-3 months postoperatively. Predictive factors for CME after DMEK require further study. PMID: 32865037 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - August 31, 2020 Category: Opthalmology Authors: Ching G, Covello AT, Bae SS, Holland S, McCarthy M, Ritenour R, Iovieno A, Yeung SN Tags: Curr Eye Res Source Type: research

Cystathionine β-synthase deficiency impairs vision in the fruit fly, Drosophila melanogaster.
CONCLUSIONS: The vision phenotype of CBS knock down flies is consistent with severe myopia in homocystinuria patients. We propose to use Drosophila as a model to investigate ocular manifestations underlying homocystinuria. PMID: 32865440 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - August 31, 2020 Category: Opthalmology Authors: Flores-Flores M, Moreno-García L, Castro-Martínez F, Nahmad M Tags: Curr Eye Res Source Type: research

Fibroblasts from Retinoblastoma Patients Show Radiosensitivity Linked to Abnormal Localization of the ATM Protein.
CONCLUSIONS: Our findings strongly suggest the involvement of the ATM kinase in the radiosensitivity/radiosusceptibility phenotype observed in Rb cases. PMID: 32862699 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - August 30, 2020 Category: Opthalmology Authors: Moulay Lakhdar I, Ferlazzo ML, Al Choboq J, Berthel E, Sonzogni L, Devic C, Granzotto A, Thariat J, Foray N Tags: Curr Eye Res Source Type: research

PEDF Attenuates Ocular Surface Damage in Diabetic Mice Model Through Its Antioxidant Properties.
CONCLUSIONS: Topical application of PEDF can alleviate diabetes-related ocular surface damage and increase tear volume, along with the improvement of oxidative stress status. PMID: 32862727 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - August 30, 2020 Category: Opthalmology Authors: Liu X, Liu H, Lu X, Tombran-Tink J, Zhao S Tags: Curr Eye Res Source Type: research

Circular RNAs: Potential Star Molecules Involved in Diabetic Retinopathy.
Conclusion: CircRNAs are involved in the development of DR. CircRNAs can not only serve as DR biomarkers, but also become therapeutic targets for DR. The role of plenty of circRNAs in DR is yet to be discovered. PMID: 32865040 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - August 30, 2020 Category: Opthalmology Authors: He M, Zhou R, Liu S, Cheng W, Wang W Tags: Curr Eye Res Source Type: research

Microstructure and Chemical Analysis in Pseudoexfoliation Syndrome.
Abstract PURPOSE: The aim of this study is to show the pseudoexfoliation syndrome (PES) material accumulated in the lens anterior capsule and the trace elements directly with using scanning electron microscopy (SEM) and to investigate the effect of PES materials on aqueous humor by chemical analyses. METHODS: The study groups consisted of 30 patients with PES and 30 patients without PES. 0.1-0.3 mL of aqueous humor was aspirated from anterior chamber and anterior capsule sample was obtained by applying continuous curvilinear capsulorhexis. The level of selected elements (Zn, Cu, Se, Fe, Si, Al, Ca, K) were de...
Source: Current Eye Research - August 28, 2020 Category: Opthalmology Authors: Yavuzer K, Akinay Y Tags: Curr Eye Res Source Type: research

Magnetic Resonance Imaging Features of Medial Canthal Tendon in Centurion Syndrome.
CONCLUSION: The anterior limb of the MCT may not always be inserted anteriorly in cases of Centurion syndrome; it can be normal or mal-developed . Disinsertion of the MCT, which is the most common procedure done for Centurion syndrome might not be helpful in cases where the MCT is normally inserted or mal-developed. PMID: 32857945 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - August 28, 2020 Category: Opthalmology Authors: Alam S, Tongbram A, Noronha OV Tags: Curr Eye Res Source Type: research

Correlation between Corneal Endothelial Cell Density and Central Ocular Surface Temperature in Normal and Keratoconus Eyes.
aacute;ry N Abstract PURPOSE: In keratoconus (KC), an increase of the corneal back surface area may result in endothelial cell density (ECD) decrease and an increase of the corneal front surface area in ocular surface temperature (OST) decrease due to increased heat dissipation. Along with these hypotheses, we aimed to analyse the correlation between ECD and central corneal OST in patients with KC and healthy controls. PATIENTS AND METHODS: A total of 154 eyes with KC (mean age 36.1 ± 12.5 years) and 92 healthy eyes (mean age 36.4 ± 12.8 years) were examined. Cornea...
Source: Current Eye Research - August 27, 2020 Category: Opthalmology Authors: Németh O, Langenbucher A, Eppig T, Lepper S, Milioti G, Abdin A, Nagy ZZ, Seitz B, Szentmáry N Tags: Curr Eye Res Source Type: research

RhoA activation decreases phagocytosis of trabecular meshwork cells.
CONCLUSIONS: These results suggest that the RhoA signal pathway regulates the phagocytic activity of TM cells. PMID: 32847411 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - August 26, 2020 Category: Opthalmology Authors: Fujimoto T, Sato-Ohira S, Tanihara H, Inoue T Tags: Curr Eye Res Source Type: research

Quantitative Analysis of Human Corneal Lenticule Surface Microstructure Irregularity with 3D Optical Profiler Using White Light Interferometry.
Abstract PURPOSE: To quantitatively evaluate the cutting quality of small incision lenticule extraction (SMILE) by measuring human corneal lenticule surface roughness in different areas with white light interferometer. METHOD: A white light interferometer was used to quantitatively measure the corneal lenticule surface roughness in different areas. Sixty-three myopic patients (102 eyes) who underwent SMILE surgery were recruited. The surface roughness of the central, pericentral, and peripheral parts of the corneal lenticule surface was measured in both the anterior and posterior planes. Differences in cornea...
Source: Current Eye Research - August 26, 2020 Category: Opthalmology Authors: Wu Y, Wang Y, Zhang Z, Yu X, Zhao X Tags: Curr Eye Res Source Type: research

Macular Pigment Optical Density Fluctuation as a Function of Pupillary Mydriasis: Methodological Considerations for Dual-Wavelength Autofluorescence.
Abstract Purpose of the study Macular pigment (MP), comprising the dietary carotenoids lutein, zeaxanthin and meso-zeaxanthin, is believed to benefit eye health and vision. Numerous clinical and research devices and techniques are currently available to facilitate MP optical density (MPOD) measurement. One of those techniques, dual-wavelength fundus autofluorescence (AF) is being increasingly used for measurement of MP in the eye. There is substantial methodological variation across the published studies that have employed this technique, including in relation to the use of mydriasis, the possible influence of whi...
Source: Current Eye Research - August 25, 2020 Category: Opthalmology Authors: Loskutova E, Butler JS, Hernandez Martinez G, Flitcroft I, Loughman J Tags: Curr Eye Res Source Type: research

Strain Specific Responses in a Microbead Rat Model of Experimental Glaucoma.
Abstract PURPOSE: A major challenge in glaucoma research is the lack of reproducible animal models of RGC and optic nerve damage, the characteristic features of this condition. We therefore examined the glaucomatous responses of two different rat strains, the Brown Norway (BN) and Lister Hooded (LH) rats, to high intraocular pressure (IOP) induced by injection of magnetic beads into the anterior chamber. METHODS: Magnetic microsphere suspensions (20 µl of 5-20 mg/ml) were injected into the anterior chamber of BN (n = 9) or LH (N = 15) rats. Animals from each strain were divided ...
Source: Current Eye Research - August 25, 2020 Category: Opthalmology Authors: Eastlake K, Jayaram H, Luis J, Hayes M, Khaw PT, Limb GA Tags: Curr Eye Res Source Type: research

Prolonged melanopsin-based photoresponses depend in part on RPE65 and cellular retinaldehyde-binding protein (CRALBP).
CONCLUSIONS: These results confirm that ipRGCs rely partly on the retinoid cycle to continuously regenerate melanopsin during prolonged photostimulation, and suggest that CRALBP in Müller glia likely transports 11-cis-retinal from the RPE to ipRGCs - this is the first proposed functional role for CRALBP in the inner retina. PMID: 32841098 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - August 25, 2020 Category: Opthalmology Authors: Harrison KR, Reifler AN, Chervenak AP, Wong KY Tags: Curr Eye Res Source Type: research

Glutathione Improves the Antioxidant Activity of Vitamin C in Human Lens and Retinal Epithelial Cells: Implications for Vitreous Substitutes.
CONCLUSIONS: These results indicate glutathione might be an effective addition to vitamin C in intraocular implants, including potential vitreous substitutes, and warrants additional studies on the effectiveness of the vitamin C - glutathione combination in preventing oxidative stress post-vitrectomy. PMID: 32838548 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - August 24, 2020 Category: Opthalmology Authors: Tram NK, McLean RM, Swindle-Reilly KE Tags: Curr Eye Res Source Type: research

Exosomal miRNA Analysis of Aqueous Humour of Diabetes and Cataract Patients.
CONCLUSIONS: Exosomes isolated from human aqueous humour contained abundant miRNAs. A highly expressed miRNA, miR-551b, could regulate the functions of HLEC by targeting CRYAA. METHODS: We pooled all the aqueous humour of each group into one sample and isolated exosomes from human aqueous humour by ultracentrifugation, measured the size and concentration of exosomes by nanoparticle tracking analysis (NTA), observed the morphology of exosomes by transmission electron microscopy (TEM), and sequenced exosomal miRNAs. We performed bioinformatic analysis of the sequencing results, including GO analysis and KEGG pathway enr...
Source: Current Eye Research - August 23, 2020 Category: Opthalmology Authors: Gao C, Fan F, Liu X, Yang J, Zhou X, Mei H, Lin X, Luo Y Tags: Curr Eye Res Source Type: research

Effect of Regulating the Expression of HSP47 on Collagen Metabolism in Scleral Fibroblasts.
CONCLUSION: HSP 47 affects collagen metabolism in scleral fibroblasts. It appears to promote the synthesis and secretion of collagen I as well as inhibit degradation. PMID: 32814454 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - August 19, 2020 Category: Opthalmology Authors: Guo Q, Tian Q, Tian X, Liu T Tags: Curr Eye Res Source Type: research

Correlation of Response between Both Eyes to First and Second Line Anti-VEGF Therapy in Diabetic Macular Edema.
CONCLUSIONS: This study demonstrated a strong anatomical correlation responses between the eyes in patients with bilateral DME for both first-line bevacizumab therapy and second-line ranibizumab therapy. Response to second-line therapy was favorable and correlated among eyes regardless they were from the same or different individuals. PMID: 32804540 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - August 17, 2020 Category: Opthalmology Authors: Tiosano L, Ayalon A, Banin E, Averbukh E, Jaouni T, Chowers I Tags: Curr Eye Res Source Type: research

A New Retinal Detachment Treatment Model for Evaluation of Vitreous Tamponades.
CONCLUSIONS: The RRD repeat vitrectomy model offers a possibility to explore the efficacy and complications of novel potential vitreous tamponades. Gel-based Healaflow® displays excellent anatomic reattachment, however, vitritis and retinal degeneration in some cases warrants further investigation. PMID: 32806983 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - August 17, 2020 Category: Opthalmology Authors: Barth H, Crafoord S, Ghosh F Tags: Curr Eye Res Source Type: research

The Effects of Acute Intracranial Pressure Changes on the Episcleral Venous Pressure, Retinal Vein Diameter and Intraocular Pressure in a Pig Model.
Abstract PURPOSE: Orbital veins such as the retinal veins and episcleral veins drain into the cavernous sinus, an intracranial venous structure. We studied the effects of acute intracranial pressure (ICP) elevation on episcleral venous pressure, intraocular pressure and retinal vein diameter in an established non-survival pig model. METHODS: In six adult female domestic pigs, we increased ICP in 5 mm Hg increments using saline infusion through a lumbar drain. We measured ICP (using parenchymal pressure monitor), intraocular pressure (using pneumatonometer), episcleral venous pressure (using venomanometer), re...
Source: Current Eye Research - August 17, 2020 Category: Opthalmology Authors: Ghate D, Kedar S, Havens S, Fan S, Thorell W, Nelson C, Gu L, Tong J, Gulati V Tags: Curr Eye Res Source Type: research

Biomechanical Effects of Two forms of PGF2 α on ex-vivo Rabbit Cornea.
Biomechanical Effects of Two forms of PGF2α on ex-vivo Rabbit Cornea. Curr Eye Res. 2020 Aug 14;: Authors: Zhu R, Zheng X, Guo L, Zhao Y, Wang Y, Wu J, Yu A, Wang J, Bao F, Elsheikh A Abstract PURPOSE: To investigate the biomechanical effects of two synthetic prostaglandin F2α analogues (PGF2α), namely Travoprost and Tafluprost, on the ex-vivo rabbit cornea. MATERIALS AND METHODS: 96 eyes of 48 Japanese white rabbits were divided into 3 equal groups randomly; the Travoprost treated group (Tra), the Tafluprost treated group (Taf) and the control group (Co). Eyes in Tra and Taf gr...
Source: Current Eye Research - August 14, 2020 Category: Opthalmology Authors: Zhu R, Zheng X, Guo L, Zhao Y, Wang Y, Wu J, Yu A, Wang J, Bao F, Elsheikh A Tags: Curr Eye Res Source Type: research

Similar dependence of acuity measures on exposure duration irrespective of acuity level in artificially degraded vision.
CONCLUSIONS: . The present study confirms previous findings also for the case of reduced acuity. The data suggest that small physiological fluctuations in retinal image quality are not a dominant factor regarding the effect of presentation duration. Overall, and in particular for sub-second presentation durations, there is little difference between normal and degraded vision. PMID: 32776796 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - August 10, 2020 Category: Opthalmology Authors: Heinrich SP Tags: Curr Eye Res Source Type: research

The Silk Protein Sericin Promotes Viability of ARPE-19 and Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelial Cells In Vitro.
CONCLUSIONS: This is the first study to demonstrate that supplementing the culture media with sericin promotes viability of iPSC-RPE and ARPE-19. Sericin's viability-promoting effects may have important implications for retinal therapeutics and regenerative medicine research. PMID: 32777180 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - August 10, 2020 Category: Opthalmology Authors: Khan AZ, Utheim TP, Moe MC, Aass HCD, Sapkota D, Vallenari EM, Eidet JR Tags: Curr Eye Res Source Type: research

The Expression and Role of Hypoxia-induced Factor-1 α in Human Tenon's Capsule Fibroblasts under Hypoxia.
Conclusions: Regulating HIF-1α and its downstream factors effectively regulated HTFs proliferation, migration and collagen synthesis. HIF-1α is a promising regulator in the study of wound healing after glaucoma surgery. PMID: 32767899 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - August 7, 2020 Category: Opthalmology Authors: Qin X, Wu K, Zuo C, Lin M Tags: Curr Eye Res Source Type: research

The effect of software versions on the measurement of retinal vascular densities using optical coherence tomography angiography.
Abstract BACKGROUND: The goal of the study was to determine the effect of different software versions on the measurement of retinal vessel densities using optical coherence tomography angiography (OCTA) in normal subjects. METHODS: Thirty-two eyes of eighteen healthy subjects were imaged using two OCTA devices: the Optovue RTVue and the Zeiss Cirrus. The macular 3 × 3 mm scan protocol was used. The images acquired using the Optovue OCTA device were exported using two different software versions in the system and compared to the images acquired through the Zeiss OCTA. In addition, the Optovue OCTA images...
Source: Current Eye Research - August 7, 2020 Category: Opthalmology Authors: Wang H, Hu H, Gregori G, Zhang J, Jiang H, Wang J Tags: Curr Eye Res Source Type: research

miR-340 Exerts Suppressive Effect on Retinoblastoma Progression by Targeting KIF14.
Conclusions Overall, we proved that miR-340 can decrease the proliferation and increase the apoptosis of RB cells, and its function in RB cells was at least partially achieved via down-regulation of KIF14, prompting that miR-340 was expected to supply a new direction for clinical therapy of RB in the future. PMID: 32757684 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - August 6, 2020 Category: Opthalmology Authors: Xu HK, Wang XD, Wang DG, Wei DD, Liang L, Liu CH Tags: Curr Eye Res Source Type: research

Expression of α-Klotho is downregulated and associated with oxidative stress in the lens in streptozotocin-induced diabetic rats.
Conclusions: These findings suggest that DM selectively reduces α-Klotho levels in the circulation and lens, which may attenuate transcriptional activity of Nrf2 and impair antioxidant defenses in response to oxidative insults, contributing to oxidative stress and cataract formation in DM. PMID: 32744464 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - August 3, 2020 Category: Opthalmology Authors: Ma Z, Li J, Jiang H, Chu Y Tags: Curr Eye Res Source Type: research

Gender Specific Differences in Signs and Symptoms of Dry Eye Disease.
CONCLUSION: Although the majority of the investigated parameters did not show gender specific differences, women reported higher OSDI scores. These findings could be explained by an increased frequency of neuropathic symptoms or ocular surface sensitivity in women or higher resilience of men to consult an ophthalmologist. Sex may have an effect on the clinical characteristics of DED, but further studies are needed to confirm these findings. PMID: 32735461 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - July 31, 2020 Category: Opthalmology Authors: Borrelli M, Frings A, Geerling G, Finis D Tags: Curr Eye Res Source Type: research

Can applying a risk stratification system, preoperatively, reduce intraoperative complications during Phacoemulsification?
Conclusions Risk stratification, allowing adequate theatre time and appropriate surgical experience, can reduce the rates of intraoperative complications. The risk stratification system allows for better planning of surgical lists and could be used as a transition for those trainees deemed to have sufficient experience for the more 'challenging' cases under adequate supervision. PMID: 32730130 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - July 30, 2020 Category: Opthalmology Authors: Pooprasert P, Hansell J, Young-Zvandasara T, Muhtaseb M Tags: Curr Eye Res Source Type: research

The Effect of Resveratrol on Radioiodine Therapy-associated Lacrimal Gland Damage.
Abstract PURPOSE: We have evaluated the potential radioprotective, antioxidant and anti-apoptotic effects of resveratrol (RSV) against high-dose radioactive iodine (RAI) therapy associated damage of the lacrimal glands by biochemical, histopathological and immunohistochemical methods. MATERIALS AND METHODS: Thirty Wistar-albino rats were randomly divided into three groups; the control group received no treatment or medication, the RAI group received RAI but no medication and the RSV group received oral RAI and intraperitoneal RSV. RSV was started at day one, before RAI administration, and continued for eight ...
Source: Current Eye Research - July 30, 2020 Category: Opthalmology Authors: Koca G, Singar E, Akbulut A, Yazihan N, YumuŞak N, Demir A, Korkmaz M Tags: Curr Eye Res Source Type: research

OCT-Angiography comparison between obstructive sleep apnea children and normal subjects in China.
Abstract PURPOSE: Using optical coherence tomography angiography (OCT-A) to compare the retinal micro vessel alteration between obstructive sleep apnea (OSA) children and normal subjects. METHODS: One hundred-thirty-two eyes (132 participants) were recruited in this study. The average age of OSA group (66 eyes) and healthy control group (66 eyes) were 6.23 ± 1.73 and 6.76 ±1.89 years, respectively). The retinal vascular network density indices and the fovea avascular zone (FAZ) size were analyzed by OCT-A. RESULTS: All of the OCT-A parafoveal vessel indices, including the vascular diameter ...
Source: Current Eye Research - July 30, 2020 Category: Opthalmology Authors: Ye H, Jin C, Li X, Zhao L, Li Y, Qiao T Tags: Curr Eye Res Source Type: research

IL-1 α modulates IFN-γ induced production of CXCL9/MIG during Herpes Simplex Virus type-1 corneal infection.
CONCLUSIONS: Our data provides evidence demonstrating the potential for expression patterns of MIG and IP-10 to be modulated by IL-1α, during the inflammatory response to HSV-1 corneal infection. Both corneal cells and neutrophils contribute to the production of T cell recruiting chemokines. However, IL-1α has the potential to up-regulate MIG production by corneal cells while down-regulating MIG production by neutrophils. PMID: 32730721 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - July 30, 2020 Category: Opthalmology Authors: Armstrong S, Arroyo M, Decker-Pulice K, Lane M, Mckinney M, Molesworth-Kenyon SJ Tags: Curr Eye Res Source Type: research

Re: Facing COVID-19 in Ophthalmology Department.
PMID: 32727220 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - July 29, 2020 Category: Opthalmology Authors: Teh BL, Duggan R, Hewick S, Knight D, Macleod S Tags: Curr Eye Res Source Type: research

Improving Endothelial Explant Tissue Culture by Novel Thermoresponsive Cell Culture System.
CONCLUSION: This study proves that temperature-reversible hydrogel is a very useful matrix for studying in vitro corneal endothelial cell migration from explant grafts and allows for subsequent biological investigation after gel removal. PMID: 32727221 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - July 29, 2020 Category: Opthalmology Authors: Miron A, Spinozzi D, Lie J, Melles GR, Oellerich S, Ni Dhubhghaill S Tags: Curr Eye Res Source Type: research

Novel histopathologic and immunohistochemical observations in explanted orbital peri-implant capsules.
Abstract PURPOSE: To describe the histopathologic and immunohistochemical characteristics of peri-orbital implant capsule and correlate the observed changes with delayed implant extrusion. MATERIALS AND METHODS: Prospective, ex-vivo, histopathologic, immunohistochemical study of peri-implant capsules excised from capsules surrounding a poly-methyl metha acrylate (PMMA) implant. Thirteen capsules were harvested and divided into two groups. Group 1 (implant extrusion group) consisted of capsules harvested from around exposed/extruded implants and Group 2 (implant non-extrusion group) from implants that were sur...
Source: Current Eye Research - July 29, 2020 Category: Opthalmology Authors: Dave TV, Mishra DK, Singh V, Kumar S, Mitragotri N, Rao BS Tags: Curr Eye Res Source Type: research

Canaloplasty with Suprachoroidal Drainage in Patients with Pseudoexfoliation Glaucoma - Four Years Results.
Abstract PURPOSE: To evaluate the long-term efficacy and safety of the modified canaloplasty technique with additional suprachoroidal drainage in patients with pseudoexfoliation glaucoma. METHODS: This retrospective clinical trial included 131 patients with pseudoexfoliation glaucoma who underwent canaloplasty with suprachoroidal drainage (scD). One hundred and eleven of 131 patients underwent the follow-up examination after 48 months. Primary endpoints were the pressure-lowering and drug-sparing effect as well as the success rates. Secondary endpoints were intra- and postoperative complications and the ...
Source: Current Eye Research - July 27, 2020 Category: Opthalmology Authors: Seuthe AM, Szurman P, Januschowski K Tags: Curr Eye Res Source Type: research

Five-Year Outcomes Prospective Study of Two First-Generation Trabecular Micro-Bypass Stents (iStent ®) in Open-Angle Glaucoma.
Five-Year Outcomes Prospective Study of Two First-Generation Trabecular Micro-Bypass Stents (iStent®) in Open-Angle Glaucoma. Curr Eye Res. 2020 Jul 25;:1-8 Authors: Saheb H, Donnenfeld ED, Solomon KD, Voskanyan L, Chang DF, Samuelson TW, Ahmed IIK, Katz LJ Abstract PURPOSE: To assess 5-year effectiveness and safety of 2 iStent® trabecular micro-bypass stents in eyes with open-angle glaucoma (OAG) not controlled on 1 medication. MATERIALS AND METHODS: This prospective, interventional, single-arm, multi-surgeon study (NCT #1252862, clinicaltrials.gov) enrolled eyes with OAG, preoperative i...
Source: Current Eye Research - July 25, 2020 Category: Opthalmology Authors: Saheb H, Donnenfeld ED, Solomon KD, Voskanyan L, Chang DF, Samuelson TW, Ahmed IIK, Katz LJ Tags: Curr Eye Res Source Type: research

Ocular and Systemic Pharmacokinetics of Brimonidine and Brinzolamide After Topical Administration in Rabbits: Comparison Between Fixed-combination and Single-drug Formulations.
CONCLUSIONS: FCBB achieved drug distribution in the aqueous humor and systemic exposure that were comparable to those for the single-drug formulations. The viscosity of FCBB may increase BMD distribution in the retina/choroid. The administration interval affects ocular drug absorption with the concomitant administration of 0.1% BMD and 1% BZM, which can be overcome by using the fixed-combination of both drugs. PMID: 32706598 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - July 24, 2020 Category: Opthalmology Authors: Suzuki G, Kunikane E, Shigemi W, Shinno K, Kozai S, Kurata M, Kawamura A Tags: Curr Eye Res Source Type: research

Transient Macular Thinning during the Use of Heavy Silicone Oil, Densiron 68.
CONCLUSIONS: We found transient macular thinning that resolved after Densiron removal with no evidence of long-term macular thinning in eyes treated with Densiron tamponade for retinal detachment. PMID: 32700981 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - July 23, 2020 Category: Opthalmology Authors: Hostovsky A, Mandelcorn MS, Mandelcorn ED Tags: Curr Eye Res Source Type: research

Effects of superficial keratectomy in peripheral hypertrophic subepithelial corneal opacification on front and back corneal astigmatism.
Abstract PURPOSE: To evaluate changes of anterior and posterior corneal astigmatism after superficial keratectomy in peripheral hypertrophic subepithelial corneal opacification (PHSCO). METHODS: Patients with PHSCO, who had received superficial keratectomy with mitomycin C 0.02 %, were included in this retrospective study. Scheimpflug imaging of the cornea (Pentacam®, Oculus, Wetzlar, Germany), best corrected visual acuity (BCVA) and objective refraction were determined preoperatively and three months after superficial keratectomy. RESULTS: Fifteen eyes of 15 patients (age: 55 ± 16 years; rang...
Source: Current Eye Research - July 20, 2020 Category: Opthalmology Authors: Riedl JC, Schuster AK, Musayeva A, Wasielica-Poslednik J, Marx-Gross S, Gericke A Tags: Curr Eye Res Source Type: research

Eye Socket Regeneration and Reconstruction.
PMID: 32664765 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - July 15, 2020 Category: Opthalmology Authors: Borrelli M, Geerling G, Spaniol K, Witt J Tags: Curr Eye Res Source Type: research