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Total 791 results found since Jan 2013.
Integration of ultra-high-pressure liquid chromatography-tandem mass spectrometry with machine learning for identifying fatty acid metabolite biomarkers of ischemic stroke
We report for the first time the integration of ultra-high-pressure liquid chromatography-tandem mass spectrometry with machine learning for identifying fatty acid metabolite biomarkers of ischemic stroke. Especially, we develop an... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - May 8, 2020 Category: Chemistry Authors: Lijian Zhang Source Type: research
Integration of ultra-high-pressure liquid chromatography –tandem mass spectrometry with machine learning for identifying fatty acid metabolite biomarkers of ischemic stroke
Chem. Commun., 2020, Advance Article DOI: 10.1039/D0CC02329A, CommunicationLijian Zhang, Fei Ma, Ao Qi, Lulu Liu, Junjie Zhang, Simin Xu, Qisheng Zhong, Yusen Chen, Chun-yang Zhang, Chun Cai We demonstrated the integration of UHPLC –MS/MS with machine learning for identifying fatty acid metabolite biomarkers of ischemic stroke. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - May 15, 2020 Category: Chemistry Authors: Lijian Zhang Source Type: research
A highly specific probe for the imaging of inflammation-induced endogenous nitric oxide produced during the stroke process
Analyst, 2020, Advance Article DOI: 10.1039/D0AN00824A, PaperChenchen Li, Wei Hu, Jinchen Wang, Xinjian Song, Xiaoxing Xiong, Zhihong Liu A two-photon fluorescent probe with high selectivity and sensitivity was constructed and applied to image stroke-induced NO inflammation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - August 27, 2020 Category: Chemistry Authors: Chenchen Li Source Type: research
An AIE probe for imaging mitochondrial SO2-induced stress and SO2 levels during heat stroke
Chem. Commun., 2020, Advance Article DOI: 10.1039/D0CC05803C, CommunicationXiaopeng Yang, Jun Tang, Di Zhang, Xiaojing Han, Jianfei Liu, Jinsa Li, Yufen Zhao, Yong Ye An AIE-based fluorescent probe was developed for imaging the misregulation of SO2 levels in mitochondria during heat stroke. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - October 8, 2020 Category: Chemistry Authors: Xiaopeng Yang Source Type: research
Observation of inflammation-induced mitophagy during stroke by mitochondria-targeting two-photon ratiometric probe
This study reports the development of a new, pH-sensitive, mitochondria-targeting two-photon ratiometric probe (Mito-BNO) for real-time tracking of mitophagy, a process that accelerates in brain tissue during stroke. Mito-BNO demonstrated... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - February 11, 2021 Category: Chemistry Authors: Fei Cheng Source Type: research
Omentin-1: protective impact on ischemic stroke via ameliorating atherosclerosis
This study is the first to summarize the comprehensive mechanisms between omentin-1 and atherosclerosis and to review the shielding effect of omentin-1 on IS. We shed light on omentin-1 as a novel therapeutic target for combating IS.PMID:33607071 | DOI:10.1016/j.cca.2021.02.004
Source: International Journal of Clinical Chemistry - February 19, 2021 Category: Chemistry Authors: Shiyi Lin Xin Li Jiabei Zhang Yuyang Zhang Source Type: research
Observation of inflammation-induced mitophagy during stroke by a mitochondria-targeting two-photon ratiometric probe
Analyst, 2021, Advance Article DOI: 10.1039/D1AN00208B, PaperFei Cheng, Taotao Qiang, Longfang Ren, Tianyu Liang, Xiaoyang Gao, Baoshuai Wang, Wei Hu The probe we developed is the first visual tool capable of accurate real-time monitoring of mitophagy during stroke. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - March 4, 2021 Category: Chemistry Authors: Fei Cheng Source Type: research
Design, synthesis and biological evaluation of brain penetrant benzazepine-based histone deacetylase 6 inhibitors for alleviating stroke-induced brain infarction
Eur J Med Chem. 2021 Mar 17;218:113383. doi: 10.1016/j.ejmech.2021.113383. Online ahead of print.ABSTRACTHistone deacetylase 6 (HDAC6) has become a promising therapeutic target for central nervous system diseases due to its more complex protein structure and biological functions. However, low brain penetration of reported HDAC6 inhibitors limits its clinical application in neurological disorders. Therefore, the benzazepine, a brain-penetrant rigid fragment, was utilized to design a series of selective HDAC6 inhibitors to improve brain bioavailability. Various synthetic strategies were applied to assemble the tetrahydro-ben...
Source: European Journal of Medicinal Chemistry - April 2, 2021 Category: Chemistry Authors: Zheng Guo Zixue Zhang Yi Zhang Guan Wang Ziyi Huang Qinwei Zhang Jianqi Li Source Type: research
Molecules, Vol. 26, Pages 4473: Synthesis and Biological Assessment of 4,1-Benzothiazepines with Neuroprotective Activity on the Ca2+ Overload for the Treatment of Neurodegenerative Diseases and Stroke
los Ríos
In excitable cells, mitochondria play a key role in the regulation of the cytosolic Ca2+ levels. A dysregulation of the mitochondrial Ca2+ buffering machinery derives in serious pathologies, where neurodegenerative diseases highlight. Since the mitochondrial Na+/Ca2+ exchanger (NCLX) is the principal efflux pathway of Ca2+ to the cytosol, drugs capable of blocking NCLX have been proposed to act as neuroprotectants in neuronal damage scenarios exacerbated by Ca2+ overload. In our search of optimized NCLX blockers with augmented drug-likeness, we herein describe the synthesis and pharmacological characterizatio...
Source: Molecules - July 24, 2021 Category: Chemistry Authors: Luc ía Viejo Marcos Rubio-Alarc ón Raquel L. Arribas Manuel Moreno-Castro Raquel P érez-Marín Mar ía Braun-Cornejo Mart ín Estrada-Valencia Crist óbal de los Ríos Tags: Article Source Type: research
Molecules, Vol. 26, Pages 6124: A Novel Phenylpyrrolidine Derivative: Synthesis and Effect on Cognitive Functions in Rats with Experimental Ishemic Stroke
Vladimir P. Chekhonin
Sophia S. Borisevich
Maxim A. Gureev
Anastasia D. Shagina
Nina M. Kiseleva
Vadim V. Negrebetsky
Yuri I. Baukov
We performed an in silico, in vitro, and in vivo assessment of a potassium 2-[2-(2-oxo-4-phenylpyrrolidin-1-yl) acetamido]ethanesulfonate (compound 1) as a potential prodrug for cognitive function improvement in ischemic brain injury. Using in silico methods, we predicted the pharmacological efficacy and possible safety in rat models. In addition, in silico data showed neuroprotective features of compound 1, which were further supported by in vitro experiments in a glutamate e...
Source: Molecules - October 11, 2021 Category: Chemistry Authors: Denis A. Borozdenko Aiarpi A. Ezdoglian Tatiana A. Shmigol Darya I. Gonchar Dmitri N. Lyakhmun Dmitri V. Tarasenko Yaroslav V. Golubev Elvira A. Cherkashova Daria D. Namestnikova Ilya L. Gubskiy Alexey A. Lagunin Leonid V. Gubsky Vladimir P. Chekhonin Sop Tags: Article Source Type: research
A pump-free microfluidic device for fast magnetic labeling of ischemic stroke biomarkers
Anal Bioanal Chem. 2022 Jan 27. doi: 10.1007/s00216-022-03915-w. Online ahead of print.ABSTRACTThis research proposes a low-cost and simple operation microfluidic chip to enhance the magnetic labeling efficiency of two ischemic stroke biomarkers: cellular fibronectin (c-Fn) and matrix metallopeptidase 9 (MMP9). This fully portable and pump-free microfluidic chip is operated based on capillary attractions without any external power source and battery. It uses an integrated cellulose sponge to absorb the samples. At the same time, a magnetic field is aligned to hold the target labeled by the magnetic nanoparticles (MNPs) in ...
Source: Analytical and Bioanalytical Chemistry - January 28, 2022 Category: Chemistry Authors: Briliant Adhi Prabowo Elisabete Fernandes Paulo Freitas Source Type: research
Molecules, Vol. 27, Pages 1554: The Protective Effects of Hydrogen Sulfide New Donor Methyl S-(4-Fluorobenzyl)-N-(3,4,5-Trimethoxybenzoyl)-l-Cysteinate on the Ischemic Stroke
Lv
Kui Cheng
Kun Chen
In this paper, we report the design, synthesis and biological evaluation of a novel S-allyl-l-cysteine (SAC) and gallic acid conjugate S-(4-fluorobenzyl)-N-(3,4,5-trimethoxybenzoyl)-l-cysteinate (MTC). We evaluate the effects on ischemia-reperfusion-induced PC12 cells, primary neurons in neonatal rats, and cerebral ischemic neuronal damage in rats, and the results showed that MTC increased SOD, CAT, GPx activity and decreased LDH release. PI3K and p-AKT protein levels were significantly increased by activating PI3K/AKT pathway. Mitochondrial pro-apoptotic proteins Bax and Bim levels were reduc...
Source: Molecules - February 25, 2022 Category: Chemistry Authors: Jing Fan Junxi Du Zhongwei Zhang Wenjing Shi Binyan Hu Jiaqin Hu Yan Xue Haipeng Li Wenjin Ji Jian Zhuang Pengcheng Lv Kui Cheng Kun Chen Tags: Article Source Type: research
Hybrid molecules of scutellarein and 3, 5, 6-trimethylpyrazine-2-formic acid linked with polar amino acid for ischemic stroke
AbstractScutellarin has been found to possess a certain protective activity against oxidative damage, and scutellarein has been proved to be the main absorption component of scutellarin in the small intestine. Tertramethylpyrazine is a commonly used antiplatelet drug, and its active metabolite 3, 5, 6-trimethylpyrazine-2-formic acid displays similar pharmacological activities with lower toxicity. Based on the principle of molecular hybridization and previous work, five hybrid molecules of scutellarein and 3, 5, 6-trimethylpyrazine-2-formic acid linked with polar amino acids were synthesized, and their anti-oxidative and an...
Source: Medicinal Chemistry Research - April 22, 2022 Category: Chemistry Source Type: research
