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Total 791 results found since Jan 2013.

Risk of Ischemic Stroke in Primary Aldosteronism Patients.
CONCLUSIONS: Proteinuria, a medical history of coronary artery disease or left ventricular hypertrophy were associated with an increased risk of ischemic stroke in PA patients. Our results suggest that a public health initiative is necessary to enhance the follow up of proteinuria and to manage subsequent stroke among patients with aldosteronism. PMID: 25124866 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - August 11, 2014 Category: Chemistry Authors: Kao CC, Lin YH, Chang CC, Wu MS, Wu VC, TAIPAI Study Group Tags: Clin Chim Acta Source Type: research

Oxidative stress and post-stroke depression: possible therapeutic role of polyphenols?
Abstract Post-stroke depression is a common neuropsychiatric affective disorder that may develop after a stroke event. In addition to abnormalities in the biogenic amine neurotransmitters and cytokine expression induced by stroke we will focus on the role of oxidative stress and hypothesize that polyphenols may be useful as therapeutics targets for the treatment of post-stroke depression. In this paper, we discuss the hypothesis that increased oxidative stress in cerebral tissues during ischemia is implicated in the pathogenesis of depressive-like symptoms following stroke. There is substantive evidence regarding ...
Source: Current Medicinal Chemistry - November 12, 2014 Category: Chemistry Authors: Nabavi SF, Dean OM, Turner A, Sureda A, Daglia M, Nabavi SM Tags: Curr Med Chem Source Type: research

Molecular Basis of Young Ischemic Stroke.
This article reviews the existing literature on the most investigated monogenic disorders (CADASIL, Fabry disease, MELAS, RVCL, COL4A1, Marfan and Ehlers-Danlos syndromes) causing stroke in young and a number of candidate genes associated with stroke occurring in patients younger than 50 years. Although our study failed in identifying strong and reliable associations between specific genes and young stroke, our detailed literature revision on the field allowed us to compile a panel of genes possibly generating a susceptibility to stroke, which could be a starting point for future research. Since stroke is a potentially pre...
Source: Current Medicinal Chemistry - July 24, 2013 Category: Chemistry Authors: Bersano A, Borellini L, Motto C, Lanfranconi S, Pezzini A, Basilico P, Micieli G, Padovani A, Parati E, Candelise L Tags: Curr Med Chem Source Type: research

Serum lipoprotein(a) complexes with beta2-glycoprotein I levels in patients with ischemic stroke.
CONCLUSIONS: Serum β2-GPI-Lp(a) levels were increased in ischemic stroke patients. Elevated β2-GPI-Lp(a) levels were associated with the severity and clinical outcome of ischemic stroke. PMID: 24315780 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - December 4, 2013 Category: Chemistry Authors: Ma L, Wu J, Niu D, Yu R, Song J, Zhang C, Wang J Tags: Clin Chim Acta Source Type: research

Statins in stroke.
Conclusion: Treatment with statins prevents ischemic stroke, especially in patients with high cardiovascular risk and established atherosclerotic disease. It seems that both lipid lowering and pleiotropic effects contribute to these effects. PMID: 31218948 [PubMed - as supplied by publisher]
Source: Current Medicinal Chemistry - June 18, 2019 Category: Chemistry Authors: Aznaouridis K, Masoura C, Vlachopoulos C, Tousoulis D Tags: Curr Med Chem Source Type: research

Virtual Screening of the multi-pathway and multi-gene regulatory molecular mechanism of Dachengqi decoction in the treatment of stroke Based on Network Pharmacology.
CONCLUSION: Based on the methods of network pharmacology and GEO analysis, it was found that, during stroke treatment, DCQD regulates and controls multiple genes and multiple pathways in a synergistic manner, providing a new strategy for stroke treatment. PMID: 32160845 [PubMed - as supplied by publisher]
Source: Combinatorial Chemistry and High Throughput Screening - March 10, 2020 Category: Chemistry Authors: Pei L, Shen X, Yan Y, Tan C, Qu K, Zou J, Wang Y, Ping F Tags: Comb Chem High Throughput Screen Source Type: research

Mesenchymal stem cells for ischemic stroke: progresses and possibilities.
Abstract Stroke is the most common reason of death and quality of life impairments due to neurological deficits in industrialized countries, currently afflicting 15 million people every year, and the numbers are expected to increase, mostly due to population aging. Although some acute phase therapies such as intravenous recombinant tissue plasminogen activator (rt-PA) and more recently endovascular treatment have been identified to improve stroke outcome, these therapies are available only for a small proportion of patients. The social and economic impact of stroke is immense because one of five stroke patient's d...
Source: Current Medicinal Chemistry - February 21, 2016 Category: Chemistry Authors: Ferri AL, Bersano A, Lisini D, Boncoraglio G, Frigerio S, Parati E Tags: Curr Med Chem Source Type: research

Serum levels of endocan and endoglin are associated with large-artery atherosclerotic stroke.
CONCLUSIONS: Endocan levels are higher in patients with LAA stroke and can help in predicting the short-term unfavourable outcome. Endoglin levels are changed after stroke. PMID: 29287901 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - December 26, 2017 Category: Chemistry Authors: He XW, Ke SF, Bao YY, Hong WJ, Shen YG, Li C, Zhu F, Wang E, Jin XP Tags: Clin Chim Acta Source Type: research

Elevated circulating homocysteine and high-sensitivity C-reactive protein jointly predicts post-stroke depression among Chinese patients with acute ischemic stroke.
CONCLUSIONS: Coexistence of both higher HCY and higher hs-CRP in the acute phase of ischemic stroke were associated with subsequent PSD, independently of established conventional risk factors. PMID: 29325799 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - January 8, 2018 Category: Chemistry Authors: Yin J, Zhong C, Zhu Z, Bu X, Xu T, Guo L, Wang X, Zhang J, Cui Y, Li D, Zhang J, Ju Z, Chen CS, Chen J, Zhang Y, He J Tags: Clin Chim Acta Source Type: research

Increased Growth Differentiation Factor 15 Is Associated with Unfavorable Clinical Outcomes of Acute Ischemic Stroke Proteomics and Protein Markers
CONCLUSIONS: High GDF-15 concentrations are independently associated with adverse clinical outcomes of acute ischemic stroke, suggesting that baseline serum GDF-15 could provide additional information to identify ischemic stroke patients at high risk of poor prognosis.
Source: Clinical Chemistry - March 27, 2019 Category: Chemistry Authors: Yin, J., Zhu, Z., Guo, D., Wang, A., Zeng, N., Zheng, X., Peng, Y., Zhong, C., Wang, G., Zhou, Y., Chen, C.-S., Chen, J., Zhang, Y., He, J. Tags: Proteomics and Protein Markers Source Type: research

Neuro-Clinical signatures of language impairments after acute stroke: a VBQ analysis of quantitative native CT scans.
CONCLUSION: In summary, the method applied to nCT scans performed in the acute stage of stroke provided robust and accurate information about brain lesions' location and size, as well as quantitative values. We found that nCT and VBQ analyses areeffective for identifying neural signatures of concomitant language impairments at the individual level, and neuroanatomical maps of aphasia at the population level. The signatures explicate the neurophysiological mechanisms underlying aetiology of the stroke. Ultimately, similar analyses with larger cohorts could lead to a more integrated multimodal model of behavior and brain ana...
Source: Current Topics in Medicinal Chemistry - February 9, 2020 Category: Chemistry Authors: Muller S, Dauyey K, Ruef A, Lorio S, Eskandari A, Schneider L, Beaud V, Roggenhofer E, Draganski B, Michel P, Kherif F Tags: Curr Top Med Chem Source Type: research

Ultrasound controlled anti-inflammatory polarization of platelet decorated microglia for targeted ischemic stroke therapy.
Abstract Stroke is a neurological disease with poor prognosis. Strong inflammatory and immune response exist after stroke, resulting in severe sequelae with high mortality. Microglia, the main immune cell in cerebrum, possess therapeutic potential for stroke as its specific anti-inflammatory phenotype can reduce inflammation and promote neuron regeneration. However, the on-demand anti-inflammatory polarization of microglia at stroke site is uncontrollable for therapeutic application. Here, we develop a platelet hybrid microglia platform which can specifically polarize to anti-inflammatory phenotype by ultrasound i...
Source: Angewandte Chemie - December 1, 2020 Category: Chemistry Authors: Li J, Li Y, Teng X, Yang C, Wang Y, Wang L, Dai Y, Sun H Tags: Angew Chem Int Ed Engl Source Type: research

Community planning for a "healthy built environment" via a human-environment nexus? A multifactorial assessment of environmental characteristics and age-specific stroke mortality in Hong Kong
In conclusion, urban plans and designs for stroke mortality prevention should implement age-specific health care to neighborhoods with particular population segments.PMID:34543905 | DOI:10.1016/j.chemosphere.2021.132043
Source: Chemosphere - September 20, 2021 Category: Chemistry Authors: Hung Chak Ho Huagui Guo Ta-Chien Chan Yuan Shi Chris Webster Kenneth N K Fong Source Type: research