Filtered By:
Specialty: Chemistry

This page shows you your search results in order of relevance. This is page number 7.

Order by Relevance | Date

Total 791 results found since Jan 2013.

Thrombomodulin - a New Target for Treating Stroke at the Crossroad of Coagulation and Inflammation.
Abstract Thrombomodulin (TM) is a membrane protein mainly expressed by endothelial cells. It is part of the anticoagulant protein C system but recently several effects were discovered which occur independently of protein C activation. TM binds thrombin and promotes the cleavage of protein C and the thrombin activatable fibrinolysis inhibitor (TAFI), thereby inhibiting coagulation and fibrinolysis. Additionally, it interferes with inflammation, stabilizes barrier function, and increases blood flow under pathological conditions. Recombinant soluble TM protects against tissue damage and partially restores normal func...
Source: Current Medicinal Chemistry - December 28, 2013 Category: Chemistry Authors: Wenzel J, Assmann JC, Schwaninger M Tags: Curr Med Chem Source Type: research

Anti-inflammatory Target of a Novel Thrombolytic Stroke Drug Enzymology
Although ischemic stroke is a major cause of death and disability worldwide, only a small fraction of patients benefit from the current thrombolytic therapy due to a risk of cerebral hemorrhage caused by inflammation. Thus, the development of a new strategy to combat inflammation during thrombolysis is an urgent demand. The small molecule thrombolytic SMTP-7 effectively treats ischemic stroke in several animal models with reducing cerebral hemorrhage. Here we revealed that SMTP-7 targeted soluble epoxide hydrolase (sEH) to suppress inflammation. SMTP-7 inhibited both of the two sEH enzyme activities: epoxide hydrolase (whi...
Source: Journal of Biological Chemistry - December 26, 2014 Category: Chemistry Authors: Matsumoto, N., Suzuki, E., Ishikawa, M., Shirafuji, T., Hasumi, K. Tags: Enzymology Source Type: research

New missions for an old agent: Granulocyte-colony Stimulating Factor in the Treatment of Stroke Patients.
Abstract Granulocyte-colony stimulating factor (G-CSF) has a multimodal neuroprotective profile and the cumulative preclinical data from numerous translational studies statistically confirmed the efficacy of G-CSF as a treatment option in ischemic stroke. G-CSF activates anti-apoptotic, anti-oxidative, and anti-inflammatory signaling pathways and stimulates angiogenesis and neurogenesis. In this review, we summarize the role of G-CSF and the corresponding signal transduction pathways regulated by G-CSF in neuroprotection and discuss its potential as a new drug for stroke treatment. PMID: 25666797 [PubMed - as...
Source: Current Medicinal Chemistry - February 9, 2015 Category: Chemistry Authors: Solaroglu I, Digicaylioglu M, Keles GE, Zhang JH Tags: Curr Med Chem Source Type: research

Biomarkers associated with stroke risk in atrial fibrillation.
Abstract Atrial fibrillation is associated with increased risk for cardioembolic stroke. The risk of cardioembolism is not adequately reduced with the administration of oral anticoagulants, since a number of patients continue to experience thromboembolic events despite receiving anti-thrombotic treatment. Several biomarkers have been proposed to predict cardioembolic stroke in patients with atrial fibrillation. Some of them are already used in the clinical practice, such as D-Dimers, Troponin and brain natriuretic peptide. Novel ones such as the inflammatory growth differentiation factor-15, appear to be promising...
Source: Current Medicinal Chemistry - July 18, 2017 Category: Chemistry Authors: Ioannou A, Papageorgiou N, Falconer D, Rehal O, Sewart E, Zacharia E, Toutouzas K, Vlachopoulos C, Siasos G, Tsioufis C, Tousoulis D Tags: Curr Med Chem Source Type: research

A hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells.
Abstract Heat stroke is a lethal condition which can cause dysfunction in the central nervous system, multi-organ damage and even death. However, there is still limited knowledge of the detailed mechanism about the roles of lysosomes in heat stroke due to lack of effective tools. Herein, we introduce our previously developed hemicyanine with a large D-π-A structure as the key fluorophore to develop a new fluorescent probe (CPY) for ratiometric mapping of lysosomal pH changes in live cells under a heat shock stimulus. PMID: 29670954 [PubMed - as supplied by publisher]
Source: Chemical Communications - April 19, 2018 Category: Chemistry Authors: Wu L, Wang Y, James TD, Jia N, Huang C Tags: Chem Commun (Camb) Source Type: research

Molecules, Vol. 23, Pages 1406: Dexamethasone-Loaded, PEGylated, Vertically Aligned, Multiwalled Carbon Nanotubes for Potential Ischemic Stroke Intervention
Viness Pillay The complete synthesis, optimization, purification, functionalization and evaluation of vertically aligned multiwalled carbon nanotubes (VA-MWCNTs) was reported for potential application in dexamethasone delivery to the ischemic brain tissue. The conditions for high yield were optimized and carbon nanotubes functionalized and PEGylated prior to dexamethasone loading. Morphological changes were confirmed by SEM and TEM. Addition of functional groups to MWCNTs was demonstrated by FTIR. Thermal stability reduced following MWCNTs functionalization as demonstrated in TGA. The presence of carbon at 2&th...
Source: Molecules - June 10, 2018 Category: Chemistry Authors: Patrick P. Komane Pradeep Kumar Thashree Marimuthu Lisa C. du Toit Pierre P. D. Kondiah Yahya E. Choonara Viness Pillay Tags: Article Source Type: research

Molecules, Vol. 24, Pages 1831: A NMR-Based Metabonomics Approach to Determine Protective Effect of a Combination of Multiple Components Derived from Naodesheng on Ischemic Stroke Rats
This study aimed to investigate the protective effect of the ten-component combination derived from NDS (TCNDS) on ischemic stroke rats with a middle cerebral artery occlusion (MCAO) model by integrating an NMR-based metabonomics approach with biochemical assessment. Our results showed that TCNDS could improve neurobehavioral function, decrease the cerebral infarct area, and ameliorate pathological features in MCAO model rats. In addition, TCNDS was found to decrease plasma lactate dehydrogenase (LDH) and malondialdehyde (MDA) production and increase plasma superoxide dismutase (SOD) production. Furthermore, 1H-NMR metabon...
Source: Molecules - May 12, 2019 Category: Chemistry Authors: Lan Luo Jiazhen Kang Qiong He Yue Qi Xingyu Chen Shumei Wang Shengwang Liang Tags: Article Source Type: research

In situ metabolite and lipid analysis of GluN2D-/- and wild-type mice after ischemic stroke using MALDI MSI.
Abstract The N-methyl-D-aspartate (NMDA) receptor is a crucial mediator of pathological glutamate-driven excitotoxicity and subsequent neuronal death in acute ischemic stroke. Although the roles of the NMDAR's composite GluN2A-C subunits have been investigated in this phenomenon, the relative importance of the GluN2D subunit has yet to be evaluated. Herein, GluN2D-/- mice were studied in a model of ischemic stroke using MALDI FT-ICR mass spectrometry imaging to investigate the role of the GluN2D subunit of the NMDA receptor in brain ischemia. GluN2D-/- mice underwent middle cerebral artery occlusion (MCAO) and bra...
Source: Analytical and Bioanalytical Chemistry - February 27, 2020 Category: Chemistry Authors: Andrews WT, Donahue D, Holmes A, Balsara R, Castellino FJ, Hummon AB Tags: Anal Bioanal Chem Source Type: research

Loss of thioredoxin reductase function in a mouse stroke model disclosed by a two-photon fluorescent probe.
We report the first two-photon fluorescent probe of mammalian TrxR (TP-TRFS). TP-TRFS retains high specificity in recognizing TrxR. More importantly, the two-photon absorbing character of TP-TRFS enables it to be used in vivo. With the aid of TP-TRFS, a remarkable decline of the TrxR function was observed in the brain of a mouse model of stroke for the first time, providing a mechanistic link of TrxR dysfunction with stroke. PMID: 33107534 [PubMed - as supplied by publisher]
Source: Chemical Communications - October 27, 2020 Category: Chemistry Authors: Zhao J, Qu Y, Gao H, Zhong M, Li X, Zhang F, Chen Y, Gan L, Hu G, Zhang H, Zhang S, Fang J Tags: Chem Commun (Camb) Source Type: research

Serum ceramide concentrations are associated with depression in patients after ischemic stroke-A two-center case-controlled Study
CONCLUSION: There was a stage-specific association between serum ceramides and PSD, and the potential pathophysiological mechanism has to be investigated in future research.PMID:33775701 | DOI:10.1016/j.cca.2021.03.014
Source: International Journal of Clinical Chemistry - March 29, 2021 Category: Chemistry Authors: Lv Hong Wang Hongmei Xie Leijie Zou Dandan Liu Peng Hu Zhifei Ma Ruimin Shi Yijun Zheng Guanghui Zhang Guojun Source Type: research

Ιmmunity, Vascular Aging, and Stroke
Curr Med Chem. 2022 Jan 3. doi: 10.2174/0929867329666220103101700. Online ahead of print.ABSTRACTStroke is one of the most devastating manifestations of cardiovascular disease. Growing age, arterial hypertension, and atherosclerosis are identified as independent risk factors for stroke, primarily due to structural and functional alterations in the cerebrovascular tree. Recent data from in vitro and clinical studies have suggested that the immune system influences atherosclerosis, promoting vascular stiffness and vascular aging and contributing to ischemic stroke, intracranial haemorrhage and microbleeds, white matter disea...
Source: Current Medicinal Chemistry - January 4, 2022 Category: Chemistry Authors: Anna-Maria Louka Dimitrios Sagris George Ntaios Source Type: research

Molecules, Vol. 27, Pages 1573: Comprehensive Analysis of the Effect of 20(R)-Ginsenoside Rg3 on Stroke Recovery in Rats via the Integrative miRNA & ndash;mRNA Regulatory Network
This study provides new insights into the protective mechanism of 20(R)-Rg3 against CIRI, and the mechanism may be partly associated with the regulation of brain miRNA expression and its target signaling pathways.
Source: Molecules - February 27, 2022 Category: Chemistry Authors: Rui Zhang De-Yun Chen Xing-Wei Luo Yuan Yang Xiao-Chao Zhang Ren-Hua Yang Peng Chen Zhi-Qiang Shen Bo He Tags: Article Source Type: research