Peroxiredoxin II exerts neuroprotective effects by inhibiting endoplasmic reticulum stress and oxidative stress-induced neuronal pyroptosis
CONCLUSIONS: Our study not only underlines Prx II importance in neuroprotection but also opens new therapeutic intervention avenues in intracerebral hemorrhage, stressing the complex interplay between redox regulation, ER stress, and mitochondrial dynamics in neuroinflammation and cell death management.PMID:38704801 | DOI:10.1007/s11033-024-09568-5 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - May 5, 2024 Category: Molecular Biology Authors: Mei-Hua Jin Xiao-Dong Liu Hu-Nan Sun Ying-Hao Han Taeho Kwon Source Type: research
Linagliptin ameliorates tacrolimus-induced renal injury: role of Nrf2/HO-1 and HIF-1 α/CTGF/PAI-1
CONCLUSION: Lina ameliorated TAC-induced kidney injury through modulation of oxidative stress, hypoxia, and apoptosis related proteins.PMID:38704766 | DOI:10.1007/s11033-024-09533-2 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - May 5, 2024 Category: Molecular Biology Authors: Mohamed E Nady Ola M Abd El-Raouf El-Sayed M El-Sayed Source Type: research
Therapeutic potential of Lactobacillus casei and Chlorella vulgaris in high-fat diet-induced non-alcoholic fatty liver disease (NAFLD)-associated kidney damages: a stereological study
CONCLUSION: This study highlights the potential therapeutic efficacy of C. vulgaris and L. casei in mitigating kidney damage caused by NAFLD. These findings provide valuable insights for developing novel treatment approaches for managing NAFLD and its associated complications.PMID:38704764 | DOI:10.1007/s11033-024-09542-1 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - May 5, 2024 Category: Molecular Biology Authors: Haniyeh Keyghobadi Hadis Bozorgpoursavadjani Farhad Koohpeyma Nazanin Mohammadipoor Marzieh Nemati Farshad Dehghani Iman Jamhiri Gholamhossein Keighobadi Sanaz Dastghaib Source Type: research
The long non-coding RNAs (lncRNA) in the pathogenesis of gastric cancer cells: molecular mechanisms and involvement miRNAs
Mol Biol Rep. 2024 May 5;51(1):615. doi: 10.1007/s11033-024-09546-x.ABSTRACTA complex sequence of occurrences, including host genetic vulnerability, Helicobacter pylori infection, and other environmental variables, culminate in gastric cancer (GC). The development of several genetic and epigenetic changes in oncogenes and tumor suppressor genes causes dysregulation of several signaling pathways, which upsets the cell cycle and the equilibrium between cell division and apoptosis, leading to GC. Developments in computational biology and RNA-seq technology enable quick detection and characterization of long non-coding RNAs (l...
Source: Molecular Biology Reports - May 5, 2024 Category: Molecular Biology Authors: Raed Obaid Saleh Sulieman Ibraheem Shelash Al-Hawary Ahmad Hammoud Ahmed Hjazi Sumaya Ayad Abdulrazzaq Pranchal Rajput Taif Alawsi Mohammed Jawad Alnajar Ahmed Alawadi Source Type: research
Ancestry of the major long-range regulatory site of the α-globin genes in the Portuguese population with the common 3.7 kb α-thalassemia deletion
CONCLUSION: This study revealed for the first time an association of the HS-40 haplotype D with the -α3.7del in the Portuguese population, and its likely African ancestry. These results may have clinical importance as in vitro analysis of haplotype D showed a decrease in its enhancer activity on α-globin gene.PMID:38704770 | DOI:10.1007/s11033-024-09530-5 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - May 5, 2024 Category: Molecular Biology Authors: Rita Pena Pedro Lopes Gisela Gaspar Armandina Miranda Paula Faustino Source Type: research
A study of the association between single nucleotide polymorphisms of the endoplasmic reticulum aminopeptidase 2 (ERAP2) gene and the risk of ankylosing spondylitis in Egyptians
CONCLUSIONS: ERAP2 gene SNPs have been identified as valuable diagnostic biomarkers for AS patients in the Egyptian population being a sensitive and non-invasive approach for AS diagnosis especially rs2910686. Highly statistically significant variations existed among the AS patients and the healthy control group regarding rs2910686 alleles and genotypes.Further research is recommended to explore the potential therapeutic implications of these SNPs.PMID:38704785 | DOI:10.1007/s11033-024-09404-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - May 5, 2024 Category: Molecular Biology Authors: Randa Mohamed Ibrahim Mesahel Dina Salem Fotoh Mahmoud Mohammed Hadhoud Mohamed Farag Ali Assar Source Type: research
Inhibiting DNA methyltransferase DNMT3B confers protection against ferroptosis in nucleus pulposus and ameliorates intervertebral disc degeneration via upregulating SLC40A1
This study aimed to demonstrate that methyltransferase mediated hypermethylation was responsible for IVDD by integrative bioinformatics and experimental verification. Methyltransferase DNMT3B was highly expressed in severely degenerated NP tissue (involving human and rats) and in-vitro degenerated human NP cells (NPCs). Bioinformatics elucidated that hypermethylated genes were enriched in oxidative stress and ferroptosis, and the ferroptosis suppressor gene SLC40A1 was identified with lower expression and higher methylation in severely degenerated human NP tissue. Cell culture using human NPCs showed that DNMT3B induced fe...
Source: Free Radical Biology and Medicine - May 5, 2024 Category: Biology Authors: Jiaxing Chen Xinyu Yang Qiaochu Li Jingjin Ma Huanhuan Li Linbang Wang Zhiyu Chen Zhengxue Quan Source Type: research
The intriguing role of IL33/ST2 axis signaling in oral diseases - A systematic review
CONCLUSIONS: Accumulating evidence demonstrates that the IL-33/ST2 axis is a fundamental pathogenetic mechanism of oral diseases of inflammatory, autoimmune, or neoplastic origin.PMID:38705460 | DOI:10.1016/j.advms.2024.04.007 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - May 5, 2024 Category: Biomedical Science Authors: Mala Kamboj R Keerthika Anjali Narwal Ambika Gupta Anju Devi Adarsh Kumar Gitika Sharma Source Type: research
Modulation of proteasome subunit selectivity of syringolins
Bioorg Med Chem. 2024 Apr 27;106:117733. doi: 10.1016/j.bmc.2024.117733. Online ahead of print.ABSTRACTDevelopment of selective or dual proteasome subunit inhibitors based on syringolin B as a scaffold is described. We focused our efforts on a structure-activity relationship study of inhibitors with various substituents at the 3-position of the macrolactam moiety of syringolin B analogue to evaluate whether this would be sufficient to confer subunit selectivity by using sets of analogues with hydrophobic, basic and acidic substituents, which were designed to target Met45, Glu53 and Arg45 embedded in the S1 subsite, respect...
Source: Bioorganic and Medicinal Chemistry - May 5, 2024 Category: Chemistry Authors: Kengo Tatsumi Shun Kitahata Yuya Komatani Akira Katsuyama Fumika Yakushiji Satoshi Ichikawa Source Type: research
Macroevolution of the plant-hummingbird pollination system
Biol Rev Camb Philos Soc. 2024 May 5. doi: 10.1111/brv.13094. Online ahead of print.ABSTRACTPlant-hummingbird interactions are considered a classic example of coevolution, a process in which mutually dependent species influence each other's evolution. Plants depend on hummingbirds for pollination, whereas hummingbirds rely on nectar for food. As a step towards understanding coevolution, this review focuses on the macroevolutionary consequences of plant-hummingbird interactions, a relatively underexplored area in the current literature. We synthesize prior studies, illustrating the origins and dynamics of hummingbird pollin...
Source: Biological Reviews of the Cambridge Philosophical Society - May 5, 2024 Category: Biology Authors: Elisa Barreto Mannfred M A Boehm Ezgi Ogutcen Stefan Abrahamczyk Michael Kessler Jordi Bascompte Agnes S Dellinger Carolina Bello D Matthias Dehling Fran çois Duchenne Miriam Kaehler Laura P Lagomarsino L úcia G Lohmann Mar ía A Maglianesi H élène Mo Source Type: research
Review on the impacts of external pressure on sonochemistry
Ultrason Sonochem. 2024 May 1;106:106893. doi: 10.1016/j.ultsonch.2024.106893. Online ahead of print.ABSTRACTThe impact of hydrostatic pressure, commonly known as ambient or external pressure, on the phenomenon of sonochemistry and/or sonoluminescence has been extensively investigated through a multitude of experimental and computational studies, all of which have emphasized the crucial role played by this particular parameter. Numerous previous studies have successfully demonstrated the existence of an optimal static pressure for the occurrence of sonoluminescence and multi-bubble or single-bubble sonochemistry. However, ...
Source: Ultrasonics Sonochemistry - May 5, 2024 Category: Chemistry Authors: Slimane Merouani Aissa Dehane Oualid Hamdaoui Kyuichi Yasui Muthupandian Ashokkumar Source Type: research
A Pilot, Predictive Surveillance Model in Pharmacovigilance Using Machine Learning Approaches
CONCLUSION: This model demonstrated acceptable accuracy for safety signal detection and potential for earlier detection when compared to humans. Expert judgment, flexibility, and critical thinking are essential human skills required for the final, accurate assessment of adverse event cases.PMID:38704799 | DOI:10.1007/s12325-024-02870-5 (Source: Adv Data)
Source: Adv Data - May 5, 2024 Category: Epidemiology Authors: Rosa De Abreu Ferreira Sheng Zhong Charlotte Moureaud Michelle T Le Adrienne Rothstein Xiaomeng Li Li Wang Meenal Patwardhan Source Type: research
Metritis and the uterine disease microbiome are associated with long-term changes in the endometrium of dairy cows †
Biol Reprod. 2024 May 5:ioae067. doi: 10.1093/biolre/ioae067. Online ahead of print.ABSTRACTCows with metritis (uterine disease) during the first 1 to 2 wk postpartum have lower pregnancy rates when inseminated later postpartum (typically >10 wk). We hypothesized that metritis and the disease-associated uterine microbiome have a long-term effect on endometrial gene expression. Changes in gene expression may inform a mechanism through which disease lowers pregnancy rates. A total of 20 cows were enrolled at 1 to 2 wk postpartum to either metritis (clinical disease; n = 10) or healthy (control; n = 10) groups and randomly...
Source: Biology of Reproduction - May 5, 2024 Category: Reproduction Medicine Authors: Josiane C C Silva Monica O Caldeira Joao G N Moraes Isabella Sellmer Ramos Tamara Gull Aaron C Ericsson Scott E Poock Thomas E Spencer Matthew C Lucy Source Type: research
Thresholds of adversity for endocrine disrupting substances: a conceptual case study
Arch Toxicol. 2024 May 5. doi: 10.1007/s00204-024-03748-9. Online ahead of print.ABSTRACTFor endocrine disrupting chemicals (EDC) the existence of "safe exposure levels", that is exposure levels that do not present an appreciable risk to human health is most controversially discussed, as is the existence of health-based reference values. Concerns have been especially raised that EDCs might not possess a threshold level such that no exposure level to EDCs can be considered safe. To explore whether or not threshold levels can be identified, we performed a screening exercise on 14 pesticidal and biocidal active substances pre...
Source: Archives of Toxicology - May 5, 2024 Category: Toxicology Authors: Judy Choi Stefanie Rotter Vera Ritz Carsten Kneuer Philip Marx-Stoelting Marize de Lourdes Marzo Solano Angelika Oertel Susanne Rudzok Andrea Zikov á-Kloas Tewes Tralau Andreas Hensel Source Type: research
The Neuropsychological Assessment Battery Driving Scenes Test in a Dementia Clinic
CONCLUSION: Driving Scenes is a clinically and functionally relevant measure of memory. Although the Driving Scenes total score remains useful in dementia evaluations, component scores and error scores contribute additional practical information.PMID:38704735 | DOI:10.1093/arclin/acae034 (Source: Archives of Clinical Neuropsychology)
Source: Archives of Clinical Neuropsychology - May 5, 2024 Category: Psychiatry & Psychology Authors: Lee Ashendorf Susanne Withrow Brandon E Gavett Source Type: research
