Molecules, Vol. 29, Pages 2143: Isolation and Structure Determination of New Pyrones from Dictyostelium spp. Cellular Slime Molds Coincubated with Pseudomonas spp.
Haruhisa Kikuchi
Cellular slime molds are excellent model organisms in the field of cell and developmental biology because of their simple developmental patterns. During our studies on the identification of bioactive molecules from secondary metabolites of cellular slime molds toward the development of novel pharmaceuticals, we revealed the structural diversity of secondary metabolites. Cellular slime molds grow by feeding on bacteria, such as Klebsiella aerogenes and Escherichia coli, without using medium components. Although changing the feeding bacteria is expected to affect dramatically the secondary metabolite pr...
Source: Molecules - May 5, 2024 Category: Chemistry Authors: Takehiro Nishimura Takuya Murotani Hitomi Sasaki Yoshinori Uekusa Hiromi Eguchi Hirotaka Ishigaki Katsunori Takahashi Yuzuru Kubohara Haruhisa Kikuchi Tags: Article Source Type: research
Molecules, Vol. 29, Pages 2142: Deposition of Pd, Pt, and PdPt Nanoparticles on TiO2 Powder Using Supercritical Fluid Reactive Deposition: Application in the Direct Synthesis of H2O2
In this study, we investigated the catalytic properties of mono- and bimetallic palladium (Pd) and platinum (Pt) nanoparticles deposited via supercritical fluid reactive deposition (SFRD) on titanium dioxide (TiO2) powder. Transmission electron microscopy analyses verified that SFRD experiments performed at 353 K and 15.6 MPa enabled the deposition of uniform mono- and bimetallic nanoparticles smaller than 3 nm on TiO2. Electron-dispersive X-ray spectroscopy demonstrated the formation of alloy-type structures for the bimetallic PdPt nanoparticles. H2O2 is an excellent oxidizing reagent for the production of fine and bulk c...
Source: Molecules - May 5, 2024 Category: Chemistry Authors: Marlene Crone Laura L. Trinkies Roland Dittmeyer Michael T ürk Tags: Article Source Type: research
Molecules, Vol. 29, Pages 2141: Exploring the Influence of Cation and Halide Substitution in the Structure and Optical Properties of CH3NH3NiCl3 Perovskite
stillo
This manuscript details a comprehensive investigation into the synthesis, structural characterization, thermal stability, and optical properties of nickel-containing hybrid perovskites, namely CH3NH3NiCl3, CsNiCl3, and CH3NH3NiBrCl2. The focal point of this study is to unravel the intricate crystal structures, thermal behaviors, and optical characteristics of these materials, thereby elucidating their potential application in energy conversion and storage technologies. X-ray powder diffraction measurements confirm that CH3NH3NiCl3 adopts a crystal structure within the Cmcm space group, while CsNiCl3 is organized...
Source: Molecules - May 5, 2024 Category: Chemistry Authors: Natal í Navarro Ronald Nelson Karem Gallardo Rodrigo Castillo Tags: Article Source Type: research
IJERPH, Vol. 21, Pages 596: The Role of Career Adaptability and Academic Engagement in College Student & rsquo;s Life Satisfaction
This study included 201 participants, 156 women (77.6%) and 45 men (22.4%), aged between 18 and 55 years (M = 21.13, SD = 4.51). Students answered a sociodemographic questionnaire, the Career Adapt-Abilities Scale, the University Student Engagement Inventory, and the Satisfaction with Life Scale. Positive and statistically significant correlations between career adaptability and academic engagement, as well as between these variables and life satisfaction, were found. The results of a hierarchical linear regression analysis suggested that career adaptability and academic engagement statistically significantly contribute to...
Source: International Journal of Environmental Research and Public Health - May 5, 2024 Category: Environmental Health Authors: Íris M. Oliveira C átia Marques Tags: Article Source Type: research
IJERPH, Vol. 21, Pages 597: Assessing the Relationship between Physical Health, Mental Health and Students & rsquo; Success among Universities in Lebanon: A Cross-Sectional Study
Conclusions: This is the first investigation into Lebanese university students’ academic success in relation to lifestyle and mental health profiles. The findings indicate that implementing public health programs and interventions targeting mental health and lifestyle behaviors is essential for enhancing student success. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - May 5, 2024 Category: Environmental Health Authors: Samer A. Kharroubi Nayla Al-Akl Sarah-Joe Chamate Tarek Abou Omar Rouba Ballout Tags: Article Source Type: research
Genes, Vol. 15, Pages 586: Immunogenetics of Systemic Sclerosis
tyla
Systemic sclerosis (SSc) is a rare autoimmune connective tissue disorder characterized by massive fibrosis, vascular damage, and immune imbalance. Advances in rheumatology and immunology over the past two decades have led to a redefinition of systemic sclerosis, shifting from its initial perception as primarily a “hyperfibrotic” state towards a recognition of systemic sclerosis as an immune-mediated disease. Consequently, the search for genetic markers has transitioned from focusing on fibrotic mechanisms to exploring immune regulatory pathways. Immunogenetics, an emerging field at the ...
Source: Genes - May 5, 2024 Category: Genetics & Stem Cells Authors: Olga Gumkowska-Sroka Kacper Kotyla Przemys ław Kotyla Tags: Review Source Type: research
Genes, Vol. 15, Pages 587: Genome-Wide Analysis of Transcription Factor R2R3-MYB Gene Family and Gene Expression Profiles during Anthocyanin Synthesis in Common Walnut (Juglans regia L.)
This study proceeded as follows: the JrR2R3-MYB gene family was analyzed genome-wide, and the family members were identified and characterized using the high-quality walnut reference genome “Chandler 2.0”. All 204 JrR2R3-MYBs were established and categorized into 30 subgroups via phylogenetic analysis. JrR2R3-MYBs were unevenly distributed over 16 chromosomes. Most JrR2R3-MYBs had similar structures and conservative motifs. The cis-acting elements exhibit multiple functions of JrR2R3-MYBs such as light response, metabolite response, and stress response. We found that the expansion of JrR2R3-MYBs...
Source: Genes - May 5, 2024 Category: Genetics & Stem Cells Authors: Dongjun Zuo Yujie Yan Jiayu Ma Peng Zhao Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1778: The Diagnostic Performance of 2-[18F]FDG PET/CT in Identifying Richter Transformation in Chronic Lymphocytic Leukemia: An Updated Systematic Review and Bivariate Meta-Analysis
a
Treglia
Richter transformation is a rare phenomenon characterized by the transformation of cell chronic lymphocytic leukemia (CLL) into a more aggressive lymphoma variant. The early identification of CLLs with a high risk of RT is fundamental. In this field, 2-deoxy-2-[18F]-fluoro-D-glucose positron emission tomography/computed tomography (2-[18F]FDG PET/CT) has been shown to be a non-invasive and promising tool, but apparently, unclear data seem to be present in the literature. This systematic review and bivariate meta-analysis aimed to investigate the diagnostic performance of 2-[18F]FDG PET/CT and its parameter...
Source: Cancers - May 5, 2024 Category: Cancer & Oncology Authors: Albano Rizzo Racca Muoio Bertagna Treglia Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1779: Opaganib Downregulates N-Myc Expression and Suppresses In Vitro and In Vivo Growth of Neuroblastoma Cells
D. Smith
Neuroblastoma (NB), the most common cancer in infants and the most common solid tumor outside the brain in children, grows aggressively and responds poorly to current therapies. We have identified a new drug (opaganib, also known as ABC294640) that modulates sphingolipid metabolism by inhibiting the synthesis of sphingosine 1-phosphate (S1P) by sphingosine kinase-2 and elevating dihydroceramides by inhibition of dihydroceramide desaturase. The present studies sought to determine the potential therapeutic activity of opaganib in cell culture and xenograft models of NB. Cytotoxicity assays demonstrated that NB ...
Source: Cancers - May 5, 2024 Category: Cancer & Oncology Authors: Lynn W. Maines Staci N. Keller Ryan A. Smith Randy S. Schrecengost Charles D. Smith Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1781: Amplification of Hippo Signaling Pathway Genes Is Governed and Implicated in the Serous Subtype-Specific Ovarian Carcino-Genesis
This study examined the impact of Hippo signaling pathway on ovarian carcinogenesis. Therefore, the signatures related to Hippo signaling pathway were derived from the molecular signatures database (MSigDB) and were used for further analysis. The Z score-based pathway activation scoring method was employed to investigate the expression patterns of these signatures in the mRNA expression profiles of ovarian cancer cohorts. Compared to other subtype tumors, the results of this study show that the Hippo signaling pathway signatures are dysregulated prominently in serous subtype-specific ovarian carcinogenesis. A receiver oper...
Source: Cancers - May 5, 2024 Category: Cancer & Oncology Authors: Karthik Balakrishnan Yuanhong Chen Jixin Dong Tags: Article Source Type: research
Nano-Crystallites of Ruthenium(III) Violurate Complex: Synthesis, Characterization, PXRD and DFT Structural Analysis. DNA/ HSA -Binding, Antiviral Activity Against COVID-19 and Molecular Docking Study
New J. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4NJ00670D, PaperAbdulrahman Alhadhrami Bis-(violurate) - based ruthenium(III) complex was synthesized in a pure form as nano-crystallites. Mass spectrum, elemental and thermal analysis as well as molar conductance measurements assigned the molecular formula [Ru(VA)2ClH2O].... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - May 4, 2024 Category: Chemistry Authors: Abdulrahman Alhadhrami Source Type: research
Tracking Li atoms in real-time with ultra-fast NMR simulations
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Angela F Harper, Tabea Huss, Simone Koecher, Christoph Scheurer We present for the first time a multiscale machine learning approach to jointly simulate atomic structure and dynamics with the corresponding solid state Nuclear Magnetic Resonance (ssNMR) observables. We study... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Faraday Discuss. latest articles)
Source: RSC - Faraday Discuss. latest articles - May 4, 2024 Category: Chemistry Authors: Angela F Harper Source Type: research
Metal-doped niobate pyrochlores and double-perovskites for glycerol valorization: Structural and electronic properties and DFT calculations
In this study, metal-doped niobates and perovskites were obtained by a solid state reaction. The solids were evaluated in the esterification of glycerol in the presence of acetic acid to... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)
Source: RSC - Dalton Trans. latest articles - May 4, 2024 Category: Chemistry Authors: Gabriela M Bertoldo Source Type: research
Six-coordinated nickel (II) complexes with benzothiadiazole Schiff-base ligands: synthesis, crystal structure, magnetic and HFEPR study
Dalton Trans., 2024, Accepted Manuscript DOI: 10.1039/D4DT01143K, PaperNataliya Plyuta, Anne-Laure Barra, Gh énadie Novitchi, Narcis Avarvari Two new nickel(II) complexes, namely Ni(L1)2 (1) and Ni(L2)2 ·CH2Cl2(2) were obtained by reacting nickel (II) acetate tetrahydrate with the benzothiadiazole Schiff base ligands HL1 = 2-[4-(2,1,3-benzothiadiazole)imino]methyl-phenol or HL2 = 2-[(2,1,3-benzothiadiazol-4-ylimino)methyl]-6-methoxyphenol... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)
Source: RSC - Dalton Trans. latest articles - May 4, 2024 Category: Chemistry Authors: Nataliya Plyuta Source Type: research
Calreticulin regulates hepatic stellate cell activation through modulating TGF-beta-induced Smad signaling
Cell Calcium. 2024 Apr 30;121:102895. doi: 10.1016/j.ceca.2024.102895. Online ahead of print.ABSTRACTLiver fibrosis is characterized by excessive deposition of extracellular matrix (ECM) as a wound healing process. Activated hepatic stellate cells (HpSCs) are the major producer of the ECM and play a central role in liver fibrogenesis. It has been widely accepted that elimination of activated HpSCs or reversion to a quiescent state can be a feasible strategy for resolving the disease, further highlighting the urgent need for novel therapeutic targets. Calreticulin (CRT) is a molecular chaperone that normally resides in the ...
Source: Cell Calcium - May 4, 2024 Category: Cytology Authors: Chien-Chih Chen Li-Wen Hsu Kuang-Den Chen King-Wah Chiu Chao-Pin Kung Shu-Rong Li Chao-Long Chen Kuang-Tzu Huang Source Type: research
