Filtered By:
Specialty: Chemistry
This page shows you your search results in order of date.
Order by Relevance | Date
Total 791 results found since Jan 2013.
Graphene Oxide Nanosheets Hamper Glutamate Mediated Excitotoxicity and Protect Neuronal Survival In An In vitro Stroke Model
Chemistry. 2023 Sep 14:e202301762. doi: 10.1002/chem.202301762. Online ahead of print.ABSTRACTSmall graphene oxide (s-GO) nanosheets reversibly downregulate central nervous system (CNS) excitatory synapses, with potential developments as future therapeutic tools to treat neuro-disorders characterized by altered glutamatergic transmission. Excitotoxicity, namely cell death triggered by exceeding ambient glutamate fueling over-activation of excitatory synapses, is a pathogenic mechanism shared by several neural diseases, from ischemic stroke to neurodegenerative disorders. Here we exposed CNS cultures to oxygen-glucose depri...
Source: Chemistry - September 14, 2023 Category: Chemistry Authors: Lorenza Tortella Irene Santini Neus Lozano Kostas Kostarelos Giada Cellot Laura Ballerini Source Type: research
Mediation analysis of urinary metals and stroke risk by inflammatory markers
CONCLUSIONS: At the epidemiological level, CRP mediates the association between cadmium and stroke risk, suggesting that inflammation may be a potential mechanism for metal-induced stroke.PMID:37689152 | DOI:10.1016/j.chemosphere.2023.140084
Source: Chemosphere - September 9, 2023 Category: Chemistry Authors: Lei Zheng Xi Jing Xianli Zhang Chunyu Zhong Dezhi Qiu Qing Yan Zhe Gao Source Type: research
Carbohydrate antigen 125 in atrial fibrillation
This article reviews the role of CA-125 in patients with atrial fibrillation.PMID:37683718 | DOI:10.1016/j.cca.2023.117550
Source: International Journal of Clinical Chemistry - September 8, 2023 Category: Chemistry Authors: Rangrang Zhang Weidong Jin Minglei Han Yonglan Hou Source Type: research
Genetic Polymorphism Detection of Pathophysiological Pathways of Ischemic Stroke in Asian
This study aims to summarize specific variants relevant to Asian populations that may aid in the early detection of ischemic stroke and explore their impact on the disease's pathophysiology. These variants give us important information about the genes that play a role in ischemic stroke by affecting things like atherosclerosis pathway, blood coagulation pathway, homocysteine metabolism, transporter function, transcription, and the activity of neurons regulation. It is important to recognize the variations in genetic variants among different ethnicities and avoid generalizing the pathogenesis of ischemic stroke.PMID:3766638...
Source: International Journal of Clinical Chemistry - September 4, 2023 Category: Chemistry Authors: Valentinus Besin Trilis Yulianti Paulus Budiono Notopuro Farizky Martriano Humardani Source Type: research
A new multi-parameter imaging platform for in vivo drug efficacy evaluation of ischemic stroke
Talanta. 2023 Aug 28;266(Pt 2):125133. doi: 10.1016/j.talanta.2023.125133. Online ahead of print.ABSTRACTIschemic stroke with high incidence and disability rate severely endangers human health. Current clinical treatment strategies are quite limited, new drugs for ischemic stroke are urgently needed. However, most existing methods for the efficacy evaluation of new drugs possess deficiencies of divorcing from the true biological context, single detection indicator and complex operations, leading to evaluation biases and delaying drug development process. In this work, leveraging the advantages of fluorescence imaging with ...
Source: Talanta - September 2, 2023 Category: Chemistry Authors: Di Su Ran Zhang Xin Wang Qi Ding Feida Che Wen Zhang Wei Wu Ping Li Bo Tang Source Type: research
Synthesis of 1,3,5-triphenyl-1,2,4-triazole derivatives and their neuroprotection by anti-oxidative stress and anti-inflammation and protecting BBB
Eur J Med Chem. 2023 Aug 21;260:115742. doi: 10.1016/j.ejmech.2023.115742. Online ahead of print.ABSTRACTAcute ischemic stroke (AIS) is a serious cardiovascular and cerebrovascular disease; Oxidative stress and neuroinflammation are important factors which destroy blood-brain barrier (BBB) in AIS. In the study, a series of 1,3,5-triphenyl-1,2,4-triazole derivatives were designed and synthesized; the optimal compound 9 was obtained by screening their anti-oxidant and anti-inflammatory effects; the neuroprotection effect of compound 9 was evaluated with a rat middle cerebral artery occlusion (MCAO) model. Subsequently, the m...
Source: European Journal of Medicinal Chemistry - August 31, 2023 Category: Chemistry Authors: Yang Wang Ruiqi Su Jianwen Chen Xuan Liu Jingning Luo Yaoqiang Lao Ping Huang Jinguo Shi Caibao Jiang Liping Liao Jingxia Zhang Source Type: research
