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Total 791 results found since Jan 2013.

Critical Appraisal of Ischemic Stroke Pathophysiology: Road to Cerebral Resuscitation? Part II.
PMID: 24735370 [PubMed - as supplied by publisher]
Source: Current Medicinal Chemistry - April 13, 2014 Category: Chemistry Authors: G K R, Pretorius E Tags: Curr Med Chem Source Type: research

Organic nanoparticles with aggregation-induced emission for tracking bone marrow stromal cells in the rat ischemic stroke model
Chem. Commun., 2014, Advance ArticleDOI: 10.1039/C4CC06921H, CommunicationKai Li, Mie Yamamoto, Su Jing Chan, Mun Yee Chiam, Wei Qin, Peter Tsun Hon Wong, Evelyn King Fai Yim, Ben Zhong Tang, Bin LiuFluorescent nanoparticles with aggregation-induced emission were successfully used for tracking bone marrow-derived mesenchymal stromal cells in rats with ischemic stroke.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - September 30, 2014 Category: Chemistry Authors: Kai Li Source Type: research

Biomarkers identify stroke victims with cognitive problems
A metabolomics approach to check whether a stroke has affected a patient’s memory or thinking processes
Source: Chemistry World | Latest News - November 2, 2015 Category: Chemistry Authors: Charlie Quigg Source Type: research

A 2-Stroke 2-CylinderPiston Rotaxane Motor.
Abstract We introduce amodel for a rotaxane motor. This usestwo major themes of rotaxane physics - the ability tochange the potential of different regions of the axle (switching), and the entropy associated with free rings.The motor is based on free rings being trapped and released by potential stripes or stations. We calculate the power produced by such a motor, which is in the femtoWatt range. The power is proportional to the square of the number of rings. PMID: 26945475 [PubMed - as supplied by publisher]
Source: Chemphyschem - March 4, 2016 Category: Chemistry Authors: Sevick EM, Williams DR Tags: Chemphyschem Source Type: research

Power Stroke Angular Velocity Profiles of Archaeal A-ATP Synthase Versus Thermophilic and Mesophilic F-ATP Synthase Molecular Motors Molecular Biophysics
The angular velocities of ATPase-dependent power strokes as a function of the rotational position for the A-type molecular motor A3B3DF, from the Methanosarcina mazei Gö1 A-ATP synthase, and the thermophilic motor α3β3γ, from Geobacillus stearothermophilus (formerly known as Bacillus PS3) F-ATP synthase, are resolved at 5 μs resolution for the first time. Unexpectedly, the angular velocity profile of the A-type was closely similar in the angular positions of accelerations and decelerations to the profiles of the evolutionarily distant F-type motors of thermophilic and mesophilic origins, and they differ only in the ma...
Source: Journal of Biological Chemistry - December 1, 2016 Category: Chemistry Authors: Hendrik Sielaff, James Martin, Dhirendra Singh, Goran Biuković, Gerhard Gruber, Wayne D. Frasch Tags: Bioenergetics Source Type: research

Mesenchymal Stem Cell Therapy in Intracerebral Haemorrhagic Stroke.
CONCLUSION: Further studies have to be implemented in order to achieve standardized methods of MSCs isolation, characterization and administration to improve ICH treatments with MSCs or MSC-derived products. PMID: 29332564 [PubMed - as supplied by publisher]
Source: Current Medicinal Chemistry - January 10, 2018 Category: Chemistry Authors: Bedini G, Bersano A, Zanier ER, Pischiutta F, Parati EA Tags: Curr Med Chem Source Type: research

Identification and initial optimization of inhibitors of Clostridium difficile (C. difficile) toxin B (TcdB).
Abstract The discovery, synthesis and preliminary structure-activity relationship (SAR) of a novel class of inhibitors of Clostridium difficile (C. difficile) toxin B (TcdB) is described. A high throughput screening (HTS) campaign resulted in the identification of moderately active screening hits 1-5 the most potent of which was compound 1 (IC50 = 0.77 µM). In silico docking of an early analog offered suggestions for structural modification which resulted in the design and synthesis of highly potent analogs 13j(IC50 = 1 nM) and 13 l(IC50 = 7 nM) which were chosen as leads for further optimizat...
Source: Bioorganic and Medicinal Chemistry Letters - January 5, 2018 Category: Chemistry Authors: Letourneau JJ, Stroke IL, Hilbert DW, Sturzenbecker LJ, Marinelli BA, Quintero JG, Sabalski J, Ma L, Diller DJ, Stein PD, Webb ML Tags: Bioorg Med Chem Lett Source Type: research

Hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Luling Wu, Yang Wang, Tony D. James, Nengqin Jia, Chusen Huang Heat stroke is a lethal condition, which can cause dysfunction in central nervous system, multi-organ damage and even death. However, there is still limited knowledge of detailed mechanism about the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - April 11, 2018 Category: Chemistry Authors: Luling Wu Source Type: research

A hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Luling Wu, Yang Wang, Tony D. James, Nengqin Jia, Chusen Huang Heat stroke is a lethal condition which can cause dysfunction in the central nervous system, multi-organ damage and even death. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - April 19, 2018 Category: Chemistry Authors: Luling Wu Source Type: research

An Angiopep-2 functionalized nanoformulation enhances brain accumulation of tanshinone IIA and exerts neuroprotective effects against ischemic stroke
New J. Chem., 2018, Advance Article DOI: 10.1039/C8NJ02441C, PaperYutao Li, Yanxin Dang, Dandan Han, Yong Tan, Xin Liu, Fengming Zhang, Yuan Xu, Haiyan Zhang, Xianfeng Yan, Xiaoxu Zhang, Zhiyong Zeng, Xiaojun Sun Effective intervention against ischemic stroke requires delivery of potent neuroprotective drugs to the brain. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - October 5, 2018 Category: Chemistry Authors: Yutao Li Source Type: research

Neutrophil affinity for PGP and HAIYPRH (T7) peptide dual-ligand functionalized nanoformulation enhances the brain delivery of tanshinone IIA and exerts neuroprotective effects against ischemic stroke by inhibiting proinflammatory signaling pathways
New J. Chem., 2018, Advance Article DOI: 10.1039/C8NJ04819C, PaperYutao Li, Chiying An, Danan Han, Yanxin Dang, Xin Liu, Fengming Zhang, Yuan Xu, Haijing Zhong, Xiaojun Sun A great challenge to the therapy of ischemic stroke is the poor physicochemical properties and inability of the drug to cross the blood –brain barrier (BBB). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - November 5, 2018 Category: Chemistry Authors: Yutao Li Source Type: research

Design and photoisomerization dynamics of a new family of synthetic 2-stroke light driven molecular rotary motors.
Abstract A new family of light driven molecular rotary motors, which can be synthesized from easily available precursor compounds and which are capable of completing a full 360° revolution by two photoisomerization steps only, is proposed. The non-adiabatic molecular dynamic simulations show that the photoisomerization steps of the motor's working cycle occur on an ultrafast time scale (ca. 200-300 fs), have a very high quantum yield of isomerization (0.91-0.97), and display high selectivity of torsion in the same direction. It is expected that the new motor should remain operational at lower temperatures than th...
Source: Chemical Communications - April 15, 2019 Category: Chemistry Authors: Filatov M, Paolino M, Min SK, Choi CH Tags: Chem Commun (Camb) Source Type: research

Multiplexed electrochemical and SERS dual-mode detection of stroke biomarkers: rapid screening with high sensitivity
New J. Chem., 2019, Advance Article DOI: 10.1039/C9NJ01598A, PaperJingyi Sun, Yi Zhao, Yajun Hou, Hanxia Li, Mingfeng Yang, Ying Wang, Baoliang Sun In this work, a real-time assay for a highly sensitive, label-free, multiplexed electrochemical and surface-enhanced Raman spectroscopic (SERS) detection of stroke biomarkers by neuron-specific enolase (NSE) and S100- β protein was developed using lateral flow devices. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - August 1, 2019 Category: Chemistry Authors: Jingyi Sun Source Type: research

Global metabolomics analysis of serum from humans at risk of thrombotic stroke
Analyst, 2020, Accepted Manuscript DOI: 10.1039/C9AN02032B, PaperAdnan Khan, Mal-Soon Shin, Sun Ha Jee, Youngja H Park We aimed to determine the serum concentrations of altered compounds to understand the changes in metabolism and pathophysiology that occur prior to thrombotic stroke. In this prospective cohort study, high-resolution... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - December 17, 2019 Category: Chemistry Authors: Adnan Khan Source Type: research

Experimental investigation and mathematical modeling of the reaction between SO2(g) and CaCO3(s)-containing micelles in lube oil for large two-stroke marine diesel engines
In this study, the CaCO3 + SO2 reaction was investigated in a batch reactor setup at temperatures and pressures similar to those on the cylinder liner in an engine. The conversion of CaCO3 and the formation of products were determined by Fourier Transform Infrared Spectroscopy (FTIR). CaSO3 was the main product, but CaSO4 was observed at extended residence times and increased temperature. The SO2-CaCO3 reaction exhibited only a small temperature dependence; the increase in the rate constant with temperature was partly off-set because the absorption of SO2 in the lube oil emulsion decreases at increased temperature. The r...
Source: Chemical Engineering Journal - February 8, 2020 Category: Chemistry Source Type: research