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Total 791 results found since Jan 2013.
Synthesis and characterization of different sodium hyaluronate nanoparticles to transport large neurotherapheutic molecules through blood brain barrier after stroke
Publication date: Available online 16 January 2019Source: European Polymer JournalAuthor(s): Sebastián Peralta, Santos Blanco, Raquel Hernández, Herminia Castán, Eva Siles, Esther Martínez-Lara, María Encarnación Morales, María Ángeles Peinado, María Adolfina RuizAbstractSome biological drugs with proven neuroprotective capacity are unable to cross the blood brain barrier (BBB), preventing its use in neuroregenerative diseases such as stroke. The use of nanoparticles as a delivery system to transport large therapeutic molecules to the cerebral parenchyma may be a good option to overcome this limitation.To achieve ...
Source: European Polymer Journal - January 16, 2019 Category: Chemistry Source Type: research
Stable isotope labeling derivatization and magnetic dispersive solid phase extraction coupled with UHPLC-MS/MS for the measurement of brain neurotransmitters in post-stroke depression rats administrated with gastrodin.
Abstract
Synchronous measurement of brain neurotransmitters and blood drug metabolism by dual sites in vivo microdialysis can provide very important information for several neurological disorders such as post-stroke depression (PSD). In this work, d0/d3-6-N-methyl-rhodamine 6G-N-hydroxysuccinimidyl formate (d0/d3-MRSF) were firstly designed, synthesized and used as stable isotope labeling derivatization reagents for the determination of multiple neurotransmitters by ultra-high performance liquid chromatography-tandem mass spectrometry. The light d0-MRSF was used to label neurotransmitters in real samples and the ...
Source: Analytica Chimica Acta - January 23, 2019 Category: Chemistry Authors: Zhao XE, He Y, Zhu S, Xu Y, You J, Bai Y, Liu H Tags: Anal Chim Acta Source Type: research
Omentin-1: protective impact on ischemic stroke via ameliorating atherosclerosis.
This study is the first to summarize the comprehensive mechanisms between omentin-1 and atherosclerosis and to review the shielding effect of omentin-1 on IS. We shed light on omentin-1 as a novel therapeutic target for combating IS.
PMID: 33607071 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - February 16, 2021 Category: Chemistry Authors: Lin S, Li X, Zhang J, Zhang Y Tags: Clin Chim Acta Source Type: research
Molecules, Vol. 26, Pages 5173: Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke
Conclusions: Intranasal administration of DSIP in the course of 8 days leads to accelerated recovery of motor functions.
Source: Molecules - August 26, 2021 Category: Chemistry Authors: Elena A. Tukhovskaya Alina M. Ismailova Elvira R. Shaykhutdinova Gulsara A. Slashcheva Igor A. Prudchenko Inessa I. Mikhaleva Oksana N. Khokhlova Arkady N. Murashev Vadim T. Ivanov Tags: Article Source Type: research
Inflammatory Molecular Mediators and Pathways Involved in Vascular Aging and Stroke: A Comprehensive Review
Curr Med Chem. 2021 Sep 1. doi: 10.2174/0929867328666210901122359. Online ahead of print.ABSTRACTThere is an increase in the incidence of cardiovascular diseases with aging and it is one of the leading causes of death worldwide. The main cardiovascular pathologies include atherosclerosis, stroke, myocardial infarction, hypertension and stroke. Chronic inflammation is one of the significant contributors to the age-related vascular diseases. Therefore, it is important to understand the molecular mechanisms of the persistent inflammatory conditions occurring in the blood vessels as well as the signaling pathways involved. Her...
Source: Current Medicinal Chemistry - September 7, 2021 Category: Chemistry Authors: Amro M Soliman Srijit Das Pasuk Mahakkanukrauh Source Type: research
Quantum binding energy features of the drug olmesartan bounded to angiotensin type-1 receptor in the therapeutics of stroke
New J. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1NJ03975J, PaperStephany Campanelli Esmaile, Daniel Melo de Oliveira Campos, Maria Karolaynne da Silva, Katyanna Sales Bezerra, J. X. Lima Neto, Vin ícius Manzoni, U. L. Fulco, Jonas Ivan Nobre Oliveira Stroke is the second most common cause of mortality worldwide and the third most common cause of disability. Stroke causes and hemodynamic consequences are heterogeneous, making blood pressure management in... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - September 14, 2021 Category: Chemistry Authors: Stephany Campanelli Esmaile Source Type: research
Molecules, Vol. 26, Pages 6365: Lack of Neuroprotective Effects of High-Density Lipoprotein Therapy in Stroke under Acute Hyperglycemic Conditions
Conclusion: We observed a nonsignificant decrease in cerebral infarct size in the HDL group. The deleterious consequences of reperfusion such as hemorrhagic transformation or inflammation were not improved by HDL infusion. In acute hyperglycemia, HDLs are not potent enough to counteract the adverse effects of hyperglycemia. The addition of antioxidants to therapeutic HDLs could improve their neuroprotective capacity.
Source: Molecules - October 21, 2021 Category: Chemistry Authors: David Couret Cynthia Planesse Jessica Patche Nicolas Diotel Brice Nativel Steeve Bourane Olivier Meilhac Tags: Article Source Type: research
Discovery of novel brain-penetrant GluN2B NMDAR antagonists via pharmacophore-merging strategy as anti-stroke therapeutic agents
Eur J Med Chem. 2021 Oct 8;227:113876. doi: 10.1016/j.ejmech.2021.113876. Online ahead of print.ABSTRACTIn this work, a novel structural series of brain-penetrant GluN2B NMDAR antagonists were designed, synthesized and biologically evaluated as anti-stroke therapeutic agents via merging the structures of NBP and known GluN2B ligands. Approximately half of them exhibited superior neuroprotective activity to NBP against NMDA-induced neurotoxicity in hippocampal neurons at 10 μM, and compound 45e and 45f exerted equipotent activity to ifenprodil, an approved GluN2B- selective NMDAR antagonist. In particular, 45e, with the mo...
Source: European Journal of Medicinal Chemistry - October 28, 2021 Category: Chemistry Authors: Qinlong Xu Mengqi Hu Jiaming Li Xiaodong Ma Zhaoxing Chu Qihua Zhu Yanchun Zhang Panhu Zhu Yuanzheng Huang Guangwei He Source Type: research
Alamandine Induces Neuroprotection in Ischemic Stroke Models
CONCLUSION: This study showed, for the first time, a neuroprotective role for Alamandine in different ischemic stroke models.PMID:35125076 | DOI:10.2174/0929867329666220204145730
Source: Current Medicinal Chemistry - February 7, 2022 Category: Chemistry Authors: Sth éfanie C A Gonçalves Beatriz L T Bassi Lucas M Kangussu Daniele T Alves Lorena K S Ramos Lorena F Fernandes Marco T R Alves Ruben Sinisterra Gisele E Bruch Robson A S Santos Andr é R Massensini Maria Jos é Campagnole-Santos Source Type: research
Molecules, Vol. 27, Pages 1984: Positive Effect of & alpha;-Asaronol on the Incidence of Post-Stroke Epilepsy for Rat with Cerebral Ischemia-Reperfusion Injury
This study provides valuable data for the follow-up prodrug research of α-asaronol and n-butylphthalide.
Source: Molecules - March 18, 2022 Category: Chemistry Authors: Lan Jiang Xiangnan Hu Tags: Article Source Type: research
