Heat shock protein 72 supports extracellular matrix production in metastatic mammary tumors
This study identified tumorigenic processes most dependent on murine HSP72 in the MMTV-PyMT mammary tumor model, which give rise to spontaneous mammary tumors that exhibit HSP72-dependent metastasis to the lung. RNA-seq expression profiling of Hspa1a/Hspa1b (Hsp72) WT and Hsp72-/- primary mammary tumors discovered significantly lower expression of genes encoding components of the extracellular matrix (ECM) in Hsp72 knockout mammary tumors compared to WT controls. In vitro studies found that genetic or chemical inhibition of HSP72 activity in cultured collagen-expressing human or murine cells also reduces mRNA and protein l...
Source: Cell Stress and Chaperones - May 4, 2024 Category: Cytology Authors: Benjamin J Lang Kristina M Holton Martin E Guerrero-Gimenez Yuka Okusha Patrick T Magahis Amy Shi Mary Neguse Shreya Venkatesh Anh M Nhu Jason E Gestwicki Stuart K Calderwood Source Type: research
Comparative study of the removal of sulfate by UASB in light and dark environment
Bioprocess Biosyst Eng. 2024 May 4. doi: 10.1007/s00449-024-03024-1. Online ahead of print.ABSTRACTAt present, the application of sewage treatment technologies is restricted by high sulfate concentrations. In the present work, the sulfate removal was biologically treated using an upflow anaerobic sludge blanket (UASB) in the absence/presence of light. First, the start-up of UASB for the sulfate removal was studied in terms of COD degradation, sulfate removal, and effluent pH. Second, the impacts of different operation parameters (i.e., COD/SO42- ratio, temperature and illumination time) on the UASB performance were explore...
Source: Bioprocess and Biosystems Engineering - May 4, 2024 Category: Biomedical Engineering Authors: Yuanyao Ye Xueyi Yan Hui Luo Jianxiong Kang Dongqi Liu Yongzheng Ren Huu Hao Ngo Wenshan Guo Dongle Cheng Wei Jiang Source Type: research
The Efficacy of Different Material Scaffold-Guided Cell Transplantation in the Treatment of Spinal Cord Injury in Rats: A Systematic Review and Network Meta-analysis
This study aims to evaluate the efficacy of different material scaffold-mediated cell transplantation in treating SCI in rats. According to PRISMA's principle, Embase, PubMed, Web of Science, and Cochrane databases were searched, and relevant literature was referenced. Only original research on cell transplantation plus natural or synthetic scaffolds in SCI rats was included. Direct and indirect evidence for improving hind limb motor function was pooled through meta-analysis. A subgroup analysis of some factors that may affect the therapeutic effect was conducted to understand the results fully. In total, 25 studies met th...
Source: Cellular and Molecular Neurobiology - May 4, 2024 Category: Cytology Authors: Zhihua Wang Jun Li Tianqi Xu Boyu Guo Zhiping Xie Meihua Li Source Type: research
Identification of the circRNA-miRNA-mRNA network for treating methamphetamine-induced relapse and behavioral sensitization with cannabidiol
CONCLUSIONS: This study constructed the ceRNAs network for the first time, revealing the potential mechanism of CBD in treating METH-induced CPP reinstatement and behavioral sensitization, thus advancing the application of CBD in METH use disorders.PMID:38702929 | DOI:10.1111/cns.14737 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2024 Category: Neuroscience Authors: Liu Liu Chan Wang Haowei Wang Lin Miao Tong Xie Yunqing Tian Xiaodong Li Yizhen Huang Xiaofeng Zeng Bofeng Zhu Source Type: research
Integrated analysis of single cell-RNA sequencing and Mendelian randomization identifies lactate dehydrogenase B as a target of melatonin in ischemic stroke
CONCLUSION: Our study identifies LDHB as a novel biomarker for ischemic stroke via combining the sc RNA-seq and MR analysis.PMID:38702940 | DOI:10.1111/cns.14741 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2024 Category: Neuroscience Authors: Fei Shi Guiyun Zhang Jinshi Li Liang Shu Cong Yu Dabin Ren Yisong Zhang Ping Zheng Source Type: research
Factors associated with food label use: focus on healthy aspects of orthorexia and orthorexia nervosa
CONCLUSIONS: The study demonstrates that food label users have higher orthorexia tendencies compared to non-users. Of the food label sections, healthy orthorexia showed the strongest association with use of the list of ingredients, while pathological orthorexia showed the strongest association with use of the nutrition facts panel.LEVEL OF EVIDENCE: Level V, cross-sectional study.PMID:38703233 | DOI:10.1007/s40519-024-01661-9 (Source: Eating and weight disorders : EWD)
Source: Eating and weight disorders : EWD - May 4, 2024 Category: Eating Disorders & Weight Management Authors: Ezgi Bellikci-Koyu Yasemin Karaa ğaç Arma ğan Aytuğ Yürük Source Type: research
Murine cochlear damage models in the context of hair cell regeneration research
Hear Res. 2024 Apr 27;447:109021. doi: 10.1016/j.heares.2024.109021. Online ahead of print.ABSTRACTUnderstanding the complex pathologies associated with hearing loss is a significant motivation for conducting inner ear research. Lifelong exposure to loud noise, ototoxic drugs, genetic diversity, sex, and aging collectively contribute to human hearing loss. Replicating this pathology in research animals is challenging because hearing impairment has varied causes and different manifestations. A central aspect, however, is the loss of sensory hair cells and the inability of the mammalian cochlea to replace them. Researching t...
Source: Hearing Research - May 4, 2024 Category: Audiology Authors: Ayse Maraslioglu-Sperber Fabian Blanc Stefan Heller Source Type: research
Neurophenomenological Investigation of Mindfulness Meditation "Cessation" Experiences Using EEG Network Analysis in an Intensively Sampled Adept Meditator
Brain Topogr. 2024 May 4. doi: 10.1007/s10548-024-01052-4. Online ahead of print.ABSTRACTMindfulness meditation is a contemplative practice that is informed by Buddhism. It has been proven effective for improving mental and physical health in clinical and non-clinical contexts. To date, mainstream dialogue and scientific research on mindfulness has focused primarily on short-term mindfulness training and applications of mindfulness for reducing stress. Understanding advanced mindfulness practice has important implications for mental health and general wellbeing. According to Theravada Buddhist meditation, a "cessation" eve...
Source: Brain Topography - May 4, 2024 Category: Neuroscience Authors: Remko van Lutterveld Avijit Chowdhury Daniel M Ingram Matthew D Sacchet Source Type: research
Magnetic domain wall dynamics studied by in-situ lorentz microscopy with aid of custom-made Hall-effect sensor holder
Ultramicroscopy. 2024 Apr 26;262:113979. doi: 10.1016/j.ultramic.2024.113979. Online ahead of print.ABSTRACTWe built a custom-made holder with a Hall-effect sensor to measure the single point magnetic flux density inside a transmission electron microscope (TEM, JEM-F200, JEOL). The measurement point is at the same place as the sample inside the TEM. We utilized information collected with the Hall-effect sensor holder to study magnetic domain wall (DW) dynamics by in-situ Lorentz microscopy. We generated an external magnetic field to the sample using the objective lens (OL) of the TEM. Based on our measurements with the Hal...
Source: Ultramicroscopy - May 4, 2024 Category: Laboratory Medicine Authors: Mari Honkanen Henri Lukinmaa Sami Kaappa Suvi Santa-Aho Jaakko Kajan Samuli Savolainen Lucio Azzari Lasse Laurson Mikko Palosaari Minnamari Vippola Source Type: research
Psychological inflexibility as a predictor associated with insomnia
J Sleep Res. 2024 May 4:e14232. doi: 10.1111/jsr.14232. Online ahead of print.ABSTRACTPsychological flexibility has recently attracted the attention of researchers in the field of sleep disorders; therefore, in the study, psychological flexibility was evaluated as a predictor or factor related to the presence/severity of insomnia. We included 2218 individuals selected from the randomized-control trial for behavioural therapy for insomnia and cross-sectional studies, including 1797 individuals with insomnia and 421 controls without insomnia. All participants completed the DSM-5-based insomnia diagnosis interview, Insomnia S...
Source: Journal of Sleep Research - May 4, 2024 Category: Sleep Medicine Authors: Renatha El Rafihi-Ferreira Ila Marques Porto Linares L éo Paulos-Guarnieri Ali Zakiei Source Type: research
Impact of the Acetyl Group on Cysteine: A Study of N-Acetyl-Cysteine through Rotational Spectroscopy
Chemphyschem. 2024 May 4:e202400191. doi: 10.1002/cphc.202400191. Online ahead of print.ABSTRACTHerein, we report a spectroscopic study of N-acetyl-L-cysteine, an important antioxidant drug, using Fourier-transform microwave techniques and in isolated conditions. Two conformers are observed, where most stable structure adopts a cis disposition, and the second conformer has a lower abundance and adopts a trans disposition. The rotational constants and the barriers to methyl internal rotation are determined for each conformer, allowing a precise conformation identification. The results show that the cis form adopts an identi...
Source: Chemphyschem - May 4, 2024 Category: Chemistry Authors: Sergio Mato Sof ía Municio Jos é Luis Alonso Elena Rita Alonso Iker Leon Source Type: research
Family characteristics, responses, and dynamics associated with sibling sexual abuse: A scoping review
CONCLUSIONS: Research and practice need to ensure that SSA is understood within the context of family dynamics and histories, in a way that may not be necessary when understanding other 'types' of child sexual abuse (CSA). Consideration must be given to the fact that children affected by SSA can be situated in families where, as well as SSA, there is a history of abuse and neglect within the family, and various environmental stressors are present.PMID:38704331 | DOI:10.1016/j.chiabu.2024.106795 (Source: Child Abuse and Neglect)
Source: Child Abuse and Neglect - May 4, 2024 Category: Child Development Authors: Amy Adams Source Type: research
Trajectories of risk and resilience: The role of empathy and perceived social support in the context of early adversity
CONCLUSIONS: Study results highlight the role of affective empathy and PSS as transdiagnostic mechanisms influencing the pathway between early adversity and adult mental health, and the importance of taking these into account when designing interventions aiming to promote well-being among those who have experienced childhood adversity.PMID:38703490 | DOI:10.1016/j.chiabu.2024.106811 (Source: Child Abuse and Neglect)
Source: Child Abuse and Neglect - May 4, 2024 Category: Child Development Authors: Corinna Panagou Angus Macbeth Source Type: research
Maternal and neonatal outcomes in pregnant women with multiple sclerosis disease: A systematic review and meta-analysis
CONCLUSION: Pregnant women with MS have a greater chance of adverse pregnancy results than pregnant women without MS. Consequently, pregnant women with MS should create detailed before and after pregnancy plans, in consultation with their doctors, spouses, families, and friends, regarding the necessary care and supplements. Future studies applying a prospective cohort design that control for potential confounders are needed to further validate the findings.PMID:38703425 | DOI:10.1016/j.midw.2024.104004 (Source: Midwifery)
Source: Midwifery - May 4, 2024 Category: Midwifery Authors: Shoboo Rahmati Zahra Galavi Batoul Kavyani Homa Arshadi Jaason Geerts Hamid Sharifi Source Type: research
Midwives' experiences with PPE during the COVID-19 pandemic: The Birth in the Time of COVID (BITTOC) study
CONCLUSION: These findings highlight the need for future comprehensive pandemic preparedness that ensures policy and procedure recommendations are consistent and PPE is available, of approriate quality, and individually fitted in order to ensure that Australian maternity services are well placed to manage future pandemics.PMID:38703427 | DOI:10.1016/j.midw.2024.104016 (Source: Midwifery)
Source: Midwifery - May 4, 2024 Category: Midwifery Authors: Emma C Collins Virginia Schmied Sue Kildea Hazel Keedle Melanie Jackson Hannah G Dahlen Source Type: research
