What factors influence the uptake of vaccinations amongst pregnant women following the Covid-19 pandemic: A qualitative study
DISCUSSION: Findings of this study increase awareness of some of the factors influencing vaccination decisions of pregnant women. It informs practice regarding healthcare professionals' discussions with pregnant women about vaccinations, and future vaccination campaigns and interventions that are targeting an increase in vaccination uptake amongst this population.PMID:38703426 | DOI:10.1016/j.midw.2024.104021 (Source: Midwifery)
Source: Midwifery - May 4, 2024 Category: Midwifery Authors: Dr Jo Parsons Dr Cath Grimley Professor Helen Atherton Louise Clarke Dr Sarah Hillman Professor Debra Bick Source Type: research
Revealing the Causal Impact of Obstructive Sleep Apnea on Cancer Risk: Insights from Mendelian randomization analysis
CONCLUSION: Our MR provided important insights into the causal associations between OSA and cancer risk, highlighting both protective and potentially harmful effects of OSA on different cancer types.PMID:38703296 | DOI:10.1007/s11325-024-03046-9 (Source: Sleep and Breathing)
Source: Sleep and Breathing - May 4, 2024 Category: Sleep Medicine Authors: Wenjie Li Wei Wang Source Type: research
Is axillary artery cannulation necessary in type II hybrid aortic arch repair for acute type A aortic dissection?
CONCLUSIONS: Axillary artery cannulation may decrease the incidence of postoperative transient neurological dysfunction (TND) in type II HAR for ATAAD. Nonetheless, studies with larger sample sizes are necessary.PMID:38703049 | DOI:10.1177/02676591241252721 (Source: Perfusion)
Source: Perfusion - May 4, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Zhonglai Zhu Long Wu Yanhong Yuan Source Type: research
Exploring casual effects and shared molecular mechanism between psoriasis and liver cancer through Mendelian randomization and comprehensive bioinformatic analyses
Comput Biol Chem. 2024 Apr 30;110:108089. doi: 10.1016/j.compbiolchem.2024.108089. Online ahead of print.ABSTRACTPsoriasis (Ps), a chronic inflammatory disease affecting approximately 2 % of the global population, has been associated with an increased risk of liver cancer in observational studies. However, their causal relationships as well as underlying shared molecular mechanisms between Ps and liver cancer remain unclear. Using bidirectional Mendelian randomization analysis, we revealed that a genetic predisposition to liver cancer increased the risk of Ps in European and East Asian populations but not the other way aro...
Source: Computational Biology and Chemistry - May 4, 2024 Category: Bioinformatics Authors: Maoxin Ran Ou Sha Kin Yip Tam Source Type: research
Diversity and Functionality of Bacteria Associated with Different Tissues of Spider Heteropoda venatoria Revealed through Integration of High-Throughput Sequencing and Culturomics Approaches
This study aimed to investigate the community diversity and functional characteristics of spider-associated bacteria in four tissues of Heteropoda venatoria using HTS of the 16S rRNA gene and culturomics technologies, as well as the functional verification of the isolated strains. The results of HTS showed that the spider-associated bacteria in different tissues belonged to 34 phyla, 72 classes, 170 orders, 277 families, and 458 genera. Bacillus was found to be the most abundant bacteria in the venom gland, silk gland, and ovary, while Stenotrophomonas, Acinetobacter, and Sphingomonas were dominant in the gut microbiota. B...
Source: Microbial Ecology - May 4, 2024 Category: Microbiology Authors: Likun Zhao Shanfeng Zhang Ruoyi Xiao Chao Zhang Zhitang Lyu Feng Zhang Source Type: research
A Clinical Scoring System and Impact of Athymic Nude Mouse Age on < em > Corynebacterium bovis < /em > Clinical Disease
Comp Med. 2024 May 4. doi: 10.30802/AALAS-CM-23-000088. Online ahead of print.ABSTRACTCorynebacterium bovis infection in biomedical research is synonymous with skin hyperkeratosis of athymic nude mice. This clinical sign can be obvious and is the namesake for 'scaly skin disease.' Other clinical signs that accompany scaly skin, including early presentation, duration, and rate of resolution, are less well known. The goal of this study was to characterize the clinical signs of C. bovis infection in nude mice under experimental conditions and develop a quantifiable scoring system. For the development, prospective trial, and a...
Source: Comparative Medicine - May 4, 2024 Category: Zoology Authors: Christopher A Manuel Dvm PhD Daclam Umarani Pugazhenthi Bs Michael K Fink Dvm PhD Daclam Lauren M Habenicht Dvm Ms Daclam Derek L Fong Vmd Daclam Jori K Leszczynski Dvm Daclam Michael J Schurr PhD Source Type: research
Novel polymorphisms in the octopamine receptor gene of amitraz resistant population of Rhipicephalus sanguineus sensu lato, in south India
Exp Parasitol. 2024 May 2:108763. doi: 10.1016/j.exppara.2024.108763. Online ahead of print.ABSTRACTThe brown dog tick or Rhipicephalus sanguineus sensu lato is an ixodid tick, responsible for the dissemination of pathogens that cause canine infectious diseases besides inflicting the direct effects of tick bite. The hot humid climate of Kerala, a south Indian state, is favorable for propagation of tick vectors and acaricides are the main stay of tick control. Though the resistance against synthetic pyrethroids is reported among these species, the status of amitraz resistance in R. sanguineus s. l. in the country is uncerta...
Source: Experimental Parasitology - May 4, 2024 Category: Parasitology Authors: Nikhat Reena Shaik Bindu Lakshmanan N Suresh Nair Amrutha Anand R Radhika K Syamala Source Type: research
Women's experiences with Centering-Based Group Care in Zhejiang China: A pilot study
CONCLUSION: CBGC quality cannot be determined based on limited the sample size. This pilot study provides evidence regarding the beneficial effects of knowledge, socialization, and psychological healing on CBGC. Further research is suggested to measure CBGC effectiveness and quality.PMID:38703517 | DOI:10.1016/j.wombi.2024.101618 (Source: Women Birth)
Source: Women Birth - May 4, 2024 Category: Midwifery Authors: Danqi Chen Qian Cai Rui Yang Wenli Xu HongMei Lu Jinghua Yu Peihua Chen Xinfen Xu Source Type: research
Long-term continuous monitoring of arrhythmias in pigs with insertable cardiac monitors
Pflugers Arch. 2024 May 4. doi: 10.1007/s00424-024-02962-9. Online ahead of print.ABSTRACTArrhythmia detection is essential when assessing the safety of novel drugs and therapies in preclinical studies. Many short-term arrhythmia monitoring methods exist, including non-invasive ECG and Holter. However, there are no reliable, long-term, non-invasive, or minimally invasive methods for cardiac arrhythmia follow-up in large animals that allows free movement with littermates. A long follow-up time is needed when estimating the impact of long-lasting drugs or therapies, such as gene therapy. We evaluated the feasibility and perf...
Source: Pflugers Archiv : European Journal of Physiology - May 4, 2024 Category: Physiology Authors: Jonna Airaksinen Satu Siimes Juha Hartikainen Seppo Yl รค-Herttuala Source Type: research
Development of a real-time fluorescent reverse transcription loop-mediated isothermal amplification assay with quenching primers for rapid detection of rubella virus
J Virol Methods. 2024 May 2:114947. doi: 10.1016/j.jviromet.2024.114947. Online ahead of print.ABSTRACTRubella virus infection during early pregnancy sometimes causes severe birth defects termed congenital rubella syndrome. Although there are safe and effective live-attenuated vaccines, rubella has only been certified as eliminated in the Americas within the six World Health Organization regions. Rubella remains an endemic disease in many regions, and outbreaks occur wherever population immunity is insufficient. There are two main methods for diagnosis of rubella: detection of anti-rubella IgM antibodies by enzyme immunoas...
Source: Journal of Virological Methods - May 4, 2024 Category: Virology Authors: Kiyoko Okamoto Kazue Kadosawa Rieko Suzuki Eri Aonuma Kyoko Tomioka Kota Yokono Kunihiro Oba Yoshio Mori Source Type: research
Heterozygous RB1 mutation enhanced ATP production in human iPSC-derived retinal organoids
CONCLUSION: The study provides novel insights into the metabolic phenotype of heterozygous RB1 mutant suggesting dysregulation of energy metabolism and glycolytic pathways to be first step even before the changes in cellular proliferation or other phenotypic consequences ensue.PMID:38704498 | DOI:10.1007/s11033-024-09564-9 (Source: Molecular Medicine)
Source: Molecular Medicine - May 4, 2024 Category: Molecular Biology Authors: Ambily Vincent Subramanian Krishnakumar Sowmya Parameswaran Source Type: research
Machine learning and deep learning to identifying subarachnoid haemorrhage macrophage-associated biomarkers by bulk and single-cell sequencing
J Cell Mol Med. 2024 May;28(9):e18296. doi: 10.1111/jcmm.18296.ABSTRACTWe investigated subarachnoid haemorrhage (SAH) macrophage subpopulations and identified relevant key genes for improving diagnostic and therapeutic strategies. SAH rat models were established, and brain tissue samples underwent single-cell transcriptome sequencing and bulk RNA-seq. Using single-cell data, distinct macrophage subpopulations, including a unique SAH subset, were identified. The hdWGCNA method revealed 160 key macrophage-related genes. Univariate analysis and lasso regression selected 10 genes for constructing a diagnostic model. Machine le...
Source: Molecular Medicine - May 4, 2024 Category: Molecular Biology Authors: Sha Yang Yunjia Hu Xiang Wang Mei Deng Jun Ma Yin Hao Zhongying Ran Tao Luo Guoqiang Han Xin Xiang Jian Liu Hui Shi Ying Tan Source Type: research
Compound heterozygous ABCA12 variants identified in a Chinese patient with congenital ichthyosiform erythroderma: Advancing genotype-phenotype correlations and literature review
CONCLUSIONS: The compound heterozygous ABCA12 variants caused the CIE phenotype observed in the patient. The spectrum of ABCA12 pathogenic variants were broaden. Genotype-phenotype correlation analysis provided detailed evidence which can be used in future prenatal diagnosis and can inform the need for genetic counselling for patients with ABCA12-related ARCIs.PMID:38702946 | DOI:10.1002/mgg3.2431 (Source: Molecular Medicine)
Source: Molecular Medicine - May 4, 2024 Category: Molecular Biology Authors: Jia-Wei Liu Kexin Guo Rui Zhang Rongrong Wang Dong-Lai Ma Xue Zhang Source Type: research
Leishmania donovani mitogen-activated protein kinases as a host-parasite interaction interface
Cytokine. 2024 May 3;179:156627. doi: 10.1016/j.cyto.2024.156627. Online ahead of print.ABSTRACTLeishmaniasis, a major globally re-emerging neglected tropical disease, has a restricted repertoire of chemotherapeutic options due to a narrow therapeutic index, drug resistance, or patient non-compliance due to toxicity. The disease is caused by the parasite Leishmania that resides in two different forms in two different environments: as sessile intracellular amastigotes within mammalian macrophages and as motile promastigotes in sandfly gut. As mitogen-activated protein kinases (MAPKs) play important roles in cellular differe...
Source: Cytokine - May 4, 2024 Category: Molecular Biology Authors: Neelam Bodhale Saptaparnee Saha Dhiraj Gurjar Nicolas Grandchamp Arup Sarkar Bhaskar Saha Source Type: research
High above the rest: standing behaviors in the amoebae of Sappinia and Thecamoeba
Eur J Protistol. 2024 Apr 12;94:126082. doi: 10.1016/j.ejop.2024.126082. Online ahead of print.ABSTRACTMany terrestrial microbes have evolved cell behaviors that help them rise above their substrate, often to facilitate dispersal. One example of these behaviors is found in the amoebae of Sappinia pedata, which actively lift most of their cell mass above the substrate, known as standing. This standing behavior was first described in S. pedata in the 1890s from horse dung isolates but never molecularly characterized from dung. Our study expands this understanding, revealing the first molecularly confirmed S. pedata from herb...
Source: European Journal of Protistology - May 4, 2024 Category: Microbiology Authors: Tristan C Henderson Lucia Garcia-Gimeno Charles E Beasley Nicholas W Fry Jayden Bess Matthew W Brown Source Type: research
