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Total 791 results found since Jan 2013.

Molecules, Vol. 24, Pages 793: GC-MS-Based Metabolomics to Reveal the Protective Effect of Gross Saponins of Tribulus terrestris Fruit against Ischemic Stroke in Rat
In this study, the protective effect of GSTTF on ischemic stroke in a middle cerebral artery occlusion (MCAO) rat model was investigated by the GC-MS-based metabolomics approach. 2,3,5-triphenyltetrazolium chloride (TTC) staining of brain tissues showed that GSTTF significantly reduced the infarct area after MCAO surgery. Metabolomic profiling showed a series of metabolic perturbation occurs in ischemic stroke compared with sham group. GSTTF can reverse the MCAO-induced serum metabolic deviations by regulating multiple metabolic pathways including fatty acids metabolism, amino acids metabolism, and carbohydrates metabolism...
Source: Molecules - February 22, 2019 Category: Chemistry Authors: Yang Wang Hongyu Zhao Yue Liu Wenjun Guo Yanru Bao Manqi Zhang Tunhai Xu Shengxu Xie Xinyu Liu Yajuan Xu Tags: Article Source Type: research

A photostable Si-rhodamine-based near-infrared fluorescent probe for monitoring lysosomal pH during heat stroke.
Abstract Heat stroke is a symptom of hyperthermia with a temperature of more than 40 °C, which usually leads to all kinds of physical discomfort and even death. It is necessary to study the mechanism of action of heat stroke on cells or organelles (such as cytotoxicity of heat) and the processes of cells or organelles during heat stroke. Recent studies have shown that there is a certain correlation between heat stroke and lysosome acidity. In order to clarify their relationship, Lyso-NIR-pH, a photostable Si-rhodamine-based near-infrared fluorescent probe, was developed for sensing pH changes in lysosomes durin...
Source: Analytica Chimica Acta - November 13, 2019 Category: Chemistry Authors: Mao GJ, Liang ZZ, Gao GQ, Wang YY, Guo XY, Su L, Zhang H, Ma QJ, Zhang G Tags: Anal Chim Acta Source Type: research

Serum omentin-1 and risk of one-year mortality in patients with ischemic stroke.
CONCLUSIONS: Among patients with ischemic stroke, high baseline serum omentin-1 was associated with a decreased risk of 1-y mortality. These findings, if confirmed by clinical trials, suggest that increasing omentin-1 concentrations may lower the risk of mortality among ischemic stroke patients. PMID: 32145276 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - March 3, 2020 Category: Chemistry Authors: Xu T, Li Y, Su Y, Zuo P, Gao Z, Ke K Tags: Clin Chim Acta Source Type: research

HDL cholesterol efflux capacity and phospholipid content are associated with the severity of acute ischemic stroke and predict its outcome
CONCLUSIONS: Changes in CEC and composition of HDL appear to be associated with the severity and outcome of acute ischemic stroke and could represent biomarkers that may inform risk stratification and management strategies in these patients.PMID:36657609 | DOI:10.1016/j.cca.2023.117229
Source: International Journal of Clinical Chemistry - January 19, 2023 Category: Chemistry Authors: Achilleas Papagiannis Christina Gkolfinopoulou Konstantinos Tziomalos Anastasia-Georgia Dedemadi Georgios Polychronopoulos Dimitrios Milonas Christos Savopoulos Apostolos I Hatzitolios Angeliki Chroni Source Type: research

Genetic Polymorphism Detection of Pathophysiological Pathways of Ischemic Stroke in Asian
This study aims to summarize specific variants relevant to Asian populations that may aid in the early detection of ischemic stroke and explore their impact on the disease's pathophysiology. These variants give us important information about the genes that play a role in ischemic stroke by affecting things like atherosclerosis pathway, blood coagulation pathway, homocysteine metabolism, transporter function, transcription, and the activity of neurons regulation. It is important to recognize the variations in genetic variants among different ethnicities and avoid generalizing the pathogenesis of ischemic stroke.PMID:3766638...
Source: International Journal of Clinical Chemistry - September 4, 2023 Category: Chemistry Authors: Valentinus Besin Trilis Yulianti Paulus Budiono Notopuro Farizky Martriano Humardani Source Type: research

Targeting Microglial Activation in Stroke Therapy: Pharmacological Tools and Gender Effects.
Abstract Ischemic stroke is caused by critical reductions in blood flow to a part of brain or spinal cord. Microglia are the resident immune cells of the central nervous system, and they respond to stroke by assuming an activated phenotype that releases cytotoxic cytokines, reactive oxygen species, proteases, and other factors. This acute, innate immune response may be teleologically adapted to limit infection, but in stroke this response can exacerbate injury by further damaging or killing nearby neurons and other cell types and by recruiting infiltration of circulating cytotoxic immune cells. The microglial resp...
Source: Current Medicinal Chemistry - December 28, 2013 Category: Chemistry Authors: Chen Y, Won SJ, Xu Y, Swanson RA Tags: Curr Med Chem Source Type: research

Comparison of miR-124-3p and miR-16 for early diagnosis of hemorrhagic and ischemic stroke.
CONCLUSION:: Both miR-124-3p and miR-16 are diagnostic markers to discriminate HS and IS. PMID: 24650689 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - March 17, 2014 Category: Chemistry Authors: Leung LY, Chan CP, Leung YK, Jiang HL, Abrigo JM, Wang D, Chung JS, Rainer TH, Graham CA Tags: Clin Chim Acta Source Type: research

Hs-CRP in stroke: A meta-analysis.
CONCLUSIONS: Elevated baseline hs-CRP levels are independently associated with excessive ischaemic stroke risk but exhibit no clear effect on haemorrhagic stroke. PMID: 26633855 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - November 26, 2015 Category: Chemistry Authors: Zhou Y, Han W, Gong D, Man C, Fan Y Tags: Clin Chim Acta Source Type: research

Molecules, Vol. 21, Pages 1143: In Vivo Targeted MR Imaging of Endogenous Neural Stem Cells in Ischemic Stroke
Acute ischemic stroke remains a leading cause of death and disability. Endogenous neurogenesis enhanced via activation of neural stem cells (NSCs) could be a promising method for stroke treatment. In vivo targeted tracking is highly desirable for monitoring the dynamics of endogenous NSCs in stroke. Previously, we have successfully realized in vivo targeted MR imaging of endogenous NSCs in normal adult mice brains by using anti-CD15 antibody-conjugated superparamagnetic iron oxide nanoparticles (anti-CD15-SPIONs) as the molecular probe. Herein, we explore the performance of this molecular probe in targeted in vivo tracking...
Source: Molecules - August 28, 2016 Category: Chemistry Authors: Fang Zhang Xiaohui Duan Liejing Lu Xiang Zhang Xiaomei Zhong Jiaji Mao Meiwei Chen Jun Shen Tags: Article Source Type: research

Advances in Studies on Stroke-Induced Secondary Neurodegeneration (SND) and Its Treatment.
CONCLUSION: In this article, we have reviewed the available reports on SND pathophysiology, detection techniques and possible treatment modalities that have not been attempted till date. PMID: 32297583 [PubMed - as supplied by publisher]
Source: Current Topics in Medicinal Chemistry - April 14, 2020 Category: Chemistry Authors: Datta A, Sarmah D, Kalia K, Borah A, Wang X, Dave KR, Yavagal DR, Bhattacharya P Tags: Curr Top Med Chem Source Type: research

FRET and optical trapping reveal mechanisms of actin activation of the power stroke and phosphate release in myosin V Enzymology
Myosins generate force and motion by precisely coordinating their mechanical and chemical cycles, but the nature and timing of this coordination remains controversial. We utilized a FRET approach to examine the kinetics of structural changes in the force-generating lever arm in myosin V. We directly compared the FRET results with single-molecule mechanical events examined by optical trapping. We introduced a mutation (S217A) in the conserved switch I region of the active site to examine how myosin couples structural changes in the actin- and nucleotide-binding regions with force generation. Specifically, S217A enhanced the...
Source: Journal of Biological Chemistry - December 18, 2020 Category: Chemistry Authors: Laura K. Gunther, John A. Rohde, Wanjian Tang, Joseph A. Cirilo Jr., Christopher P. Marang, Brent D. Scott, David D. Thomas, Edward P. Debold, Christopher M. Yengo Tags: Editors ' Picks Source Type: research