The AALAS Journals: 2020 in Review
Comp Med. 2021 Apr 1;71(2):111-115.NO ABSTRACTPMID:33879279 | PMC:PMC8063201 (Source: Comparative Medicine)
Source: Comparative Medicine - April 21, 2021 Category: Zoology Authors: Linda A Toth Susan R Compton Ravi J Tolwani Virginia K Dawson John D Farrar Source Type: research

The AALAS Journals: 2020 in Review
Comp Med. 2021 Apr 1;71(2):111-115.NO ABSTRACTPMID:33879279 | PMC:PMC8063201 (Source: Comparative Medicine)
Source: Comparative Medicine - April 21, 2021 Category: Zoology Authors: Linda A Toth Susan R Compton Ravi J Tolwani Virginia K Dawson John D Farrar Source Type: research

The AALAS Journals: 2020 in Review
Comp Med. 2021 Apr 1;71(2):111-115.NO ABSTRACTPMID:33879279 | PMC:PMC8063201 (Source: Comparative Medicine)
Source: Comparative Medicine - April 21, 2021 Category: Zoology Authors: Linda A Toth Susan R Compton Ravi J Tolwani Virginia K Dawson John D Farrar Source Type: research

The AALAS Journals: 2020 in Review
Comp Med. 2021 Apr 1;71(2):111-115.NO ABSTRACTPMID:33879279 | PMC:PMC8063201 (Source: Comparative Medicine)
Source: Comparative Medicine - April 21, 2021 Category: Zoology Authors: Linda A Toth Susan R Compton Ravi J Tolwani Virginia K Dawson John D Farrar Source Type: research

The AALAS Journals: 2020 in Review
Comp Med. 2021 Apr 1;71(2):111-115.NO ABSTRACTPMID:33879279 | PMC:PMC8063201 (Source: Comparative Medicine)
Source: Comparative Medicine - April 21, 2021 Category: Zoology Authors: Linda A Toth Susan R Compton Ravi J Tolwani Virginia K Dawson John D Farrar Source Type: research

The AALAS Journals: 2020 in Review
Comp Med. 2021 Apr 1;71(2):111-115.NO ABSTRACTPMID:33879279 | PMC:PMC8063201 (Source: Comparative Medicine)
Source: Comparative Medicine - April 21, 2021 Category: Zoology Authors: Linda A Toth Susan R Compton Ravi J Tolwani Virginia K Dawson John D Farrar Source Type: research

The AALAS Journals: 2020 in Review
Comp Med. 2021 Apr 1;71(2):111-115.NO ABSTRACTPMID:33879279 | PMC:PMC8063201 (Source: Comparative Medicine)
Source: Comparative Medicine - April 21, 2021 Category: Zoology Authors: Linda A Toth Susan R Compton Ravi J Tolwani Virginia K Dawson John D Farrar Source Type: research

The AALAS Journals: 2020 in Review
Comp Med. 2021 Apr 1;71(2):111-115.NO ABSTRACTPMID:33879279 | PMC:PMC8063201 (Source: Comparative Medicine)
Source: Comparative Medicine - April 21, 2021 Category: Zoology Authors: Linda A Toth Susan R Compton Ravi J Tolwani Virginia K Dawson John D Farrar Source Type: research

The AALAS Journals: 2020 in Review
Comp Med. 2021 Apr 1;71(2):111-115.NO ABSTRACTPMID:33879279 | PMC:PMC8063201 (Source: Comparative Medicine)
Source: Comparative Medicine - April 21, 2021 Category: Zoology Authors: Linda A Toth Susan R Compton Ravi J Tolwani Virginia K Dawson John D Farrar Source Type: research

The AALAS Journals: 2020 in Review
Comp Med. 2021 Apr 1;71(2):111-115.NO ABSTRACTPMID:33879279 | PMC:PMC8063201 (Source: Comparative Medicine)
Source: Comparative Medicine - April 21, 2021 Category: Zoology Authors: Linda A Toth Susan R Compton Ravi J Tolwani Virginia K Dawson John D Farrar Source Type: research

The AALAS Journals: 2020 in Review
Comp Med. 2021 Apr 1;71(2):111-115.NO ABSTRACTPMID:33879279 | PMC:PMC8063201 (Source: Comparative Medicine)
Source: Comparative Medicine - April 21, 2021 Category: Zoology Authors: Linda A Toth Susan R Compton Ravi J Tolwani Virginia K Dawson John D Farrar Source Type: research

The AALAS Journals: 2020 in Review
Comp Med. 2021 Apr 1;71(2):111-115.NO ABSTRACTPMID:33879279 (Source: Comparative Medicine)
Source: Comparative Medicine - April 21, 2021 Category: Zoology Authors: Linda A Toth Susan R Compton Ravi J Tolwani Virginia K Dawson John D Farrar Source Type: research

The AALAS Journals: 2020 in Review
Comp Med. 2021 Apr 1;71(2):111-115.NO ABSTRACTPMID:33879279 (Source: Comparative Medicine)
Source: Comparative Medicine - April 21, 2021 Category: Zoology Authors: Linda A Toth Susan R Compton Ravi J Tolwani Virginia K Dawson John D Farrar Source Type: research

The AALAS Journals: 2020 in Review
Comp Med. 2021 Apr 1;71(2):111-115.NO ABSTRACTPMID:33879279 (Source: Comparative Medicine)
Source: Comparative Medicine - April 21, 2021 Category: Zoology Authors: Linda A Toth Susan R Compton Ravi J Tolwani Virginia K Dawson John D Farrar Source Type: research

The AALAS Journals: 2020 in Review
Comp Med. 2021 Apr 1;71(2):111-115.NO ABSTRACTPMID:33879279 (Source: Comparative Medicine)
Source: Comparative Medicine - April 21, 2021 Category: Zoology Authors: Linda A Toth Susan R Compton Ravi J Tolwani Virginia K Dawson John D Farrar Source Type: research

The AALAS Journals: 2020 in Review
Comp Med. 2021 Apr 1;71(2):111-115.NO ABSTRACTPMID:33879279 (Source: Comparative Medicine)
Source: Comparative Medicine - April 21, 2021 Category: Zoology Authors: Linda A Toth Susan R Compton Ravi J Tolwani Virginia K Dawson John D Farrar Source Type: research

The AALAS Journals: 2020 in Review
Comp Med. 2021 Apr 1;71(2):111-115.NO ABSTRACTPMID:33879279 (Source: Comparative Medicine)
Source: Comparative Medicine - April 21, 2021 Category: Zoology Authors: Linda A Toth Susan R Compton Ravi J Tolwani Virginia K Dawson John D Farrar Source Type: research

Effects of Buprenorphine, Chlorhexidine, and Low-level Laser Therapy on Wound Healing in Mice
Comp Med. 2021 Apr 16. doi: 10.30802/AALAS-CM-20-000104. Online ahead of print.ABSTRACTSystemic buprenorphine and topical antiseptics such as chlorhexidine are frequently used in research animals to aid inpain control and to reduce infection, respectively. These therapeutics are controversial, especially when used in wound healing studies, due to conflicting data suggesting that they delay wound healing. Low-level laser therapy (LLLT) has been used to aid in wound healing without exerting the systemic effects of therapies such as buprenorphine. We conducted 2 studies to investigate the effects of these common treatment mod...
Source: Comparative Medicine - April 17, 2021 Category: Zoology Authors: Donna R Webb Sheba R Churchill Georgette D Hill Christopher A McGee Min Shi Angela P King-Herbert Terry L Blankenship-Paris Source Type: research

Effects of Buprenorphine, Chlorhexidine, and Low-level Laser Therapy on Wound Healing in Mice
Comp Med. 2021 Apr 16. doi: 10.30802/AALAS-CM-20-000104. Online ahead of print.ABSTRACTSystemic buprenorphine and topical antiseptics such as chlorhexidine are frequently used in research animals to aid inpain control and to reduce infection, respectively. These therapeutics are controversial, especially when used in wound healing studies, due to conflicting data suggesting that they delay wound healing. Low-level laser therapy (LLLT) has been used to aid in wound healing without exerting the systemic effects of therapies such as buprenorphine. We conducted 2 studies to investigate the effects of these common treatment mod...
Source: Comparative Medicine - April 17, 2021 Category: Zoology Authors: Donna R Webb Sheba R Churchill Georgette D Hill Christopher A McGee Min Shi Angela P King-Herbert Terry L Blankenship-Paris Source Type: research

Effects of Buprenorphine, Chlorhexidine, and Low-level Laser Therapy on Wound Healing in Mice
Comp Med. 2021 Apr 16. doi: 10.30802/AALAS-CM-20-000104. Online ahead of print.ABSTRACTSystemic buprenorphine and topical antiseptics such as chlorhexidine are frequently used in research animals to aid inpain control and to reduce infection, respectively. These therapeutics are controversial, especially when used in wound healing studies, due to conflicting data suggesting that they delay wound healing. Low-level laser therapy (LLLT) has been used to aid in wound healing without exerting the systemic effects of therapies such as buprenorphine. We conducted 2 studies to investigate the effects of these common treatment mod...
Source: Comparative Medicine - April 17, 2021 Category: Zoology Authors: Donna R Webb Sheba R Churchill Georgette D Hill Christopher A McGee Min Shi Angela P King-Herbert Terry L Blankenship-Paris Source Type: research

Antimicrobial Susceptibility of Corynebacterium bovis Isolates from Immunodeficient Rodents
Comp Med. 2021 Apr 8. doi: 10.30802/AALAS-CM-20-000107. Online ahead of print.ABSTRACTCorynebacterium bovis, the causative agent of hyperkeratotic dermatitis in immunodeficient mice, is a significant problemin preclinical oncology research. Infection results in lifelong skin colonization and a decrease in successful engraftment ofpatient-derived xenograft tumor models. The use of antimicrobial agents for C. bovis is controversial in light of reports of poor efficacy and the possibility of selection for resistant strains. The purpose of this study was to describe the antimicrobial susceptibilities of C. bovis isolates obtai...
Source: Comparative Medicine - April 10, 2021 Category: Zoology Authors: Anna C Fagre Uma Pugazhenthi Christopher Cheleuitte-Nieves Marcus J Crim Kenneth S Henderson Derek L Fong Jori K Leszczynski Michael J Schurr Joshua B Daniels Christopher A Manuel Source Type: research

Antimicrobial Susceptibility of Corynebacterium bovis Isolates from Immunodeficient Rodents
Comp Med. 2021 Apr 8. doi: 10.30802/AALAS-CM-20-000107. Online ahead of print.ABSTRACTCorynebacterium bovis, the causative agent of hyperkeratotic dermatitis in immunodeficient mice, is a significant problemin preclinical oncology research. Infection results in lifelong skin colonization and a decrease in successful engraftment ofpatient-derived xenograft tumor models. The use of antimicrobial agents for C. bovis is controversial in light of reports of poor efficacy and the possibility of selection for resistant strains. The purpose of this study was to describe the antimicrobial susceptibilities of C. bovis isolates obtai...
Source: Comparative Medicine - April 10, 2021 Category: Zoology Authors: Anna C Fagre Uma Pugazhenthi Christopher Cheleuitte-Nieves Marcus J Crim Kenneth S Henderson Derek L Fong Jori K Leszczynski Michael J Schurr Joshua B Daniels Christopher A Manuel Source Type: research

Antimicrobial Susceptibility of Corynebacterium bovis Isolates from Immunodeficient Rodents
Comp Med. 2021 Apr 8. doi: 10.30802/AALAS-CM-20-000107. Online ahead of print.ABSTRACTCorynebacterium bovis, the causative agent of hyperkeratotic dermatitis in immunodeficient mice, is a significant problemin preclinical oncology research. Infection results in lifelong skin colonization and a decrease in successful engraftment ofpatient-derived xenograft tumor models. The use of antimicrobial agents for C. bovis is controversial in light of reports of poor efficacy and the possibility of selection for resistant strains. The purpose of this study was to describe the antimicrobial susceptibilities of C. bovis isolates obtai...
Source: Comparative Medicine - April 10, 2021 Category: Zoology Authors: Anna C Fagre Uma Pugazhenthi Christopher Cheleuitte-Nieves Marcus J Crim Kenneth S Henderson Derek L Fong Jori K Leszczynski Michael J Schurr Joshua B Daniels Christopher A Manuel Source Type: research

Antimicrobial Susceptibility of Corynebacterium bovis Isolates from Immunodeficient Rodents
Comp Med. 2021 Apr 8. doi: 10.30802/AALAS-CM-20-000107. Online ahead of print.ABSTRACTCorynebacterium bovis, the causative agent of hyperkeratotic dermatitis in immunodeficient mice, is a significant problemin preclinical oncology research. Infection results in lifelong skin colonization and a decrease in successful engraftment ofpatient-derived xenograft tumor models. The use of antimicrobial agents for C. bovis is controversial in light of reports of poor efficacy and the possibility of selection for resistant strains. The purpose of this study was to describe the antimicrobial susceptibilities of C. bovis isolates obtai...
Source: Comparative Medicine - April 10, 2021 Category: Zoology Authors: Anna C Fagre Uma Pugazhenthi Christopher Cheleuitte-Nieves Marcus J Crim Kenneth S Henderson Derek L Fong Jori K Leszczynski Michael J Schurr Joshua B Daniels Christopher A Manuel Source Type: research

Antimicrobial Susceptibility of Corynebacterium bovis Isolates from Immunodeficient Rodents
Comp Med. 2021 Apr 8. doi: 10.30802/AALAS-CM-20-000107. Online ahead of print.ABSTRACTCorynebacterium bovis, the causative agent of hyperkeratotic dermatitis in immunodeficient mice, is a significant problemin preclinical oncology research. Infection results in lifelong skin colonization and a decrease in successful engraftment ofpatient-derived xenograft tumor models. The use of antimicrobial agents for C. bovis is controversial in light of reports of poor efficacy and the possibility of selection for resistant strains. The purpose of this study was to describe the antimicrobial susceptibilities of C. bovis isolates obtai...
Source: Comparative Medicine - April 10, 2021 Category: Zoology Authors: Anna C Fagre Uma Pugazhenthi Christopher Cheleuitte-Nieves Marcus J Crim Kenneth S Henderson Derek L Fong Jori K Leszczynski Michael J Schurr Joshua B Daniels Christopher A Manuel Source Type: research

Antimicrobial Susceptibility of Corynebacterium bovis Isolates from Immunodeficient Rodents
Comp Med. 2021 Apr 8. doi: 10.30802/AALAS-CM-20-000107. Online ahead of print.ABSTRACTCorynebacterium bovis, the causative agent of hyperkeratotic dermatitis in immunodeficient mice, is a significant problemin preclinical oncology research. Infection results in lifelong skin colonization and a decrease in successful engraftment ofpatient-derived xenograft tumor models. The use of antimicrobial agents for C. bovis is controversial in light of reports of poor efficacy and the possibility of selection for resistant strains. The purpose of this study was to describe the antimicrobial susceptibilities of C. bovis isolates obtai...
Source: Comparative Medicine - April 10, 2021 Category: Zoology Authors: Anna C Fagre Uma Pugazhenthi Christopher Cheleuitte-Nieves Marcus J Crim Kenneth S Henderson Derek L Fong Jori K Leszczynski Michael J Schurr Joshua B Daniels Christopher A Manuel Source Type: research

Automated Blood Sampling in a Canine Telemetry Cardiovascular Model
Comp Med. 2021 Apr 4. doi: 10.30802/AALAS-CM-20-000083. Online ahead of print.ABSTRACTSuccessful implementation of automated blood sampling (ABS) into a telemetry instrumented canine cardiovascular model provides simultaneous cardiovascular assessment of novel compounds while collecting multiple blood samples for analysis of drug level, cytokines, and biomarkers. Purpose-bred male Beagle dogs (n = 36) were instrumented with a dual-pressure telemetry transmitter and vascular access port. Modifications to acclimation practices, surgical procedures, and housing were required for implementation of ABS in our established cardio...
Source: Comparative Medicine - April 5, 2021 Category: Zoology Authors: Amanda S Wilsey Yevgeniya E Koshman Debra A Weisbecker Brandan M Bird Kuldip K Mirakhur Sabine Sadilek Paige A Ebert James S Polakowski C Michael Foley Chris L Medina Scott W Mittelstadt Source Type: research

Fecal Bacterial Microbiota of Healthy Free-Ranging, Healthy Corralled, and Chronic Diarrheic Corralled Rhesus Macaques (Macaca mulatta)
Comp Med. 2021 Apr 4. doi: 10.30802/AALAS-CM-20-000080. Online ahead of print.ABSTRACTA clinical challenge to nearly every primate facility in North America is chronic idiopathic diarrhea (CID), the pathogenesis of which has yet to be fully elucidated. However, wild macaques appear resistant to CID, a trend that we observed in the free-ranging population of the Caribbean Primate Research Center. The gastrointestinal microbiota has been shown to have a significant role in the pathogenesis of disease and in maintaining normal health and development of the gut. In humans, chronic diarrhea is associated with alteration of the ...
Source: Comparative Medicine - April 5, 2021 Category: Zoology Authors: Nicole R Compo Luis Mieles-Rodriguez Diego E Gomez Source Type: research

Automated Blood Sampling in a Canine Telemetry Cardiovascular Model
Comp Med. 2021 Apr 4. doi: 10.30802/AALAS-CM-20-000083. Online ahead of print.ABSTRACTSuccessful implementation of automated blood sampling (ABS) into a telemetry instrumented canine cardiovascular model provides simultaneous cardiovascular assessment of novel compounds while collecting multiple blood samples for analysis of drug level, cytokines, and biomarkers. Purpose-bred male Beagle dogs (n = 36) were instrumented with a dual-pressure telemetry transmitter and vascular access port. Modifications to acclimation practices, surgical procedures, and housing were required for implementation of ABS in our established cardio...
Source: Comparative Medicine - April 5, 2021 Category: Zoology Authors: Amanda S Wilsey Yevgeniya E Koshman Debra A Weisbecker Brandan M Bird Kuldip K Mirakhur Sabine Sadilek Paige A Ebert James S Polakowski C Michael Foley Chris L Medina Scott W Mittelstadt Source Type: research

Fecal Bacterial Microbiota of Healthy Free-Ranging, Healthy Corralled, and Chronic Diarrheic Corralled Rhesus Macaques (Macaca mulatta)
Comp Med. 2021 Apr 4. doi: 10.30802/AALAS-CM-20-000080. Online ahead of print.ABSTRACTA clinical challenge to nearly every primate facility in North America is chronic idiopathic diarrhea (CID), the pathogenesis of which has yet to be fully elucidated. However, wild macaques appear resistant to CID, a trend that we observed in the free-ranging population of the Caribbean Primate Research Center. The gastrointestinal microbiota has been shown to have a significant role in the pathogenesis of disease and in maintaining normal health and development of the gut. In humans, chronic diarrhea is associated with alteration of the ...
Source: Comparative Medicine - April 5, 2021 Category: Zoology Authors: Nicole R Compo Luis Mieles-Rodriguez Diego E Gomez Source Type: research

Automated Blood Sampling in a Canine Telemetry Cardiovascular Model
Comp Med. 2021 Apr 4. doi: 10.30802/AALAS-CM-20-000083. Online ahead of print.ABSTRACTSuccessful implementation of automated blood sampling (ABS) into a telemetry instrumented canine cardiovascular model provides simultaneous cardiovascular assessment of novel compounds while collecting multiple blood samples for analysis of drug level, cytokines, and biomarkers. Purpose-bred male Beagle dogs (n = 36) were instrumented with a dual-pressure telemetry transmitter and vascular access port. Modifications to acclimation practices, surgical procedures, and housing were required for implementation of ABS in our established cardio...
Source: Comparative Medicine - April 5, 2021 Category: Zoology Authors: Amanda S Wilsey Yevgeniya E Koshman Debra A Weisbecker Brandan M Bird Kuldip K Mirakhur Sabine Sadilek Paige A Ebert James S Polakowski C Michael Foley Chris L Medina Scott W Mittelstadt Source Type: research

Fecal Bacterial Microbiota of Healthy Free-Ranging, Healthy Corralled, and Chronic Diarrheic Corralled Rhesus Macaques (Macaca mulatta)
Comp Med. 2021 Apr 4. doi: 10.30802/AALAS-CM-20-000080. Online ahead of print.ABSTRACTA clinical challenge to nearly every primate facility in North America is chronic idiopathic diarrhea (CID), the pathogenesis of which has yet to be fully elucidated. However, wild macaques appear resistant to CID, a trend that we observed in the free-ranging population of the Caribbean Primate Research Center. The gastrointestinal microbiota has been shown to have a significant role in the pathogenesis of disease and in maintaining normal health and development of the gut. In humans, chronic diarrhea is associated with alteration of the ...
Source: Comparative Medicine - April 5, 2021 Category: Zoology Authors: Nicole R Compo Luis Mieles-Rodriguez Diego E Gomez Source Type: research

Automated Blood Sampling in a Canine Telemetry Cardiovascular Model
Comp Med. 2021 Apr 4. doi: 10.30802/AALAS-CM-20-000083. Online ahead of print.ABSTRACTSuccessful implementation of automated blood sampling (ABS) into a telemetry instrumented canine cardiovascular model provides simultaneous cardiovascular assessment of novel compounds while collecting multiple blood samples for analysis of drug level, cytokines, and biomarkers. Purpose-bred male Beagle dogs (n = 36) were instrumented with a dual-pressure telemetry transmitter and vascular access port. Modifications to acclimation practices, surgical procedures, and housing were required for implementation of ABS in our established cardio...
Source: Comparative Medicine - April 5, 2021 Category: Zoology Authors: Amanda S Wilsey Yevgeniya E Koshman Debra A Weisbecker Brandan M Bird Kuldip K Mirakhur Sabine Sadilek Paige A Ebert James S Polakowski C Michael Foley Chris L Medina Scott W Mittelstadt Source Type: research

Fecal Bacterial Microbiota of Healthy Free-Ranging, Healthy Corralled, and Chronic Diarrheic Corralled Rhesus Macaques (Macaca mulatta)
Comp Med. 2021 Apr 4. doi: 10.30802/AALAS-CM-20-000080. Online ahead of print.ABSTRACTA clinical challenge to nearly every primate facility in North America is chronic idiopathic diarrhea (CID), the pathogenesis of which has yet to be fully elucidated. However, wild macaques appear resistant to CID, a trend that we observed in the free-ranging population of the Caribbean Primate Research Center. The gastrointestinal microbiota has been shown to have a significant role in the pathogenesis of disease and in maintaining normal health and development of the gut. In humans, chronic diarrhea is associated with alteration of the ...
Source: Comparative Medicine - April 5, 2021 Category: Zoology Authors: Nicole R Compo Luis Mieles-Rodriguez Diego E Gomez Source Type: research

Automated Blood Sampling in a Canine Telemetry Cardiovascular Model
Comp Med. 2021 Apr 4. doi: 10.30802/AALAS-CM-20-000083. Online ahead of print.ABSTRACTSuccessful implementation of automated blood sampling (ABS) into a telemetry instrumented canine cardiovascular model provides simultaneous cardiovascular assessment of novel compounds while collecting multiple blood samples for analysis of drug level, cytokines, and biomarkers. Purpose-bred male Beagle dogs (n = 36) were instrumented with a dual-pressure telemetry transmitter and vascular access port. Modifications to acclimation practices, surgical procedures, and housing were required for implementation of ABS in our established cardio...
Source: Comparative Medicine - April 5, 2021 Category: Zoology Authors: Amanda S Wilsey Yevgeniya E Koshman Debra A Weisbecker Brandan M Bird Kuldip K Mirakhur Sabine Sadilek Paige A Ebert James S Polakowski C Michael Foley Chris L Medina Scott W Mittelstadt Source Type: research

Fecal Bacterial Microbiota of Healthy Free-Ranging, Healthy Corralled, and Chronic Diarrheic Corralled Rhesus Macaques (Macaca mulatta)
Comp Med. 2021 Apr 4. doi: 10.30802/AALAS-CM-20-000080. Online ahead of print.ABSTRACTA clinical challenge to nearly every primate facility in North America is chronic idiopathic diarrhea (CID), the pathogenesis of which has yet to be fully elucidated. However, wild macaques appear resistant to CID, a trend that we observed in the free-ranging population of the Caribbean Primate Research Center. The gastrointestinal microbiota has been shown to have a significant role in the pathogenesis of disease and in maintaining normal health and development of the gut. In humans, chronic diarrhea is associated with alteration of the ...
Source: Comparative Medicine - April 5, 2021 Category: Zoology Authors: Nicole R Compo Luis Mieles-Rodriguez Diego E Gomez Source Type: research

Alpha-1 Acid Glycoprotein as a Biomarker for Subclinical Illness and Altered Drug Binding in Rats
Comp Med. 2021 Mar 31. doi: 10.30802/AALAS-CM-20-000088. Online ahead of print.ABSTRACTAlpha-1 acid glycoprotein (AGP) is a significant drug binding acute phase protein that is present in rats. AGP levels areknown to increase during tissue injury, cancer and infection. Accordingly, when determining effective drug ranges and toxicity limits, consideration of drug binding to AGP is essential. However, AGP levels have not been well established during subclinical infections. The goal of this study was to establish a subclinical infection model in rats using AGP as a biomarker. This information could enhance health surveillance...
Source: Comparative Medicine - April 1, 2021 Category: Zoology Authors: Catherine A Boyle Robert W Coatney Alexandra Wickham Suman K Mukherjee LaVonne D Meunier Source Type: research

Alpha-1 Acid Glycoprotein as a Biomarker for Subclinical Illness and Altered Drug Binding in Rats
Comp Med. 2021 Mar 31. doi: 10.30802/AALAS-CM-20-000088. Online ahead of print.ABSTRACTAlpha-1 acid glycoprotein (AGP) is a significant drug binding acute phase protein that is present in rats. AGP levels areknown to increase during tissue injury, cancer and infection. Accordingly, when determining effective drug ranges and toxicity limits, consideration of drug binding to AGP is essential. However, AGP levels have not been well established during subclinical infections. The goal of this study was to establish a subclinical infection model in rats using AGP as a biomarker. This information could enhance health surveillance...
Source: Comparative Medicine - April 1, 2021 Category: Zoology Authors: Catherine A Boyle Robert W Coatney Alexandra Wickham Suman K Mukherjee LaVonne D Meunier Source Type: research

Alpha-1 Acid Glycoprotein as a Biomarker for Subclinical Illness and Altered Drug Binding in Rats
Comp Med. 2021 Mar 31. doi: 10.30802/AALAS-CM-20-000088. Online ahead of print.ABSTRACTAlpha-1 acid glycoprotein (AGP) is a significant drug binding acute phase protein that is present in rats. AGP levels areknown to increase during tissue injury, cancer and infection. Accordingly, when determining effective drug ranges and toxicity limits, consideration of drug binding to AGP is essential. However, AGP levels have not been well established during subclinical infections. The goal of this study was to establish a subclinical infection model in rats using AGP as a biomarker. This information could enhance health surveillance...
Source: Comparative Medicine - April 1, 2021 Category: Zoology Authors: Catherine A Boyle Robert W Coatney Alexandra Wickham Suman K Mukherjee LaVonne D Meunier Source Type: research

Alpha-1 Acid Glycoprotein as a Biomarker for Subclinical Illness and Altered Drug Binding in Rats
Comp Med. 2021 Mar 31. doi: 10.30802/AALAS-CM-20-000088. Online ahead of print.ABSTRACTAlpha-1 acid glycoprotein (AGP) is a significant drug binding acute phase protein that is present in rats. AGP levels areknown to increase during tissue injury, cancer and infection. Accordingly, when determining effective drug ranges and toxicity limits, consideration of drug binding to AGP is essential. However, AGP levels have not been well established during subclinical infections. The goal of this study was to establish a subclinical infection model in rats using AGP as a biomarker. This information could enhance health surveillance...
Source: Comparative Medicine - April 1, 2021 Category: Zoology Authors: Catherine A Boyle Robert W Coatney Alexandra Wickham Suman K Mukherjee LaVonne D Meunier Source Type: research

The Effect of Body Region on Hair Cortisol Concentration in Common Marmosets (Callithrix jacchus)
Comp Med. 2021 Mar 22. doi: 10.30802/AALAS-CM-20-000091. Online ahead of print.ABSTRACTCommon marmosets (Callithrix jacchus) are a valuable research model for the study of neuroscience and the biologicimpact of aging due to their adaptivity, physiologic characteristics, and ease of handling for experimental manipulations. Quantification of cortisol in hair provides a noninvasive, retrospective biomarker of hypothalamics-pituitary-adrenal (HPA)axis activity and information on animal wellbeing, including responses to environmental and social stimuli. To obtain valid and reliable measurements of long-term HPA activity, we inv...
Source: Comparative Medicine - March 23, 2021 Category: Zoology Authors: Evelyn E Bartling-John Kimberley A Phillips Source Type: research

The Effect of Body Region on Hair Cortisol Concentration in Common Marmosets (Callithrix jacchus)
Comp Med. 2021 Mar 22. doi: 10.30802/AALAS-CM-20-000091. Online ahead of print.ABSTRACTCommon marmosets (Callithrix jacchus) are a valuable research model for the study of neuroscience and the biologicimpact of aging due to their adaptivity, physiologic characteristics, and ease of handling for experimental manipulations. Quantification of cortisol in hair provides a noninvasive, retrospective biomarker of hypothalamics-pituitary-adrenal (HPA)axis activity and information on animal wellbeing, including responses to environmental and social stimuli. To obtain valid and reliable measurements of long-term HPA activity, we inv...
Source: Comparative Medicine - March 23, 2021 Category: Zoology Authors: Evelyn E Bartling-John Kimberley A Phillips Source Type: research

The Effect of Body Region on Hair Cortisol Concentration in Common Marmosets (Callithrix jacchus)
Comp Med. 2021 Mar 22. doi: 10.30802/AALAS-CM-20-000091. Online ahead of print.ABSTRACTCommon marmosets (Callithrix jacchus) are a valuable research model for the study of neuroscience and the biologicimpact of aging due to their adaptivity, physiologic characteristics, and ease of handling for experimental manipulations. Quantification of cortisol in hair provides a noninvasive, retrospective biomarker of hypothalamics-pituitary-adrenal (HPA)axis activity and information on animal wellbeing, including responses to environmental and social stimuli. To obtain valid and reliable measurements of long-term HPA activity, we inv...
Source: Comparative Medicine - March 23, 2021 Category: Zoology Authors: Evelyn E Bartling-John Kimberley A Phillips Source Type: research

The Effect of Body Region on Hair Cortisol Concentration in Common Marmosets (Callithrix jacchus)
Comp Med. 2021 Mar 22. doi: 10.30802/AALAS-CM-20-000091. Online ahead of print.ABSTRACTCommon marmosets (Callithrix jacchus) are a valuable research model for the study of neuroscience and the biologicimpact of aging due to their adaptivity, physiologic characteristics, and ease of handling for experimental manipulations. Quantification of cortisol in hair provides a noninvasive, retrospective biomarker of hypothalamics-pituitary-adrenal (HPA)axis activity and information on animal wellbeing, including responses to environmental and social stimuli. To obtain valid and reliable measurements of long-term HPA activity, we inv...
Source: Comparative Medicine - March 23, 2021 Category: Zoology Authors: Evelyn E Bartling-John Kimberley A Phillips Source Type: research

The Effect of Body Region on Hair Cortisol Concentration in Common Marmosets (Callithrix jacchus)
Comp Med. 2021 Mar 22. doi: 10.30802/AALAS-CM-20-000091. Online ahead of print.ABSTRACTCommon marmosets (Callithrix jacchus) are a valuable research model for the study of neuroscience and the biologicimpact of aging due to their adaptivity, physiologic characteristics, and ease of handling for experimental manipulations. Quantification of cortisol in hair provides a noninvasive, retrospective biomarker of hypothalamics-pituitary-adrenal (HPA)axis activity and information on animal wellbeing, including responses to environmental and social stimuli. To obtain valid and reliable measurements of long-term HPA activity, we inv...
Source: Comparative Medicine - March 23, 2021 Category: Zoology Authors: Evelyn E Bartling-John Kimberley A Phillips Source Type: research

The Effect of Body Region on Hair Cortisol Concentration in Common Marmosets (Callithrix jacchus)
Comp Med. 2021 Mar 22. doi: 10.30802/AALAS-CM-20-000091. Online ahead of print.ABSTRACTCommon marmosets (Callithrix jacchus) are a valuable research model for the study of neuroscience and the biologicimpact of aging due to their adaptivity, physiologic characteristics, and ease of handling for experimental manipulations. Quantification of cortisol in hair provides a noninvasive, retrospective biomarker of hypothalamics-pituitary-adrenal (HPA)axis activity and information on animal wellbeing, including responses to environmental and social stimuli. To obtain valid and reliable measurements of long-term HPA activity, we inv...
Source: Comparative Medicine - March 23, 2021 Category: Zoology Authors: Evelyn E Bartling-John Kimberley A Phillips Source Type: research

The Effect of Body Region on Hair Cortisol Concentration in Common Marmosets (Callithrix jacchus)
Comp Med. 2021 Mar 22. doi: 10.30802/AALAS-CM-20-000091. Online ahead of print.ABSTRACTCommon marmosets (Callithrix jacchus) are a valuable research model for the study of neuroscience and the biologicimpact of aging due to their adaptivity, physiologic characteristics, and ease of handling for experimental manipulations. Quantification of cortisol in hair provides a noninvasive, retrospective biomarker of hypothalamics-pituitary-adrenal (HPA)axis activity and information on animal wellbeing, including responses to environmental and social stimuli. To obtain valid and reliable measurements of long-term HPA activity, we inv...
Source: Comparative Medicine - March 23, 2021 Category: Zoology Authors: Evelyn E Bartling-John Kimberley A Phillips Source Type: research

A 3D-printed Apparatus for Imaging Multiple Rats Simultaneously
Comp Med. 2021 Mar 11. doi: 10.30802/AALAS-CM-20-000089. Online ahead of print.ABSTRACTCT (computerized tomography) is a necessary imaging modality for cancer staging and disease monitoring. Rodent models of cancer are commonly studied prior to human clinical trials, but CT in rodents can be difficult due to their small size and constant movement, which necessitates general anesthesia. Because microCT equipment is not always available, clinical CT may be a viable alternative. Limitations of microCT and clinical CT include biosecurity, anesthesia to limit image distortion due to motion, and cost. To address several of these...
Source: Comparative Medicine - March 12, 2021 Category: Zoology Authors: Nicholas J Harrison Kate L Shumway Sarah A Hansen Charles A Maitz Lori A Thombs Brian K Flesner Source Type: research

A 3D-printed Apparatus for Imaging Multiple Rats Simultaneously
Comp Med. 2021 Mar 11. doi: 10.30802/AALAS-CM-20-000089. Online ahead of print.ABSTRACTCT (computerized tomography) is a necessary imaging modality for cancer staging and disease monitoring. Rodent models of cancer are commonly studied prior to human clinical trials, but CT in rodents can be difficult due to their small size and constant movement, which necessitates general anesthesia. Because microCT equipment is not always available, clinical CT may be a viable alternative. Limitations of microCT and clinical CT include biosecurity, anesthesia to limit image distortion due to motion, and cost. To address several of these...
Source: Comparative Medicine - March 12, 2021 Category: Zoology Authors: Nicholas J Harrison Kate L Shumway Sarah A Hansen Charles A Maitz Lori A Thombs Brian K Flesner Source Type: research

A 3D-printed Apparatus for Imaging Multiple Rats Simultaneously
Comp Med. 2021 Mar 11. doi: 10.30802/AALAS-CM-20-000089. Online ahead of print.ABSTRACTCT (computerized tomography) is a necessary imaging modality for cancer staging and disease monitoring. Rodent models of cancer are commonly studied prior to human clinical trials, but CT in rodents can be difficult due to their small size and constant movement, which necessitates general anesthesia. Because microCT equipment is not always available, clinical CT may be a viable alternative. Limitations of microCT and clinical CT include biosecurity, anesthesia to limit image distortion due to motion, and cost. To address several of these...
Source: Comparative Medicine - March 12, 2021 Category: Zoology Authors: Nicholas J Harrison Kate L Shumway Sarah A Hansen Charles A Maitz Lori A Thombs Brian K Flesner Source Type: research