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Total 791 results found since Jan 2013.

Serum LRG1 as a novel biomarker for cardioembolic stroke
CONCLUSION: Serum LRG1 was a promising indicator to predict cardioembolic stroke, as well as stroke severity and the 3-month prognosis of it.PMID:33838125 | DOI:10.1016/j.cca.2021.04.002
Source: International Journal of Clinical Chemistry - April 10, 2021 Category: Chemistry Authors: Meng Zhang Yuan Wang Jing Wang Xuening Li Aijun Ma Xudong Pan Source Type: research

Prognostic molecular markers for motor recovery in acute hemorrhagic stroke: a systematic review
CONCLUSION: This systematic review shows that motor functional recovery can be predicted by 61 independent prognostic molecular biomarkers assessed in the acute phase after a hemorrhagic stroke.PMID:34389283 | DOI:10.1016/j.cca.2021.08.006
Source: International Journal of Clinical Chemistry - August 14, 2021 Category: Chemistry Authors: Jean Alex Matos Ribeiro Luisa Fernanda Garc ía-Salazar C ássia Regina Saade-Pacheco Érika Shirley Moreira Silva Simone Garcia Oliveira Ana Fl ávia Silveira Adriana Sanches Garcia-Ara újo Thiago Luiz Russo Source Type: research

Utility of fibrinogen level for predicting survival and functional outcome in patients with acute ischemic stroke: A meta-analysis
Conclusion Elevated fibrinogen level at baseline is possibly an independent predictor of short-term poor functional outcome and long-term all-cause mortality, particularly in elderly acute ischemic stroke patients. Blood fibrinogen level may serve as a useful biomarker for risk classification of acute ischemic stroke patients.PMID:35909293 | DOI:10.2174/0929867329666220728125624
Source: Current Medicinal Chemistry - August 1, 2022 Category: Chemistry Authors: Juan Xu Yimeng Sun Dandan Gong Yu Fan Source Type: research

Molecules, Vol. 27, Pages 5783: Therapeutic Effect of Icaritin on Cerebral Ischemia-Reperfusion-Induced Senescence and Apoptosis in an Acute Ischemic Stroke Mouse Model
ing-Hwa Liu An ischemic stroke is brain damage caused by interruption of blood supply to the brain that can cause death and long-term disability. New medical strategies or therapies are urgently needed for ischemic stroke. Icaritin (ICT) is a metabolite of icariin (ICA), which are two active flavonoid components extracted from Herba epimedii and considered neuroprotective agents in animal models of Alzheimer’s disease and ischemic stroke. The therapeutic effect of ICT on ischemic still remains to be clarified. The aim of this study was to investigate the therapeutic effect of ICT on cerebral ischemia-repe...
Source: Molecules - September 7, 2022 Category: Chemistry Authors: Cheng-Tien Wu Ting-Hua Yang Man-Chih Chen Siao-Syun Guan Chang-Mu Chen Shing-Hwa Liu Tags: Article Source Type: research

A new multi-parameter imaging platform for in vivo drug efficacy evaluation of ischemic stroke
Talanta. 2023 Aug 28;266(Pt 2):125133. doi: 10.1016/j.talanta.2023.125133. Online ahead of print.ABSTRACTIschemic stroke with high incidence and disability rate severely endangers human health. Current clinical treatment strategies are quite limited, new drugs for ischemic stroke are urgently needed. However, most existing methods for the efficacy evaluation of new drugs possess deficiencies of divorcing from the true biological context, single detection indicator and complex operations, leading to evaluation biases and delaying drug development process. In this work, leveraging the advantages of fluorescence imaging with ...
Source: Talanta - September 2, 2023 Category: Chemistry Authors: Di Su Ran Zhang Xin Wang Qi Ding Feida Che Wen Zhang Wei Wu Ping Li Bo Tang Source Type: research

Minocycline Repurposing in Critical Illness: Focus on Stroke.
Abstract Stroke is a devastating disease associated with high morbidity and mortality. Despite the approved indication of systemic thrombolytic therapy in the United States for the acute management of ischemic stroke, its use is limited given a strict eligibility criteria and a risk for hemorrhagic transformation as a feared adverse effect. Many agents have been studied without success for neuroprotection in patients with stroke to reduce vascular injury and improve long-term functional outcomes. Minocycline is a tetracycline antibiotic that shows promise for its neuroprotective effects in multiple animal models a...
Source: Current Topics in Medicinal Chemistry - September 20, 2013 Category: Chemistry Authors: Vivian Liao T, C Forehand C, Hess DC, Fagan SC Tags: Curr Top Med Chem Source Type: research

The Association between Circulating Endothelial Progenitor Cells and Outcome in Different Subtypes of Acute Ischemic Stroke.
CONCLUSIONS: The number of circulating EPCs is significantly lower in patients with large-vessel disease than in those with small-vessel disease. Fewer EPCs is an independent risk factor for poor 6-month outcome in patients with AIS. PMID: 24076252 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - September 26, 2013 Category: Chemistry Authors: Tsai NW, Hung SH, Huang CR, Chang HW, Chang WN, Lee LH, Wang HC, Lin YJ, Lin WC, Cheng BC, Chiang YF, Su YJ, Tsai TR, Lu CH Tags: Clin Chim Acta Source Type: research

Essential Hypertension, Cerebral White Matter Pathology And Ischemic Stroke.
Abstract Stroke is one of the most-frequent cause of death and the number one cause of disability worldwide. Different mechanisms are related to the pathogenesis of stroke involving multiple biological systems, which are often connected among them. Besides age, hypertension is the most important risk factor for stroke and may also predispose to the development of more subtle cerebral damage based on arteriolar narrowing or pathological microvascular changes. Age and high blood pressure are responsible for silent structural and functional cerebral changes leading to white matter lesions and cognitive impairment. Th...
Source: Current Medicinal Chemistry - December 27, 2013 Category: Chemistry Authors: Sierra C Tags: Curr Med Chem Source Type: research