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Total 791 results found since Jan 2013.

Assessment of atherosclerosis in ischemic stroke by means of ultrasound of extracranial/intracranial circulation and serum, urine, and tissue biomarkers
Curr Med Chem. 2022 Aug 17. doi: 10.2174/0929867329666220817123442. Online ahead of print.ABSTRACTIt is a common practice to take into consideration: age, diabetes, smoking, treated and untreated systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol for the prediction of atherosclerosis and stroke. There are, however, ultrasound markers in use for the assessment of atherosclerosis and the evaluation of stroke risk. Two areas of investigation are of interest: the carotid artery and the intracranial arterial circulation. Again, within the domain of the carotid artery, two ultrasonic markers have at...
Source: Current Medicinal Chemistry - August 18, 2022 Category: Chemistry Authors: Grigorios G Dimas Maria Zilakaki Argyrios Giannopoulos Stylianos Daios Nikolaos Kakaletsis Georgia Kaiafa Triantafyllos Didangelos Christos Savopoulos Kyriakos Ktenidis Thomas Tegos Source Type: research

Thrombus inhibition and neuroprotection for ischemic stroke treatment through platelet regulation and ROS scavenging
This study may provide a promising therapeutic routine for regulating the microenvironment of ischemic stroke through a combined function of ROS scavenging, microthrombus inhibition, and BBB penetration.PMID:36220787 | DOI:10.1002/cmdc.202200317
Source: ChemMedChem - October 11, 2022 Category: Chemistry Authors: Hongbo Ye Zhifang Ma Lei Liu Tianci Zhang Qiaoyi Han Zehong Xiang Yu Xia Yue Ke Xinghua Guan Qiang Shi Fazly I Ataullakhanov Mikhail Panteleev Source Type: research

Discovery of novel danshensu derivatives bearing pyrazolone moiety as potential anti-ischemic stroke agents with antioxidant activity
In this study, a series of novel danshensu derivatives bearing pyrazolone moieties with dual antioxidant effects were synthesized for the treatment of ischemic stroke. Most compounds exhibited considerable DPPH free radical scavenging ability and neuroprotective activity against H2O2-induced oxidative injury in PC12 neuronal cells, without cytotoxicity. Among these target compounds, Del03 displayed the strongest dose-dependent neuroprotective activity in vitro, directly downregulated intracellular ROS levels, and improved the oxidative stress parameters MDA, SOD, and LDH. Del03 also promoted Nrf2 translocation to the nucle...
Source: Bioorganic Chemistry - November 27, 2022 Category: Chemistry Authors: Yi Li Yunchun Luo Jing Wang Hao Shi Jun Liao Yan Wang Zhesheng Chen Liyan Xiong Chuan Zhang Tingfang Wang Source Type: research

Molecules, Vol. 28, Pages 390: Sigma-1 Receptor Activation Improves Oligodendrogenesis and Promotes White-Matter Integrity after Stroke in Mice with Diabetic Mellitus
In this study, C57BL/6 mice were treated with high-fat diets (HFDs) combined with streptozotocin (STZ) injection to mimic type 2 diabetes mellitus (T2DM). Focal cerebral ischemia in T2DM mice was established via injection of the vasoconstrictor peptide endothelin-1 (ET-1) into the hippocampus. Three different treatment plans were used in this study. In one plan, 1 mg/kg of PRE084 (intraperitoneally) was administered for 7 d before ET-1 injection; the mice were sacrificed 24 h after ET-1 injection. In another plan, PRE084 treatment was initiated 24 h after ET-1 injection and lasted for 7 d. In the third plan, PRE084 treatme...
Source: Molecules - January 2, 2023 Category: Chemistry Authors: Wenjing Song Yang Yao Heling Zhang Xin Hao Liping Zhou Zhixiao Song Tiantian Wei Tianyan Chi Peng Liu Xuefei Ji Libo Zou Tags: Article Source Type: research

Ischemic stroke progress evaluation by 31P NMR-based metabonomic of human serum
In this work, chemometric analyses over 31P{¹H} NMR (nuclear magnetic ressonance) spectra of human blood serum permitted to discriminated ischemic stroke patients from health individuals due to changes in the chemical composition of phosphorus-containing compounds. These results indicate that 31P NMR-based metabonomic allowed insights over the mechanism triggered by ischemic stroke.Neste trabalho, análises quimiométricas de espectros de NMR (ressonância magnética nuclear) de 31P{¹H} obtidos de soro sanguíneo permitiram discriminar pacientes que sofreram acidente vascular encefálico isquêmico daqueles saudáveis de...
Source: Journal of the Brazilian Chemical Society - July 4, 2014 Category: Chemistry Source Type: research

Organic nanoparticles with aggregation-induced emission for tracking bone marrow stromal cells in the rat ischemic stroke model.
Abstract Organic nanoparticles (NPs) with aggregation-induced emission (AIE) have been successfully used for tracking bone marrow stromal cells (BMSCs) in rats with ischemic stroke, highlighting the great potential of such fluorescent NPs in understanding the fate of transplanted stem cells for cell-based therapies. PMID: 25267167 [PubMed - as supplied by publisher]
Source: Chemical Communications - September 30, 2014 Category: Chemistry Authors: Li K, Yamamoto M, Chan SJ, Chiam MY, Qin W, Wong PT, Yim EK, Tang BZ, Liu B Tags: Chem Commun (Camb) Source Type: research

Nuclear GAPDH Promotes PARP-1 in Stroke Signal Transduction
In addition to its role in DNA repair, nuclear poly(ADP-ribose) polymerase-1 (PARP-1) mediates brain damage when it is over-activated by oxidative/nitrosative stress. Nonetheless, it remains unclear how PARP-1 is activated in neuropathological contexts. Here we report that PARP-1 interacts with a pool of glyceradehyde-3-phosphate dehydrogenase (GAPDH) that translocates into the nucleus under oxidative/nitrosative stress both in vitro and in vivo. A well conserved amino acid at the N terminus of GAPDH determines its protein binding with PARP-1. Wild-type (WT) but not mutant GAPDH, that lacks the ability to bind PARP-1, can ...
Source: Journal of Biological Chemistry - June 4, 2015 Category: Chemistry Authors: Nakajima, H., Kubo, T., Ihara, H., Hikida, T., Danjo, T., Nakatsuji, M., Shahani, N., Itakura, M., Ono, Y., Azuma, Y.-T., Inui, T., Kamiya, A., Sawa, A., Takeuchi, T. Tags: Neurobiology Source Type: research

Novel POLG Mutation in a Patient with Sensory Ataxia, Neuropathy, Ophthalmoparesis and Stroke.
CONCLUSIONS: The novel mutation contributes to the expanding spectrum of disease-causing mutations. A definitive diagnosis can benefit our patient and also the relatives by avoiding sodium valproate induced liver toxicity in POLG patients and also the heterozygotes. PMID: 26169155 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - July 10, 2015 Category: Chemistry Authors: Ching-Wan L, Chun-Yiu L, Wai-Kwan S, Cheuk-Wing F, Man-Mut Y, Kwai-Fun H, Hencher LH, Chloe MM Tags: Clin Chim Acta Source Type: research

Extraction and isolation of potential anti-stroke compounds from flowers of Pueraria lobata guided by in vitro PC12 cell model.
Abstract A simple and efficient method based on ultrafiltration liquid chromatography-mass spectrometry (UFLC-MS) was applied to rapidly screen and identify ligands for lactate dehydrogenase (LDH) from the flowers of Pueraria lobata, and the compounds were assessed for anti-stroke activity using a PC12 cell model. Seven major isoflavones, kakkalide, 3'-hydroxy puerarin, puerarin, puerarin xyloside, tectoridin, tectorigenin, and ononin, were identified as potent LDH inhibitors. A continuous online method, which consisted of microwave-assisted extraction and countercurrent chromatography (MAE-CCC), was newly develop...
Source: Anal Sci - March 17, 2017 Category: Chemistry Authors: Li S, Li S, Liu C, Liu C, Zhang Y Tags: J Chromatogr B Analyt Technol Biomed Life Sci Source Type: research

MALDI IMS of Intraperitoneally Injected Danegaptide (ZP1609) for Treatment of Stroke-Reperfusion Injury in Mice.
CONCLUSIONS: Overall, the data reveals successful penetration of ZP1609 across the blood-brain barrier. The benefits of tissue acidification in the enhancement of detection sensitivity for low abundance peptides were demonstrated. MALDI IMS has shown to be a useful technique in the direct detection of drugs within intact brain tissue sections. PMID: 29575411 [PubMed - as supplied by publisher]
Source: Rapid Communications in Mass Spectrometry : RCM - March 25, 2018 Category: Chemistry Authors: Wang JSH, Freitas-Andrade M, Bechberger JF, Naus C, Yeung KK, Whitehead SN Tags: Rapid Commun Mass Spectrom Source Type: research

Synthetic approaches to isocarbacyclin and analogues as potential neuroprotective agents against ischemic stroke.
Abstract Isocarbacyclin is a valuable synthetic analogue of prostacyclin with potential neuroprotective effects for the treatment of ischemic stroke. Herein, we describe the synthesis of isocarbacyclin and bicyclic analogues in only 7-10 steps, with the ω-side chain diversified at a late stage. A combination of new reaction design, function-oriented synthesis, and late-stage diversification led to a series of compounds that were tested for their neuroprotective activities. Efforts toward the synthesis of tricyclic analogues of isocarbacyclin, using the same combination of metal-catalyzed reactions, is also descri...
Source: Bioorganic and Medicinal Chemistry - December 6, 2018 Category: Chemistry Authors: Abu Deiab GI, Croatt MP Tags: Bioorg Med Chem Source Type: research