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Total 791 results found since Jan 2013.

Molecules, Vol. 24, Pages 2323: Advances in Biosynthesis, Pharmacology, and Pharmacokinetics of Pinocembrin, a Promising Natural Small-Molecule Drug
ng Yang Pinocembrin is one of the most abundant flavonoids in propolis, and it may also be widely found in a variety of plants. In addition to natural extraction, pinocembrin can be obtained by biosynthesis. Biosynthesis efficiency can be improved by a metabolic engineering strategy and a two-phase pH fermentation strategy. Pinocembrin poses an interest for its remarkable pharmacological activities, such as neuroprotection, anti-oxidation, and anti-inflammation. Studies have shown that pinocembrin works excellently in treating ischemic stroke. Pinocembrin can reduce nerve damage in the ischemic area and reduce mitochon...
Source: Molecules - June 23, 2019 Category: Chemistry Authors: Xiaoling Shen Yeju Liu Xiaoya Luo Zhihong Yang Tags: Review Source Type: research

Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 concentrations and prognosis of aneurysmal subarachnoid hemorrhage.
CONCLUSIONS: Serum soluble LOX-1 appears to have the potential to become a promising prognostic predictor after human aneurysmal SAH. PMID: 31626762 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - October 14, 2019 Category: Chemistry Authors: Lin Q, Ba HJ, Dai JX, Sun J, Lu C, Chen MH, Chen XD, Cai JY Tags: Clin Chim Acta Source Type: research

Dilated cardiomyopathy mutation in the converter domain of human cardiac myosin alters motor activity and response to omecamtiv mecarbil Molecular Biophysics
We investigated a dilated cardiomyopathy (DCM) mutation (F764L) in human β-cardiac myosin by determining its motor properties in the presence and absence of the heart failure drug omecamtive mecarbil (OM). The mutation is located in the converter domain, a key region of communication between the catalytic motor and lever arm in myosins, and is nearby but not directly in the OM-binding site. We expressed and purified human β-cardiac myosin subfragment 1 (M2β-S1) containing the F764L mutation, and compared it to WT with in vitro motility as well as steady-state and transient kinetics measurements. In the absence of OM we ...
Source: Journal of Biological Chemistry - November 14, 2019 Category: Chemistry Authors: Wanjian Tang, William C. Unrath, Rohini Desetty, Christopher M. Yengo Tags: Enzymology Source Type: research

MicroRNAs in Venous Thrombo-Embolism.
Abstract BACKGROUND: Venous Thrombo-embolism (VTE) is the major preventable cause of death and disability worldwide. It has the third highest incidence rate of hospital death after coronary artery disease (CAD) and stroke. With the establishment of Virchow's triad stating the major factors responsible for VTE including stasis, hypercoagulability and endothelial dysfunction, the last decade reported number of studies regarding its diagnosis and prophylaxis. Till date the most commonly used clinical marker for its diagnosis is the D-dimer test, detecting endogenous fibrinolysis. This test often gives false positive ...
Source: International Journal of Clinical Chemistry - January 31, 2020 Category: Chemistry Authors: Angelina Hembrom A, Srivastava S, Garg I, Kumar B Tags: Clin Chim Acta Source Type: research

Design and synthesis of the ring-opened derivative of 3-n-butylphthalide-ferulic acid-glucose trihybrids as potential anti-ischemic agents
Publication date: Available online 18 February 2020Source: Chinese Chemical LettersAuthor(s): Jianbing Wu, Wei Yin, Yinqiu Zhang, Hui Ye, Yunman Li, Jide Tian, Zhangjian Huang, Yihua ZhangABSTRACTTo improve aqueous solubility and anti-ischemic activity of 3-n-butylphthalide (NBP), we designed and synthesized the ring-opened derivative of NBP-ferulic acid-glucose trihybrids (S1-S8). These hybrids inhibited adenosine diphosphate (ADP)- or arachidonic acid (AA)-induced platelet aggregation, among them, S2 was 30-fold more water-soluble, and over 10-fold more potent in inhibition of platelet aggregation, as well as reduced ROS...
Source: Chinese Chemical Letters - February 19, 2020 Category: Chemistry Source Type: research

CpG preconditioning reduces accumulation of lysophosphatidylcholine in ischemic brain tissue after middle cerebral artery occlusion.
Abstract Ischemic stroke is one of the major causes of death and permanent disability in the world. However, the molecular mechanisms surrounding tissue damage are complex and further studies are needed to gain insights necessary for development of treatment. Prophylactic treatment by administration of cytosine-guanine (CpG) oligodeoxynucleotides has been shown to provide neuroprotection against anticipated ischemic injury. CpG binds to Toll-like receptor 9 (TLR9) causing initialization of an inflammatory response that limits visible ischemic damages upon subsequent stroke. Here, we use nanospray desorption electr...
Source: Analytical and Bioanalytical Chemistry - October 19, 2020 Category: Chemistry Authors: Mavroudakis L, Stevens SL, Duncan KD, Stenzel-Poore MP, Laskin J, Lanekoff I Tags: Anal Bioanal Chem Source Type: research

Utility of serum NOX4 as a potential prognostic biomarker for aneurysmal subarachnoid hemorrhage.
CONCLUSIONS: Serum NOX4 concentrations, in close correlation with hemorrhagic severity, were independently associated with DCI and poor clinical outcome after hemorrhagic stroke, substantializing serum NOX4 as a promising prognostic biomarker for aSAH. PMID: 33607069 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - February 16, 2021 Category: Chemistry Authors: Pan J, Lao L, Shen J, Huang S, Zhang T, Fan W, Yan M, Gu J, Liu W Tags: Clin Chim Acta Source Type: research

Utility of serum NOX4 as a potential prognostic biomarker for aneurysmal subarachnoid hemorrhage
CONCLUSIONS: Serum NOX4 concentrations, in close correlation with hemorrhagic severity, were independently associated with DCI and poor clinical outcome after hemorrhagic stroke, substantializing serum NOX4 as a promising prognostic biomarker for aSAH.PMID:33607069 | DOI:10.1016/j.cca.2021.02.007
Source: International Journal of Clinical Chemistry - February 19, 2021 Category: Chemistry Authors: Jianwei Pan Lingdi Lao Jian Shen Sichong Huang Tiesong Zhang Weijian Fan Ming Yan Jun Gu Wenchao Liu Source Type: research

Molecules, Vol. 26, Pages 1212: Sigma-1 Receptor Agonist TS-157 Improves Motor Functional Recovery by Promoting Neurite Outgrowth and pERK in Rats with Focal Cerebral Ischemia
o Pang Li-Fang Yu Sigma-1 (σ-1) receptor agonists are considered as potential treatment for stroke. TS-157 is an alkoxyisoxazole-based σ-1 receptor agonist previously discovered in our group. The present study describes TS-157 profile in a battery of tests for cerebral ischemia. Initial evaluation demonstrated the compound’s safety profile and blood–brain barrier permeability, as well as its ability to induce neurite outgrowth in vitro. The neurite outgrowth was shown to be mediated via σ-1 receptor agonism and involves upregulation of ERK phosphorylation (pERK). In particular, TS-157 also significantly accele...
Source: Molecules - February 24, 2021 Category: Chemistry Authors: Jun-Jie Shi Qi-Hui Jiang Tian-Ning Zhang Hao Sun Wen-Wen Shi Hendra Gunosewoyo Fan Yang Jie Tang Tao Pang Li-Fang Yu Tags: Article Source Type: research

Long-term tracking and dynamically quantifying of reversible changes of extracellular Ca2+ in multiple brain regions of freely moving animals
Angew Chem Int Ed Engl. 2021 Apr 1. doi: 10.1002/anie.202102833. Online ahead of print.ABSTRACTUnderstanding physiological and pathological processes in the brain requires tracking the reversible changes in chemical signals with long-term stability. We developed a new anti-biofouling microfiber array to real-time quantify extracellular Ca 2+ concentrations together with neuron activity across many regions in the mammalian brain for 60 days, in which the signal degradation was < ∼8%. The developed microarray with high tempo-spatial resolution (∼10 μm, ∼1.3 s) was implanted into 7 brain regions of free-moving mice ...
Source: Angewandte Chemie - April 2, 2021 Category: Chemistry Authors: Yuandong Liu Zhichao Liu Fan Zhao Yang Tian Source Type: research

Role Of Glp-1 Analogs In The Management Of Diabetes And Its Secondary Complication
Mini Rev Med Chem. 2021 Apr 21. doi: 10.2174/1389557521666210422114909. Online ahead of print.ABSTRACTThe cardiovascular complications of type 2 diabetes mellitus (T2DM) include myocardial infarction, heart failure, peripheral vascular disease and, stroke and retinopathy, nephropathy and neuropathy are microvascular complications. While the newer therapies like glitazones or even dipeptidyl-peptidase-IV (DPP-IV) inhibitors increase the risk of therapy, the Glucagon Like Peptide-1 Receptor Agonists (GLP-1RAs), were reported as suitable alternates. The GLP-1RAs reduce the major adverse cardiovascular events (MACE), have anti...
Source: Mini Reviews in Medicinal Chemistry - April 23, 2021 Category: Chemistry Authors: Ponnurengam Malliappan Sivakumar B Premkumar Prabhawathi Veluchamy Pranav Kumar Prabhakar Source Type: research