Reviewing Approaches to Improving Aged Stem Cell Function
A variety of approaches show some promise in improving the function of stem cells in aged tissues. Stem cell populations support their tissue by providing a supply of daughter somatic cells to replace losses. This supply diminishes over time as stem cells reduce their activity for reasons that descend from the known root causes of aging, but which are not fully understood in detail. To the degree that reduced stem cell function is a response to the aged environment rather than a consequence of damage inherent to these cells, then it is useful to find ways to force stem cells to be more active. Whether this is the case may ...
Source: Fight Aging! - April 24, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Genetics by the Numbers
Even though scientists have been studying genetics since the mid-19th century, they continue to make new discoveries about genes and how they impact our health on a regular basis. NIGMS researchers study how genes are expressed and regulated, how gene variants with different “spellings” of their genetic code affect health, and much more. Get the drop on DNA and the gist of genes with these fast facts:
3.2 Billion
A marbled lungfish has a genome over 40 times larger than humans. Credit: iStock.
That’s how many base pairs—or sets of genetic “letters”—make up the human genome. If you were...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - April 24, 2024 Category: Research Authors: Chrissa Chverchko Tags: Genes By the Numbers DNA Genomics Source Type: blogs
Wednesday Bible Study: Rehashing
Psalm 105 is a lengthy song of praise that recounts God ' s faithfulness to the Israelites, mostly reciting purported events in Exodus. The introduction is adapted -- largely copied actually -- from 1 Chronicles 16, in which David sets up the Ark and commissions a song of praise by Asaph. Note verse 35 -- there are no caterpillars in the canonical version of Exodus. The caterpillars have come up before, which presumably means that they were working from an alternative version of the story. I don ' t need to harp on the moral depravity of the story -- the 7 year famine God causes, the murder of Egyptian children, the g...
Source: Stayin' Alive - April 24, 2024 Category: American Health Source Type: blogs
Inconclusive Effects on Telomere Length from the CALERIE 2 Study
In recent years, researchers have been putting more effect into analyses of the CALERIE 2 study of human calorie restriction. The study took place some years ago, but new results continue to be published. Here, researchers show that effects on telomere length and a related aging clock are inconclusive. Telomere length measured in the white blood cells of a blood sample is not a great measure of aging. It is highly variable between individuals, is influenced day to day changes in immune status, and it takes a fairly large study group for age-related trends to show up. It has rightfully been eclipsed by the development of ag...
Source: Fight Aging! - April 24, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Regular Transfusion of Young Plasma Improves Health of Old Rats
Researchers here report on the results of transfusion of young rat plasma into old rats, starting every other week in later life. The study is small, and is one more data point to add to a mixed set of results. Plasma transfusion from young individual to old individual doesn't look that impressive, all told, either in animals or in human patients. That doesn't appear to be discouraging the community of researchers and developers who continue to work on approaches to transfusion that they believe may move the needle. The example here is a straightforward approach to transfusion, the procedure conducted every other week, and...
Source: Fight Aging! - April 24, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Ambitious Goals at Mitrix Bio
Mitrix Bio is one of the companies developing the means to produce large amounts of mitochondria for transplantation. Cells will take up new mitochondria from the surrounding environment, and mitochondria can be harvested from cell cultures. Mitochondrial function declines with age, the result of (a) gene expression changes in the cell nucleus that alter mitochondrial dynamics and the quality control process of mitophagy, and (b) damage to mitochondrial DNA. Evidence from animal studies suggests that replacing mitochondria in aged tissues produces benefits to health and organ function that last for long enough to be intere...
Source: Fight Aging! - April 23, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Investigating the Mechanisms of Very Early Alzheimer's Disease
Researchers here look at cellular dysfunction that may form the earliest stages of Alzheimer's disease, prior to the accumulation of misfolded amyloid-β and cognitive decline. In general, intervening early in the progression of a disease will always be easier, given the right target. The challenge lies in identifying and understanding the causative mechanisms, in an environment in which (a) there is little access to brain tissue in the earliest stages of Alzheimer's disease, and (b) the animal models are highly artificial, as mice do not normally develop anything resembling Alzheimer's disease, and thus may not accurately...
Source: Fight Aging! - April 23, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Decline in Stemness in Many Human Stem Cell Populations with Aging
In conclusion, we assigned stemness scores to human samples and show evidence of a pan-tissue loss of stemness during human aging, which adds weight to the idea that stem cell deterioration may contribute to human aging. (Source: Fight Aging!)
Source: Fight Aging! - April 22, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Hippocratic AI Raises $53 Million Series A at a $500 Million Valuation
Company Releases First Product: Generative AI-Powered Staffing Marketplace for Healthcare and will use Funds to Accelerate Further Product Development and Conduct Phase Three Safety Testing for its LLM
Hippocratic AI, the company building the first safety-focused Large Language Model (LLM) for healthcare, today announced the close of a $53 million Series A funding round at a $500 million valuation, bringing total funding to $120 million. Today, the company also released its first product for phase three safety testing: a staffing marketplace for healthcare where health systems, payors, and others can “hire” generative ...
Source: EMR and HIPAA - April 22, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT a16z Andreessen Horowitz Bio Health Capsule Cincinnati Children’s ELNA Evernow Fraser Health General Catalyst Guidehealth HarmonyCares Health IT Funding Health IT Fundings Health IT Investmen Source Type: blogs
Exercise, Stress, and Cardiovascular Risk
Exercise is well known to correlate with reduced risk of cardiovascular disease in human epidemiological studies. In animal studies, it is possible to demonstrate that increased physical activity does in fact cause a lower incidence of cardiovascular disease. Here researchers argue that stress has a significant effect on cardiovascular outcomes, as demonstrated by the fact that patients with greater degrees of stress, such as those with major depressive disorder, exhibit a larger beneficial correlation of reduced cardiovascular disease with exercise. It is interesting to ask which mechanisms are causing this association; e...
Source: Fight Aging! - April 22, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fractional flow reserve for guiding coronary intervention and functional SYNTAX score
Coronary angiography gives a visual impression about the severity of the stenosis. But it need not imply the actual functional significance of the stenosis in terms of flow physiology. It is often difficult to decide which are the flow limiting lesions when there are multiple stenoses in same or different territories. It is here that the fractional flow reserve estimation helps.
FFR is estimated using a guide wire with a pressure transducer. FFR wires have properties similar to the floppy guide wires so that they can passed across coronary lesions back and forth easily to assess the pressure drop across the lesions.
The f...
Source: Cardiophile MD - April 22, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Chest pain, resolved. Does it need emergent cath lab activation (some controversy here)? And much much more.
In this study, the major outcomes were the same for both groups, but of 70 patients in the delayed group,4 required emergent intervention for sudden re-occlusion. You can make your own conclusions. I think I would want to intervene before there is risk of re-occlusion.However, one could make a reasonable argument for delaying, especially if you would need to awaken your cath team in the middle of the night. It requires full antiplatelent and antithrombotic therapy, and, in my opinion, if you delay, you should institute continuous 12-lead ECG monitoring. This is why:1. Why we need cont...
Source: Dr. Smith's ECG Blog - April 22, 2024 Category: Cardiology Authors: Steve Smith Source Type: blogs
Catastrophising – and controversy
There are few constructs more widely known in pain psychology than catastrophising. Defined as “an exaggerated negative mental set brought to bear during actual or anticipated pain experience” (Sullivan et al., 2001), catastrophising is associated with poor outcomes including greater pain intensity, distress and disability in almost every situation where pain is experienced (Sullivan & Tripp, 2024). Cognitive biases associated with catastrophising include interpretive bias, attentional bias and attentional fixation – in other words negatively interpreting situations, attending to the negative in a situation, ...
Source: HealthSkills Weblog - April 21, 2024 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Coping Skills Pain Pain conditions Research Science in practice catastrophising catastrophizing Chronic pain pain-related worry Source Type: blogs
Bonus Features – April 21, 2024 – 89% of physicians said generative AI vendors need to be transparent about where info comes from, 73% of consumers expect a 4-star rating before they ’ ll engage with a provider, plus 21 more stories
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
Studies
According to a Wolters Kluwer survey, 68% of physicians think generative AI will benefit healthcare – but to trust the technology, 89% said vendors need to be transparent about where information was sourced and wh...
Source: EMR and HIPAA - April 21, 2024 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Brand Engagement Network Butterfly Network CharmHealth CHG Healthcare Clarify Health Cured Databricks Donna Boyer eClinicalWorks Epic Research Google Cloud Harvard Medical School HCTec Healthcare IT Today Bonus Fe Source Type: blogs
Fight Aging! Newsletter, April 22nd 2024
This study reveals a potential treatment for human mitochondrial diseases.
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A Population Study Correlates Air Pollution with Faster Cognitive Aging
https://www.fightaging.org/archives/2024/04/a-population-study-correlates-air-pollution-with-faster-cognitive-aging/
A number of large epidemiological studies provide evidence for long-term exposure to greater levels of air pollution to accelerate the onset and progression of age-related disease. A few of these manage to control for the tendency for wealthier people to avoid living in areas with higher particulate air pollution, ...
Source: Fight Aging! - April 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
