GSE266269 ENL reads histone β-hydroxybutyrylation to modulate gene transcription (RNA-Seq)
Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHistone modifications are typically recognized by chromatin-binding protein modules (referred to as “readers”) to mediate fundamental processes such as transcription. Lysine β-hydroxybutyrylation (Kbhb) is a new type of histone mark that couples metabolism to gene expression. However, the readers that prefer histone Kbhb remain elusive. This knowledge gap must be filled in order to reveal the molecular mechanism of this epigenetic regulation. Herein, we developed a chemical proteomic approach, relying upon multivalent photoaffinity...
Source: GEO: Gene Expression Omnibus - May 6, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE254689 A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex [ATAC-seq]
Contributors : Xiaoyi G Liang ; Kendy Hoang ; Yue Zhang ; Sol Katzman ; Bin ChenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusDuring development neural stem cells (NSCs) in the cerebral cortex, also known as radial glial cells (RGCs), generate excitatory neurons, followed by production of cortical macroglia and inhibitory neurons that migrate to the olfactory bulb (OB). Understanding the mechanisms for this lineage switch is fundamental for unraveling how proper numbers of diverse neuronal and glial cell types are controlled. We and others recently showed that Shh ...
Source: GEO: Gene Expression Omnibus - May 6, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
GSE254658 Six1 regulates mouse lower incisor development by coordinating Dlx1/2/5 [scRNA-seq]
This study employs Six1 deletion mouse models to elucidate the critical regulatory role of Six1 in governing dental mesenchyme development. By performing single-cell RNA sequencing (scRNA-seq), we constructed a comprehensive transcriptome atlas of tooth germ development from the bud to bell stage. Our analyses suggest that the dental follicle (DF) and the dental papilla (DP) are differentiated from dental ectomesenchyme (DEM), and identify the key transcription factors (TFs) underlying these distinct states. Notably, we show that Dlx1, Dlx2, and Dlx5 (Dlx1/2/5) may function as the key TFs that promote the formation of DP. ...
Source: GEO: Gene Expression Omnibus - May 6, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE254482 Six1 regulates mouse lower incisor development by coordinating Dlx1/2/5 [CUT & Tag]
This study employs Six1 deletion mouse models to elucidate the critical regulatory role of Six1 in governing dental mesenchyme development. By performing single-cell RNA sequencing (scRNA-seq), we constructed a comprehensive transcriptome atlas of tooth germ development from the bud to bell stage. Our analyses suggest that the dental follicle (DF) and the dental papilla (DP) are differentiated from dental ectomesenchyme (DEM), and identify the key transcription factors (TFs) underlying these distinct states. Notably, we show that Dlx1, Dlx2, and Dlx5 (Dlx1/2/5) may function as the key TFs that promote the formation of DP. ...
Source: GEO: Gene Expression Omnibus - May 6, 2024 Category: Genetics & Stem Cells Tags: Other Mus musculus Source Type: research
GSE246851 The evolutionarily conserved zebrafish choroid plexus maintains the size of brain ventricles
Contributors : Jeong Inyoung ; Jurisch-Yaksi NathalieSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioThe choroid plexus produces cerebrospinal fluid (CSF) by transport of electrolytes and water from the vasculature to the brain ventricles. The choroid plexus plays additional roles in brain development and homeostasis by secreting neurotrophic molecules, and by serving as a CSF-blood barrier and immune interface. Prior studies have identified transporters on the epithelial cells that transport water and ions into the ventricles and tight junctions involved in the CSF-blood barrier. Ye...
Source: GEO: Gene Expression Omnibus - May 6, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Danio rerio Source Type: research
GSE243982 Deciphering bat influenza H18N11 infection dynamics in Jamaican fruit bats on a single cell level
Contributors : Geoffroy Andrieux ; Melanie Boerries ; Kevin Ciminski ; Susanne Kessler ; Tony SchountzSeries Type : Expression profiling by high throughput sequencingOrganism : Artibeus jamaicensisJamaican fruit bats (Artibeus jamaicensis) naturally harbor a wide range of viruses of human relevance. These infections are typically mild in bats, suggesting unique features of their immune system. To better understand the immune response to viral infections in bats, we infected Jamaican fruit bats with the bat-derived influenza A virus H18N11. Using comparative single-cell RNA sequencing, we generated a single-cell atlas ...
Source: GEO: Gene Expression Omnibus - May 6, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Artibeus jamaicensis Source Type: research
GSE232630 Dnmt3a1 regulates memory formation via the downstram target Nrp1
In this study, we investigated the requirement for Dnmt3a1, the predominant Dnmt in the adult brain, in hippocampal long-term memory formation. Furthermore, we identified an activity-regulated Dnmt3a1-dependent genomic program. Our data showed that Dnmt3a1, similarly to its isoform Dnmt3a2, plays a critical role in memory formation. Furthermore, we uncovered Neuropilin 1 (Nrp1) as a downstream target of Dnmt3a1 during the formation of memory. Intriguingly, we found that Nrp1 expression is selectively regulated and a specific downstream effector of Dnmt3a1, but not Dnmt3a2. Taken together, our study uncovered a Dnmt3a isofo...
Source: GEO: Gene Expression Omnibus - May 6, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE234337 Occupancy profiling of HAND2, MEIS2 and TCF4 by CUT & Tag from Neuroblastoma cells
Contributors : Ran Zhuo ; Jian PanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensHAND2, MEIS2 and TCF4 are master transcription factors (TFs) in neuroblastoma and create an interconnected core regulatory circuitry (CRC) by directly occupying each other's and their own super-enhancers (SEs), which leads to high levels of each TF expression inside the CRC. Additionally, CRC TFs cooperatively co-occupy the same SE components, which promotes the expression of genes involved in cell identity and cell-type-specific activities. Super-enhancer-mediated CRC enriched at key onc...
Source: GEO: Gene Expression Omnibus - May 6, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
Efficacy and Safety of Kuoxin Formula in the Treatment of Dilated Cardiomyopathy-Related Heart Failure: Study Protocol of a Randomized, Double-Blind, Placebo-Controlled, Multi-Center Clinical Trial
(Source: International Journal of General Medicine)
Source: International Journal of General Medicine - May 6, 2024 Category: General Medicine Tags: International Journal of General Medicine Source Type: research
Two-Dimensional Ultrasound-Based Radiomics Nomogram for Diabetic Kidney Disease: A Pilot Study
(Source: International Journal of General Medicine)
Source: International Journal of General Medicine - May 6, 2024 Category: General Medicine Tags: International Journal of General Medicine Source Type: research
Solvated Electrons Generated on the Surface of Na ‐SPHI for Boosting Visible Light Photocatalytic Hydrogen Evolution with Ultra‐High AQE
In this study, a fully condensed sulfur-doped poly(heptazine imide) metalized with Na (Na-SPHI) is synthesized by an ionothermal method by using eutectic NaCl/LiCl mixture as the ionic solvent. Comprehensive characterizations of the obtained Na-SPHI reveal several advantageous features, including heightened light absorption, facilitated exciton dissociation, and expedited charge transfer. More importantly, solvated electron, powerful reducing agents, can be generated on the surface of Na-SPHI upon irradiation with visible light. Benefiting from above advantage, the Na-SPHI exhibits an excellent H2 evolution rate of 571.8 ...
Source: Small - May 6, 2024 Category: Nanotechnology Authors: Yuxuan Li,
Dachuan Ge,
Hui Zhang,
Li Shangguan,
Zhigang Mou,
Feifei Xia,
Jianhua Sun,
Xiaofeng Liu,
Yuyu Su,
Weiwei Lei Tags: Research Article Source Type: research
High ‐Energy Facet Engineering for Electrocatalytic Applications
This study also addresses future directions and challenges, emphasizing the need to better understand fundamental mechanisms. Overall, high-energy facets offer exciting opportunities for advancing electrocatalysis. (Source: Small)
Source: Small - May 6, 2024 Category: Nanotechnology Authors: Rui Wang,
Jong ‐Min Lee Tags: Review Source Type: research
Self ‐Thermal Management in Filtered Selenium‐Terminated MXene Films for Flexible Safe Batteries
A filtered Se-terminated MXene flexible electrode not only enhances the Li storage capacity but also possesses a unique ability of low thermal emissivity, significantly reducing the risk of overheating. The developed flexible battery enables large, fast, and safe energy storage, promising for safe and fast-charging applications. AbstractLi-ion batteries with superior interior thermal management are crucial to prevent thermal runaway and ensure safe, long-lasting operation at high temperatures or during rapid discharging and charging. Typically, such thermal management is achieved by focusing on the separator and electrolyt...
Source: Small - May 6, 2024 Category: Nanotechnology Authors: Xin Pang,
Hyunjin Lee,
Jingzhi Rong,
Qiaoyu Zhu,
Shumao Xu Tags: Research Article Source Type: research
Recent Advances in Catalyst Design and Performance Optimization of Nanostructured Cathode Materials in Zinc –Air Batteries
In conclusion, porous nanostructures and nanoscale materials significantly boost the energy density, longevity, and efficiency of Zn–air batteries. It is suggested that future research should focus on the fundamental design principles of these materials to further enhance the battery performance and drive sustainable energy solutions. (Source: Small)
Source: Small - May 6, 2024 Category: Nanotechnology Authors: Haiyang Shi,
Sanshuang Gao,
Xijun Liu,
Yin Wang,
Shuxing Zhou,
Qian Liu,
Lei Zhang,
Guangzhi Hu Tags: Review Source Type: research
Association of Overweight and Inflammatory Indicators with Breast Cancer: A Cross-Sectional Study in Chinese Women
(Source: International Journal of Womens Health)
Source: International Journal of Womens Health - May 6, 2024 Category: OBGYN Tags: International Journal of Women's Health Source Type: research
